Histocompatibility Antigens Class I
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Subject Areas on Research
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A Phase I clinical trial of immunotherapy with interferon-gamma gene-modified autologous melanoma cells: monitoring the humoral immune response.
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A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo.
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A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
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A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays.
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A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection.
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ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers.
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ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency.
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Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.
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Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles.
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Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene.
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Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality.
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An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.
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Analysis of corneal and conjunctival microenvironments using monoclonal antibodies.
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Analysis of regulatory CD8 T cells in Qa-1-deficient mice.
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Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis.
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Anti-HLA antibodies detected in posttransplant renal allograft recipient sera correlate with chronic rejection.
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Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines.
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Are DNA-HLA class II interactions the missing link in SLE?
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Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians.
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Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.
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Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation.
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CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism.
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Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface?
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Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter.
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Cells treated with TAP-2 antisense oligonucleotides are potent antigen-presenting cells in vitro and in vivo.
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Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion.
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Chlamydia trachomatis immune evasion via downregulation of MHC class I surface expression involves direct and indirect mechanisms.
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Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice.
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Chronic rejection of mouse kidney allografts.
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Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines.
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Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
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Comparison of PRA-STAT, sHLA-EIA, and anti-human globulin-panel reactive antibody to identify alloreactivity in pretransplantation sera of heart transplant recipients: correlation to rejection and posttransplantation coronary artery disease.
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Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.
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Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.
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Construction and destruction of MHC class I in the peptide-loading complex.
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Contribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection.
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Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys.
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Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.
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Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction.
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Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses.
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Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells.
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Detailed analysis of gene expression during development of T cell lineages in the thymus.
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Direct MHC class I complementary DNA transfer to thymus induces donor-specific unresponsiveness, which involves multiple immunologic mechanisms.
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Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology.
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ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
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ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum.
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Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies.
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Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection.
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Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.
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Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
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Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand.
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Estradiol regulates MICA expression in human endometrial cells.
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Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates.
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Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection.
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Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes.
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Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins.
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Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer.
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Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss.
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Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice.
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Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.
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Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE.
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Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells.
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Genes that modify the hemochromatosis phenotype in mice.
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H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
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HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression.
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HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.
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HLA class I serotypes and cytotoxic T-lymphocyte responses among human immunodeficiency virus-1-uninfected Thai volunteers immunized with ALVAC-HIV in combination with monomeric gp120 or oligomeric gp160 protein boosting.
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HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.
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HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression.
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Haptoglobin modifies the hemochromatosis phenotype in mice.
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Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
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Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.
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Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice.
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Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
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Hereditary hemochromatosis: gene discovery and its implications for population-based screening.
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Herpes simplex virus blocks intracellular transport of HLA-G in placentally derived human cells.
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Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.
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High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes.
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Histocompatibility and liver transplantation.
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Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice.
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Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner.
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Human immunodeficiency virus type 1-specific cytotoxic T lymphocyte activity is inversely correlated with HIV type 1 viral load in HIV type 1-infected long-term survivors.
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Human interleukin-2 and lymphoproliferative (T-helper cell) responses to soluble HLA class I antigens in vitro: I. Specificity for polymorphic domains.
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Human leukocyte antigen class II alleles are associated with risk of alopecia areata.
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Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs.
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Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection.
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Immune interactions at the maternal-fetal interface: a focus on antigen presentation.
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Immunity to MHC class I antigen after direct DNA transfer into skeletal muscle.
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Immunization with recombinant HLA classes I and II, HIV-1 gp140, and SIV p27 elicits protection against heterologous SHIV infection in rhesus macaques.
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Immunologic characterization of CD7-deficient mice.
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Immunologic suppression mediated by genetically modified hepatocytes expressing secreted allo-MHC class I molecules.
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Immunologic targeting of FOXP3 in inflammatory breast cancer cells.
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Immunopathogenesis of juvenile dermatomyositis.
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Immunosuppressive effects of an HLA class I-derived peptide in a rat cardiac allograft model.
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Immunotherapeutic targeting of Wilms' tumor protein.
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Implications of leukoregulin to autologous tumor-specific human T-cell populations.
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Improved renal function in mouse kidney allografts lacking MHC class I antigens.
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Improving peptide-MHC class I binding prediction for unbalanced datasets.
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In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
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Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.
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Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.
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Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
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Inhibition of established pancreatic cancers following specific active immunotherapy with interleukin-2 gene-transduced tumor cells.
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Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is poorly responsive to IFNgamma stimulation: increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC.
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Interferon-gamma and tumour necrosis factor induce expression of major histocompatibility complex antigen on rat retinal astrocytes.
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Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C.
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Iron in skin of mice with three etiologies of systemic iron overload.
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Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes.
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Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.
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Liposomal delivery of soluble protein antigens for class I MHC-mediated antigen presentation.
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Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity.
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Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.
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MHC class I-peptide interactions and TCR recognition.
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MHC class I-presented tumor antigens identified in ovarian cancer by immunoproteomic analysis are targets for T-cell responses against breast and ovarian cancer.
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Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction.
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Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells.
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Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model.
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Melanoma-specific cytotoxic T cells generated from peripheral blood lymphocytes. Implications of a renewable source of precursors for adoptive cellular immunotherapy.
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Minors come of age: Minor histocompatibility antigens and graft-versus-host disease.
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Modulation of MICA on the surface of Chlamydia trachomatis-infected endocervical epithelial cells promotes NK cell-mediated killing.
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Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo.
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Modulation of the transformed and neoplastic phenotype of rat fibroblasts by MHC-I gene expression.
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Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine.
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Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells.
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Molecular insights into mechanisms of iron transport.
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Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.
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Multiple CTL specificities against autologous HIV-1-infected BLCLs.
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Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.
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Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells.
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Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding.
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NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system.
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NK cell education: Physiological and pathological influences.
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Novel adeno-associated virus vector vaccine restricts replication of simian immunodeficiency virus in macaques.
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Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1.
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Pentoxifylline and other methyl xanthines inhibit interleukin-2 receptor expression in human lymphocytes.
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Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry.
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Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America.
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Post-transplant HLA class II antibodies and high soluble CD30 levels are independently associated with poor kidney graft survival.
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Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival.
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Premature translational termination products are rapidly degraded substrates for MHC class I presentation.
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Qa-1 restriction of CD8+ suppressor T cells.
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Qa-1, a nonclassical MHC molecule with immunomodulatory functions, is ubiquitously expressed in the immune-privileged anterior chamber of the eye.
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Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes.
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Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV.
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Reduced antigenicity of formaldehyde-fixed arterial allografts and their potential clinical application.
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Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo.
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Regulation of iron absorption in Hfe mutant mice.
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Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.
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Rejection of kidney allografts by MHC class I-deficient mice.
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Relationship between sensitivity to natural killer cells and MHC class-I antigen expression in colon carcinoma cell lines.
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Replicating adenovirus HIV/SIV recombinant priming alone or in combination with a gp140 protein boost results in significant control of viremia following a SHIV89.6P challenge in Mamu-A*01 negative rhesus macaques.
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Role of HFE gene mutations in liver diseases other than hereditary hemochromatosis.
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Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus.
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Seek and you will find: antibody and the liver.
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Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions.
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Swine Leukocyte Antigen Class II Is a Xenoantigen.
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TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys.
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The C282Y mutation causing hereditary hemochromatosis does not produce a null allele.
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The DRiP hypothesis decennial: support, controversy, refinement and extension.
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The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules.
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The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses.
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The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif.
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The desirable donor pig to eliminate all xenoreactive antigens.
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The effect of pretreatment with class I major histocompatibility complex (MHC) antigens on hepatic or cardiac allograft survival in the rat.
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The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation.
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The fetal allograft revisited: does the study of an ancient invertebrate species shed light on the role of natural killer cells at the maternal-fetal interface?
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The final touches make perfect the peptide-MHC class I repertoire.
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The immune checkpoint molecule, VTCN1/B7-H4, guides differentiation and suppresses proinflammatory responses and MHC class I expression in an embryonic stem cell-derived model of human trophoblast.
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The immunological properties of endoplasmic reticulum chaperones: a conflict of interest?
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The importance of class I and class II HLA in cadaveric renal transplantation.
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The neonatal Fc receptor is a pan-echovirus receptor.
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The role of class I antigens in hyperacute rejection of hepatic allografts in rats.
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The role of class I major histocompatibility complex antigens in prolonging the survival of hepatic allografts in the rat.
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The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
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Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.
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Tolerance and the "Holy Grail" of transplantation.
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Transcription of H-2 and Qa genes in embryonic and adult mice.
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Transcriptionally abundant major histocompatibility complex class I alleles are fundamental to nonhuman primate simian immunodeficiency virus-specific CD8+ T cell responses.
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Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules.
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Treatment of human melanoma hepatic metastases in nude mice with human cytotoxic T lymphocytes.
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Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.
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Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.
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Tumor MHC class I expression improves the prognostic value of T-cell density in resected colorectal liver metastases.
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Two distinct forms of soluble MHC class I molecules synthesized by different mechanisms in normal rat cells in vitro.
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Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells.
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Use of donor serum to prevent passive transfer of hyperacute rejection.
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Use of synthetic peptides in primates to induce high-titered neutralizing antibodies and MHC class I-restricted cytotoxic T cells against acquired immunodeficiency syndrome retroviruses: an HLA-based vaccine strategy.
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Vaccine-Mediated Inhibition of the Transporter Associated with Antigen Processing Is Insufficient To Induce Major Histocompatibility Complex E-Restricted CD8+ T Cells in Nonhuman Primates.
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Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens.
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Viral subversion of the immune system.
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Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents.
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Keywords of People
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
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Shinohara, Mari L.,
Professor of Integrative Immunobiology,
Cell Biology
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Weinhold, Kent James,
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery,
Integrative Immunobiology