Gene Rearrangement

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  Subject Areas on Research

  • A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. 
  • A Therapeutic Antibody for Cancer, Derived from Single Human B Cells. 
  • A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. 
  • A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • AID: a riddle wrapped in a mystery inside an enigma. 
  • ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. 
  • Absence of genomic BRCA1 and BRCA2 rearrangements in Ashkenazi breast and ovarian cancer families. 
  • Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements. 
  • Assessment of individuals with BRCA1 and BRCA2 large rearrangements in high-risk breast and ovarian cancer families. 
  • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. 
  • BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. 
  • CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5. 
  • Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. 
  • Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma. 
  • Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge. 
  • Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. 
  • Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. 
  • Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia. 
  • Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution. 
  • Composite lymphoma of mycosis fungoides and cutaneous small B-cell lymphoma in a 73-year-old male patient. 
  • Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes. 
  • Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. 
  • DNA sequence characterization and molecular evolution of MAT1 and MAT2 mating-type loci of the self-compatible ascomycete mold Neosartorya fischeri. 
  • Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function. 
  • Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells. 
  • Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer. 
  • Diffuse Large B-Cell Lymphoma Version 1.2016. 
  • Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination. 
  • Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL. 
  • Dramatic mitochondrial gene rearrangements in the hermit crab Pagurus longicarpus (Crustacea, anomura). 
  • Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. 
  • Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. 
  • Evidence for Dobzhansky-Muller incompatibilites contributing to the sterility of hybrids between Mimulus guttatus and M. nasutus. 
  • Expanding the Spectrum of EBV-positive Marginal Zone Lymphomas: A Lesion Associated With Diverse Immunodeficiency Settings. 
  • Follicular lymphoma with prominent Dutcher body formation: a pathologic study of 3 cases in comparison with nodal or splenic lymphoplasmacytic lymphoma and marginal zone lymphoma. 
  • Gene segment selection in V(D)J recombination: accessibility and beyond. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Genetic structure and DNA sequences at junctions involved in the rearrangements of Bacillus subtilis strains carrying the trpE26 mutation. 
  • Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis. 
  • Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. 
  • Heart rate decrease during crizotinib treatment and potential correlation to clinical response. 
  • Hepatosplenic T-cell lymphoma: an unusual case of a gamma delta T-cell lymphoma with a blast-like terminal transformation. 
  • High dose cyclophosphamide plus recombinant human granulocyte-colony stimulating factor (rhG-CSF) in the treatment of follicular, low grade non-Hodgkin's lymphoma: CALGB 9150. 
  • High levels of nuclear MYC protein predict the presence of MYC rearrangement in diffuse large B-cell lymphoma. 
  • Hobnail variant of papillary thyroid carcinoma: an institutional case series and molecular profile. 
  • Immunoglobulin gene rearrangement in multiple myeloma: limitations of Southern blot analysis. 
  • Impact of TP53 mutation status on systemic treatment outcome in ALK-rearranged non-small-cell lung cancer. 
  • In situ studies of the antigen-driven somatic hypermutation of immunoglobulin genes. 
  • In situ studies of the germinal center reaction. 
  • Inclusion of a sensitivity control to add a quality-control parameter and improve reproducibility in BCR, immunoglobulin, and T-cell receptor gene-rearrangement studies. 
  • Intracranial Ewing sarcoma. 
  • Localization of the X inactivation centre on the human X chromosome in Xq13. 
  • Mapping of the distal boundary of the X-inactivation center in a rearranged X chromosome from a female expressing XIST. 
  • Molecular analysis of highly enriched populations of T-cell-depleted monocytes. 
  • Molecular evidence of a genotypically novel large T-cell lymphoma after anti-CD4 therapy for refractory mycosis fungoides. 
  • Molecular-Directed Treatment of Differentiated Thyroid Cancer: Advances in Diagnosis and Treatment. 
  • Morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 rearrangements 
  • Multiple genetic lesions in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair. 
  • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. 
  • Neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia and myelodysplastic and myeloproliferative syndromes. 
  • Oncogenes and anti-oncogenes in human central nervous system tumors. 
  • Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization. 
  • PAX8/PPARγ rearrangement in thyroid nodules predicts follicular-pattern carcinomas, in particular the encapsulated follicular variant of papillary carcinoma. 
  • PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer. 
  • Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement. 
  • Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. 
  • Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study. 
  • Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling. 
  • Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. 
  • Recombination between retrotransposons as a source of chromosome rearrangements in the yeast Saccharomyces cerevisiae. 
  • Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial. 
  • Sakacin P non-producing Lactobacillus sakei strains contain homologues of the sakacin P gene cluster. 
  • Sequence signatures of a recent chromosomal rearrangement in Drosophila mojavensis. 
  • Single nucleotide polymorphisms act as modifiers and correlate with the development of medullary and simultaneous medullary/papillary thyroid carcinomas in 2 large, non-related families with the RET V804M proto-oncogene mutation. 
  • Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients. 
  • Structural alterations of the epidermal growth factor receptor gene in human gliomas. 
  • TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome. 
  • The fractionated orthology of Bs2 and Rx/Gpa2 supports shared synteny of disease resistance in the Solanaceae. 
  • The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation. 
  • The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. 
  • The structural basis of repertoire shift in an immune response to phosphocholine. 
  • V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development. 
  • VCL-ALK renal cell carcinoma in children with sickle-cell trait: the eighth sickle-cell nephropathy? 
  • Value of molecular monitoring during the treatment of chronic myeloid leukemia: a Cancer and Leukemia Group B study. 
  • Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene. 
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  Keywords of People

  • Ciofani, Maria, Associate Professor of Immunology, Immunology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Immunology
  • Stoecker, Maggie Marie, Assistant Professor of Pathology, Pathology