Transducin
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Subject Areas on Research
- A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules.
- Adenylyl cyclase expression and modulation of cAMP in rat taste cells.
- An effector site that stimulates G-protein GTPase in photoreceptors.
- Analysis of the molecular interaction of the farnesyl moiety of transducin through the use of a photoreactive farnesyl analogue.
- Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.
- CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.
- Co-expression of nAChRs and molecules of the bitter taste transduction pathway by epithelial cells of intrapulmonary airways.
- Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.
- Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation.
- Enzymology of GTPase acceleration in phototransduction.
- Fluorescent probes as indicators of conformation changes in transducin on activation.
- Functional comparison of RGS9 splice isoforms in a living cell.
- Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.
- Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.
- Functional roles of the two domains of phosducin and phosducin-like protein.
- Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy.
- G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t.
- G proteins and phototransduction.
- Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.
- Histologic development of the human fovea from midgestation to maturity.
- Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.
- Interacting targets of the farnesyl of transducin gamma-subunit.
- Interaction sites of the C-terminal region of the cGMP phosphodiesterase inhibitory subunit with the GDP-bound transducin alpha-subunit.
- Interaction sites of the COOH-terminal region of the gamma subunit of cGMP phosphodiesterase with the GTP-bound alpha subunit of transducin.
- Kinetic approaches to study the function of RGS9 isoforms.
- Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras.
- Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation.
- Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
- Mechanisms regulating variability of the single photon responses of mammalian rod photoreceptors.
- Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.
- Molecular basis for interactions of G protein betagamma subunits with effectors.
- Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium.
- Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation.
- Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity.
- On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision.
- Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.
- Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: developmental expression of mRNAs and proteins and light/dark cycling of mRNAs.
- Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.
- Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.
- Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.
- Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity.
- Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
- RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex.
- Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP.
- Regulation of transducin GTPase activity in bovine rod outer segments.
- Role for the target enzyme in deactivation of photoreceptor G protein in vivo.
- Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
- Structural requirements of the photoreceptor phosphodiesterase gamma-subunit for inhibition of rod PDE6 holoenzyme and for its activation by transducin.
- The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.
- The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit.
- The alpha-helical domain of Galphat determines specific interaction with regulator of G protein signaling 9.
- The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin.
- The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein.
- The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
- Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments.
- Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems.
- Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.
- Transducin translocation in rods is triggered by saturation of the GTPase-activating complex.
- Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.
- Transducin β-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.
- Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin.
- cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.
- cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.
- mRNAs coding for proteins of the cGMP cascade in the degenerative retina of the rd mouse.
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Keywords of People
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology