Propofol

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  Subject Areas on Research

  • A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield skull clamp placement. 
  • A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopy. 
  • A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury. 
  • A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide. 
  • A randomized comparison of a multimodal management strategy versus combination antiemetics for the prevention of postoperative nausea and vomiting. 
  • A randomized double-blinded multicenter comparison of remifentanil versus fentanyl when combined with isoflurane/propofol for early extubation in coronary artery bypass graft surgery. 
  • A randomized evaluation of bispectral index-augmented sedation assessment in neurological patients. 
  • A randomized, open-label study of the safety and tolerability of fospropofol for patients requiring intubation and mechanical ventilation in the intensive care unit. 
  • A randomized, prospective double-blind comparison of the efficacy of generic propofol (sulphite additive) with diprivan. 
  • A retrospective analysis of a remifentanil/propofol general anesthetic for craniotomy before awake functional brain mapping. 
  • A survey of propofol abuse in academic anesthesia programs. 
  • Adenosine-induced flow arrest to facilitate intracranial aneurysm clip ligation: dose-response data and safety profile. 
  • An evaluation of remifentanil propofol response surfaces for loss of responsiveness, loss of response to surrogates of painful stimuli and laryngoscopy in patients undergoing elective surgery. 
  • Anaesthetic considerations for a child with combined Prader-Willi syndrome and mitochondrial myopathy. 
  • Anesthesia and mitochondrial disorders. 
  • Anesthesia for cesarean section in a patient with spinal muscular atrophy. 
  • Anesthetic management of a pediatric Wada test. 
  • Assessment of intubating conditions in adults after induction with propofol and varying doses of remifentanil. 
  • Assessment of pain in sedated and mechanically ventilated patients: an observational study. 
  • Bispectral index monitoring allows faster emergence and improved recovery from propofol, alfentanil, and nitrous oxide anesthesia. BIS Utility Study Group. 
  • Blood propofol concentration and psychomotor effects on driving skills. 
  • Cardiac arrhythmias following anesthesia induction in infantile-onset Pompe disease: a case series. 
  • Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. CNS Subgroup of McSPI. 
  • Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil. 
  • Clinical policy: procedural sedation and analgesia in the emergency department. 
  • Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat. 
  • Comparison of electrophysiologic effects of propofol and isoflurane-based anesthetics in children undergoing radiofrequency catheter ablation for supraventricular tachycardia. 
  • Comparison of remifentanil with alfentanil or suxamethonium following propofol anaesthesia for tracheal intubation. 
  • Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat. 
  • Comparison of the effects of propofol versus thiopental induction on postoperative outcomes following surgical procedures longer than 2 hours. 
  • Compartment syndrome caused by a properly functioning infusion pump. 
  • Determination of plasma concentrations of propofol associated with 50% reduction in postoperative nausea. 
  • Determination of the effective therapeutic dose of intrathecal sufentanil for extracorporeal shock wave lithotripsy. 
  • Dosing study of remifentanil and propofol for tracheal intubation without the use of muscle relaxants. 
  • Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting. 
  • Duration and recovery profile of cisatracurium after succinylcholine during propofol or isoflurane anesthesia. 
  • Early extubation and neurologic examination following combined carotid endarterectomy and coronary artery bypass grafting using remifentanil. 
  • Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation. 
  • Effect of sedative and hypnotic doses of propofol on the EEG activity of patients with or without a history of seizure disorders. 
  • Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone. 
  • Extracranial radiosurgery: immobilizing liver motion in dogs using high-frequency jet ventilation and total intravenous anesthesia. 
  • General anesthesia is not defined by a BIS level. 
  • Guidelines for sedation and anesthesia in GI endoscopy. 
  • Impact of stepwise hyperventilation on cerebral tissue oxygen saturation in anesthetized patients: a mechanistic study. 
  • Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. 
  • Interactions between propofol and lipid mediator receptors: inhibition of lysophosphatidate signaling. 
  • Intracarotid propofol testing: a comparative study with amobarbital. 
  • Intraoperative electrocorticography and cortical stimulation in children. 
  • Intraoperative gut hypoperfusion may be a risk factor for postoperative nausea and vomiting. 
  • Intubating conditions after propofol and remifentanil. 
  • Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. 
  • Laparo-endoscopic single-site (LESS) cholecystectomy with epidural vs. general anesthesia. 
  • Light versus heavy sedation after cardiac surgery: myocardial ischemia and the stress response. Maritime Heart Centre and Dalhousie University. 
  • Multicenter study of target-controlled infusion of propofol-sufentanil or sufentanil-midazolam for coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. 
  • Pharmacokinetic and pharmacodynamic characteristics of medications used for moderate sedation. 
  • Pharmacokinetics of propofol. 
  • Postoperative nausea and vomiting in children and adolescents undergoing radiofrequency catheter ablation: a randomized comparison of propofol- and isoflurane-based anesthetics. 
  • Propofol and postoperative nausea and vomiting. 
  • Propofol and the risk of delirium: exploring the anticholinergic properties of propofol. 
  • Propofol infusion during regional anesthesia: sedative, amnestic, and anxiolytic properties. 
  • Propofol sedation for longitudinal pediatric neuroimaging research. 
  • Remifentanil versus propofol as adjuncts to regional anesthesia. Remifentanil 3010 Study Group. 
  • Safety evaluation of fospropofol for sedation during minor surgical procedures. 
  • Safety of patient-maintained propofol sedation using a target-controlled system in healthy volunteers. 
  • Sedation in the intensive care unit. 
  • Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. 
  • The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial. 
  • The effect of propofol on the canine sphincter of Oddi. 
  • The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index. 
  • The efficacy and resource utilization of remifentanil and fentanyl in fast-track coronary artery bypass graft surgery: a prospective randomized, double-blinded controlled, multi-center trial. 
  • The impact of bispectral index monitoring on rates of propofol administration. 
  • The use of propofol for its antiemetic effect: a survey of clinical practice in the United States. 
  • Too much of a good thing? Tracing the history of the propofol infusion syndrome. 
  • Tracheal intubating conditions after induction with propofol, remifentanil and lignocaine. 
  • [Effects of intravenous anesthetics on LPS-induced production of tumour necrosis factor-alpha from primary cultures of rat glial cells in vitro]. 
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  Keywords of People

  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology