Genes, rev

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  Subject Areas on Research

  • An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. 
  • Derivation of a biologically contained replication system for human immunodeficiency virus type 1. 
  • Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals. 
  • HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. 
  • Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences. 
  • Identification of the activation domain of equine infectious anemia virus rev. 
  • Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization. 
  • Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells. 
  • Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. 
  • Regulation of HIV-1 gene expression. 
  • Retroviruses as model systems for the study of nuclear RNA export pathways. 
  • Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes. 
  • Structural and functional analysis of the visna virus Rev-response element. 
  • The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators. 
  • The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence.