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Subject Areas on Research
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3,4-Diaminopyridine (DAP) in the treatment of Lambert-Eaton myasthenic syndrome (LEMS).
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3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
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A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations.
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A high-density genome-wide association screen of sporadic ALS in US veterans.
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A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.
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A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.
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A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits.
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ATP-sensitive K+ channels in a plasma membrane H+-ATPase mutant of the yeast Saccharomyces cerevisiae.
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Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains.
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Activation of the 9E3/cCAF chemokine by phorbol esters occurs via multiple signal transduction pathways that converge to MEK1/ERK2 and activate the Elk1 transcription factor.
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Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits.
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Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.
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Adenosine A(3)-receptor stimulation attenuates postischemic dysfunction through K(ATP) channels.
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Alteration and restoration of K+ channel function by deletions at the N- and C-termini.
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Antidromic propagation of action potentials in branched axons: implications for the mechanisms of action of deep brain stimulation.
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Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.
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Antiplatelet effects of a novel antianginal agent, nicorandil.
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Asymmetrical electrically induced injury of rabbit ventricular myocytes.
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Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore.
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Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice.
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Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs.
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Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.
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Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels.
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Calcium-activated potassium channels mask vascular dysfunction associated with oxidized LDL exposure in rabbit aorta.
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Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma.
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Cardiac repolarization: current knowledge, critical gaps, and new approaches to drug development and patient management.
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Cardiac transient outward potassium current: a pulse chemistry model of frequency-dependent properties.
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Case 4--1997. The role of ischemic preconditioning during minimally invasive coronary artery bypass surgery.
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Channel shutdown: a response of hippocampal neurons to adverse environments.
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Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias.
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Characterization of ATP-sensitive potassium channels in intestinal, cholecystokinin-secreting cells.
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Cholecystokinin action on layer 6b neurons in somatosensory cortex.
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Clinical pharmacokinetics of pinacidil, a potassium channel opener, in hypertension.
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Clinical relevance of defects in signalling pathways.
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Computer simulations of neuron-glia interactions mediated by ion flux.
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Control of K+ channels by G proteins.
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Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse.
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Defective potassium currents in ataxia telangiectasia fibroblasts.
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Defining G protein beta gamma specificity for effector recognition.
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Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.
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Differential abscisic acid regulation of guard cell slow anion channels in Arabidopsis wild-type and abi1 and abi2 mutants.
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Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK.
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Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus.
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Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability.
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Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.
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Distinct cardioprotective mechanisms of immediate, early and delayed ischaemic postconditioning.
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Does age affect response to quinidine in patients with KCNT1 mutations? Report of three new cases and review of the literature.
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Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves.
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Effects of hypertonia on voltage-gated ion currents in freshly isolated hippocampal neurons, and on synaptic currents in neurons in hippocampal slices.
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Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway.
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Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells.
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Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.
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Expression of a Cs(+)-resistant guard cell K+ channel confers Cs(+)-resistant, light-induced stomatal opening in transgenic arabidopsis.
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Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.
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Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade.
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Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.
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Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.
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GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.
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Gating currents from a delayed rectifier K+ channel with altered pore structure and function.
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Gene-gene Interaction Analyses for Atrial Fibrillation.
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Genetic engineering of somatic cells to study and improve cardiac function.
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Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
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High-threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.
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Hysteresis in human HCN4 channels: a crucial feature potentially affecting sinoatrial node pacemaking.
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Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
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Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion.
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Inhibitory and excitatory mechanisms underlying auditory responses to learned vocalizations in the songbird nucleus HVC.
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Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics.
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Introduction to the idiopathic epilepsies.
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Ion channels: an open and shut case.
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Ion regulation in the brain: implications for pathophysiology.
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Isaacs' syndrome as a potassium channelopathy of the nerve.
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Isoflurane provides long-term protection against focal cerebral ischemia in the rat.
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Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels.
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Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.
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K channel gating by an affinity-switching selectivity filter.
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Kv3.1b is a novel component of CNS nodes.
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Lambert-Eaton myasthenic syndrome: electrodiagnostic findings and response to treatment.
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Localization of the activation gate for small conductance Ca2+-activated K+ channels.
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Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood.
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Low external NaCl concentration and low osmolarity enhance voltage-gated Ca currents but depress K currents in freshly isolated rat hippocampal neurons.
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Mechanisms of spreading depression and hypoxic spreading depression-like depolarization.
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Metabolic coupling factors in pancreatic beta-cell signal transduction.
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Metabolic cycling in control of glucose-stimulated insulin secretion.
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Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels.
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Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle.
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Molecular basis for interactions of G protein betagamma subunits with effectors.
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Multiple different missense mutations in the pore region of HERG in patients with long QT syndrome.
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Neurotrophins differentially regulate voltage-gated ion channels.
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Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
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Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome.
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On the mechanism of action of antiarrhythmic agents.
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Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
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Patch-clamp recording methods for examining adrenergic regulation of potassium currents in ocular epithelial cells.
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Patterns of internal and external tetraethylammonium block in four homologous K+ channels.
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Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10).
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Photochemical control of endogenous ion channels and cellular excitability.
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Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes.
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Potassium channels regulate cholecystokinin secretion in STC-1 cells.
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Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica.
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Pulmonary vasodilator responses to RP 52891 are mediated by activation of a glibenclamide-sensitive K+ATP channel.
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Quinidine blocks adenosine 5'-triphosphate-sensitive potassium channels in heart.
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Quinidine in the treatment of KCNT1-positive epilepsies.
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Reconstitution of Ca(2+)-dependent K+ transport in erythrocyte membrane vesicles requires a cytoplasmic protein.
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Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle.
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Regulation of cholecystokinin secretion by ATP-sensitive potassium channels.
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Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide.
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Role of K+ATP channels and EDRF in reactive hyperemia in the hindquarters vascular bed of cats.
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Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling.
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Stimulation of secretion by the T84 colonic epithelial cell line with dietary flavonols.
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Structural conservation of ion conduction pathways in K channels and glutamate receptors.
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Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin.
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TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
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Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice.
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The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening.
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The cardiac vulnerable period and reentrant arrhythmias: targets of anti- and proarrhythmic processes.
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The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina.
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The variability of the electrical properties of the pulmonary veins.
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Trigeminal nerve responses in the rat elicited by chemical stimulation of the tongue.
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Two-dimensional crystallization and projection structure of KcsA potassium channel.
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Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease.
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Voltage-dependent action of valproate on potassium channels in frog node of Ranvier.
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