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Subject Areas on Research
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A lentiviral vector bearing a reverse intron demonstrates superior expression of both proteins and microRNAs.
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A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.
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A map of human cancer signaling.
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A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
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A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula.
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Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
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Addition of rituximab to chemotherapy overcomes the negative prognostic impact of cyclin E expression in diffuse large B-cell lymphoma.
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Adjuvant chemotherapy for non-small cell lung cancer.
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Androgen-independent prostate cancer progression in the TRAMP model.
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Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.
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Autoantibodies to DEK oncoprotein in human inflammatory disease.
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BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
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BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.
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BP1, a new homeobox gene, is frequently expressed in acute leukemias.
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Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin.
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Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function.
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C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
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CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
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CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
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Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
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Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer.
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Characterization of PDK2 activity against protein kinase B gamma.
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Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.
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Concise review: role of DEK in stem/progenitor cell biology.
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Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation.
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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog.
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DEK expression in Merkel cell carcinoma and small cell carcinoma.
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DEK expression in melanocytic lesions.
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DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen.
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DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.
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DEK is required for homologous recombination repair of DNA breaks.
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DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML).
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DEK over-expression promotes mitotic defects and micronucleus formation.
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DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.
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Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.
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Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury.
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Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.
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Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene.
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Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.
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Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.
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Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
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Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
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Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer.
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Functional domains of the ubiquitous chromatin protein DEK.
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G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications.
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GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.
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Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
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High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length.
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Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform.
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Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.
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Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma.
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Intercellular trafficking of the nuclear oncoprotein DEK.
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Kidney α-intercalated cells and lipocalin 2: defending the urinary tract.
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Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
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Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.
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MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis.
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Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
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Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines.
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Molecular pathophysiology of Parkinson's disease.
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Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer.
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Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.
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NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.
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Neuroblastoma in a pediatric patient with a microduplication of 2p involving the MYCN locus.
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Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression.
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Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs.
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P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype.
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Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).
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Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.
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Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma.
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Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
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Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A.
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Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
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RET polymorphisms and haplotypes and risk of differentiated thyroid cancer.
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Role of transforming growth factor-beta in hematologic malignancies.
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Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
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Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.
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Solution NMR structure of the N-terminal domain of the human DEK protein.
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Stacking the DEK: from chromatin topology to cancer stem cells.
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Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
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Subcellular localization of the human proto-oncogene protein DEK.
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Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
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Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival.
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The DEK nuclear autoantigen is a secreted chemotactic factor.
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The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.
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The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.
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The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
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The N-terminal Set-β Protein Isoform Induces Neuronal Death.
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The SAF-box domain of chromatin protein DEK.
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The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.
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The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress.
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The nuclear DEK interactome supports multi-functionality.
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The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.
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The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3.
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The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress.
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The unique DEK oncoprotein in women's health: A potential novel biomarker.
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Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.
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USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.
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Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
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c-Myc is required for maintenance of glioma cancer stem cells.
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gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum.
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Keywords of People