Sodium Channels

• 

  Subject Areas on Research

  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defect. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. 
  • A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance. 
  • A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. 
  • A proarrhythmic response to sodium channel blockade: modulation of the vulnerable period in guinea pig ventricular myocardium. 
  • A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides. 
  • A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach. 
  • A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids. 
  • A source of bias in the analysis of single channel data: assessing the apparent interaction between channel proteins. 
  • A voltage-gated calcium-selective channel encoded by a sodium channel-like gene. 
  • Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. 
  • Acidic stimuli activates two distinct pathways in taste receptor cells from rat fungiform papillae. 
  • Action of six pyrethrins purified from the botanical insecticide pyrethrum on cockroach sodium channels expressed in Xenopus oocytes. 
  • Aldosterone, ion channels, and sudden death: another piece of the circle? 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. 
  • Analysis of the action of lidocaine on insect sodium channels. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Basic concepts in cellular cardiac electrophysiology: Part II: Block of ion channels by antiarrhythmic drugs. 
  • Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels. 
  • Being there: cellular targeting of voltage-gated sodium channels in the heart. 
  • Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways. 
  • Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones. 
  • Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells. 
  • Blockade of cardiac sodium channels by amitriptyline and diphenylhydantoin. Evidence for two use-dependent binding sites. 
  • Blockade of cardiac sodium channels by lidocaine. Single-channel analysis. 
  • Blockade of cardiac sodium channels. Competition between the permeant ion and antiarrhythmic drugs. 
  • Blockade of rabbit atrial sodium channels by lidocaine. Characterization of continuous and frequency-dependent blocking. 
  • Brugada-like syndrome in infancy presenting with rapid ventricular tachycardia and intraventricular conduction delay. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. 
  • Calmodulin mediates Ca2+ sensitivity of sodium channels. 
  • Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons. 
  • Cardiac instability amplified by use-dependent Na channel blockade. 
  • Changes in anisotropic conduction caused by remodeling cell size and the cellular distribution of gap junctions and Na(+) channels. 
  • Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers. 
  • Characterization of two kdr mutations at predicted pyrethroid receptor site 2 in the sodium channels of Aedes aegypti and Nilaparvata lugens. 
  • Charge substitutions at the voltage-sensing module of domain III enhance actions of site-3 and site-4 toxins on an insect sodium channel. 
  • Chronic IL-1beta signaling potentiates voltage-dependent sodium currents in trigeminal nociceptive neurons. 
  • Chronology of sodium channel mutations associated with pyrethroid resistance in Aedes aegypti. 
  • Clinical relevance of defects in signalling pathways. 
  • Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. 
  • Combination ethacizin and ethmozin treatment of resistant ventricular ectopy: theoretical, experimental, and clinical study. 
  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. 
  • Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. 
  • Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. 
  • De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay. 
  • Detection of a new pyrethroid resistance mutation (V410L) in the sodium channel of Aedes aegypti: a potential challenge for mosquito control. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster. 
  • Dinucleotide repeat polymorphisms at the SCN4A locus suggest allelic heterogeneity of hyperkalemic periodic paralysis and paramyotonia congenita. 
  • Discovery of a Novel Series of Tricyclic Oxadiazine 4a-Methyl Esters Based on Indoxacarb as Potential Sodium Channel Blocker/Modulator Insecticides. 
  • Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. 
  • Distinct roles of the DmNav and DSC1 channels in the action of DDT and pyrethroids. 
  • Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • Effect of a fluvalinate-resistance-associated sodium channel mutation from varroa mites on cockroach sodium channel sensitivity to fluvalinate, a pyrethroid insecticide. 
  • Effect of cocaine and cocaine congeners on veratridine-induced depolarization in mouse cerebrocortical synaptoneurosomes. 
  • Effects of stochastic sodium channels on extracellular excitation of myelinated nerve fibers. 
  • Electrophysiological basis and genetics of Brugada syndrome. 
  • Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. 
  • Evidence that there is no direct correlation between alpha 2-adrenoceptor antagonism and inhibition of voltage-dependent sodium channels. 
  • Evolutionary adaptation of the amino acid and codon usage of the mosquito sodium channel following insecticide selection in the field mosquitoes. 
  • Existence of both fast and slow channel activity during the early stages of ventricular fibrillation. 
  • Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue. 
  • Extracellular pH modulates block of both sodium and calcium channels by nicardipine. 
  • FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons. 
  • Fast and slow gating of sodium channels encoded by a single mRNA. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Field stimulation of isolated chick heart cells: comparison of experimental and theoretical activation thresholds. 
  • Functional expression of an arachnid sodium channel reveals residues responsible for tetrodotoxin resistance in invertebrate sodium channels. 
  • Genetic engineering of somatic cells to study and improve cardiac function. 
  • Genome-wide association studies of the PR interval in African Americans. 
  • How spike generation mechanisms determine the neuronal response to fluctuating inputs. 
  • Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. 
  • Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding. 
  • Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel. 
  • Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. 
  • Impaired firing and sodium channel function in CA1 hippocampal interneurons after transient cerebral ischemia. 
  • Induction of sodium channel clustering by oligodendrocytes. 
  • Inhibition of cardiac Na+ currents by isoproterenol. 
  • Insect sodium channels and insecticide resistance. 
  • Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure. 
  • Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport. 
  • Ischemic modulation of vulnerable period and the effects of pharmacological treatment of ischemia-induced arrhythmias: a simulation study. 
  • Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. 
  • Kinetics of interaction of the lidocaine metabolite glycylxylidide with the cardiac sodium channel. Additive blockade with lidocaine. 
  • Kv3.1b is a novel component of CNS nodes. 
  • Lack of variation in voltage-gated sodium channels of common bottlenose dolphins (Tursiops truncatus) exposed to neurotoxic algal blooms. 
  • Late Na channels in cardiac cells: the physiological role of background Na channels. 
  • Lidocaine blockade of continuously and transiently accessible sites in cardiac sodium channels. 
  • Linkage of kdr-type resistance and the para-homologous sodium channel gene in German cockroaches (Blattella germanica). 
  • Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation. 
  • Mapping the interaction surface of scorpion β-toxins with an insect sodium channel. 
  • Marked QRS complex abnormalities and sodium channel blockade by propoxyphene reversed with lidocaine. 
  • Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila. 
  • Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial. 
  • Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. 
  • Models of drug interaction with the sodium channel. 
  • Molecular and functional characterization of a novel sodium channel TipE-like auxiliary subunit from the American cockroach Periplaneta americana. 
  • Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster. 
  • Molecular basis of differential sensitivity of insect sodium channels to DCJW, a bioactive metabolite of the oxadiazine insecticide indoxacarb. 
  • Molecular biology of insect sodium channels and pyrethroid resistance. 
  • Molecular biology of sodium channels and their role in cardiac arrhythmias. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori. 
  • Molecular characterization of an arachnid sodium channel gene from the varroa mite (Varroa destructor). 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Molecular determinants on the insect sodium channel for the specific action of type II pyrethroid insecticides. 
  • Molecular evidence for dual pyrethroid-receptor sites on a mosquito sodium channel. 
  • Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • Multiple arrhythmic syndromes in a newborn, owing to a novel mutation in SCN5A. 
  • Multiple effects of KPQ deletion mutation on gating of human cardiac Na+channels expressed in mammalian cells. 
  • Multiple mutations and mutation combinations in the sodium channel of permethrin resistant mosquitoes, Culex quinquefasciatus. 
  • Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels. 
  • Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics. 
  • Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance. 
  • Na channel kinetics remain stable during perforated-patch recordings. 
  • Na+ channel function, regulation, structure, trafficking and sequestration. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • Neurotrophin regulation of ionic currents and cell size depends on cell context. 
  • Neurotrophins differentially regulate voltage-gated ion channels. 
  • Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. 
  • Novel Brugada SCN5A mutation causing sudden death in children. 
  • Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides. 
  • Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin. 
  • On the mechanism of action of antiarrhythmic agents. 
  • Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine. 
  • PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. 
  • Pain perception is altered by a nucleotide polymorphism in SCN9A. 
  • Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. 
  • Pharmacologically defined components of the normal porcine multifocal ERG. 
  • Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels. 
  • Polarized localization of voltage-gated Na+ channels is regulated by concerted FGF13 and FGF14 action. 
  • Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes. 
  • Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments. 
  • RNA editing generates tissue-specific sodium channels with distinct gating properties. 
  • Role of sodium channel deglycosylation in the genesis of cardiac arrhythmias in heart failure. 
  • Selective suppression of in vitro electrographic seizures by low-dose tetrodotoxin: a novel anticonvulsant effect. 
  • Sensitivity analysis of a model of mammalian neural membrane. 
  • Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels. 
  • Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue. 
  • Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. 
  • Sodium channel activation underlies transfluthrin repellency in Aedes aegypti. 
  • Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion. 
  • Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease. 
  • Sodium channels and mammalian sensory mechanotransduction. 
  • Solution structure of the NaV1.2 C-terminal EF-hand domain. 
  • Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. 
  • State dependence of ethacizin and ethmozin block of sodium current in voltage clamped and internally perfused cardiac Purkinje cells. 
  • Structural basis of diverse membrane target recognitions by ankyrins. 
  • Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. 
  • Suppression of the tetrodotoxin-resistant sodium channel (PN3/SNS): a possible new treatment for bladder pain. 
  • Synergistic interaction between two cockroach sodium channel mutations and a tobacco budworm sodium channel mutation in reducing channel sensitivity to a pyrethroid insecticide. 
  • Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice. 
  • Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita. 
  • The Drosophila Sodium Channel 1 (DSC1): The founding member of a new family of voltage-gated cation channels. 
  • The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. 
  • The cardiac sodium channel: a target for antiarrhythmic drug action. 
  • The cardiac vulnerable period and reentrant arrhythmias: targets of anti- and proarrhythmic processes. 
  • The differential preference of scorpion alpha-toxins for insect or mammalian sodium channels: implications for improved insect control. 
  • The insecticidal potential of scorpion beta-toxins. 
  • The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. 
  • The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. 
  • The protein tyrosine kinase inhibitor, genistein, decreases excitability of nociceptive neurons. 
  • The role of inactivation in open-channel block of the sodium channel: studies with inactivation-deficient mutant channels. 
  • Topology of an amiloride-binding protein. 
  • Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes. 
  • Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction. 
  • Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain. 
  • Trigeminal nerve responses in the rat elicited by chemical stimulation of the tongue. 
  • Two novel sodium channel mutations associated with resistance to indoxacarb and metaflumizone in the diamondback moth, Plutella xylostella. 
  • Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. 
  • Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat. 
  • Use of ionic currents to identify and estimate parameters in models of channel blockade. 
  • Use of non-mammalian alternative models for neurotoxicological study. 
  • VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. 
  • Voltage-independent effects of extracellular K+ on the Na+ current and phase 0 of the action potential in isolated cardiac myocytes. 
  • What happens when cardiac Na channel function is compromised? 2. Numerical studies of the vulnerable period in tissue altered by drugs. 
  • What happens when cardiac Na channels lose their function? 1--numerical studies of the vulnerable period in tissue expressing mutant channels. 
  • beta-Adrenergic action on wild-type and KPQ mutant human cardiac Na+ channels: shift in gating but no change in Ca2+:Na+ selectivity. 
  • pH dependence of kinetics and steady-state block of cardiac sodium channels by lidocaine. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Jabba, Sairam V., Research Scientist, Anesthesiology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Starmer, Charles Franklin, Professor Emeritus of Computer Science, Computer Science