Cell Hypoxia

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  Subject Areas on Research

  • 18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model. 
  • 4-Fluorobenzylamine and phenylalanine methyl ester conjugates of 2-nitroimidazole: evaluation as hypoxic cell radiosensitizers. 
  • A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo. 
  • A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. 
  • A mathematical model of O2 transport in the rat outer medulla. I. Model formulation and baseline results. 
  • A mathematical model of O2 transport in the rat outer medulla. II. Impact of outer medullary architecture. 
  • A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion. 
  • A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. 
  • A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells. 
  • A potential solution for eliminating hypoxia as a cause for radioresistance. 
  • A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5). 
  • A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation. 
  • ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. 
  • Acute renal injury and lowest hematocrit during cardiopulmonary bypass: not only a matter of cellular hypoxemia. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. 
  • Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue. 
  • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. 
  • Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes. 
  • Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules. 
  • Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. 
  • Application of optical imaging and spectroscopy to radiation biology. 
  • BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. 
  • Biological chemistry of carbon monoxide. 
  • Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. 
  • Carbon monoxide poisoning. 
  • Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification. 
  • Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. 
  • Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. 
  • Changes in primary lymphoid organs with aging. 
  • Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas. 
  • Cloning and characterization of the rat alpha 1a-adrenergic receptor gene promoter. Demonstration of cell specificity and regulation by hypoxia. 
  • Co-transactivation of the 3' erythropoietin hypoxia inducible enhancer by the HIF-1 protein. 
  • Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. 
  • Comparison of fluctuations of oxygen tension in FSA, 9L, and R3230AC tumors in rats. 
  • Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models. 
  • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. 
  • Concepts of oxygen transport at the microcirculatory level. 
  • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. 
  • Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development. 
  • Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. 
  • Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary. 
  • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. 
  • Degradation of spectrin and ankyrin in the ischemic rat kidney. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. 
  • Direct measurement of hypoxia in a xenograft multiple myeloma model by optical-resolution photoacoustic microscopy. 
  • Does concurrent or prior nicotine exposure interact with neonatal hypoxia to produce cardiac cell damage? 
  • Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. 
  • Early wound healing exhibits cytokine surge without evidence of hypoxia. 
  • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. 
  • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. 
  • Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions. 
  • Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions. 
  • Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. 
  • Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. 
  • Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. 
  • Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. 
  • Engineered transcription factors for therapeutic angiogenesis. 
  • Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. 
  • Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures. 
  • Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy. 
  • Evolution of adverse changes in stored RBCs. 
  • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. 
  • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. 
  • Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. 
  • Functional significance of erythropoietin receptor expression in breast cancer. 
  • Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. 
  • Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. 
  • HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation. 
  • HIF-1 and tumour radiosensitivity. 
  • HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia. 
  • Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. 
  • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. 
  • Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. 
  • Human umbilical cord mesenchymal stromal cells exhibit immature nucleus pulposus cell phenotype in a laminin-rich pseudo-three-dimensional culture system. 
  • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. 
  • Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies. 
  • Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. 
  • Hypoxia and Lou Gehrig. 
  • Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy? 
  • Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. 
  • Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation. 
  • Hypoxia of the growing liver accelerates regeneration. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. 
  • Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. 
  • Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. 
  • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. 
  • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. 
  • Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. 
  • Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation. 
  • Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue. 
  • Imaging molecular pathways: reporter genes. 
  • Imaging tumor hypoxia to advance radiation oncology. 
  • Impact of nitric-oxide-mediated vasodilation and oxidative stress on renal medullary oxygenation: a modeling study. 
  • Impacts of nitric oxide and superoxide on renal medullary oxygen transport and urine concentration. 
  • Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. 
  • In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212). 
  • Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression. 
  • Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program. 
  • Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker. 
  • Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. 
  • Interstitial volume changes during spreading depression (SD) and SD-like hypoxic depolarization in hippocampal tissue slices. 
  • Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone). 
  • Is spreading depression bad for you? Focus on "repetitive normoxic spreading depression-like events result in cell damage in juvenile hippocampal slice cultures". 
  • Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels. 
  • Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers. 
  • Longitudinal optical imaging of tumor metabolism and hemodynamics. 
  • Lysyl oxidase is essential for hypoxia-induced metastasis. 
  • Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe. 
  • Mechanisms underlying hypoxia development in tumors. 
  • Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization. 
  • Metabolic disturbances in hippocampal slices of fetal guinea pigs during and after oxygen-glucose deprivation: is nitric oxide involved? 
  • Metabolic stress in autophagy and cell death pathways. 
  • Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9. 
  • MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B. 
  • Microvascular studies on the origins of perfusion-limited hypoxia. 
  • Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. 
  • Morphology of hypoxia following cryoablation in a prostate cancer murine model: its relationship to necrosis, apoptosis and, microvessel density. 
  • Multiple etiologies of tumor hypoxia require multifaceted solutions. 
  • NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. 
  • NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. 
  • Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain. 
  • Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Novel cell-free strategy for therapeutic angiogenesis: in vitro generated conditioned medium can replace progenitor cell transplantation. 
  • Novel imaging provides new insights into mechanisms of oxygen transport in tumors. 
  • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. 
  • Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. 
  • Optical imaging of tumor hypoxia dynamics. 
  • Oxygen and glucose deprivation in an organotypic hippocampal slice model of the developing rat brain: the effects on N-methyl-D-aspartate subunit composition. 
  • Oxygen dependency of synaptic transmission at the squid Loligo pealei giant synapse. 
  • Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging. 
  • PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. 
  • Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. 
  • Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases. 
  • Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. 
  • Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition. 
  • Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel. 
  • Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. 
  • Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas. 
  • Pretreatment oxygenation profiles of human soft tissue sarcomas. 
  • Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. 
  • Radiation-induced hypoxia may perpetuate late normal tissue injury. 
  • Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. 
  • Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2. 
  • Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. 
  • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. 
  • Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia. 
  • Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion. 
  • Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha. 
  • S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. 
  • SUMO2/3 conjugation is an endogenous neuroprotective mechanism. 
  • Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. 
  • Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically. 
  • Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. 
  • Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice. 
  • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. 
  • Spreading depression-like hypoxic depolarization in CA1 and fascia dentata of hippocampal slices: relationship to selective vulnerability. 
  • Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure. 
  • Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins. 
  • Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages. 
  • Superoxide-mediated actin response in post-hypoxic endothelial cells. 
  • Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model. 
  • Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia. 
  • Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. 
  • Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • Targeting the molecular effects of a hypoxic tumor microenvironment. 
  • Temperature matters! And why it should matter to tumor immunologists. 
  • Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats. 
  • Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. 
  • The Biology of Pulmonary Metastasis. 
  • The accelerated repopulation of a murine fibrosarcoma, FSA-II, during the fractionated irradiation and the linear-quadratic model. 
  • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. 
  • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. 
  • The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation. 
  • The pervasive presence of fluctuating oxygenation in tumors. 
  • The relationship between hypoxia and angiogenesis. 
  • The relationship between the tumor physiologic microenvironment and angiogenesis. 
  • The role of hypoxia in canine cancer. 
  • Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. 
  • Tirapazamine: a hypoxia-activated topoisomerase II poison. 
  • Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model. 
  • Transcriptional response to hypoxia in human tumors. 
  • Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling. 
  • Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study. 
  • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. 
  • Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. 
  • Tumor oxygenation: a matter of supply and demand. 
  • Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing. 
  • Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus. 
  • Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. 
  • Whole-cell membrane current and membrane resistance during hypoxic spreading depression. 
  • [Renal fibrosis and anemia]. 
  • gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. 
  • p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. 
  • rHuEPO and improved treatment outcomes: potential modes of action. 
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  Keywords of People

  • Karhausen, Jorn, Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology