Bone Density

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  Subject Areas on Research

  • 25-Hydroxyvitamin D therapy in children with active juvenile rheumatoid arthritis: short-term effects on serum osteocalcin levels and bone mineral density. 
  • A 1-y walking program and increased dietary calcium in postmenopausal women: effects on bone. 
  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. 
  • A claims database analysis of persistence with alendronate therapy and fracture risk in post-menopausal women with osteoporosis. 
  • A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. 
  • A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone versus cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis. 
  • A review of the effect of anticonvulsant medications on bone mineral density and fracture risk. 
  • Abnormal bone turnover in cystic fibrosis adults. 
  • Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases. 
  • Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. 
  • Altered skeletal maturation in moderate to severe cerebral palsy. 
  • Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. 
  • An endocrine perspective on menstrual suppression for adolescents: achieving good suppression while optimizing bone health. 
  • An evaluation of patient preferences for osteoporosis medication attributes: results from the PREFER-US study. 
  • Androgen deprivation therapy for prostate cancer results in significant loss of bone density. 
  • Anthropometric risk factors for prostate cancer. 
  • Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. 
  • Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. 
  • Assessment of gene-by-sex interaction effect on bone mineral density. 
  • Benefits, risk, and uncertainty: preferences of antiretroviral-naïve African Americans for HIV treatments. 
  • Biomechanical Comparison of External Fixation and Compression Screws for Transverse Tarsal Joint Arthrodesis. 
  • Biomechanical comparison of 4 different lateral plate constructs for distal fibula fractures. 
  • Biomechanical comparison of screws and plates for hallux valgus opening-wedge and Ludloff osteotomies. 
  • Body composition and bone mineral density in breast cancer survivors and non-cancer controls: A 12- to 15-month follow-up. 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • Bone density and amenorrhea in ballet dancers are related to a decreased resting metabolic rate and lower leptin levels. 
  • Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy. 
  • Bone density changes in women who receive thromboprophylaxis in pregnancy. 
  • Bone density loss after allogeneic hematopoietic stem cell transplantation: a prospective study. 
  • Bone density loss during treatment of chronic GVHD. 
  • Bone density status in a large population of patients with anorexia nervosa. 
  • Bone formation induced by BMP-2 in human osteosarcoma cells. 
  • Bone metabolism in childhood rheumatic disease. 
  • Bone mineral status in juvenile rheumatoid arthritis. 
  • Bone outcomes and technical measurement issues of bone health among children and adolescents: considerations for nutrition and physical activity intervention trials. 
  • Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss. 
  • Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • CT scans and 3D reconstructions of Florida manatee (Trichechus manatus latirostris) heads and ear bones. 
  • Can we identify women at high risk of osteoporotic fractures? 
  • Changes in bone health and skeletal-related events following implementation of a multidisciplinary consensus statement guiding surveillance and treatment of men undergoing androgen deprivation therapy for prostate cancer. 
  • Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. 
  • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. 
  • Clinical Fractures Among Older Men With Diabetes Are Mediated by Diabetic Complications. 
  • Competing Risks of Fracture and Death in Older Adults with Chronic Kidney Disease. 
  • Conditional estimation for generalized linear models when covariates are subject-specific parameters in a mixed model for longitudinal measurements. 
  • Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease. 
  • Cortical Bone Thickness of the Distal Part of the Tibia Predicts Bone Mineral Density. 
  • Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 
  • Denosumab for the treatment of osteoporosis. 
  • Depressive symptomatology and fracture risk in community-dwelling older men and women. 
  • Determining changes in bone metabolism after bariatric surgery in postmenopausal women. 
  • Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD). 
  • Diabetes is associated with a lower minimum moment of inertia among older women: An analysis of 3D reconstructions of clinical CT scans. 
  • Diagnostic findings in painful adult scoliosis. 
  • Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. 
  • Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. 
  • Distribution and correlates of serum 25-hydroxyvitamin D levels in a sample of patients with hip fracture. 
  • Does femoral component loosening predispose to femoral fracture?: an in vitro comparison of cemented hips. 
  • Does low bone mineral density cause a broken heart? 
  • Drug therapy increases bone density in osteonecrosis of the femoral head in canines. 
  • Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders. 
  • Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. 
  • Effect of alendronate on bone mineral density in male idiopathic osteoporosis. 
  • Effect of antiepileptic drugs on bone density in ambulatory patients. 
  • Effect of selective serotonin reuptake inhibitors on the risk of fracture. 
  • Effects of Roux-en-Y Gastric Bypass on Osteoclast Activity and Bone Density in Morbidly Obese Patients with Type 2 Diabetes. 
  • Effects of exercise training on bone density in older men and women. 
  • Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. 
  • Effects of lead exposure on skeletal development in rats. 
  • Effects of phosphate binders in moderate CKD. 
  • Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal men. 
  • Effects of vitamin D insufficiency on bone mineral density in African American men. 
  • Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged 75 and older. 
  • Efficacy of alendronate in adults with cystic fibrosis with low bone density. 
  • Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. 
  • Eliglustat maintains long-term clinical stability in patients with Gaucher disease type 1 stabilized on enzyme therapy. 
  • Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue. 
  • Exercise and nutritional needs of elderly people: effects on muscle and bone. 
  • Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones. 
  • Experimental confirmation of the sheep model for studying the role of calcified fibrocartilage in hip fractures and tendon attachments. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • FRAX without BMD can be used to risk-stratify Veterans who recently sustained a low trauma non-vertebral/non-hip fracture. 
  • Femoral neck and shaft structure in Homo naledi from the Dinaledi Chamber (Rising Star System, South Africa). 
  • Fibrogenesis imperfecta ossium: MR imaging of the axial and appendicular skeleton and correlation with a unique radiographic appearance. 
  • Five-year efficacy and safety of asfotase alfa therapy for adults and adolescents with hypophosphatasia. 
  • Fracture Rates and Bone Density Among Postmenopausal Veteran and Non-Veteran Women From the Women's Health Initiative. 
  • Fracture Reduction Affects Medicare Economics (FRAME): impact of increased osteoporosis diagnosis and treatment. 
  • Fractures in children with Pompe disease: a potential long-term complication. 
  • Functional Impairments Mediate Association Between Clinical Fracture Risk and Type 2 Diabetes Mellitus in Older Women. 
  • Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men. 
  • Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci. 
  • Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. 
  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 
  • Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus. 
  • How bone density testing influenced osteoporosis treatment in a community hospital. 
  • How does women's bone health recover after lactation? A systematic review and meta-analysis. 
  • Hypercalciuria due to combined growth hormone and calcitriol therapy in uremia: effects of growth hormone on mineral homeostasis in 75% nephrectomized weanling rats. 
  • Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density. 
  • Improved assessment of lumbar vertebral body strength using supine lateral dual-energy x-ray absorptiometry. 
  • Increasing weight-bearing physical activity and calcium intake for bone mass growth in children and adolescents: a review of intervention trials. 
  • Influence of cognitive eating restraint on total-body measurements of bone mineral density and bone mineral content in premenopausal women aged 18-45 y: a cross-sectional study. 
  • Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial. 
  • Interlimb differences in lower extremity bone mineral density following anterior cruciate ligament reconstruction. 
  • Interventions to address chronic disease and HIV: strategies to promote exercise and nutrition among HIV-infected individuals. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. 
  • Life-long caloric restriction does not alter the severity of age-related osteoarthritis. 
  • Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. 
  • Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. 
  • Low bone mass in behaviorally HIV-infected young men on antiretroviral therapy: Adolescent Trials Network Study 021B. 
  • Lower Bone Density on Preoperative Computed Tomography Predicts Periprosthetic Fracture Risk in Total Ankle Arthroplasty. 
  • MRI assessment of bone structure and microarchitecture. 
  • Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis. 
  • Mechanical effects of the extended trochanteric osteotomy. 
  • Medical screening participation in the childhood cancer survivor study. 
  • Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. 
  • Metacarpal head biomechanics: a comparative backscattered electron image analysis of trabecular bone mineral density in Pan troglodytes, Pongo pygmaeus, and Homo sapiens. 
  • Muscle strength and body composition: associations with bone density in older subjects. 
  • Older men's explanatory model for osteoporosis. 
  • Oligodontia is caused by mutation in LTBP3, the gene encoding latent TGF-beta binding protein 3. 
  • Once-yearly zoledronic acid in older men compared with women with recent hip fracture. 
  • Osteoporosis and depression: a historical perspective. 
  • Osteoporosis in lung transplant candidates compared to matched healthy controls. 
  • Osteoporosis prevention and management: an evidence-based review. 
  • Osteoporosis: a pediatric perspective. 
  • Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. 
  • Pamidronate treatment and posttreatment bone density in children with spastic quadriplegic cerebral palsy. 
  • Parathyroid Hormone and the Use of Diuretics and Calcium-Channel Blockers: The Multi-Ethnic Study of Atherosclerosis. 
  • Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT study. 
  • Pediatric reference data for dual X-ray absorptiometric measures of normal bone density in the distal femur. 
  • Persistence at 12 months with denosumab in postmenopausal women with osteoporosis: interim results from a prospective observational study. 
  • Persistence at 24 months with denosumab among postmenopausal women with osteoporosis: results of a prospective cohort study. 
  • Phase II study of single-agent orteronel (TAK-700) in patients with nonmetastatic castration-resistant prostate cancer and rising prostate-specific antigen. 
  • Physical activity alters limb bone structure but not entheseal morphology. 
  • Potential kidney toxicity from the antiviral drug tenofovir: new indications, new formulations, and a new prodrug. 
  • Precision and accuracy of a transportable dual-energy X-ray absorptiometry unit for bone mineral measurements in guinea pigs. 
  • Predictors of bone density in ambulatory patients on antiepileptic drugs. 
  • Protocol for the models of primary osteoporosis screening in men (MOPS) cluster randomized trial. 
  • Pullout strength of suture anchors: effect of mechanical properties of trabecular bone. 
  • Racial and ethnic differences in physical activity and bone density: National Health and Nutrition Examination Survey, 2007-2008. 
  • Rationale and Design for a Higher (Dairy) Protein Weight Loss Intervention That Promotes Muscle Quality and Bone Health in Older Adults with Obesity: A Randomized, Controlled Pilot Study. 
  • Rationale, objectives and design of the Direct Analysis of Nonvertebral Fracture in the Community Experience (DANCE) study. 
  • Re: Epilepsy-associated bone mineral density loss should be prevented. 
  • Recommendations for the registration of agents for prevention and treatment of glucocorticoid-induced osteoporosis: an update from the Group for the Respect of Ethics and Excellence in Science. 
  • Reduction in the risk of clinical fractures after a single dose of zoledronic Acid 5 milligrams. 
  • Repair of osteopenia in children with juvenile rheumatoid arthritis. 
  • Repeat bone mineral density screening and prediction of hip and major osteoporotic fracture. 
  • Response to Sabour: Dual-energy X-ray absorptiometry and fracture prediction in patients with spinal cord injuries and disorders: methodological issues. 
  • Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. 
  • Safety of two-year caloric restriction in non-obese healthy individuals. 
  • Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users. 
  • Should there be a fracas over FRAX and other fracture prediction tools?: Comment on "A comparison of prediction models for fractures in older women". 
  • Strength and stability of posterior lumbar interbody fusion. Comparison of titanium fiber mesh implant and tricortical bone graft. 
  • Subchondral bone remodeling is related to clinical improvement after joint distraction in the treatment of ankle osteoarthritis. 
  • Subgroup variations in bone mineral density response to zoledronic acid after hip fracture. 
  • Survivor typologies predict medical surveillance participation: the childhood cancer survivor study. 
  • Ten vs five years of bisphosphonate treatment for postmenopausal osteoporosis: enough of a good thing. 
  • Tenofovir Has Minimal Effect on Biomarkers of Bone Health in Youth with HIV Receiving Initial Antiretroviral Therapy. 
  • The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy. 
  • The HORIZON Recurrent Fracture Trial: design of a clinical trial in the prevention of subsequent fractures after low trauma hip fracture repair. 
  • The assessment of bone mineral content and density of the lumbar spine and proximal femur in US submariners. 
  • The clinical impact of vertebral fractures: quality of life in women with osteoporosis. 
  • The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. 
  • The effect of intermittent pneumatic compression on fracture healing. 
  • The effect of the trabecular microstructure on the pullout strength of suture anchors. 
  • The effects of bone density and disc degeneration on the structural property distributions in the lower lumbar vertebral endplates. 
  • The effects of medications on bone. 
  • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. 
  • The influence of patient age and bone mineral density on osteotomy fixation stability after hallux valgus surgery: A biomechanical study. 
  • The response of circulating parameters of bone mineral metabolism to ethanol- and EDTA-induced hypocalcemia in the rat. 
  • The review process fails to require appropriate statistical analysis of a group-randomized trial. 
  • The role of imaging and in situ biomechanical testing in assessing pedicle screw pull-out strength. 
  • The role of menopausal hormone therapy in preventing osteoporotic fractures: a critical review of the clinical evidence. 
  • Three-Dimensional Characterization of Trabecular Bone Mineral Density of the Distal Radius Utilizing Quantitative Computed Tomography. 
  • Three-dimensional characterization of trabecular bone mineral density of the proximal ulna using quantitative computed tomography. 
  • Time to onset of antifracture efficacy and year-by-year persistence of effect of zoledronic acid in women with osteoporosis. 
  • Topical calcipotriene has no short-term effect on calcium and bone metabolism of patients with psoriasis. 
  • Trabecular bone in the bird knee responds with high sensitivity to changes in load orientation. 
  • Treatment of anorexia nervosa is associated with increases in bone mineral density, and recovery is a biphasic process involving both nutrition and return of menses. 
  • Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density. 
  • Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone. 
  • Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone. 
  • Type 2 diabetes, thiazolidinediones: bad to the bone? 
  • Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. 
  • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). 
  • Update on the use of distal radial bone density measurements in prediction of hip and Colles' fracture risk. 
  • Vitamin D and the athlete-patient: state of the art. 
  • Vitamin D receptor alleles do not correlate with bone mineral density in premenopausal Caucasian women from the southeastern United States. 
  • Weight loss, exercise, or both and physical function in obese older adults. 
  • Zoledronic Acid in Reducing Clinical Fracture and Mortality after Hip Fracture. 
  • Zoledronic acid preserves bone mineral density in premenopausal women who develop ovarian failure due to adjuvant chemotherapy: final results from CALGB trial 79809. 
  • Zoledronic acid reduces the rate of clinical fractures after surgical repair of a hip fracture regardless of the Pretreatment bone mineral density. 
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  Keywords of People

  • Case, Laura Elizabeth, Associate Professor in Orthopaedic Surgery, Pediatrics, Medical Genetics
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Gall, Ken, Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science
  • Gold, Deborah T., Professor Emeritus in Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry
  • Lee, Richard H., Assistant Professor of Medicine, Medicine, Endocrinology, Metabolism, and Nutrition
  • Lyles, Kenneth Ward, Professor of Medicine, Medicine, Geriatrics
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics