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Subject Areas on Research
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Assessment of platelet activity by measuring platelet-derived substances in plasma from patients with acute myocardial infarction: surprising lessons from the GUSTO-III Platelet Study.
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Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model.
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Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues.
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Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region.
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Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.
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Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11.
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Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization.
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Developmental regulation of mouse SPARC (osteonectin) gene expression.
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Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum.
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Effect of coronary thrombolysis on the plasma concentration of osteonectin (SPARC, BM40) in patients with acute myocardial infarction.
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Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene.
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Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000.
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Expression of genes for non-collagenous proteins during embryonic bone formation.
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Gene expression profiling and genetic markers in glioblastoma survival.
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Growth of mesenchymal stem cells on electrospun type I collagen nanofibers.
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Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.
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In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.
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Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy.
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Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.
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Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33.
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Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer.
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SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.
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Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.
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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
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Soluble PECAM-1, but not P-selectin, nor osteonectin identify acute myocardial infarction in patients presenting with chest pain.
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Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.
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Keywords of People
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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O'Connor, Christopher Michael,
Richard Sean Stack, M.D. Distinguished Professor,
Medicine, Clinical Pharmacology