Multicenter Studies as Topic

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  Subject Areas on Research

  • "I wish I had seen this test result earlier!": Dissatisfaction with test result management systems in primary care. 
  • 21st century--Reproductive Medicine Network (RMN). 
  • A Community-based Assessment of Skin Care, Allergies, and Eczema (CASCADE): an atopic dermatitis primary prevention study using emollients-protocol for a randomized controlled trial. 
  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator: The VICTORIA Trial. 
  • A Programme for Risk Assessment and Minimisation of Progressive Multifocal Leukoencephalopathy Developed for Vedolizumab Clinical Trials. 
  • A challenge to the therapeutic nihilism of ESPAC-1. 
  • A cooperative network of trained sites for the conduct of a complex clinical trial: a new concept in multicenter clinical research. 
  • A design alternative for two-stage, phase II, multicenter cancer clinical trials. 
  • A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trial. 
  • A method for assembling a collaborative research team from multiple disciplines and academic centers to study the relationships between ECG estimation and MRI measurement of myocardial infarct size. 
  • A multicenter cluster randomized, stepped wedge implementation trial for targeted normoxia in critically ill trauma patients: study protocol and statistical analysis plan for the Strategy to Avoid Excessive Oxygen (SAVE-O2) trial. 
  • A multicenter program for electronic health record screening for patients with heart failure with preserved ejection fraction: Lessons from the DELIVER-EHR initiative. 
  • A multicenter trial of oral zidovudine in children with advanced human immunodeficiency virus disease. The Protocol 043 Study Group. 
  • A multicenter, double-blind, trimethoprim-sulfamethoxazole controlled study of enoxacin in the treatment of patients with complicated urinary tract infections. 
  • A phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy. 
  • A phase II trial for minimally invasive esophagectomy. 
  • A pooled analysis of continued prophylactic efficacy of quadrivalent human papillomavirus (Types 6/11/16/18) vaccine against high-grade cervical and external genital lesions. 
  • A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial. 
  • A simplified prognostic index for chronic lymphocytic leukemia treated with ibrutinib: Results from a multicenter retrospective cohort study. 
  • A simulation based technique to estimate intracluster correlation for a binary variable. 
  • A survey of monitoring practices in cancer clinical trials. 
  • A systematic review of models to predict recruitment to multicentre clinical trials. 
  • A tale of two countries: Insights from the differences in Canadian/American patterns of care for patients with acute coronary syndromes. 
  • A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22. 
  • AIDS-related Pneumocystis carinii pneumonia in older patients. 
  • AUA-recommended Antibiotic Prophylaxis for Primary Penile Implantation Results in a Higher, Not Lower, Risk for Postoperative Infection: A Multicenter Analysis. 
  • Abciximab and bleeding during coronary surgery: results from the EPILOG and EPISTENT trials. Improve Long-term Outcome with abciximab GP IIb/IIIa blockade. Evaluation of Platelet IIb/IIIa Inhibition in STENTing. 
  • Acceptance of HIV testing during prenatal care. Perinatal Guidelines Evaluation Project. 
  • Achieving the Full "PROMISE" of Imaging Outcomes Research. 
  • Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial: study design and rationale. 
  • Acute coronary care in the elderly, part I: Non-ST-segment-elevation acute coronary syndromes: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. 
  • Acute coronary care in the elderly, part II: ST-segment-elevation myocardial infarction: a scientific statement for healthcare professionals from the American Heart Association Council on Clinical Cardiology: in collaboration with the Society of Geriatric Cardiology. 
  • Acute decline in renal function, inflammation, and cardiovascular risk after an acute coronary syndrome. 
  • Adaptation and Implementation of a Family Caregiver Skills Training Program: From Single Site RCT to Multisite Pragmatic Intervention. 
  • Adding injury to insult: fracture risk after stroke in veterans. 
  • Adherence support approaches in biomedical HIV prevention trials: experiences, insights and future directions from four multisite prevention trials. 
  • Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease. 
  • Advances in antithrombotic therapy in acute myocardial infarction: the ExTRACT-TIMI 25 and OASIS-6 Trials. 
  • Allogeneic hematopoietic cell transplantation for primary immune deficiency diseases: current status and critical needs. 
  • An after-school obesity prevention program for African-American girls: the Minnesota GEMS pilot study. 
  • An electronic family health history tool to identify and manage patients at increased risk for colorectal cancer: protocol for a randomized controlled trial. 
  • An evaluation of the combination of sodium phenylbutyrate and taurursodiol for the treatment of amyotrophic lateral sclerosis. 
  • An evaluation of torsemide in patients with heart failure and renal disease. 
  • An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. 
  • Anaemia of CKD--the CHOIR study revisited. 
  • Analysis of electrocardiographic data following use of paroxetine in pediatric depression and obsessive-compulsive disorder. 
  • Analytic considerations in economic evaluations of multinational cardiovascular clinical trials. 
  • Anticoagulants and antiplatelet agents in acute ischemic stroke: report of the Joint Stroke Guideline Development Committee of the American Academy of Neurology and the American Stroke Association (a division of the American Heart Association). 
  • Antigen-specific T-lymphocyte function after cord blood transplantation. 
  • Antivirals for adult patients hospitalized with SARS-CoV-2 infection: A randomized, Phase II/III, multicenter, placebo-controlled, adaptive study, with multiple arms and stages. COALITION COVID-19 BRAZIL IX - REVOLUTIOn: protocol and statistical analysis plan. 
  • Approaches to facilitate institutional review board approval of multicenter research studies. 
  • Are We At Risk of Depriving Patients Lifesaving Cardiac Surgery?: Implications of the ISCHEMIA Trial for Coronary Artery Bypass Graft Surgery. 
  • Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort. 
  • Are large clinical trials in orthopaedic trauma justified? 
  • Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI): a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. 
  • Association Between Results of a Gene Expression Signature Assay and Recurrence-Free Interval in Patients With Stage II Colon Cancer in Cancer and Leukemia Group B 9581 (Alliance). 
  • Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction. 
  • Authorship in a multicenter clinical trial: The Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) Authorship and Publication (HAP) scoring system results. 
  • Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability. 
  • B-cell function in severe combined immunodeficiency after stem cell or gene therapy: a review. 
  • BOugie or stylet in patients UnderGoing Intubation Emergently (BOUGIE): protocol and statistical analysis plan for a randomised clinical trial. 
  • Baseline clinical characteristics of patients recruited into the assessment of treatment with lisinopril and survival study. 
  • Baseline predictors of health-related quality of life after anterior cruciate ligament reconstruction: a longitudinal analysis of a multicenter cohort at two and six years. 
  • Baseline subject characteristics predictive of compliance with study-mandated prostate biopsy in men at risk of prostate cancer: results from REDUCE. 
  • Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease. 
  • Behavioral equipoise: a way to resolve ethical stalemates in clinical research. 
  • Benefit of facilitated percutaneous coronary intervention in high-risk ST-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals. 
  • Blood product transfusion and lung transplant outcomes: A systematic review. 
  • Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group. 
  • Brief educational video plus telecare to enhance recovery for older emergency department patients with acute musculoskeletal pain: study protocol for the BETTER randomized controlled trial. 
  • CT-314 Multicenter Long-Term Follow Up of Allogeneic Hematopoietic Stem Cell Transplantation With Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials. 
  • Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of the Society of Thoracic Surgeons Congenital Heart Database. 
  • Caring for patients with sickle cell disease in North Carolina. 
  • Ceftobiprole versus daptomycin in Staphylococcus aureus bacteremia: a novel protocol for a double-blind, Phase III trial. 
  • Checkpoint inhibitors in hematological malignancies. 
  • China Tongxinluo Study for myocardial protection in patients with Acute Myocardial Infarction (CTS-AMI): Rationale and design of a randomized, double-blind, placebo-controlled, multicenter clinical trial. 
  • Chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes. 
  • Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer. 
  • Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials. 
  • Classification of proliferative vitreoretinopathy used in the silicone study. The Silicone Study Group. 
  • Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II. 
  • Clinical and economic outcomes of liberal versus selective drug-eluting stent use: insights from temporal analysis of the multicenter Evaluation of Drug Eluting Stents and Ischemic Events (EVENT) registry. 
  • Clinical characteristics, process of care, and outcomes of Hispanic patients presenting with non-ST-segment elevation acute coronary syndromes: results from Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA Guidelines (CRUSADE). 
  • Clinical evidence for pharmaconutrition in major elective surgery. 
  • Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study. 
  • Clinical outcomes after implantation of a centrifugal flow left ventricular assist device and concurrent cardiac valve procedures. 
  • Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. 
  • Clinical trial design in neonatal pharmacology: effect of center differences, with lessons from the Pediatric Oncology Cooperative Research experience. 
  • Collaborative planning for formative assessment and cultural appropriateness in the Girls health Enrichment Multi-site Studies (GEMS): a retrospection. 
  • Colorectal cancer: adjuvant chemotherapy for rectal cancer-an unresolved issue. 
  • Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection. 
  • Common design elements of the Girls health Enrichment Multi-site Studies (GEMS). 
  • Common functional localizers to enhance NHP & cross-species neuroscience imaging research. 
  • Community consultation for prehospital research: experiences of study coordinators and principal investigators. 
  • Comparative Effectiveness of Tumor Response Assessment Methods: Standard of Care Versus Computer-Assisted Response Evaluation. 
  • Comparative analysis of perioperative complications between a multicenter prospective cervical deformity database and the Nationwide Inpatient Sample database. 
  • Comparative evaluation of radiometric tryptic soy broth versus radiometric tryptic soy broth with 10% sucrose for detection of bacteremia and fungemia in pediatric patients. 
  • Comparing the Benefit of Novel Therapies Across Clinical Trials: Insights From the VICTORIA Trial. 
  • Comparison between ticlopidine and clopidogrel in patients undergoing primary stenting in acute myocardial infarction: results from the CADILLAC trial. 
  • Comparison of 4 nutrient databases with chemical composition data from the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. 
  • Comparison of academic and nonacademic sites in multi-center clinical trials. 
  • Comparison of outcomes after 8 vs. 9.5 French size intra-aortic balloon counterpulsation catheters based on 9,332 patients in the prospective Benchmark registry. 
  • Comparison of spouse and nonkin controls: the experience of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). 
  • Complications in the surgical treatment of 19,360 cases of pediatric scoliosis: a review of the Scoliosis Research Society Morbidity and Mortality database. 
  • Compound GW506U78 in refractory hematologic malignancies: relationship between cellular pharmacokinetics and clinical response. 
  • Computable Phenotype Implementation for a National, Multicenter Pragmatic Clinical Trial: Lessons Learned From ADAPTABLE. 
  • Computer-assisted quantification of myocardial reperfusion after primary percutaneous coronary intervention predicts functional and contrast-enhanced cardiovascular magnetic resonance outcomes in patients with ST-segment elevation myocardial infarction. 
  • Conceptual and methodological issues in designing a randomized, controlled treatment trial for geriatric bipolar disorder: GERI-BD. 
  • Concurrent or layered treatment with radium-223 and enzalutamide or abiraterone/prednisone: real-world clinical outcomes in patients with metastatic castration-resistant prostate cancer. 
  • Conduct of multisite clinical studies by professional organizations 
  • Conducting economic evaluations alongside multinational clinical trials: toward a research consensus. 
  • Conducting multisite research studies in nursing education: brief practice of CPR skills as an exemplar. 
  • Conductive keratoplasty (CK) for presbyopia. 
  • Contemporary Multicenter Outcomes for Truncus Arteriosus With Interrupted Aortic Arch. 
  • Contemporary performance of surgical ventricular restoration procedures: data from the Society of Thoracic Surgeons' National Cardiac Database. 
  • Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial. 
  • Continuous peripheral nerve blocks: fewer excuses. 
  • Cooperative studies in health services research in the Department of Veterans Affairs. 
  • Coordinated series of studies to evaluate characteristics and mechanisms of acute coronary syndromes in high-risk patients randomly assigned to enoxaparin or unfractionated heparin: design and rationale of the SYNERGY Library. 
  • Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial. 
  • Cost effectiveness in Canada of eptifibatide treatment for acute coronary syndrome patients using PURSUIT subgroup analysis. 
  • Cost-effective models for flutamide for prostate carcinoma patients: are they helpful to policy makers? 
  • Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS). 
  • Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation. 
  • Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis. 
  • Criteria for dose-finding in two-stage seamless adaptive design. 
  • Criterion validity of Medicare chemotherapy claims in Cancer and Leukemia Group B breast and lung cancer trial participants. 
  • Current knowledge of the platelet glycoprotein IIb/IIIa receptor antagonists for the treatment of coronary artery disease. 
  • DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). 
  • DIRECT new treatments for diabetic retinopathy. 
  • Dalbavancin as an option for treatment of S. aureus bacteremia (DOTS): study protocol for a phase 2b, multicenter, randomized, open-label clinical trial. 
  • Dapagliflozin in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the DELIVER trial. 
  • Deep learning-based classification and segmentation of retinal cavitations on optical coherence tomography images of macular telangiectasia type 2. 
  • Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve. 
  • Depression, IV: STAR*D treatment trial for depression. 
  • Descriptive characteristics of the dietary patterns used in the Dietary Approaches to Stop Hypertension Trial. DASH Collaborative Research Group. 
  • Desensitization and management of allograft rejection. 
  • Design and Rationale of HiLo: A Pragmatic, Randomized Trial of Phosphate Management for Patients Receiving Maintenance Hemodialysis. 
  • Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3). 
  • Design and methodology of the ESPRIT trial: evaluating a novel dosing regimen of eptifibatide in percutaneous coronary intervention. 
  • Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial. 
  • Design of a 3-Arm Randomized Trial for Posthysterectomy Vault Prolapse Involving Sacral Colpopexy, Transvaginal Mesh, and Native Tissue Apical Repair: The Apical Suspension Repair for Vault Prolapse in a Three-Arm Randomized Trial. 
  • Design of a prospective, multicenter, global, cohort study of electromagnetic navigation bronchoscopy. 
  • Design of the Dialysis Access Consortium (DAC) Clopidogrel Prevention of Early AV Fistula Thrombosis Trial. 
  • Design of the PReferences for Open Versus Endovascular Repair of Abdominal Aortic Aneurysm (PROVE-AAA) Trial. 
  • Designing effective drug and device development programs for hospitalized heart failure: a proposal for pretrial registries. 
  • Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). 
  • Detecting treatment-by-centre interaction in multi-centre clinical trials. 
  • Developing the evidence base for palliative care: formation of the Palliative Care Research Cooperative and its first trial. 
  • Development and implementation cost analysis of telephone- and Internet-based interventions for the maintenance of weight loss. 
  • Development and implementation of a proficiency testing program for Luminex bead-based cytokine assays. 
  • Development of a clinical prediction model for the postthrombotic syndrome in a prospective cohort of patients with proximal deep vein thrombosis. 
  • Developments in Exercise Capacity Assessment in Heart Failure Clinical Trials and the Rationale for the Design of METEORIC-HF. 
  • Diagnosis and treatment of the systemic and cutaneous necrotizing vasculitis syndromes. 
  • Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance). 
  • Dietary Approaches to Stop Hypertension: a summary of study results. DASH Collaborative Research Group. 
  • Dietary Approaches to Stop Hypertension: rationale, design, and methods. DASH Collaborative Research Group. 
  • Dietary adherence in the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. 
  • Differences Between Patients Enrolled Early and Late During Clinical Trial Recruitment: Insights From the HF-ACTION Trial. 
  • Differences in Chinese diagnoses for migraine and tension-type headache: an analysis of the German acupuncture trials (GERAC) for headache. 
  • Dimensions of social support and depression in patients at increased psychosocial risk recovering from myocardial infarction. 
  • DirEct versus VIdeo LaryngosCopE (DEVICE): protocol and statistical analysis plan for a randomised clinical trial in critically ill adults undergoing emergency tracheal intubation. 
  • Discordant cardiac biomarkers: frequency and outcomes in emergency department patients with chest pain. 
  • Diurnal mood variation in outpatients with major depressive disorder. 
  • Do patients participating in clinical trials want to know study results? 
  • Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial. 
  • Dynamic prognostication in non-ST-elevation acute coronary syndromes: insights from GUSTO-IIb and PURSUIT. 
  • Dyslipidemia and Risk of Cardiovascular Events in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Therapy: Insights From the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) Trial. 
  • ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. 
  • ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. 
  • Early ambulation after 5 French diagnostic cardiac catheterization: results of a multicenter trial. 
  • Early use of glycoprotein IIb/IIIa inhibitors in non-ST-elevation acute myocardial infarction: observations from the National Registry of Myocardial Infarction 4. 
  • Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach study protocol for a multi-center, stepped-wedge randomized controlled trial. 
  • Economic analysis of the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3) study: costs of reperfusion strategies in acute myocardial infarction. 
  • Effect and neural mechanisms of the transcutaneous vagus nerve stimulation for relapse prevention in patients with remitted major depressive disorder: protocol for a longitudinal study. 
  • Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial. 
  • Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. 
  • Effect of gender on the outcomes of contemporary percutaneous coronary intervention. 
  • Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy. 
  • Effects of enhanced external counterpulsation on Health-Related Quality of Life continue 12 months after treatment: a substudy of the Multicenter Study of Enhanced External Counterpulsation. 
  • Effects of exenatide and open-label SGLT2 inhibitor treatment, given in parallel or sequentially, on mortality and cardiovascular and renal outcomes in type 2 diabetes: insights from the EXSCEL trial. 
  • Effects of switching from olanzapine, quetiapine, and risperidone to aripiprazole on 10-year coronary heart disease risk and metabolic syndrome status: results from a randomized controlled trial. 
  • Effects on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: Meta-Analysis of Individual Patient Data From 7 Multicenter Randomized Clinical Trials. 
  • Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III study. 
  • Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: a randomized, double-blinded, placebo-controlled clinical trial. The Multiple Sclerosis Study Group. 
  • Efficacy of extended release quetiapine fumarate monotherapy in patients with major depressive disorder: a pooled analysis of two 6-week, double-blind, placebo-controlled studies. 
  • Elevated body mass index predicts for longer overall survival duration in men with metastatic hormone-refractory prostate cancer. 
  • Emergency/Adjunct services and attrition prevention for randomized clinical trials in children: the MTA manual-based solution. 
  • End-of-study safety, immunogenicity, and efficacy of quadrivalent HPV (types 6, 11, 16, 18) recombinant vaccine in adult women 24-45 years of age. 
  • Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) among Surrogate Decision-Makers of ICU Patients: study protocol for a randomized controlled trial. 
  • Eptifibatide in percutaneous coronary intervention. A review. 
  • Estimating Cost-effectiveness of a Multimodal Ovarian Cancer Screening Program in the United States: Secondary Analysis of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). 
  • Estimation of the combined response to treatment in multicenter trials. 
  • Evaluation of an Opt-Out Protocol for Antibiotic De-Escalation in Patients With Suspected Sepsis: A Multicenter, Randomized, Controlled Trial. 
  • Evaluation of the accuracy and reproducibility of a practical PCR panel assay for rapid detection and differentiation of Mycobacterium avium subspecies. 
  • Evaluation of the clinical pharmacology of nilvadipine in patients with mild to moderate essential hypertension. 
  • Evolving trends in interventional device use and outcomes: results from the National Cardiovascular Network Database. 
  • External beam radiation therapy for clinically localized prostate cancer: when and how we optimize with concurrent hormonal deprivation. 
  • Extracranial carotid artery stenosis. 
  • Facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention: design and rationale of the Facilitated Intervention with Enhanced Reperfusion Speed to Stop Events (FINESSE) trial. 
  • Factors associated with changes in the use of antiretroviral therapy by a cohort of homosexual men infected with human immunodeficiency virus type 1. 
  • Failure of investigator adherence to electrocardiographic entry criteria is frequent and influences clinical outcomes: lessons from APEX-AMI. 
  • Feasibility and applicability of computer-assisted myocardial blush quantification after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. 
  • Females have the survival advantage in glioblastoma. 
  • Fixing the heart: must the brain pay the price? 
  • Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain: Rationale and Design of the FORECAST Trial. 
  • FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts. 
  • Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial. 
  • From controlled trials to clinical practice: monitoring transmyocardial revascularization use and outcomes. 
  • Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). 
  • Gender differences in the rates and correlates of HIV risk behaviors among drug abusers. 
  • Genetic counseling and testing for breast-ovarian cancer susceptibility: what do women want? 
  • Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer. 
  • Geographic variation in the treatment of acute myocardial infarction in the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. 
  • Good Studies Evaluate the Disease While Great Studies Evaluate the Patient: Development and Application of a Desirability of Outcome Ranking Endpoint for Staphylococcus aureus Bloodstream Infection. 
  • Guidance for researchers developing and conducting clinical trials in practice-based research networks (PBRNs). 
  • Guidelines for quality assurance in multicenter trials: a position paper. 
  • Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients. 
  • Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry. 
  • Hearing Norton Sound: a community randomised trial protocol to address childhood hearing loss in rural Alaska. 
  • Hearing Norton Sound: mixed methods protocol of a community randomised trial to address childhood hearing loss in rural Alaska. 
  • Heart Watch Study: protocol for a pragmatic randomised controlled trial. 
  • Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey. 
  • Heterogeneous Outcomes of Heart Failure with Better Ejection Fraction. 
  • High-frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants. 
  • Higher T-wave amplitude associated with better prognosis in patients receiving thrombolytic therapy for acute myocardial infarction (a GUSTO-I substudy). Global Utilization of Streptokinase and Tissue plasminogen Activator for Occluded Coronary Arteries. 
  • Histopathologic and ultrastructural features of surgically excised subfoveal choroidal neovascular lesions: submacular surgery trials report no. 7. 
  • Holding GUSTO up to the light. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries. 
  • Holding back the sea: the role for maintenance chemotherapy in metastatic breast cancer. 
  • Hospitalization Among Patients With Atrial Fibrillation and a Recent Acute Coronary Syndrome or Percutaneous Coronary Intervention Treated With Apixaban or Aspirin: Insights From the AUGUSTUS Trial. 
  • How obesity affects the cut-points for B-type natriuretic peptide in the diagnosis of acute heart failure. Results from the Breathing Not Properly Multinational Study. 
  • How to reduce the risk of failing to reach recruitment targets: lessons learnt from a pump pilot trial. 
  • Hyperlipidaemia in HIV-infected patients on lopinavir/ritonavir monotherapy in resource-limited settings. 
  • IMPROVE trial: a randomized controlled trial of patient-controlled analgesia for sickle cell painful episodes: rationale, design challenges, initial experience, and recommendations for future studies. 
  • ISIS-4. 
  • Impact of Human Development Index on the profile and outcomes of patients with acute coronary syndrome. 
  • Impact of Non-Infarct-Related Artery Disease on Infarct Size and Outcomes (from the CRISP-AMI Trial). 
  • Impact of acute beta-blocker therapy for patients with non-ST-segment elevation myocardial infarction. 
  • Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. 
  • Impact of race on survival in men with metastatic hormone-refractory prostate cancer. 
  • Impact of school-based health centers on children with asthma. 
  • Impact of the Patient-Reported Outcomes Management Information System (PROMIS) upon the design and operation of multi-center clinical trials: a qualitative research study. 
  • Implementation and testing of research infrastructure for practice-based research in hearing and communication disorders. 
  • Implementation considerations for multisite clinical trials with cognitive neuroscience tasks. 
  • Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives. 
  • Improved survival of surgically treated patients with triple vessel coronary artery disease and severe angina pectoris. A report from the Coronary Artery Surgery Study (CASS) registry. 
  • Improvements in quality improvement. 
  • Improving eye care in residential aged care facilities using the Residential Ocular Care (ROC) model: study protocol for a multicentered, prospective, customized, and cluster randomized controlled trial in Australia. 
  • In-hospital mortality associated with the use of intra-aortic balloon counterpulsation. 
  • Incontinence: should mesh be used to correct anterior vaginal prolapse? 
  • Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale: From the COMBINE AF (A Collaboration between Multiple institutions to Better Investigate Non-vitamin K antagonist oral anticoagulant use in Atrial Fibrillation) Investigators. 
  • Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project. 
  • Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer: study protocol of a multicentre, open-label, parallel-arms, randomized controlled study (PelvEx II). 
  • Inference on treatment effects from a randomized clinical trial in the presence of premature treatment discontinuation: the SYNERGY trial. 
  • Influence of Baseline Physical Activity Level on Exercise Training Response and Clinical Outcomes in Heart Failure: The HF-ACTION Trial. 
  • Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). 
  • Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling. 
  • Influence of global region on outcomes in heart failure β-blocker trials. 
  • Influence of imprecision on ROC curve analysis for cardiac markers. 
  • Influence of transfer-in rates on quality of care and outcomes at receiving hospitals in patients with non-ST-segment elevation myocardial infarction. 
  • Initial functional and economic status of patients with multivessel coronary artery disease randomized in the Bypass Angioplasty Revascularization Investigation (BARI). 
  • Initial table treatment of decompression sickness and arterial gas embolism. 
  • Innovations in infertility: a comprehensive analysis of the ClinicalTrials.gov database. 
  • Insights derived from the thrombolysis and angioplasty in myocardial infarction (TAMI) trials. 
  • Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial. 
  • Integrating ancillary studies in a large clinical trial: the design and rationale of the APEX library. 
  • International Workshop on Standardization in Clinical Magnetic Resonance Spectroscopy Measurements: proceedings and recommendations. 
  • International variations in the clinical, diagnostic, and treatment characteristics of emergency department patients with acute heart failure syndromes. 
  • Internet based multi-institutional clinical research: a convenient and secure option. 
  • Interplay between PCI access site, anticoagulant agent, and bleeding: Insights from the REGULATE-PCI randomized trial. 
  • Interrelationships of peak expiratory flow rate with physical and cognitive function in the elderly: MacArthur Foundation studies of aging. 
  • Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. 
  • Inverse relationship of serum albumin to the risk of venous thromboembolism among acutely ill hospitalized patients: Analysis from the APEX trial. 
  • Is Learning Worth the Trouble? - Improving Health Care System Participation in Embedded Research. 
  • Issues in the design of multisite clinical trials of psychotherapy: VA Cooperative Study No. 494 as an example. 
  • Joining a Multicenter Clinical Trial. 
  • LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study. 
  • Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivors. 
  • Lessons learned from a clinical trial. 
  • Lessons learned in pediatric clinical research to evaluate safe and effective use of drugs in pregnancy. 
  • Linking ICU practice to long-term outcome: fostering a longitudinal vision for ICU-acquired morbidity. 
  • Longitudinal associations between BMI change and the risks of colorectal cancer incidence, cancer-relate and all-cause mortality among 81,388 older adults : BMI change and the risks of colorectal cancer incidence and mortality. 
  • Low-dose aspirin in patients with stable cardiovascular disease: a meta-analysis. 
  • MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial. 
  • Malignancies after marrow transplantation for aplastic anemia and fanconi anemia: a joint Seattle and Paris analysis of results in 700 patients. 
  • Management and outcomes of gastrointestinal congenital anomalies in low, middle and high income countries: protocol for a multicentre, international, prospective cohort study. 
  • Management patterns of childhood-onset nephrotic syndrome. 
  • Managing accrual in cooperative group clinical trials. 
  • Measurement characteristics of weight concern and dieting measures in 8-10-year-old African-American girls from GEMS pilot studies. 
  • Measurement of quality of life in patients with lung cancer in multicenter trials of new therapies. Psychometric assessment of the Lung Cancer Symptom Scale. 
  • Measuring activities in clinical trials using random work sampling: implications for cost-effectiveness analysis and measurement of the intervention. 
  • Measuring costs in multisite randomized controlled trials: lessons from the VA Cooperative Studies Program. 
  • Measuring disease-free survival and cancer relapse using Medicare claims from CALGB breast cancer trial participants (companion to 9344). 
  • Medicine. The need for a global HIV vaccine enterprise. 
  • Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. 
  • Method for establishing authorship in a multicenter clinical trial. 
  • Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies. 
  • Methodologies used in nursing research designed to improve patient safety. 
  • Methods for transferring patient and plan data between radiotherapy treatment planning systems. 
  • Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D). 
  • Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial. 
  • Minimum Core Data Elements for Evaluation of TAVR: A Scientific Statement by PASSION CV, HVC, and TVT Registry. 
  • Minimum Core Data Elements for Evaluation of TAVR: A Scientific Statement by PASSION CV, HVC, and TVT Registry. 
  • Misreporting of myocardial infarction end points: results of adjudication by a central clinical events committee in the PARAGON-B trial. Second Platelet IIb/IIIa Antagonist for the Reduction of Acute Coronary Syndrome Events in a Global Organization Network Trial. 
  • Modeling of treatment response to erythropoiesis-stimulating agents as a function of center- and patient-related variables: results from the Anemia Cancer Treatment (ACT) study. 
  • Modifiable risk factors for vascular access site complications in the IMPACT II Trial of angioplasty with versus without eptifibatide. Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis. 
  • Molecular PET imaging in multicenter Alzheimer's therapeutic trials: current trends and implementation strategies. 
  • Morbidity and mortality associated with spinal surgery in children: a review of the Scoliosis Research Society morbidity and mortality database. 
  • Multi-investigator collaboration in orthopaedic surgery research compared to other medical fields. 
  • Multicenter Cardiovascular Studies and Trials: Lessons Learned From 35 Years of Productive Collaboration. 
  • Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials. 
  • Multisite formative assessment for the Pathways study to prevent obesity in American Indian schoolchildren. 
  • Multisite randomized controlled trials in health services research: scientific challenges and operational issues. 
  • National down syndrome patient database: Insights from the development of a multi-center registry study. 
  • Necessity of hospitalization and stress testing in low risk chest pain patients. 
  • Neurophysiologic intraoperative monitoring in children. 
  • Neutrophil-to-Lymphocyte Ratio as a Prognostic Factor of Disease-free Survival in Postnephrectomy High-risk Locoregional Renal Cell Carcinoma: Analysis of the S-TRAC Trial. 
  • Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. 
  • Non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. 
  • Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis. 
  • Noncentral Nervous System Systemic Embolism in Patients With Atrial Fibrillation: Results From ROCKET AF (Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). 
  • Nonparametric estimation of median survival times with applications to multi-site or multi-center studies. 
  • Obesity in patients with non-ST-segment elevation acute coronary syndromes: results from the SYNERGY trial. 
  • Objective performance goals of safety and blood pressure efficacy for clinical trials of renal artery bare metal stents in hypertensive patients with atherosclerotic renal artery stenosis. 
  • Olanzapine on trial. 
  • On evaluation of consistency in multi-regional clinical trials. 
  • Once-daily bedtime dosing regimen of cimetidine in the treatment of gastric ulcer. 
  • One-year follow-up study of blood pressure and dietary patterns in dietary approaches to stop hypertension (DASH)-sodium participants. 
  • One-year outcomes from the international multicenter study of the Zenith Alpha Thoracic Endovascular Graft for thoracic endovascular repair. 
  • Ontario Cancer Research Ethics Board: lessons learned from developing a multicenter regional institutional review board. 
  • Operative versus nonoperative treatment of leg pain in adults with scoliosis: a retrospective review of a prospective multicenter database with two-year follow-up. 
  • Opportunistic pulmonary infections with fludarabine in previously treated patients with low-grade lymphoid malignancies: a role for Pneumocystis carinii pneumonia prophylaxis. 
  • Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial. 
  • Optimizing operational efficiencies in early phase trials: The Pediatric Trials Network experience. 
  • Orofacial pain prospective evaluation and risk assessment study--the OPPERA study. 
  • Outcomes after cardioversion and atrial fibrillation ablation in patients treated with rivaroxaban and warfarin in the ROCKET AF trial. 
  • Outcomes following treatment for pelvic floor mesh complications. 
  • Outcomes of implantable cardioverter-defibrillator use in patients with comorbidities: results from a combined analysis of 4 randomized clinical trials. 
  • Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. 
  • PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN. 
  • PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial. 
  • PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories): Overview of Design and Rationale of an International Prospective Peripheral Arterial Disease Study. 
  • PROLONG Clinical Study Protocol: Hydroxyprogesterone Caproate to Reduce Recurrent Preterm Birth. 
  • Pain predicts overall survival in men with metastatic castration-refractory prostate cancer. 
  • Pancreatic cancer: future outlook, promising trials, newer systemic agents, and strategies from the Gastrointestinal Intergroup Pancreatic Cancer Task Force. 
  • Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance). 
  • Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. 
  • Pharmacokinetic-pharmacodynamic modelling of platelet response to ticagrelor in stable coronary artery disease and prior myocardial infarction patients. 
  • Pharmacotherapy of social anxiety disorder. 
  • Phenotype of Spirometric Impairment in an Aging Population. 
  • Physical activity in patients with stable coronary heart disease: an international perspective. 
  • Planning and managing a complex multisite study in the age of technology. 
  • Platelet glycoprotein IIb/IIIa integrin blockade: recent clinical trials in interventional cardiology. 
  • Potential autonomic risk factors for chronic TMD: descriptive data and empirically identified domains from the OPPERA case-control study. 
  • Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. 
  • Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. 
  • Pre-enrollment diets of Dietary Approaches to Stop Hypertension trial participants. DASH Collaborative Research Group. 
  • Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer. 
  • Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II. 
  • Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study. 
  • Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction: the CADILLAC risk score. 
  • Predictors of acute and long-term outcome with transluminal extraction atherectomy: the New Approaches to Coronary Intervention (NACI) registry. 
  • Prevention of sudden death in patients with coronary artery disease: the Multicenter Unsustained Tachycardia Trial (MUSTT). 
  • Procedural Outcomes of Pulmonary Atresia With Intact Ventricular Septum in Neonates: A Multicenter Study. 
  • Processes to activate phase III clinical trials in a Cooperative Oncology Group: the Case of Cancer and Leukemia Group B. 
  • Procoagulant effects of intraocular sodium hyaluronate (Healon) after phakic diabetic vitrectomy. A prospective, randomized study. 
  • Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. 
  • Prognostic value of ST segment depression in acute coronary syndromes: insights from PARAGON-A applied to GUSTO-IIb. PARAGON-A and GUSTO IIb Investigators. Platelet IIb/IIIa Antagonism for the Reduction of Acute Global Organization Network. 
  • Programs promoting timely sequential antimicrobial therapy: an American perspective. 
  • Prophylactic levosimendan in patients with low ejection fraction undergoing coronary artery bypass grafting: A pooled analysis of two multicentre randomised controlled trials. 
  • Proposals of statistical consideration to evaluation of results for a specific region in multi-regional trials--Asian perspective. 
  • Prospective data collection of a new procedure by a specialty society: the FIBROID registry. 
  • Prospective multicenter trial of esophageal Z-stent placement for malignant dysphagia and tracheoesophageal fistula. 
  • Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism. 
  • Protocol and statistical analysis plan for the PREventing cardiovascular collaPse with Administration of fluid REsuscitation during Induction and Intubation (PREPARE II) randomised clinical trial. 
  • Protocol for a multi-site randomized controlled trial of a stepped-care intervention for emergency department patients with panic-related anxiety. 
  • Protocol of a multicenter, single-blind, randomised, parallel controlled feeding trial evaluating the effect of a Chinese Healthy Heart (CHH) diet in lowering blood pressure and other cardiovascular risk factors. 
  • Protocolized Care for Early Septic Shock (ProCESS) statistical analysis plan. 
  • Protocols for multi-site trials using hyperpolarized 129 Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129 Xe MRI clinical trials consortium. 
  • Psychosocial factors and coronary disease. A national multicenter clinical trial (ENRICHD) with a North Carolina focus. 
  • Pulmonary hypertension and nitric oxide depletion in sickle cell disease. 
  • Quality control in the flow cytometric measurement of T-lymphocyte subsets: the multicenter AIDS cohort study experience. The Multicenter AIDS Cohort Study Group. 
  • Quality control of the nutritional component of the Growth Failure in Children with Renal Diseases Study. 
  • Quality improvement methods as applied to a multicenter effectiveness trial--STAR*D. 
  • Quality of life as a prognostic indicator of survival: A pooled analysis of individual patient data from canadian cancer trials group clinical trials. 
  • Racial differences in clinical outcomes from metastatic breast cancer: a pooled analysis of CALGB 9342 and 9840--Cancer and Leukemia Group B. 
  • Randomized clinical trials--removing unnecessary obstacles. 
  • Randomized multicenter trial of cytosine arabinoside with mitoxantrone or daunorubicin in previously untreated adult patients with acute nonlymphocytic leukemia (ANLL). Lederle Cooperative Group. 
  • Rationale and design for the study Apixaban versus ClopidoGRel on a background of aspirin in patient undergoing InfraPoPliteal angioplasty for critical limb ischemia: AGRIPPA trial. 
  • Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes. 
  • Rationale and design of PROACT Xa: A randomized, multicenter, open-label, clinical trial to evaluate the efficacy and safety of apixaban versus warfarin in patients with a mechanical On-X Aortic Heart Valve. 
  • Rationale and design of The National Emphysema Treatment Trial: a prospective randomized trial of lung volume reduction surgery. The National Emphysema Treatment Trial Research Group. 
  • Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). 
  • Rationale and design of a nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention trial (EXTRA-CVD). 
  • Rationale and design of a randomized clinical trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with advanced heart failure: the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). 
  • Rationale and design of the Home Automatic External Defibrillator Trial (HAT). 
  • Rationale and design of the pilot randomized study of nesiritide versus dobutamine in heart failure (PRESERVD-HF). 
  • Rationale, design, and baseline characteristics of a Program to Assess and Review Trending INformation and Evaluate CorRelation to Symptoms in Patients with Heart Failure (PARTNERS HF). 
  • Recruitment for a hospital-based pragmatic clinical trial using volunteer nurses and students. 
  • Recruitment of African-American pre-adolescent girls into an obesity prevention trial: the GEMS pilot studies. 
  • Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol. 
  • Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial. 
  • Reflections on early stopping of a clinical trial. 
  • Relation between time from myocardial infarction to enrolment and patient outcomes in the Multicenter UnSustained Tachycardia Trial. 
  • Relation of an elevated white blood cell count after percutaneous coronary intervention to long-term mortality. 
  • Relation of ejection fraction and inducible ventricular tachycardia to mode of death in patients with coronary artery disease: an analysis of patients enrolled in the multicenter unsustained tachycardia trial. 
  • Relationship Between Enrolling Country Income Level and Patient Profile, Protocol Completion, and Trial End Points. 
  • Relationship between antecedent angina pectoris and short-term prognosis after thrombolytic therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction (TAMI) Study Group. 
  • Relationship between timing of trial randomization, protocol completion, and clinical outcomes among patients hospitalized for heart failure: from the ASTRONAUT trial. 
  • Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery. 
  • Relationship of extent of revascularization with angina at one year in the Bypass Angioplasty Revascularization Investigation (BARI). 
  • Relationship of right- to left-sided ventricular filling pressures in advanced heart failure: insights from the ESCAPE trial. 
  • Release bias in accessing medical records in clinical trials: a STAR*D report. 
  • Repeat CT Performed Within One Month of CT Conducted in the Emergency Department for Abdominal Pain: A Secondary Analysis of Data From a Prospective Multicenter Study. 
  • Report from the working group conference on multisite trial design for cognitive remediation in schizophrenia. 
  • Rescuing the neonatal brain from hypoxic injury with autologous cord blood. 
  • Response rate as an endpoint in clinical trials. 
  • Response-independent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107. 
  • Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes. 
  • Risk stratification after hospitalization for decompensated heart failure. 
  • Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. 
  • Rivaroxaban, a direct Factor Xa inhibitor, versus acetylsalicylic acid as thromboprophylaxis in children post-Fontan procedure: Rationale and design of a prospective, randomized trial (the UNIVERSE study). 
  • Role of etoposide (VP-16) in preparatory regimens for patients with leukemia or lymphoma undergoing allogeneic bone marrow transplantation. 
  • Role of genetic polymorphisms and ovarian cancer susceptibility. 
  • SF-36 PCS benefit-cost ratio of lumbar fusion comparison to other surgical interventions: a thought experiment. 
  • Safety and immunogenicity of one vs. two injections of Oka/Merck varicella vaccine in healthy children. 
  • Safety and tolerance of intermittent intravenous and oral zidovudine therapy in human immunodeficiency virus-infected pediatric patients. Pediatric Zidovudine Phase I Study Group. 
  • Safety of transvenous cardiac resynchronization system implantation in patients with chronic heart failure: combined results of over 2,000 patients from a multicenter study program. 
  • School climate and implementation of the Pathways study. 
  • Segmental contribution toward total cervical range of motion: a comparison of cervical disc arthroplasty and fusion. 
  • Self-tolerance curtails the B cell repertoire to microbial epitopes. 
  • Sensible approaches for reducing clinical trial costs. 
  • Short- and long-term mortality following bleeding events in patients undergoing percutaneous coronary intervention: insights from four validated bleeding scales in the CHAMPION trials. 
  • Site Principal Investigators in Multicenter Clinical Trials: Appropriately Recognizing Key Contributors. 
  • Small-molecule nicotinamide for ex vivo expansion of umbilical cord blood. 
  • Stability of mismatch negativity event-related potentials in a multisite study. 
  • Staphylococcus aureus meningitis: review of 28 cases. 
  • Statin use and need for therapy in chronic lymphocytic leukemia. 
  • Statistical analysis plan for the control of blood pressure and risk attenuation-rural Bangladesh, Pakistan, Sri Lanka (COBRA-BPS) trial: a cluster randomized trial for a multicomponent intervention versus usual care in hypertensive patients. 
  • Statistical aspect of translational and correlative studies in clinical trials. 
  • Statistical methods for bridging studies. 
  • Streamlining the institutional review board process in pragmatic randomized clinical trials: challenges and lessons learned from the Aspirin Dosing: A Patient-centric Trial Assessing Benefits and Long-Term Effectiveness (ADAPTABLE) trial. 
  • Streptokinase versus alteplase in acute myocardial infarction. 
  • Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial. 
  • Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials). 
  • Study Design and Rationale of EXPLORER-HCM: Evaluation of Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy. 
  • Study protocol for a randomised controlled trial of a care partner assisted intervention to improve oral health of individuals with mild dementia. 
  • Study protocol for targeted interventions to prevent chronic low back pain in high-risk patients: A multi-site pragmatic cluster randomized controlled trial (TARGET Trial). 
  • Study protocol of a randomized controlled trial of fistula vs. graft arteriovenous vascular access in older adults with end-stage kidney disease on hemodialysis: the AV access trial. 
  • Substance use in persons with schizophrenia: baseline prevalence and correlates from the NIMH CATIE study. 
  • Success and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse. 
  • Successful recruitment of a multi-site international randomized placebo-controlled trial in people with HIV with attention to diversity of race and ethnicity: critical role of central coordination. 
  • Summary of findings from the OPPERA baseline case-control study: implications and future directions. 
  • Surgeon judgment and utility of transit time flow probes in coronary artery bypass grafting surgery. 
  • Surrogates of Patients With Severe Acute Brain Injury Experience Persistent Anxiety and Depression Over the 6 Months After ICU Admission. 
  • Surveillance of Sentinel Node-Positive Melanoma Patients with Reasons for Exclusion from MSLT-II: Multi-Institutional Propensity Score Matched Analysis. 
  • Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators. 
  • The 13- and 20-item Hopkins Symptom Checklist Depression Scale: psychometric properties in primary care patients with minor depression or dysthymia. 
  • The Adherence eValuation After Ischemic Stroke Longitudinal (AVAIL) registry: design, rationale, and baseline patient characteristics. 
  • The Alzheimer's Disease Assessment Scale: evaluation of psychometric properties and patterns of cognitive decline in multicenter clinical trials of mild to moderate Alzheimer's disease. 
  • The BRAVO Clinical Study Protocol: Oral Varespladib for Inhibition of Secretory Phospholipase A2 in the Treatment of Snakebite Envenoming. 
  • The COMPARE Registry: design and baseline patterns of care for men with biochemical failure after definitive treatment of localized prostate cancer. 
  • The Complexity of Conducting a Multicenter Clinical Trial: Taking It to the Next Level Stipulated by the Federal Agencies. 
  • The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-sodium): rationale and design. DASH-Sodium Collaborative Research Group. 
  • The Development and Early to Midterm Findings of the Multicenter Revision Anterior Cruciate Ligament Study. 
  • The Development of Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP). 
  • The Fibroid Registry for outcomes data (FIBROID) for uterine embolization: short-term outcomes. 
  • The Impact of a Rigorous Quality Program on 3D Echocardiography Data Quality in an International Multisite Randomized Trial. 
  • The Impact of the Multicenter Orthopaedic Outcomes Network (MOON) Research on Anterior Cruciate Ligament Reconstruction and Orthopaedic Practice. 
  • The Internet Tracking Registry of Acute Coronary Syndromes (i*trACS): a multicenter registry of patients with suspicion of acute coronary syndromes reported using the standardized reporting guidelines for emergency department chest pain studies. 
  • The Linear Index Model for establishing nutrient goals in the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. 
  • The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned. 
  • The NINDS Parkinson's disease biomarkers program. 
  • The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics. 
  • The Placement of Aortic Transcatheter Valve (PARTNER) trial: a health economic and policy perspective. 
  • The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) instrument was useful for refining a randomized trial design: experiences from an investigative team. 
  • The Preschool Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS) 6-year follow-up. 
  • The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. 
  • The Stanley Foundation Bipolar Network. I. Rationale and methods. 
  • The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction. 
  • The Value of Left Ventricular Support in Patients With Reduced Left Ventricular Function Undergoing Extensive Revascularization: An Analysis From the PROTECT-II Randomized Trial. 
  • The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. 
  • The World Heart Federation Global Study on COVID-19 and Cardiovascular Disease. 
  • The early glycoprotein IIb/IIIa inhibition in non-ST-segment elevation acute coronary syndrome (EARLY ACS) trial: a randomized placebo-controlled trial evaluating the clinical benefits of early front-loaded eptifibatide in the treatment of patients with non-ST-segment elevation acute coronary syndrome--study design and rationale. 
  • The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. 
  • The effects of dietary patterns on quality of life: a substudy of the Dietary Approaches to Stop Hypertension trial. 
  • The efficacy of cimetidine in the treatment of "resistant" duodenal ulcers. 
  • The evaluation of treatment when center-specific selection criteria vary with respect to patient risk. 
  • The genetic epidemiology of multiple sclerosis. 
  • The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. 
  • The glutamine debate in surgery and critical care. 
  • The impact of macular edema on visual function in intermediate, posterior, and panuveitis. 
  • The importance of transparency in industry-sponsored multicenter clinical studies. 
  • The incidence and long-term clinical outcome of iatrogenic atrial septal defects secondary to transseptal catheterization with a 12F transseptal sheath. 
  • The influence of peripheral arterial disease on outcomes: a pooled analysis of mortality in eight large randomized percutaneous coronary intervention trials. 
  • The pediatric obsessive-compulsive disorder treatment study: rationale, design, and methods. 
  • The predictive value of short-term changes in hemoglobin concentration in patients presenting with acute decompensated heart failure. 
  • The relationship of body mass index and serum testosterone with disease outcomes in men with castration-resistant metastatic prostate cancer. 
  • The role of angioplasty after successful thrombolysis for acute myocardial infarction. 
  • The role of cardiac risk factor burden in diagnosing acute coronary syndromes in the emergency department setting. 
  • The role of local institutional review boards in protecting human research subjects. 
  • The significance of repetitive hair-pulling behaviors in eating disorders. 
  • The spectrum of infection-related morbidity in hospitalized haemodialysis patients. 
  • The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. 
  • The trial to reduce antimicrobial use in nursing home residents with Alzheimer's disease and other dementias: study protocol for a cluster randomized controlled trial. 
  • The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation. 
  • The worst symptom as defined by patients during heart failure hospitalization: implications for response to therapy. 
  • Tissue plasminogen activator for the treatment of acute pulmonary embolism. A collaborative study by the PIOPED Investigators. 
  • Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction. 
  • Toward development of a comprehensive external quality assurance program for polyfunctional intracellular cytokine staining assays. 
  • Toward protecting the safety of participants in clinical trials. 
  • Transitioning to the National Institutes of Health single institutional review board model: Piloting the use of the Streamlined, Multi-site, Accelerated Resources for Trials IRB Reliance. 
  • Transluminal extraction coronary atherectomy. 
  • Treatment of children symptomatic with human immunodeficiency virus infection. 
  • Treatment of hypertension in patients with coronary artery disease: a scientific statement from the American Heart Association, American College of Cardiology, and American Society of Hypertension. 
  • Treatment of reinfarction after thrombolytic therapy for acute myocardial infarction: an analysis of outcome and treatment choices in the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries (gusto I) and assessment of the safety of a new thrombolytic (assent 2) studies. 
  • Treatment options for newly diagnosed patients with chronic lymphocytic leukemia. 
  • Two- and three-year outcomes of minimally invasive and hybrid correction of adult spinal deformity. 
  • Two-stage sampling in pharmaceutical applications. 
  • Understanding heart failure through the HF-ACTION baseline characteristics. 
  • Update in the management of patients with hormone-refractory prostate cancer. 
  • Update on multi-center clinical trials in the United States. 
  • Update: vinorelbine (navelbine) in non-small cell lung cancer. 
  • Use and impact of inotropes and vasodilator therapy in hospitalized patients with severe heart failure. 
  • Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomised control trial in an adult population (PALACE): study protocol. 
  • Use of central institutional review boards for multicenter clinical trials in the United States: a review of the literature. 
  • Usefulness of ST depression with T-wave inversion in leads V(4) to V(6) for predicting one-year mortality in non-ST-elevation acute coronary syndrome (from the Electrocardiographic Analysis of the Global Use of Strategies to Open Occluded Coronary Arteries IIB Trial). 
  • Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial). 
  • Using central IRBs for multicenter clinical trials in the United States. 
  • Using health communication best practices to develop a web-based provider-patient communication aid: the CONNECT study. 
  • Validation of diet composition for the Dietary Approaches to Stop Hypertension trial. DASH Collaborative Research Group. 
  • Variability in IRBs regarding parental acceptance of passive consent. 
  • Variation in the use of stress testing and outcomes in patients with non-ST-elevation acute coronary syndromes: insights from GUSTO IIb. 
  • Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. 
  • Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project. 
  • Where do poor women in developing countries give birth? A multi-country analysis of demographic and health survey data. 
  • Which inhibitor of the renin-angiotensin system should be used in chronic heart failure and acute myocardial infarction? 
  • Whole-genome sequencing of Staphylococcus epidermidis bloodstream isolates from a prospective clinical trial reveals that complicated bacteraemia is caused by a limited number of closely related sequence types. 
  • [Is coronary magnetic resonance angiography already a clinically useful diagnostic tool?]. 
  • {I}ndependent but coordinated trials: insights from the practice-based {O}pportunities for {W}eight {R}eduction {T}rials {C}ollaborative {R}esearch {G}roup 
  • ε-Aminocaproic acid and clinical value in cardiac anesthesia. 
• 

  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor Emeritus of Pediatrics, in the School of Medicine, Pediatrics, Allergy and Immunology
  • Charles, Hal Cecil, Adjunct Associate Professor in the Department of Radiology, Radiology
  • Middleton, John Paul, Professor of Medicine, Medicine, Nephrology
  • Muhlbaier, Lawrence H., Associate Professor Emeritus of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
  • Taekman, Jeffrey Marc, Professor Emeritus of Anesthesiology, Anesthesiology, Neuroanesthesia
  • Toth, Cynthia Ann, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, Biomedical Engineering