Respiratory Mechanics

• 

  Subject Areas on Research

  • A comparative analysis of marine mammal tracheas. 
  • A comparison of Depodur, a novel, single-dose extended-release epidural morphine, with standard epidural morphine for pain relief after lower abdominal surgery. 
  • A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF. 
  • A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study. 
  • A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. 
  • A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents. 
  • A short-breath-hold technique for lung pO2 mapping with 3He MRI. 
  • A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response. 
  • Active Breathing Coordinator reduces radiation dose to the heart and preserves local control in patients with left breast cancer: report of a prospective trial. 
  • Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasia. 
  • Aerosolized medications for altering lung surface active properties. 
  • Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. 
  • Alveolar septal structure in different species. 
  • An automated method for comparing motion artifacts in cine four-dimensional computed tomography images. 
  • Angiotensin mediates stimulation of ventilation after vasopressin V1 receptor blockade. 
  • Anterior mediastinal masses: look before you leap. 
  • Are there benefits or harm from pressure targeting during lung-protective ventilation? 
  • Artificial surfactant attenuates hyperoxic lung injury in primates. I. Physiology and biochemistry. 
  • Automated measurement of the lower inflection point in a pediatric lung model. 
  • BIPAP for management of hypoxemia associated with unilateral phrenic nerve palsy following surgery for thoracic outlet syndrome. 
  • Beneficial effects of high positive end-expiratory pressure in lung respiratory mechanics during laparoscopic surgery. 
  • Breath timing, volume and drive to breathe in conscious rats: comparative aspects. 
  • Calculation and prediction of the effect of respiratory motion on whole breast radiation therapy dose distributions. 
  • Clinical Management Strategies for Airway Pressure Release Ventilation: A Survey of Clinical Practice. 
  • Clinical outcomes and lung mechanics characteristics between COVID-19 and non-COVID-19-associated acute respiratory distress syndrome: a propensity score analysis of two major randomized trials. 
  • Clinically available new strategies for mechanical ventilatory support. 
  • Combining pressure-limiting and volume-cycling features in a patient-interactive mechanical breath. 
  • Comparison of fluctuations of oxygen tension in FSA, 9L, and R3230AC tumors in rats. 
  • Consensus statement: aerosols and delivery devices. American Association for Respiratory Care. 
  • Contour based respiratory motion analysis for free breathing CT. 
  • Design and evaluation of a new, low pressure loss, implantable artificial lung. 
  • Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. 
  • Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. 
  • Direct measurement of lung motion using hyperpolarized helium-3 MR tagging. 
  • Dose-toxicity relationship of gadoxetate disodium and transient severe respiratory motion artifact. 
  • Dynamic MRI of grid-tagged hyperpolarized helium-3 for the assessment of lung motion during breathing. 
  • Effect of dietary fat on metabolic adjustments to maximal VO2 and endurance in runners. 
  • Effect of fasting on the VO2-fh relationship in king penguins, Aptenodytes patagonicus. 
  • Effect of respiratory motion on lung counting efficiency using a 4D NURBS-based cardio-torso (NCAT) phantom. 
  • Effects of breathing variation on gating window internal target volume in respiratory gated radiation therapya). 
  • Effects of implementing adaptive support ventilation in a medical intensive care unit. 
  • End tidal-to-arterial CO2 and O2 gas gradients at low- and high-altitude during dynamic end-tidal forcing. 
  • Estimation of the heart respiratory motion with applications for cone beam computed tomography imaging: a simulation study. 
  • Evaluation of a new weaning index based on ventilatory endurance and the efficiency of gas exchange. 
  • Evaluation of integrated respiratory gating systems on a Novalis Tx system. 
  • Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine. 
  • Evolving approaches to assessing and monitoring patient-ventilator interactions. 
  • Exercise, obesity, and asthma in children and adolescents. 
  • Hyperbaric tracheobronchial compression in cetaceans and pinnipeds. 
  • Hyperpolarized 3He NMR lineshape measurements in the live guinea pig lung. 
  • Hyperpolarized helium-3 MR imaging of pulmonary function. 
  • Interhemispheric synchrony of slow oscillations of cortical blood volume and cytochrome aa3 redox state in unanesthetized rabbits. 
  • Investigation of sliced body volume (SBV) as respiratory surrogate. 
  • Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass. 
  • Living-related lobar lung transplantation. 
  • Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity. 
  • Lung mechanics and pulmonary function testing in cetaceans. 
  • MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation. 
  • Major hepatic trauma: warm ischemic tolerance of the liver after hemorrhagic shock. 
  • Maturational changes in airway smooth muscle shortening and relaxation. Implications for asthma. 
  • Measurement of regional lung function in rats using hyperpolarized 3helium dynamic MRI. 
  • Mechanisms of functional loss in patients with chronic lung disease. 
  • Micro-CT with respiratory and cardiac gating. 
  • Monitoring during peripheral nerve blockade. 
  • Monitoring respiratory function. 
  • Muscle dysfunction associated with chronic obstructive pulmonary disease. 
  • NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold. 
  • Nitric oxide in the human respiratory cycle. 
  • Oral transmucosal fentanyl citrate as an anaesthetic premedication when dosed to an opioid effect vs total opioid consumption. 
  • Oxygen therapy and exercise response in lung disease. 
  • PEEP in the morning, PEEP at night. 
  • Patient-ventilator interactions. Implications for clinical management. 
  • Patient-ventilator interactions: optimizing conventional ventilation modes. 
  • Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation. 
  • Patient-ventilator trigger dys-synchrony: a common phenomenon with important implications. 
  • Patterns of respiration in diving penguins: is the last gasp an inspired tactic? 
  • Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors. 
  • Physiorack: an integrated MRI safe/conditional, gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function. 
  • Point: should positive end-expiratory pressure in patients with ARDS be set on oxygenation? Yes. 
  • Potential underestimation of the internal target volume (ITV) from free-breathing CBCT. 
  • Psychological outcomes of a pulmonary rehabilitation program. 
  • Pulmonary drug toxicity in patients with primary breast cancer treated with high-dose combination chemotherapy and autologous bone marrow transplantation. 
  • Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats. 
  • Pulmonary gas exchange in diving. 
  • Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. 
  • Pulmonary responses to subacute ozone exposure in obese vs. lean mice. 
  • Quantifying the effect of intrafraction motion during breast IMRT planning and dose delivery. 
  • Radial artery pulse pressure variation correlates with brachial artery peak velocity variation in ventilated subjects when measured by internal medicine residents using hand-carried ultrasound devices. 
  • Rapid detection of myocardial infarction by subsecond, free-breathing delayed contrast-enhancement cardiovascular magnetic resonance. 
  • Realistic CT simulation using the 4D XCAT phantom. 
  • Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch. 
  • Regulation of brain blood flow and oxygen delivery in elite breath-hold divers. 
  • Relaxation of hyperpolarized 129Xe in a deflating polymer bag. 
  • Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. 
  • Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis. 
  • Respiratory controversies in the critical care setting. Does airway pressure release ventilation offer important new advantages in mechanical ventilator support? 
  • Respiratory function and mechanics in pinnipeds and cetaceans. 
  • Respiratory mechanics in the patient who is weaning from the ventilator. 
  • Respiratory system simulations and modeling. 
  • Safety of aerosolized amphotericin B lipid complex in lung transplant recipients. 
  • Setting the positive expiratory-end pressure-FIO2 in acute lung injury/acute respiratory distress syndrome. 
  • Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. 
  • Spiracular fluttering increases oxygen uptake 
  • The acute hypoxic ventilatory response: testing the adaptive significance in human populations. 
  • The correlation evaluation of a tumor tracking system using multiple external markers. 
  • The impact of respiratory motion and treatment technique on stereotactic body radiation therapy for liver cancer. 
  • The obesity hypoventilation syndrome. 
  • The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease. 
  • The transient relationship between pressure and volume in the pediatric pulmonary system. 
  • Time delay measurement for linac based treatment delivery in synchronized respiratory gating radiotherapy. 
  • Tracheal compression delays alveolar collapse during deep diving in marine mammals. 
  • Ventilatory drive and carbon dioxide response in ventilatory failure due to myasthenia gravis and Guillain-Barré syndrome. 
  • Ventilatory muscles and mechanical ventilatory support. 
• 

  Keywords of People

  • Badea, Cristian Tudorel, Professor in Radiology, Biomedical Engineering
  • Driehuys, Bastiaan, Professor of Radiology, Biomedical Engineering
  • Johnson, G. Allan, Charles E. Putman University Distinguished Professor of Radiology, Biomedical Engineering
  • Moon, Richard Edward, Professor of Anesthesiology, Medicine, Pulmonary, Allergy, and Critical Care Medicine
  • O'Daniel, Jennifer Colleen, Assistant Professor of Radiation Oncology, Radiation Oncology
  • Segars, William Paul, Associate Professor in Radiology, Radiology
  • Yoo, Sua, Associate Professor of Radiation Oncology, Radiation Oncology