Potassium Channels

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  Subject Areas on Research

  • 3,4-Diaminopyridine (DAP) in the treatment of Lambert-Eaton myasthenic syndrome (LEMS). 
  • 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. 
  • A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations. 
  • A high-density genome-wide association screen of sporadic ALS in US veterans. 
  • A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. 
  • A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. 
  • A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. 
  • ATP-sensitive K+ channels in a plasma membrane H+-ATPase mutant of the yeast Saccharomyces cerevisiae. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor. 
  • Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. 
  • Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating. 
  • Adenosine A(3)-receptor stimulation attenuates postischemic dysfunction through K(ATP) channels. 
  • Alteration and restoration of K+ channel function by deletions at the N- and C-termini. 
  • Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation. 
  • Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus. 
  • Antiplatelet effects of a novel antianginal agent, nicorandil. 
  • Asymmetrical electrically induced injury of rabbit ventricular myocytes. 
  • Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore. 
  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. 
  • Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. 
  • Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta. 
  • Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. 
  • Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management. 
  • Cardiac transient outward potassium current: a pulse chemistry model of frequency-dependent properties. 
  • Case 4--1997. The role of ischemic preconditioning during minimally invasive coronary artery bypass surgery. 
  • Channel shutdown: a response of hippocampal neurons to adverse environments. 
  • Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. 
  • Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells. 
  • Cholecystokinin action on layer 6b neurons in somatosensory cortex. 
  • Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension. 
  • Clinical relevance of defects in signalling pathways. 
  • Computer simulations of neuron-glia interactions mediated by ion flux. 
  • Control of K+ channels by G proteins. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Defective potassium currents in ataxia telangiectasia fibroblasts. 
  • Defining G protein beta gamma specificity for effector recognition. 
  • Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. 
  • Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants. 
  • Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. 
  • Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus. 
  • Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning. 
  • Does age affect response to quinidine in patients with KCNT1 mutations? Report of three new cases and review of the literature. 
  • Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves. 
  • Effects of hypertonia on voltage-gated ion currents in freshly isolated hippocampal neurons, and on synaptic currents in neurons in hippocampal slices. 
  • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. 
  • Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells. 
  • Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. 
  • Expression of a Cs(+)-resistant guard cell K+ channel confers Cs(+)-resistant, light-induced stomatal opening in transgenic arabidopsis. 
  • Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. 
  • Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. 
  • Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. 
  • Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. 
  • GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. 
  • Gating currents from a delayed rectifier K+ channel with altered pore structure and function. 
  • Gene-gene Interaction Analyses for Atrial Fibrillation. 
  • Genetic engineering of somatic cells to study and improve cardiac function. 
  • Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. 
  • High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors. 
  • Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking. 
  • Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells. 
  • Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion. 
  • Inhibitory and excitatory mechanisms underlying auditory responses to learned vocalizations in the songbird nucleus HVC. 
  • Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics. 
  • Introduction to the idiopathic epilepsies. 
  • Ion channels: an open and shut case. 
  • Ion regulation in the brain: implications for pathophysiology. 
  • Isaacs' syndrome as a potassium channelopathy of the nerve. 
  • Isoflurane provides long-term protection against focal cerebral ischemia in the rat. 
  • Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels. 
  • Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. 
  • K channel gating by an affinity-switching selectivity filter. 
  • Kv3.1b is a novel component of CNS nodes. 
  • Lambert-Eaton myasthenic syndrome: electrodiagnostic findings and response to treatment. 
  • Localization of the activation gate for small conductance Ca2+-activated K+ channels. 
  • Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood. 
  • Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons. 
  • Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. 
  • Metabolic coupling factors in pancreatic beta-cell signal transduction. 
  • Metabolic cycling in control of glucose-stimulated insulin secretion. 
  • Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. 
  • Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. 
  • Molecular basis for interactions of G protein betagamma subunits with effectors. 
  • Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome. 
  • Neurotrophins differentially regulate voltage-gated ion channels. 
  • Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. 
  • Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. 
  • On the mechanism of action of antiarrhythmic agents. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells. 
  • Patterns of internal and external tetraethylammonium block in four homologous K+ channels. 
  • Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10). 
  • Photochemical control of endogenous ion channels and cellular excitability. 
  • Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes. 
  • Potassium channels regulate cholecystokinin secretion in STC-1 cells. 
  • Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica. 
  • Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel. 
  • Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart. 
  • Quinidine in the treatment of KCNT1-positive epilepsies. 
  • Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein. 
  • Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle. 
  • Regulation of cholecystokinin secretion by ATP-sensitive potassium channels. 
  • Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide. 
  • Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats. 
  • Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. 
  • Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. 
  • TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction. 
  • Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The cardiac vulnerable period and reentrant arrhythmias: targets of anti- and proarrhythmic processes. 
  • The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina. 
  • The variability of the electrical properties of the pulmonary veins. 
  • Trigeminal nerve responses in the rat elicited by chemical stimulation of the tongue. 
  • Two-dimensional crystallization and projection structure of KcsA potassium channel. 
  • Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. 
  • Voltage-dependent action of valproate on potassium channels in frog node of Ranvier. 
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  Keywords of People

  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology