Autoimmunity

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  Subject Areas on Research

  • 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity. 
  • miR-146a -Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. 
  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • A Case with Purine Nucleoside Phosphorylase Deficiency Suffering from Late-Onset Systemic Lupus Erythematosus and Lymphoma. 
  • A Distinct Function of Regulatory T Cells in Tissue Protection. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. 
  • A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity. 
  • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. 
  • Advances in autoimmune myasthenia gravis management. 
  • African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. 
  • Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • Amicrobial Pustulosis of the Folds and Autoimmunity. 
  • An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication. 
  • Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. 
  • Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. 
  • Apoptosis and B cell tolerance. 
  • Association Between Thyroid Disease and Uveitis: Results From the Pacific Ocular Inflammation Study. 
  • Autoimmunity and neurological disease: antibody modulation of synaptic transmission. 
  • Autoimmunity in immunodeficiency. 
  • Autoimmunity. The Fas track. 
  • Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators. 
  • Autoimmunity: the nuclear arsenal of autoimmunity. 
  • B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • B10 cell regulation of health and disease. 
  • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. 
  • Basement membranes and autoimmune diseases. 
  • Biomaterial strategies for generating therapeutic immune responses. 
  • Bronchiolitis obliterans syndrome: the final frontier for lung transplantation. 
  • CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity. 
  • CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis. 
  • CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. 
  • Cellular targeting in autoimmunity. 
  • Changing concepts in pathophysiology of the vasculitides. 
  • Chicago 2014--30 years of γδ T cells. 
  • Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. 
  • Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity. 
  • Coughing up blood: Behçet's disease. 
  • Deconstructing B cell tolerance to basement membranes. 
  • Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis. 
  • Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies. 
  • Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups. 
  • Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease. 
  • Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. 
  • Dystrophin immunity in Duchenne's muscular dystrophy. 
  • Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. 
  • Editorial: Neuro-Immune Interactions in Inflammation and Autoimmunity. 
  • Editorial: The Role of Nuclear Molecules in the Pathogenesis of Autoimmune Disease. 
  • Effects of immune checkpoint inhibitors on B cells: relationship to immune-related adverse events. 
  • Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. 
  • Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro. 
  • Evidence for glutamate receptor autoimmunity in the pathogenesis of Rasmussen encephalitis. 
  • Evolving story of autoantibodies in systemic lupus erythematosus. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer. 
  • Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry. 
  • Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity. 
  • Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity. 
  • Fulfilling Koch's postulates of autoimmunity: anti-NR2 antibodies in mice and men. 
  • Gene expression profiling in human autoimmunity. 
  • Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas. 
  • Glutamate receptor autoimmunity in Rasmussen's encephalitis. 
  • Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunity. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • Hematopoietic Stem Cell Transplantation in ADA2 Deficiency: Early Restoration of ADA2 Enzyme Activity and Disease Relapse upon Drop of Donor Chimerism. 
  • High-mobility group box 1 (HMGB1) protein: friend and foe. 
  • How the gut inflames the joints. 
  • Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II. 
  • Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors. 
  • ICON: the early diagnosis of congenital immunodeficiencies. 
  • IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. 
  • IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis. 
  • IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. 
  • IRGM1 links mitochondrial quality control to autoimmunity. 
  • Identification of potential cytokine pathways for therapeutic intervention in murine primary biliary cirrhosis. 
  • Immune Gamma Globulin Therapeutic Indications in Immune Deficiency and Autoimmunity. 
  • Immunopathogenesis of juvenile dermatomyositis. 
  • Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. 
  • Immunoregulation on the ocular surface: 2nd Cullen Symposium. 
  • In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice. 
  • Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. 
  • Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review. 
  • Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. 
  • JunB promotes Th17 cell identity and restrains alternative CD4+ T-cell programs during inflammation. 
  • Juvenile arthritis and autoimmunity to type II collagen. 
  • Lupus-like nephrotropic autoantibodies in non-autoimmune mice harboring an anti-basement membrane/anti-DNA Ig heavy chain transgene. 
  • Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways. 
  • Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. 
  • Molecular properties of anti-DNA induced in preautoimmune NZB/W mice by immunization with bacterial DNA. 
  • Monocytes prime autoreactive T cells after myocardial infarction. 
  • Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome. 
  • Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease. 
  • Mycophenolate mofetil suppresses autoimmunity and mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus. 
  • NLRC3 expression in dendritic cells attenuates CD4+ T cell response and autoimmunity. 
  • Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. 
  • Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease--dermatitis herpetiformis. 
  • Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. 
  • Noninvasive markers in the assessment and management of autoimmune liver diseases. 
  • Optimizing the translational value of animal models of glomerulonephritis: insights from recent murine prototypes. 
  • Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. 
  • Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS). 
  • Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. 
  • Parkinson disease and the immune system - associations, mechanisms and therapeutics. 
  • Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading. 
  • Pathogenesis of heparin-induced thrombocytopenia and thrombosis. 
  • Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. 
  • Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models. 
  • Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. 
  • Pregnancy and rheumatoid arthritis: insights into the immunology of fetal tolerance and control of autoimmunity. 
  • Prevalence of autoimmunity and atopy in US adults with glioblastoma and meningioma. 
  • Profiling and targeting connective tissue remodeling in autoimmunity - A novel paradigm for diagnosing and treating chronic diseases. 
  • RNA recognition by autoantigens and autoantibodies. 
  • Regulation of Intrinsic and Bystander T Follicular Helper Cell Differentiation and Autoimmunity by Tsc1. 
  • Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice. 
  • Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. 
  • Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. 
  • Response to: "Antinuclear autoantibodies: discordance among four different assays" by Pacheco et al. 
  • Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study. 
  • Retinoic acid signaling acts as a rheostat to balance Treg function. 
  • Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. 
  • Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level. 
  • Role of complement activation in obliterative bronchiolitis post-lung transplantation. 
  • Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity. 
  • Scavenging nucleic acid debris to combat autoimmunity and infectious disease. 
  • Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. 
  • Self and non-self discrimination of intracellular membranes by the innate immune system. 
  • Self-tolerance curtails the B cell repertoire to microbial epitopes. 
  • Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. 
  • Silica Exposure Differentially Modulates Autoimmunity in Lupus Strains and Autoantibody Transgenic Mice. 
  • Stability and function of regulatory T cells expressing the transcription factor T-bet. 
  • Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation. 
  • Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. 
  • Suppressing autoimmunity by TGF-β: not just through T(reg) cells. 
  • Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity. 
  • Synthetic autoantigens of immunoglobulins and T-cell receptors: their recognition in aging, infection, and autoimmunity. 
  • T cells as a self-referential, sensory organ. 
  • T-cell-mediated pure red-cell aplasia in systemic lupus erythematosus: response to cyclosporin A and mycophenolate mofetil. 
  • TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function. 
  • Targeting anti-beta-1-adrenergic receptor antibodies for dilated cardiomyopathy. 
  • Targeting the TLR9-MyD88 pathway in the regulation of adaptive immune responses. 
  • The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity. 
  • The association between immunodeficiency and the development of autoimmune disease. 
  • The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE. 
  • The danger of sex and death in Scarf1(-/-) autoimmune mice. 
  • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. 
  • The effect of UVB on lupus skin: new light on the role of apoptosis in the pathogenesis of autoimmunity. 
  • The future of biology in driving the field of hyperthermia. 
  • The inflammatory milieu in idiopathic inflammatory myositis. 
  • The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis. 
  • The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. 
  • The nephritogenic immune response. 
  • The pathologic and clinical intersection of atopic and autoimmune disease. 
  • The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. 
  • The role of TASL in the pathogenesis of SLE: X marks the spot. 
  • The role of cpg sequences in the induction of anti-DNA antibodies. 
  • The role of extracellular DNA in autoimmunity in SLE. 
  • The role of innate immunity in the induction of autoimmunity. 
  • The role of interferon-β in the treatment of multiple sclerosis and experimental autoimmune encephalomyelitis - in the perspective of inflammasomes. 
  • The role of microparticles in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. 
  • Therapeutic CD154 antibody for lupus: promise for the future? 
  • Thymic epithelial defects and predisposition to autoimmune disease in BB rats. 
  • Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes. 
  • Tracing Self-Reactive B Cells in Normal Mice. 
  • Two Sides of the Same Coin: Pediatric-Onset and Adult-Onset Common Variable Immune Deficiency. 
  • Warts and DADA2: a Mere Coincidence? 
  • What causes hidradenitis suppurativa ?-15 years after. 
  • microRNA-142 guards against autoimmunity by controlling Treg cell homeostasis and function. 
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  Keywords of People

  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Lagoo, Anand Shreeram, Professor of Pathology, Pathology
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology