Minor Histocompatibility Antigens

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  Subject Areas on Research

  • A germ-line deletion of APOBEC3B does not contribute to subtype-specific childhood acute lymphoblastic leukemia etiology. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • A novel human endogenous retroviral protein inhibits cell-cell fusion. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. 
  • Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. 
  • Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases. 
  • Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. 
  • Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Could the Human Endogenous Retrovirus-Derived Syncytialization Inhibitor, Suppressyn, Limit Heterotypic Cell Fusion Events in the Decidua? 
  • De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome. 
  • Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. 
  • Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes. 
  • Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates. 
  • Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. 
  • Impact of Leukocyte Function-Associated Antigen-1 Blockade on Endogenous Allospecific T Cells to Multiple Minor Histocompatibility Antigen Mismatched Cardiac Allograft. 
  • Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression. 
  • Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. 
  • Mechanical homeostasis is altered in uterine leiomyoma. 
  • Minors come of age: Minor histocompatibility antigens and graft-versus-host disease. 
  • Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study. 
  • Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. 
  • Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy. 
  • Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. 
  • Potentially functional variants of ERAP1, PSMF1 and NCF2 in the MHC-I-related pathway predict non-small cell lung cancer survival. 
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. 
  • Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 
  • SLC1A5 provides glutamine and asparagine necessary for bone development in mice. 
  • Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation. 
  • The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells. 
  • The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.