Linkage Disequilibrium

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  Subject Areas on Research

  • A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. 
  • A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population. 
  • A GWAS Study on Liver Function Test Using eMERGE Network Participants. 
  • A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease. 
  • A common variant on chromosome 9p21 affects the risk of myocardial infarction. 
  • A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians. 
  • A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity. 
  • A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. 
  • A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 
  • A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. 
  • A genomic screen of autism: evidence for a multilocus etiology. 
  • A haplotype map of the human genome. 
  • A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. 
  • A highly polymorphic cDNA probe in the NF1 gene. 
  • A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. 
  • A novel XPF -357A>C polymorphism predicts risk and recurrence of bladder cancer. 
  • A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. 
  • A regression-based association test for case-control studies that uses inferred ancestral haplotype similarity. 
  • A saturated map of common genetic variants associated with human height. 
  • A second generation human haplotype map of over 3.1 million SNPs. 
  • A sparse transmission disequilibrium test for haplotypes based on Bradley-Terry graphs. 
  • A statistical method for region-based meta-analysis of genome-wide association studies in genetically diverse populations. 
  • AKT1 and neurocognition in schizophrenia. 
  • APOE region molecular signatures of Alzheimer's disease across races/ethnicities. 
  • Advances in pharmacogenomic research and development. 
  • Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. 
  • Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. 
  • Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. 
  • An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility. 
  • An investigation of genetic heterogeneity and linkage disequilibrium in 161 families with spinal muscular atrophy. 
  • Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. 
  • Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). 
  • Analysis of linkage disequilibrium in gamma-aminobutyric acid receptor subunit genes in autistic disorder. 
  • Analysis of the RELN gene as a genetic risk factor for autism. 
  • Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data. 
  • Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore? 
  • Aspirin resistance and a single gene. 
  • Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data. 
  • Assessment of LD matrix measures for the analysis of biological pathway association. 
  • Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 
  • Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. 
  • Association between chromosome 2p16.3 variants and glaucoma in populations of African descent. 
  • Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. 
  • Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age. 
  • Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. 
  • Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. 
  • Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. 
  • Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study. 
  • Autism and the serotonin transporter: the long and short of it. 
  • BMI1 enhancer polymorphism underlies chromosome 10p12.31 association with childhood acute lymphoblastic leukemia. 
  • Bayesian estimation of genetic regulatory effects in high-throughput reporter assays. 
  • CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. 
  • Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways. 
  • Clarifying the role of ATOH7 in glaucoma endophenotypes. 
  • Combined genotype and haplotype tests for region-based association studies. 
  • Common MFRP sequence variants are not associated with moderate to high hyperopia, isolated microphthalmia, and high myopia. 
  • Common genetic determinants of vitamin D insufficiency: a genome-wide association study. 
  • Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity. 
  • Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis. 
  • Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. 
  • Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma. 
  • Complement factor H variant increases the risk of age-related macular degeneration. 
  • Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects. 
  • Complete genomic screen for disease susceptibility loci in nuclear families. 
  • Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome. 
  • Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse. 
  • Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. 
  • Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets. 
  • Concordance of genetic variation that increases risk for anxiety disorders and posttraumatic stress disorders and that influences their underlying neurocircuitry. 
  • Contemporary Considerations for Constructing a Genetic Risk Score: An Empirical Approach. 
  • Continental-level population differentiation and environmental adaptation in the mushroom Suillus brevipes. 
  • Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. 
  • Defining the contribution of CNTNAP2 to autism susceptibility. 
  • Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer. 
  • Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. 
  • Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. 
  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 
  • Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. 
  • EMK: a novel program for family-based allelic and genotypic association tests on quantitative traits. 
  • Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. 
  • Estimating haplotype relative risks on human survival in population-based association studies. 
  • Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis. 
  • Evaluation of transethnic fine mapping with population-specific and cosmopolitan imputation reference panels in diverse Asian populations. 
  • Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study. 
  • Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. 
  • Experimental habitat fragmentation increases linkage disequilibrium but does not affect genetic diversity or population structure in the Amazonian liverwort Radula flaccida. 
  • Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease. 
  • Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. 
  • FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. 
  • Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease. 
  • Fast and robust association tests for untyped SNPs in case-control studies. 
  • Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. 
  • Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5. 
  • Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. 
  • Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus. 
  • Functional polymorphisms in the insulin-like binding protein-3 gene may modulate susceptibility to differentiated thyroid carcinoma in Caucasian Americans. 
  • Functional variants in DCAF4 associated with lung cancer risk in European populations. 
  • Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. 
  • Further examination of BAFF SNPs in cGVHD. 
  • Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis. 
  • G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers. 
  • Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. 
  • Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. 
  • Gene conversion and linkage: effects on genome evolution and speciation. 
  • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 
  • Gene flow biases population genetic inference of recombination rate. 
  • Gene-gene interaction between FGF20 and MAOB in Parkinson disease. 
  • Generalized admixture mapping for complex traits. 
  • Genetic association of insulin-like growth factor-1 polymorphisms with high-grade myopia in an international family cohort. 
  • Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. 
  • Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis. 
  • Genetic isolation by distance in Arabidopsis thaliana: biogeography and postglacial colonization of Europe. 
  • Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. 
  • Genetic polymorphisms of metabolic enzymes and the pharmacokinetics of indapamide in Taiwanese subjects. 
  • Genetic structure of typical and atypical populations of Candida albicans from Africa. 
  • Genetic studies of autistic disorder and chromosome 7. 
  • Genetic studies: look no further than your own backyard. 
  • Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years. 
  • Genetic variants associated with severe retinopathy of prematurity in extremely low birth weight infants. 
  • Genetic variants in nucleotide excision repair pathway predict survival of esophageal squamous cell cancer patients receiving platinum-based chemotherapy. 
  • Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma. 
  • Genetic variation at a single locus and age of onset for Alzheimer's disease. 
  • Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. 
  • Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. 
  • Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 
  • Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 
  • Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. 
  • Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. 
  • Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. 
  • Genome-wide association study of subcortical brain volume in PTSD cases and trauma-exposed controls. 
  • Genome-wide association study of treatment refractory schizophrenia in Han Chinese. 
  • Genome-wide high-density SNP linkage search for glioma susceptibility loci: results from the Gliogene Consortium. 
  • Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. 
  • Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. 
  • Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk. 
  • Genomics of human health and aging. 
  • Genotype-based association test for general pedigrees: the genotype-PDT. 
  • Geographic selection in the small heat shock gene complex differentiating populations of Drosophila pseudoobscura. 
  • Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. 
  • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. 
  • Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects. 
  • Haplotype-based analysis: a summary of GAW16 Group 4 analysis. 
  • Hepatocyte growth factor and retinal arteriolar diameter in Singapore Chinese. 
  • Heterogeneous association between engrailed-2 and autism in the CPEA network. 
  • High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. 
  • Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. 
  • Homage to Felsenstein 1981, or why are there so few/many species? 
  • Identification and replication of novel genetic variants of ABO gene to reduce the incidence of diseases and promote longevity by modulating lipid homeostasis. 
  • Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease. 
  • Impulsivity and genetic variants in DRD2 and ANKK1 moderate longitudinal associations between sleep problems and overweight from ages 5 to 11. 
  • Independent associations of TOMM40 and APOE variants with body mass index. 
  • Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression. 
  • Inter-chromosomal level of genome organization and longevity-related phenotypes in humans. 
  • Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population. 
  • Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. 
  • Interethnic analyses of blood pressure loci in populations of East Asian and European descent. 
  • Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina. 
  • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. 
  • Interploidal hybridization and mating patterns in the Sphagnum subsecundum complex. 
  • Interpretation of simultaneous linkage and family-based association tests in genome screens. 
  • Intestinal transcription and synthesis of apolipoprotein AI is regulated by five natural polymorphisms upstream of the apolipoprotein CIII gene. 
  • Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. 
  • Klotho variants and chronic hemodialysis mortality. 
  • Lack of association between UBQLN1 and Alzheimer disease. 
  • Lack of association between autism and SLC25A12. 
  • Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. 
  • Letter by Gurbel et al regarding article, "Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement". 
  • Levels of cerebrospinal fluid neurofilament light protein in healthy elderly vary as a function of TOMM40 variants. 
  • Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. 
  • Linkage and association studies of single-nucleotide polymorphism-tagged tumor necrosis factor haplotypes in juvenile oligoarthritis. 
  • Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. 
  • Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype. 
  • Linkage disequilibrium and signatures of positive selection around LINE-1 retrotransposons in the human genome. 
  • Linkage disequilibrium at the Angelman syndrome gene UBE3A in autism families. 
  • Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing. 
  • Malaria protection due to sickle haemoglobin depends on parasite genotype. 
  • Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. 
  • Matroshka and ectopic polymorphisms: Two new classes of DNA sequence variation identified at the Van der Woude syndrome locus on 1q32-q41. 
  • Measures of linkage disequilibrium among neighbouring SNPs indicate asymmetries across the house mouse hybrid zone. 
  • Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population. 
  • Modulation of the BP response to diet by genes in the renin-angiotensin system and the adrenergic nervous system. 
  • Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501. 
  • Molecular genetics of AMD and current animal models. 
  • Molecular markers reveal that population structure of the human pathogen Candida albicans exhibits both clonality and recombination. 
  • Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 
  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 
  • Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. 
  • Multilocus patterns of nucleotide diversity, population structure and linkage disequilibrium in Boechera stricta, a wild relative of Arabidopsis. 
  • Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. 
  • Mutations in the TSGA14 gene in families with autism spectrum disorders. 
  • Myocilin polymorphisms and high myopia in subjects of European origin. 
  • NCAM1 and neurocognition in schizophrenia. 
  • NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. 
  • Natural positive selection and north-south genetic diversity in East Asia. 
  • Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 
  • Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. 
  • No association between the APOE gene and autism. 
  • No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. 
  • North American origin and recent European establishments of the amphi-Atlantic peat moss Sphagnum angermanicum. 
  • Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study. 
  • Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence. 
  • Obesity-related genetic variants, human pigmentation, and risk of melanoma. 
  • Oceanic islands are not sinks of biodiversity in spore-producing plants. 
  • One haploid parent contributes 100% of the gene pool for a widespread species in northwest North America. 
  • Ordered subset analysis for case-control studies. 
  • PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. 
  • Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis. 
  • Partitioned glioma heritability shows subtype-specific enrichment in immune cells. 
  • Patterns of variation within self-incompatibility loci. 
  • Pedigree generation for analysis of genetic linkage and association. 
  • Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. 
  • Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease. 
  • Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer. 
  • Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population. 
  • Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction. 
  • Polymorphisms in the PON gene cluster are associated with Alzheimer disease. 
  • Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. 
  • Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. 
  • Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations. 
  • Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs. 
  • Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer. 
  • Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. 
  • Predicting HLA genotypes using unphased and flanking single-nucleotide polymorphisms in Han Chinese population. 
  • Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes. 
  • Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration. 
  • Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association. 
  • RFLPs for linkage analysis in families with glycogen storage disease type III. 
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 
  • Recombination and gene conversion in a 170-kb genomic region of Arabidopsis thaliana. 
  • Recombining without Hotspots: A Comprehensive Evolutionary Portrait of Recombination in Two Closely Related Species of Drosophila. 
  • Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility. 
  • Risk alleles for multiple sclerosis identified by a genomewide study. 
  • Robust estimation and testing of haplotype effects in case-control studies. 
  • SLC6A4 variation and citalopram response. 
  • SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. 
  • SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. 
  • SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects. 
  • Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men. 
  • Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. 
  • Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis. 
  • Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer. 
  • Spatial models for hybrid zones. 
  • Sporadic, Global Linkage Disequilibrium Between Unlinked Segregating Sites. 
  • Stepping-stone spatial structure causes slow decay of linkage disequilibrium and shifts the site frequency spectrum. 
  • Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. 
  • T locus shows no evidence for linkage disequilibrium or mutation in American Caucasian neural tube defect families. 
  • TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial. 
  • Taking cardiovascular genetic association studies to the next level. 
  • Telomere structure and maintenance gene variants and risk of five cancer types. 
  • Testing the effect of rare compound-heterozygous and recessive mutations in case--parent sequencing studies. 
  • The APL test: extension to general nuclear families and haplotypes and examination of its robustness. 
  • The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. 
  • The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. 
  • The G72/G30 gene complex and cognitive abnormalities in schizophrenia. 
  • The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies. 
  • The Time Scale of Recombination Rate Evolution in Great Apes. 
  • The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk. 
  • The effect of SNCA 3' region on the levels of SNCA-112 splicing variant. 
  • The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. 
  • The genomic consequences of adaptive divergence and reproductive isolation between species of manakins. 
  • The probability of HLA-C matching between patient and unrelated donor at the molecular level: estimations based on the linkage disequilibrium between DNA typed HLA-B and HLA-C alleles. 
  • The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy. 
  • The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. 
  • The shared genetic architecture between epidemiological and behavioral traits with lung cancer. 
  • The use of single-nucleotide polymorphism maps in pharmacogenomics. 
  • Tissue-specific genetic control of splicing: implications for the study of complex traits. 
  • Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource. 
  • Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. 
  • Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs. 
  • Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease. 
  • VKORC1 haplotypes in five East-Asian populations and Indians. 
  • Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. 
  • Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. 
  • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. 
  • Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. 
  • X-APL: an improved family-based test of association in the presence of linkage for the X chromosome. 
  • optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • Mitchell-Olds, Thomas, Newman Ivey White Distinguished Professor of Biology, Biology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute