Leukemia, Promyelocytic, Acute

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  Subject Areas on Research

  • "Faggot" neutrophils in acute promyelocytic leukaemia with ongoing tretinoin therapy. 
  • "Hairy" cells in acute promyelocytic leukemia: Excess myeloperoxidase with formation of needle-shaped crystalline projections on the cytochemical stain in a case with variant morphology. 
  • A win-win situation 
  • Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies. 
  • Acute myeloid leukemia clinical practice guidelines in oncology. 
  • Acute myeloid leukemia, version 2.2013. 
  • Acute promyelocytic leukemia following solid organ transplantation. 
  • Anti-c-myc DNA increases differentiation and decreases colony formation by HL-60 cells. 
  • Arsenic trioxide in recurrent urothelial cancer: a cancer and leukemia group B phase II trial (CALGB 99903). 
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. 
  • Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. 
  • Cell density-dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response. 
  • Clinical use of oral contraceptives administered vaginally: a case report. 
  • Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). 
  • Degradation of von Willebrand factor in patients with acquired clinical conditions in which there is heightened proteolysis. 
  • Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era. 
  • Highlights from the 46 th annual meeting of the American Society of Hematology. 
  • Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. 
  • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. 
  • Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation. 
  • Lack of correlation between induction of chemotactic peptide receptors and stimulus-induced actin polymerization in HL-60 cells treated with dibutyryl cyclic adenosine monophosphate or retinoic acid. 
  • Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. 
  • Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin. 
  • Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways. 
  • NCCN Practice Guidelines for Acute Myelogenous Leukemia. 
  • Nitric oxide modulation of human leukemia cell differentiation and gene expression. 
  • Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes. 
  • Requirement for myeloid growth factors in the differentiation of acute promyelocytic leukaemia. 
  • Retinoic acid receptor alpha in acute promyelocytic leukemia. 
  • Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. 
  • Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia. 
  • Specific role for protein kinase C beta in cell differentiation. 
  • The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. 
  • The acute promyelocytic leukaemia-associated PML gene is induced by interferon. 
  • The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice. 
  • The t(15;17) translocation in acute promyelocytic leukemia. 
  • The t(15;17) translocation in acute promyelocytic leukemia. 
  • Thrombosis in acute promyelocytic leukemia. 
  • Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy. 
  • Wild-type p53 is a cell cycle checkpoint determinant following irradiation. 
  • rac, a novel ras-related family of proteins that are botulinum toxin substrates. 
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  Keywords of People

  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology