Leukemia, Basophilic, Acute

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  Subject Areas on Research

  • Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity. 
  • Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. 
  • The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. 
  • Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation.