Reperfusion Injury

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  Subject Areas on Research

  • 17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice. 
  • 4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart. 
  • A marriage of enhancement: fibrinolysis and conjunctive therapy. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • Actions of glucocorticosteroids on ischemic-reperfused muscle and cutaneous tissue. 
  • Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. 
  • Acute changes in intracranial pressure and pressure-volume index after forebrain ischemia in normoglycemic and hyperglycemic rats. 
  • Acute difluoromethylornithine treatment increases skin flap survival in rats. 
  • Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail. 
  • Anti-inflammatory signaling during ex vivo liver perfusion improves the preservation of pig liver grafts before transplantation. 
  • Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. 
  • Apoptosis and hepatic allograft reperfusion injury. 
  • Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. 
  • Assessment of ischemia and reperfusion injury. 
  • B cells contribute to ischemia/reperfusion-mediated tissue injury. 
  • Blockade of L-selectin attenuates reperfusion injury in a rat model. 
  • Blockade of NAALADase: a novel neuroprotective strategy based on limiting glutamate and elevating NAAG. 
  • Blocking L-selectin function attenuates reperfusion injury following hemorrhagic shock in rabbits. 
  • Bosentan, an endothelin antagonist, augments hepatic graft function by reducing graft circulatory impairment following ischemia/reperfusion injury. 
  • Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. 
  • C1-esterase inhibitor and a novel peptide inhibitor improve contractile function in reperfused skeletal muscle. 
  • Calcitonin gene-related peptide and reperfusion injury. 
  • Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver. 
  • Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis. 
  • Capillary flow and diameter changes during reperfusion after global cerebral ischemia studied by intravital video microscopy. 
  • Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression. 
  • Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. 
  • Cardiac renin-angiotensin system. Molecular and functional aspects. 
  • Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. 
  • Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. 
  • Changes in superoxide dismutase and catalase activities of rat brain regions during early global transient ischemia/reperfusion. 
  • Characterization of a recovery global cerebral ischemia model in the mouse. 
  • Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. 
  • Commentary: Ischemia reperfusion-Looking ahead. 
  • Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery. 
  • Critical care aspects of lung transplantation. 
  • DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing. 
  • Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology. 
  • Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury. 
  • Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. 
  • Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 
  • Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System. 
  • Donor hepatic function: a factor in postreperfusion syndrome. 
  • Effect of a NOS inhibitor, L-NMMA, on the contractile function of reperfused skeletal muscle. 
  • Effect of a nitric oxide donor on microcirculation of acutely denervated skeletal muscle during reperfusion. 
  • Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial. 
  • Effect of brief myocardial ischemia on sympathetic coronary vasoconstriction. 
  • Effect of hepatic artery flow on bile secretory function after cold ischemia. 
  • Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: a systematic overview. 
  • Effects of S-nitroso- N-acetylcysteine on contractile function of reperfused skeletal muscle. 
  • Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat. 
  • Effects of cold ischemia on reflow patterns in the rat cremaster muscle microcirculation. 
  • Effects of dexamethasone on the contractile function of reperfused skeletal muscle. 
  • Effects of leukocyte depleted blood on renal reperfusion injury in a porcine model. 
  • Efficacy of Nitric Oxide Administration During Neonatal Cardiopulmonary Bypass. 
  • Efficacy of recombinant human manganese superoxide dismutase compared to allopurinol in protection of ischemic skeletal muscle against "no-reflow". 
  • Elevated monocytes in patients with critical limb ischemia diminish after bypass surgery. 
  • Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis. 
  • Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver. 
  • EndothelinA receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils. 
  • Enhancement of cardiac function by cyclocreatine in models of cardiopulmonary bypass. 
  • Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • FAK/Src family of kinases: protective or aggravating factor for ischemia reperfusion injury in nervous system? 
  • Functional Assessment of the Efficacy of Oxygen Free Radical Scavengers in the "No-Reflow" Phenomenon in Skeletal Muscle. 
  • Global analysis of gene expression in renal ischemia-reperfusion in the mouse. 
  • Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury. 
  • HIF-1α in heart: protective mechanisms. 
  • Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. 
  • Hydrogen peroxide production by monoamine oxidase during ischemia-reperfusion in the rat brain. 
  • Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Hypoxia compared with normoxia alters the effects of nitric oxide in ischemia-reperfusion lung injury. 
  • Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury. 
  • Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury. 
  • Immunological organ modification during Ex Vivo machine perfusion: The future of organ acceptance. 
  • Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. 
  • Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model. 
  • Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury. 
  • Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice. 
  • Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle. 
  • Inhibition of inducible nitric oxide synthase promotes recovery of motor function in rats after sciatic nerve ischemia and reperfusion. 
  • Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear. 
  • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. 
  • Intestinal ischemia-reperfusion injury causes pulmonary endothelial cell ATP depletion. 
  • Intestinal mast cells mediate gut injury and systemic inflammation in a rat model of deep hypothermic circulatory arrest. 
  • Ischemia/reperfusion injury in microvascular surgery. 
  • L-selectin and ICAM-1 mediate reperfusion injury and neutrophil adhesion in the warm ischemic mouse liver. 
  • Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat. 
  • Limiting impairment of muscle function following ischemia and reperfusion in rabbits. 
  • Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. 
  • Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. 
  • Mechanisms of ischemic injury are different in the steatotic and normal rat liver. 
  • Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver. 
  • Mitochondrial transplantation in cardiac surgical patients: optimism, caveats, and outstanding questions. 
  • Mn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways. 
  • Molecular and immunohistochemical characterization of the onset and resolution of human renal allograft ischemia-reperfusion injury. 
  • Monitoring changes in gene expression in renal ischemia-reperfusion in the rat. 
  • Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants. 
  • N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity. 
  • NF-kappaB p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle. 
  • Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. 
  • Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage. 
  • Nitric oxide involvement in reperfusion injury of denervated muscle. 
  • Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema. 
  • Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. 
  • Of mice and women: do sex-dependent responses to ischemia-reperfusion injury in rodents have implications for delayed graft function in humans? 
  • Osteopontin expression during early cerebral ischemia-reperfusion in rats: enhanced expression in the right cortex is suppressed by acetaminophen. 
  • P-Selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver. 
  • PO2-dependent hydroxyl radical production during ischemia-reperfusion lung injury. 
  • Parathyroid hormone-related protein and lung injury after pulmonary thromboendarterectomy. 
  • Pathophysiology and related studies of the no reflow phenomenon in skeletal muscle. 
  • Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver. 
  • Poly-ADP-ribose-polymerase inhibition ameliorates hind limb ischemia reperfusion injury in a murine model of type 2 diabetes. 
  • Porcine hepatic phospholipid efflux during reperfusion after cold ischemia. 
  • Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus. 
  • Pretreatment with an inhibitor of mac-1 alters regional and systemic platelet function during ischemia-reperfusion in swine. 
  • Prevention of Reperfusion Injury in Skeletal Muscle. 
  • Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation. 
  • Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. 
  • Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats. 
  • Pulmonary hypertensive medical therapy in chronic thromboembolic pulmonary hypertension before pulmonary thromboendarterectomy. 
  • Reamed femoral nailing in patients with multiple injuries. Adverse effects of tourniquet use. 
  • Recent advances in immunosuppressive therapy for prevention of renal allograft rejection. 
  • Reperfusion and compartment syndromes: strategies for prevention and treatment. 
  • Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice. 
  • Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. 
  • Respiratory failure early after lung transplantation: now that we know the extent of the problem, what are the solutions? 
  • Results of recent large myocardial infarction trials, adjunctive therapies, and acute myocardial infarction: improving outcomes. 
  • Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies. 
  • Risk factors for reperfusion injury after lung transplantation. 
  • Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. 
  • S-nitroso-N-acetylcysteine protects skeletal muscle against reperfusion injury. 
  • Shock wave lithotripsy causes ipsilateral renal injury remote from the focal point: the role of regional vasoconstriction. 
  • Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size. 
  • Sirtuin-1 expression and activity is diminished in aged liver grafts. 
  • Skeletal muscle reperfusion injury is enhanced in extracellular superoxide dismutase knockout mouse. 
  • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. 
  • Studies of ischemia-reperfusion injury in skeletal muscle: efficacy of 21-aminosteroids on microcirculation and muscle contraction after an extended period of warm ischemia. 
  • Subnormothermic ex vivo lung perfusion attenuates graft inflammation in a rat transplant model. 
  • Summary of FDA workshop on ischemia reperfusion injury in kidney transplantation. 
  • Synergism between platelets and leukocytes in inducing endothelial cell apoptosis in the cold ischemic rat liver: a Kupffer cell-mediated injury. 
  • Taking a sound approach to acute kidney injury. 
  • The effect of endocannabinoid system in ischemia-reperfusion injury: a friend or a foe? 
  • The effects of N(omega)-propyl-L-arginine on reperfusion injury of skeletal muscle. 
  • The effects of exogenous nitric oxide donor on motor functional recovery of reperfused peripheral nerve. 
  • The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis. 
  • The inflammatory response to cardiopulmonary bypass. 
  • The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. 
  • The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury. 
  • The use of cylexin (CY-1503) in prevention of reperfusion lung injury in patients undergoing pulmonary thromboendarterectomy. 
  • Thromboxane receptor signalling in renal ischemia reperfusion injury. 
  • Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. 
  • Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion. 
  • Transient Reperfusion-Like Injury following Endovascular Treatment of Chronic Mesenteric Ischemia. 
  • Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. 
  • Untargeted metabolomics analysis of ischemia-reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats. 
  • Updates and Critical Insights on Glissonian Approach in Liver Surgery. 
  • Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury. 
  • V-PYRRO/NO: an hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion. 
  • Vascular endothelial growth factor expression in pig latissimus dorsi myocutaneous flaps after ischemia reperfusion injury. 
  • Vascular release of nonheme iron in perfused rabbit lungs. 
  • Venovenous extracorporeal life support after pulmonary endarterectomy: indications, techniques, and outcomes. 
  • What's next in the pipeline. 
  • pH-stat cooling improves cerebral metabolic recovery after circulatory arrest in a piglet model of aortopulmonary collaterals. 
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  Keywords of People

  • Esclamado, Ramon Mitra, Richard Hall Chaney, Sr. Distinguished Professor Emeritus of Otolaryngology, Head and Neck Surgery & Communication Sciences
  • Granger, Christopher Bull, Professor of Medicine, School of Nursing
  • Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology