Molecular Probes

• 

  Subject Areas on Research

  • A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities. 
  • A new method for studying the interaction between chlorpromazine and phospholipid bilayer. 
  • A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. 
  • Anti-gene padlocks eliminate Escherichia coli based on their genotype. 
  • CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition. 
  • Capturing the mechanical unfolding pathway of a large protein with coiled-coil probes. 
  • Clinical utility of quantitative imaging. 
  • Cultured human trabecular meshwork cells express aquaporin-1 water channels. 
  • Cytochrome P450IIIA activity and cytokine-mediated synthesis of nitric oxide. 
  • Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe. 
  • Design and Characterization of Hyperpolarized ¹⁵ N-BBCP as a H₂ O₂ -Sensing Probe. 
  • Design, synthesis and evaluation of ¹⁵ N- and ¹³ C-labeled molecular probes as hyperpolarized nitric oxide sensors. 
  • Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging. 
  • Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle. 
  • Effect of colloidal gold size on the conformational changes of adsorbed cytochrome c: probing by circular dichroism, UV-visible, and infrared spectroscopy. 
  • Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. 
  • Enhanced adsorption of arsenic onto maghemites nanoparticles: As(III) as a probe of the surface structure and heterogeneity. 
  • FRET efficiency measurement in a molecular tension probe with a low-cost frequency-domain fluorescence lifetime imaging microscope. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. 
  • Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. 
  • Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. 
  • Lanthanide-binding tags as versatile protein coexpression probes. 
  • Liposome-mediated conformation transition of DNA detected by molecular probe: methyl green. 
  • Localization of alpha 2-adrenergic receptor subtypes in the anterior segment of the human eye with selective antibodies. 
  • Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues. 
  • Metal nanoshells. 
  • Methods and challenges in quantitative imaging biomarker development. 
  • Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. 
  • Monitoring intracellular proteins using fluorescence techniques: from protein synthesis and localization to activity. 
  • Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe. 
  • Physiologically regulated alternative splicing patterns of fast troponin T RNA are conserved in mammals. 
  • Plasmonic nanoprobes for intracellular sensing and imaging. 
  • Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. 
  • Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent. 
  • RNA Structural Differentiation: Opportunities with Pattern Recognition. 
  • Reaction mechanism of (6-4) photolyase. 
  • Recent progress in photoacoustic molecular imaging. 
  • Regulation of type II adenylyl cyclase mRNA in rabbit skeletal muscle by chronic motor nerve pacing. 
  • Rotational dynamics of chloroplast ATP synthase in phospholipid vesicles. 
  • Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. 
  • Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407. 
  • Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. 
  • Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction. 
  • Tandem Mass Tag Labeling Facilitates Reversed-Phase Liquid Chromatography-Mass Spectrometry Analysis of Hydrophilic Phosphopeptides. 
  • TaqMan junction probes and the reverse transcriptase polymerase chain reaction: detection of alveolar rhabdomyosarcoma, synovial sarcoma, and desmoplastic small round cell tumor. 
  • Targeting RNA with small molecules: from fundamental principles towards the clinic. 
  • The conformations of the manganese transport regulator of Bacillus subtilis in its metal-free state. 
  • The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. 
  • Three-Dimensional Deep-Tissue Functional and Molecular Imaging by Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT).