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Subject Areas on Research
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18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model.
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4-Fluorobenzylamine and phenylalanine methyl ester conjugates of 2-nitroimidazole: evaluation as hypoxic cell radiosensitizers.
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A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo.
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A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.
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A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2.
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A potential solution for eliminating hypoxia as a cause for radioresistance.
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A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5).
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A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation.
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ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.
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Acute renal injury and lowest hematocrit during cardiopulmonary bypass: not only a matter of cellular hypoxemia.
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Adaptive Transcriptome Profiling of Subterranean Zokor, Myospalax baileyi, to High- Altitude Stresses in Tibet.
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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.
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An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment.
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Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
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Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue.
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Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors.
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Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes.
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Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures.
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Anoxia induces phospholipase A2 activation in rabbit renal proximal tubules.
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Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.
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Application of optical imaging and spectroscopy to radiation biology.
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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
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Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer.
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Biological chemistry of carbon monoxide.
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CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
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Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
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Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury.
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Carbon monoxide poisoning.
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Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.
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Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart.
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Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.
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Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam.
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Changes in tumour oxygenation during fractionated hyperthermia and radiation therapy in spontaneous canine sarcomas.
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Clinical and Pre-clinical Methods for Quantifying Tumor Hypoxia.
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Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification.
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Comparison of fluctuations of oxygen tension in FSA, 9L, and R3230AC tumors in rats.
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Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models.
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Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents.
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Computational modeling of retinal hypoxia and photoreceptor degeneration in patients with age-related macular degeneration.
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Concepts of oxygen transport at the microcirculatory level.
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Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.
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Construction of a zebrafish cDNA microarray: gene expression profiling of the zebrafish during development.
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Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia.
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Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary.
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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.
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Degradation of spectrin and ankyrin in the ischemic rat kidney.
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Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint.
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Detection of Hypoxic Regions in the Bone Microenvironment.
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Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.
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Direct measurement of hypoxia in a xenograft multiple myeloma model by optical-resolution photoacoustic microscopy.
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Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion.
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Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes.
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Does concurrent or prior nicotine exposure interact with neonatal hypoxia to produce cardiac cell damage?
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Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.
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Early wound healing exhibits cytokine surge without evidence of hypoxia.
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Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.
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Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation.
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Effect of pazopanib on tumor microenvironment and liposome delivery.
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Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions.
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Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions.
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Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium.
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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer.
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Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism.
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Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.
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Engineered transcription factors for therapeutic angiogenesis.
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Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis.
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Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha.
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Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.
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Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.
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Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy.
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Evolution of adverse changes in stored RBCs.
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Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women.
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Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.
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Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.
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Functional significance of erythropoietin receptor expression in breast cancer.
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Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
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Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.
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HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation.
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HIF-1 and tumour radiosensitivity.
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HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia.
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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
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HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.
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HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia.
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Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation.
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Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors.
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High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide.
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Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis.
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Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development.
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Hyperthermic sensitization by the radical initiator 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH). I. In vitro studies.
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Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
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Hypoxia and anemia: factors in decreased sensitivity to radiation therapy and chemotherapy?
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Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment.
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Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
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Hypoxia of the growing liver accelerates regeneration.
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Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells.
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Hypoxia reprograms calcium signaling and regulates myoglobin expression.
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Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.
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Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
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Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning.
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Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.
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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
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Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
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Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation.
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Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue.
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Identification of proteins and cellular pathways targeted by 2-nitroimidazole hypoxic cytotoxins.
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Imaging molecular pathways: reporter genes.
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Imaging tumor hypoxia to advance radiation oncology.
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Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion.
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In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
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In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212).
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Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery.
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Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression.
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Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.
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Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker.
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Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.
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Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone).
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Isoflurane, but not halothane, induces protection of human myocardium via adenosine A1 receptors and adenosine triphosphate-sensitive potassium channels.
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Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.
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Longitudinal optical imaging of tumor metabolism and hemodynamics.
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Lysyl oxidase is essential for hypoxia-induced metastasis.
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Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe.
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Mechanisms underlying hypoxia development in tumors.
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Membrane currents in CA1 pyramidal cells during spreading depression (SD) and SD-like hypoxic depolarization.
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Metabolic stress in autophagy and cell death pathways.
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Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9.
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MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
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Microvascular studies on the origins of perfusion-limited hypoxia.
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Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.
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Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.
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Morphology of hypoxia following cryoablation in a prostate cancer murine model: its relationship to necrosis, apoptosis and, microvessel density.
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Multiple etiologies of tumor hypoxia require multifaceted solutions.
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NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia.
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NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.
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Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain.
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Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia.
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Nitroxyl anion regulation of the NMDA receptor.
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Novel imaging provides new insights into mechanisms of oxygen transport in tumors.
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Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
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Optical imaging of tumor hypoxia dynamics.
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Oxygen dependency of synaptic transmission at the squid Loligo pealei giant synapse.
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Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging.
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PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
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Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.
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Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases.
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Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.
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Physiologic and biochemical rationale for treating COVID-19 patients with hyperbaric oxygen.
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Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.
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Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel.
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Predicting the effect of temporal variations in PO2 on tumor radiosensitivity.
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Predictive and prognostic role of functional imaging of head and neck squamous cell carcinomas.
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Pretreatment oxygenation profiles of human soft tissue sarcomas.
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Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study.
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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.
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Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.
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Radiation-induced hypoxia may perpetuate late normal tissue injury.
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Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy.
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Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.
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Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells.
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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.
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Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial.
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Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion.
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Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells.
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Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha.
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SUMO2/3 conjugation is an endogenous neuroprotective mechanism.
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Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a.
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Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.
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Similar propagation of SD and hypoxic SD-like depolarization in rat hippocampus recorded optically and electrically.
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Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone.
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Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice.
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Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.
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Stroma-free human hemoglobin A decreases R3230Ac rat mammary adenocarcinoma blood flow and oxygen partial pressure.
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Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
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Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages.
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Superoxide-mediated actin response in post-hypoxic endothelial cells.
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Synergistic effects of hyperoxic gas breathing and reduced oxygen consumption on tumor oxygenation: a theoretical model.
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Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia.
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Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth.
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Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment.
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Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.
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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
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Targeting the molecular effects of a hypoxic tumor microenvironment.
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Temperature matters! And why it should matter to tumor immunologists.
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Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats.
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Temporal onset of hypoxia and oxidative stress after pulmonary irradiation.
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The Biology of Pulmonary Metastasis.
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The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
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The accelerated repopulation of a murine fibrosarcoma, FSA-II, during the fractionated irradiation and the linear-quadratic model.
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The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment.
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The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype.
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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.
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The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.
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The pervasive presence of fluctuating oxygenation in tumors.
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The relationship between hypoxia and angiogenesis.
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The relationship between the tumor physiologic microenvironment and angiogenesis.
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The role of hypoxia in canine cancer.
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Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels.
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Tirapazamine: a hypoxia-activated topoisomerase II poison.
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Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model.
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Transcriptional response to hypoxia in human tumors.
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Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling.
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Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study.
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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck.
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Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
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Tumor oxygenation: a matter of supply and demand.
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Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing.
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Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus.
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[Renal fibrosis and anemia].
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p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
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rHuEPO and improved treatment outcomes: potential modes of action.
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Keywords of People
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Karhausen, Jorn,
Adjunct Associate Professor in the Department of Anesthesiology,
Anesthesiology, Cardiothoracic
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Palmer, Gregory M.,
Associate Professor of Radiation Oncology,
Radiation Oncology
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Turner, Dennis Alan,
Professor of Neurosurgery,
Biomedical Engineering