Genomic Library

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  Subject Areas on Research

  • A PstI polymorphism detected by a genomic clone at the human slow troponin T (TNNT1) gene locus. 
  • A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. 
  • A highly polymorphic cDNA probe in the NF1 gene. 
  • A male linkage map of the cattle (Bos taurus) genome. 
  • An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. 
  • Autistic disorder and chromosome 15q11-q13: construction and analysis of a BAC/PAC contig. 
  • Broad host range vectors for stable genomic library construction. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Challenges for neuroscience in a post-genome world. 
  • Characterization of the rat type III hexokinase gene promoter. A functional octamer 1 motif is critical for basal promoter activity. 
  • Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. 
  • Cloning and molecular characterization of the HgiCI restriction/modification system from Herpetosiphon giganteus Hpg9 reveals high similarity to BanI. 
  • Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. 
  • Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. 
  • Construction and screening of a genomic library specific for mouse chromosome 16. 
  • De novo assembly using low-coverage short read sequence data from the rice pathogen Pseudomonas syringae pv. oryzae. 
  • Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade. 
  • Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 
  • Genome-scale analysis of anti-metabolite directed strain engineering. 
  • Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). 
  • High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. 
  • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. 
  • Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. 
  • Identifying genes within the genome: new ways for finding the needle in a haystack. 
  • Identifying transcribed sequences in arrayed bacteriophage or cosmid libraries. 
  • Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene. 
  • Isolation and localization of a slow troponin (TnT) gene on chromosome 19 by subtraction hybridization of a cDNA muscle library using myotonic dystrophy muscle cDNA. 
  • Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. 
  • Neuro-oncology: unmasking the multiforme in glioblastoma. 
  • Organization of the human zeta-crystallin/quinone reductase gene (CRYZ). 
  • Parallel mapping of genotypes to phenotypes contributing to overall biological fitness. 
  • Phosphoglycerate kinase-triose-phosphate isomerase complex from Thermotoga neapolitana. 
  • Point mutations in retinoblastoma. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Preparation and screening of an arrayed human genomic library generated with the P1 cloning system. 
  • Rapid identification of gene sequences for transcriptional map assembly by direct cDNA screening of genomic reference libraries. 
  • Rat sulfite oxidase antibodies cross-react with two gene family-related proteins: albumin and vitamin D-binding protein. 
  • Refined localization of the cerebral cavernous malformation gene (CCM1) to a 4-cM interval of chromosome 7q contained in a well-defined YAC contig. 
  • Regulation of the cyclin E gene by transcription factor E2F1. 
  • Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms. 
  • Report of the Second International Workshop on Human Chromosome 19 mapping 1992. 
  • SCALEs: multiscale analysis of library enrichment. 
  • Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. 
  • The actin gene from Cryptococcus neoformans: structure and phylogenetic analysis. 
  • The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. 
  • The identification and characterization of KRAB-domain-containing zinc finger proteins. 
  • The potassium channel MBK1 (Kv1.1) is expressed in the mouse retina. 
  • The smallest membrane anchoring subunit (QPs3) of bovine heart mitochondrial succinate-ubiquinone reductase. Cloning, sequencing, topology, and Q-binding domain. 
  • Transcriptome profiling of genes involved in neural tube closure during human embryonic development using long serial analysis of gene expression (long-SAGE). 
  • Zebrafish as a neurotoxicological model. 
  • cDNA arrays and the enigma of melanoma immune responsiveness. 
  • cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology