Gene Products, rev
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Subject Areas on Research
- A Gag-Pol/Env-Rev SIV239 DNA vaccine improves CD4 counts, and reduce viral loads after pathogenic intrarectal SIV(mac)251 challenge in rhesus Macaques.
- A comparison of regulatory features in primate lentiviruses.
- A nuclear role for the Fragile X mental retardation protein.
- Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
- An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein.
- Assaying nuclear messenger RNA export in human cells.
- Comparative analysis of Rev function in human immunodeficiency virus types 1 and 2.
- Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.
- Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
- Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.
- Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells.
- Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.
- Functional consequences of natural sequence variation in the activation domain of HIV-1 Rev.
- Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein.
- Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing.
- Generation of nuclease resistant circular RNA decoys for HIV-Tat and HIV-Rev by autocatalytic splicing.
- HIV-1 Rev promotes the nuclear export of unspliced and singly spliced RNAs in a mammalian cell-free export system.
- HIV-1 auxiliary proteins: making connections in a dying cell.
- HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.
- HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.
- Human immunodeficiency virus type 1 rev protein as a negative trans-regulator.
- Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.
- Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.
- Improved protection of rhesus macaques against intrarectal simian immunodeficiency virus SIV(mac251) challenge by a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen.
- Induction of potent humoral and cell-mediated immune responses following direct injection of DNA encoding the HIV type 1 env and rev gene products.
- Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.
- Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1.
- Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection.
- Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.
- Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.
- Near full-length clones and reference sequences for subtype C isolates of HIV type 1 from three different continents.
- Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway.
- Nuclear mRNA export: insights from virology.
- Phosphorylation of the rev gene product of human immunodeficiency virus type 1.
- Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants.
- Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference.
- RNA-sequence-mediated gene regulation in HIV-1.
- Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs.
- Retroviruses as model systems for the study of nuclear RNA export pathways.
- Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products.
- Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes.
- Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques.
- Sequence requirements for Rev multimerization in vivo.
- Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication.
- Structural and functional analysis of the visna virus Rev-response element.
- Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.
- Subcellular localization of the human immunodeficiency virus trans-acting art gene product.
- The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.
- The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence.
- The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.
- Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA.
- Using retroviruses to study the nuclear export of mRNA.
- Visna virus encodes a post-transcriptional regulator of viral structural gene expression.