Xenobiotics

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  Subject Areas on Research

  • A role for P-glycoprotein in environmental toxicology. 
  • AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). 
  • Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887. 
  • An approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults. 
  • An enzyme-linked immunosorbent assay for estrogenicity using primary hepatocyte cultures from the channel catfish (Ictalurus punctatus). 
  • Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. 
  • Computational multiscale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function. 
  • Critical windows of exposure for children's health: the reproductive system in animals and humans. 
  • Cytochrome P450 enzymes in chickens: characteristics and induction by xenobiotics. 
  • DEET (N,N-diethyl-m-toluamide) alone and in combination with permethrin increased urinary excretion of 6beta-hydroxycortisol in rats, a marker of hepatic CYP3A induction. 
  • DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase] facilitates redox cycling of menadione in channel catfish (Ictalurus punctatus) cytosol. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. 
  • Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects. 
  • Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. 
  • Glutathione and zebrafish: Old assays to address a current issue. 
  • Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. 
  • In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction. 
  • Infectious diseases of the upper respiratory tract: implications for toxicology studies. 
  • Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. 
  • Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes. 
  • Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. 
  • Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine. 
  • The restoration potential of the Mesopotamian marshes of Iraq. 
  • Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist. 
  • Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary. 
  • Xenobiotic induction of quinone oxidoreductase activity in lens epithelial cells. 
  • Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology