Keratinocytes

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  Subject Areas on Research

  • A new generation organ culture arising from cross-talk between multiple primary human cell types. 
  • A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling. 
  • A recent update of pharmacogenomics in drug-induced severe skin reactions. 
  • A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. 
  • AD2, a human molecule involved in the interaction of T cells with epidermal keratinocytes and thymic epithelial cells. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Activation of protein kinase C inhibits human keratinocyte migration. 
  • Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. 
  • BRCA2 monoclonal antibodies react with differentiating epithelium. 
  • Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-caryophyllene enhances wound healing through multiple routes. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Burn Injury Alters Epidermal Cholinergic Mediators and Increases HMGB1 and Caspase 3 in Autologous Donor Skin and Burn Margin. 
  • CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • Calcium modulates the expression of urokinase plasminogen activator and plasminogen activator inhibitor 2 by human keratinocytes. 
  • Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. 
  • Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. 
  • Characterization of an Epstein-Barr virus receptor on human epithelial cells. 
  • Characterization of human thymic epithelial cell surface antigens: phenotypic similarity of thymic epithelial cells to epidermal keratinocytes. 
  • Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1. 
  • Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes. 
  • Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. 
  • Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. 
  • Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. 
  • Correlates of skin-related quality of life (QoL) in those with multiple keratinocyte carcinomas (KCs): A cross-sectional study. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors 
  • Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle. 
  • DEK proto-oncogene expression interferes with the normal epithelial differentiation program. 
  • Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. 
  • Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies. 
  • Differential expression of plasminogen activators and their inhibitors in an organotypic skin coculture system. 
  • Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. 
  • Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. 
  • Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin. 
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 
  • E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. 
  • Effective blue light photodynamic therapy does not affect cutaneous langerhans cell number or oxidatively damage DNA. 
  • Effects of Y27632 on keratinocyte procurement and wound healing. 
  • Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. 
  • Epidermal denervation and its effects on keratinocytes and Langerhans cells. 
  • Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. 
  • Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound healing and tissue remodeling after injury. 
  • FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. 
  • Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo. 
  • Functional Advantages of Porphyromonas gingivalis Vesicles. 
  • Functions of skin-resident γδ T cells. 
  • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. 
  • Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. 
  • Host priming, not target antigen type, decides rejection rate in mice primed with MHC II "knockout" cultured keratinocytes. 
  • Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium. 
  • Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage. 
  • IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity. 
  • IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses. 
  • IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense. 
  • IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. 
  • Identification and characterization of small molecule inducers of epidermal keratinocyte differentiation 
  • In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. 
  • In vitro studies of acantholysis of keratinocytes induced by pemphigus antibody. 
  • Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1. 
  • Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. 
  • KIF18B is a cell type-specific regulator of spindle orientation in the epidermis. 
  • KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage. 
  • Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues. 
  • Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. 
  • Manganese superoxide dismutase-mediated inside-out signaling in HaCaT human keratinocytes and SKH-1 mouse skin. 
  • MicroRNAs in skin tissue engineering. 
  • NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. 
  • Nonlinear microscopy of eumelanin and pheomelanin with subcellular resolution. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures. 
  • PGC-1 coactivators regulate MITF and the tanning response. 
  • PSORS2 is due to mutations in CARD14. 
  • Pain regulation by non-neuronal cells and inflammation. 
  • Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. 
  • Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. 
  • Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1. 
  • Problematic End Points in a Trial of Topical Fluorouracil, 5%, for Chemoprevention of Keratinocyte Carcinoma-Reply. 
  • Proteomic analysis of desmosomes reveals novel components required for epidermal integrity. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • Roles for Ndel1 in keratin organization and desmosome function. 
  • Roles for microtubules in the proliferative and differentiated cells of stratified epithelia. 
  • S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. 
  • Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair. 
  • Sox2 is required for development of taste bud sensory cells. 
  • Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. 
  • Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. 
  • Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds. 
  • TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. 
  • TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation. 
  • TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. 
  • The 120-kDa soluble ectodomain of type XVII collagen is recognized by autoantibodies in patients with pemphigoid and linear IgA dermatosis. 
  • The E5 protein of human papillomavirus type 16 perturbs MHC class II antigen maturation in human foreskin keratinocytes treated with interferon-gamma. 
  • The Genomic Landscape of Actinic Keratosis. 
  • The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice. 
  • The cutaneous manifestations of atypical complete DiGeorge syndrome: a histopathologic and immunohistochemical study. 
  • The role of TRPV4 channels in cutaneous epithelia. 
  • Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. 
  • Transcriptional signature primes human oral mucosa for rapid wound healing. 
  • Transforming growth factor beta 1 dysregulation in a human oral carcinoma tumour progression model. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. 
  • Tretinoin and the prevention of keratinocyte carcinoma (Basal and squamous cell carcinoma of the skin): a veterans affairs randomized chemoprevention trial. 
  • Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis. 
  • VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. 
  • Value of skin biopsies in assessing prognosis and progression of acute graft-versus-host disease. 
  • [New developments in skin replacement materials]. 
  • beta-Catenin protects the epidermis from mechanical stresses. 
  • c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA. 
  • cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium. 
  • cFLIP regulates skin homeostasis and protects against TNF-induced keratinocyte apoptosis. 
  • mRNA for tissue-type plasminogen activator is present in lesional epidermis from patients with psoriasis, pemphigus, or bullous pemphigoid, but is not detected in normal epidermis. 
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  Keywords of People

  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Lechler, Terry H., Professor in Dermatology, Cell Biology
  • MacLeod, Amanda S, Adjunct Associate Professor in the Department of Dermatology, Integrative Immunobiology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology