Alfentanil
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Subject Areas on Research
- A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.
- Anesthesia for cesarean section in a patient with spinal muscular atrophy.
- Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe.
- CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition.
- Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.
- Changes in the auditory evoked potentials and the bispectral index following propofol or propofol and alfentanil.
- Clinical policy: procedural sedation and analgesia in the emergency department.
- Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
- Determination of alfentanil and noralfentanil in human plasma by gas chromatography-mass spectrometry.
- Determination of the potency of remifentanil compared with alfentanil using ventilatory depression as the measure of opioid effect.
- Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.
- Drug interactions: volatile anesthetics and opioids.
- Effects of remifentanil and alfentanil on the cardiovascular responses to induction of anaesthesia and tracheal intubation in the elderly.
- Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.
- Gas chromatographic-mass spectrometric analysis of alfentanil metabolites. Application to human liver microsomal alfentanil biotransformation.
- Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?
- Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.
- Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism.
- Intracranial pressure and hemodynamic effects of remifentanil versus alfentanil in patients undergoing supratentorial craniotomy.
- Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.
- Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
- Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
- Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
- Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.
- Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression.
- Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
- Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.
- Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
- Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.
- Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.
- The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the Bispectral Index.
- The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.