Fusion Proteins, gag-pol
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Subject Areas on Research
- A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques.
- CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines.
- Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/recombinant modified vaccinia virus Ankara vaccine.
- Different patterns of immune responses but similar control of a simian-human immunodeficiency virus 89.6P mucosal challenge by modified vaccinia virus Ankara (MVA) and DNA/MVA vaccines.
- Gp120-alum boosting of a Gag-Pol-Env DNA/MVA AIDS vaccine: poorer control of a pathogenic viral challenge.
- Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice.
- HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells.
- Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys.
- Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1.
- Immunization against SIVmne in macaques using multigenic DNA vaccines.
- Intracellular adhesion molecule-1 modulates beta-chemokines and directly costimulates T cells in vivo.
- Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease.
- Protective immunity to SIV challenge elicited by vaccination of macaques with multigenic DNA vaccines producing virus-like particles.
- Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques.
- Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.