Oncogene Proteins, Fusion
-
Subject Areas on Research
-
"Hairy" cells in acute promyelocytic leukemia: Excess myeloperoxidase with formation of needle-shaped crystalline projections on the cytochemical stain in a case with variant morphology.
-
A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
-
A Nanopore Sequencing-Based Assay for Rapid Detection of Gene Fusions.
-
A critical role for CRM1 in regulating HOXA gene transcription in CALM-AF10 leukemias.
-
A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia.
-
A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer.
-
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
-
Brain Metastases in Lung Cancers with Emerging Targetable Fusion Drivers.
-
Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.
-
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study.
-
Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.
-
Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes.
-
Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias.
-
Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.
-
Down syndrome childhood acute lymphoblastic leukemia has a unique spectrum of sentinel cytogenetic lesions that influences treatment outcome: a report from the Children's Oncology Group.
-
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
-
Dysregulation of hedgehog signalling predisposes to synovial chondromatosis.
-
Effects of iron depletion on CALM-AF10 leukemias.
-
Erythrophagocytosis in a cyclin D1 positive plasma cell myeloma with near-tetraploid karyotypic abnormalities and cryptic MYC/IGH fusion.
-
Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.
-
FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.
-
Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.
-
Fusion of the CRM1 nuclear export receptor to AF10 causes leukemia and transcriptional activation of HOXA genes.
-
Intraventricular Pilocytic Astrocytoma With KIAA1549/BRAF Fusion Arising in a 44-Year Old.
-
Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.
-
MLL-ENL leukemia burden initiated in femoral diaphysis and preceded by mature B-cell depletion.
-
Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity.
-
Molecular and cytogenetic characterization of a novel rearrangement involving chromosomes 9, 12, and 17 resulting in ETV6 (TEL) and ABL fusion.
-
Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia.
-
Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways.
-
Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.
-
Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics.
-
Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes.
-
PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
-
PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.
-
Personalized treatment of lung cancer.
-
Prospective analysis of TEL gene rearrangements in childhood acute lymphoblastic leukemia: a Children's Oncology Group study.
-
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
-
Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.
-
Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia.
-
Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.
-
Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
-
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
-
Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
-
TMPRSS2-ERG fusion is frequently observed in Gleason pattern 3 prostate cancer in a Canadian cohort.
-
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.
-
The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice.
-
The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice.
-
The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis.
-
The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas.
-
The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.
-
The t(15;17) translocation in acute promyelocytic leukemia.
-
The t(15;17) translocation in acute promyelocytic leukemia.
-
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.
-
t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
-
Keywords of People