Oncogene Proteins

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  Subject Areas on Research

  • A lentiviral vector bearing a reverse intron demonstrates superior expression of both proteins and microRNAs. 
  • A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction. 
  • A map of human cancer signaling. 
  • A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. 
  • A role for sonic hedgehog signaling in the pathogenesis of human tracheoesophageal fistula. 
  • Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. 
  • Addition of rituximab to chemotherapy overcomes the negative prognostic impact of cyclin E expression in diffuse large B-cell lymphoma. 
  • Adjuvant chemotherapy for non-small cell lung cancer. 
  • Androgen-independent prostate cancer progression in the TRAMP model. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Autoantibodies to DEK oncoprotein in human inflammatory disease. 
  • BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. 
  • BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. 
  • BP1, a new homeobox gene, is frequently expressed in acute leukemias. 
  • Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin. 
  • Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. 
  • C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. 
  • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. 
  • Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. 
  • Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. 
  • Concise review: role of DEK in stem/progenitor cell biology. 
  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. 
  • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. 
  • DEK expression in Merkel cell carcinoma and small cell carcinoma. 
  • DEK expression in melanocytic lesions. 
  • DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen. 
  • DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. 
  • DEK is required for homologous recombination repair of DNA breaks. 
  • DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). 
  • DEK over-expression promotes mitotic defects and micronucleus formation. 
  • DEK regulates hematopoietic stem engraftment and progenitor cell proliferation. 
  • Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. 
  • Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury. 
  • Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. 
  • Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functional domains of the ubiquitous chromatin protein DEK. 
  • G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. 
  • GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma. 
  • Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma. 
  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. 
  • Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma. 
  • Intercellular trafficking of the nuclear oncoprotein DEK. 
  • Kidney α-intercalated cells and lipocalin 2: defending the urinary tract. 
  • Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. 
  • Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice. 
  • MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis. 
  • Melanoma proliferation and chemoresistance controlled by the DEK oncogene. 
  • Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines. 
  • Molecular pathophysiology of Parkinson's disease. 
  • Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. 
  • Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. 
  • NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. 
  • Neuroblastoma in a pediatric patient with a microduplication of 2p involving the MYCN locus. 
  • Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. 
  • Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs. 
  • P311 induces a TGF-beta1-independent, nonfibrogenic myofibroblast phenotype. 
  • Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). 
  • Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. 
  • Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma. 
  • Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. 
  • Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. 
  • Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction. 
  • RET polymorphisms and haplotypes and risk of differentiated thyroid cancer. 
  • Role of transforming growth factor-beta in hematologic malignancies. 
  • Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. 
  • Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Stacking the DEK: from chromatin topology to cancer stem cells. 
  • Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. 
  • Subcellular localization of the human proto-oncogene protein DEK. 
  • Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. 
  • Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. 
  • The DEK nuclear autoantigen is a secreted chemotactic factor. 
  • The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. 
  • The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. 
  • The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 
  • The N-terminal Set-β Protein Isoform Induces Neuronal Death. 
  • The SAF-box domain of chromatin protein DEK. 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. 
  • The nuclear DEK interactome supports multi-functionality. 
  • The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes. 
  • The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3. 
  • The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress. 
  • The unique DEK oncoprotein in women's health: A potential novel biomarker. 
  • Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. 
  • USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. 
  • Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. 
  • c-Myc is required for maintenance of glioma cancer stem cells. 
  • gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Taylor, Gregory Alan, Professor in Medicine, Immunology