Cell Adhesion Molecules

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  Subject Areas on Research

  • A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease. 
  • A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. 
  • A leukocyte lipid up-regulates the avidity of lymphocyte function-associated antigen-1. 
  • A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. 
  • A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion. 
  • A single divergent exon inhibits ankyrin-B association with the plasma membrane. 
  • AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival. 
  • AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. 
  • Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. 
  • Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression. 
  • Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Adhesion molecule cascades direct lymphocyte recirculation and leukocyte migration during inflammation. 
  • Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease. 
  • Adhesion molecules, platelet activation, and cardiovascular risk. 
  • Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. 
  • Alterations in L-selectin expression and elastase activity in neutrophils from patients receiving granulocyte colony-stimulating factor alone or in conjunction with high-dose chemotherapy with autologous bone marrow transplantation. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • An effective strategy for decontamination, ex vivo expansion, and storage of human fetal liver hematopoietic stem cells. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts. 
  • Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. 
  • Assessment of clopidogrel responsiveness: measurements of maximum platelet aggregation, final platelet aggregation and their correlation with vasodilator-stimulated phosphoprotein in resistant patients. 
  • Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. 
  • Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 
  • Atherosclerosis: a cancer of the blood vessels? 
  • B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. 
  • B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. 
  • Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. 
  • Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. 
  • Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies. 
  • Biology of cerebral arteriovenous malformations with a focus on inflammation. 
  • Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. 
  • CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity. 
  • CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD22 cross-linking generates B-cell antigen receptor-independent signals that activate the JNK/SAPK signaling cascade. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. 
  • CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. 
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. 
  • CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells. 
  • CD44 antibody against In(Lu)-related p80, lymphocyte-homing receptor molecule inhibits the binding of human erythrocytes to T cells. 
  • CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1). 
  • CD6-ligand interactions: a paradigm for SRCR domain function? 
  • CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. 
  • CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease. 
  • Carcinoembryonic antigen binding proteins on elicited peritoneal macrophages. 
  • Cell adhesion in epidermal development and barrier formation. 
  • Cell adhesion molecule expression in coronary artery aneurysms in acute Kawasaki disease. 
  • Cell adhesion molecules involved in intrathymic T cell development. 
  • Cell adhesion molecules regulating astrocyte-neuron interactions. 
  • Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. 
  • Cell adhesion: separation of p120's powers? 
  • Cell recognition processes in the differentiation of embryonic sea urchins. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Changing concepts in pathophysiology of the vasculitides. 
  • Circulating adhesion molecules and inflammatory mediators in demyelination: a review. 
  • Clinical and direct immunofluorescence characteristics of cutaneous toxicity associated with enfortumab vedotin. 
  • Clinical performance and utility of a DNA methylation urine test for bladder cancer. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. 
  • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. 
  • Common variants in the periostin gene influence development of atherosclerosis in young persons. 
  • Comparison of human eosinophil and neutrophil adhesion to endothelial cells under nonstatic conditions. Role of L-selectin. 
  • Conservation of Endo16 expression in sea urchins despite evolutionary divergence in both cis and trans-acting components of transcriptional regulation. 
  • Coordinator's report--section 2D3. 
  • Critical factors in basal cell adhesion molecule/lutheran-mediated adhesion to laminin. 
  • Cytokines and adhesion molecules in the pathogenesis of vasculitis. 
  • Decrease in high on-treatment platelet reactivity (HPR) prevalence on switching from clopidogrel to prasugrel: insights from the switching anti-platelet (SWAP) study. 
  • Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. 
  • Design of a calcium-binding protein with desired structure in a cell adhesion molecule. 
  • Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury. 
  • Detection of occult N2 disease with molecular techniques. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. 
  • Differential expression of galectin-1 and its interactions with cells and laminins in the intervertebral disc. 
  • Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells. 
  • Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion. 
  • Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. 
  • Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. 
  • ELISA for quantitation of L-selectin shed from leukocytes in vivo. 
  • Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. 
  • Echinonectin: a new embryonic substrate adhesion protein. 
  • Effect of adjunctive dipyridamole to DAPT on platelet function profiles in stented patients with high platelet reactivity. The result of the ACCEL-DIP Study. 
  • Effect of receptor-ligand affinity on the strength of endothelial cell adhesion. 
  • Emerging paradigms, platforms, and unifying themes in biomarker science. 
  • Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. 
  • Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial. 
  • Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation. 
  • EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model. 
  • EpCAM: A new therapeutic target for an old cancer antigen. 
  • Epidermal keratinocytes express the adhesion molecule intercellular adhesion molecule-1 in inflammatory dermatoses. 
  • Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. 
  • Evidence for urothelial cell activation in interstitial cystitis. 
  • Evolutionary analysis of the well characterized endo16 promoter reveals substantial variation within functional sites. 
  • Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. 
  • Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. 
  • Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells: implications in the design of gammadelta-T-cell-based immunotherapies for pancreatic cancer. 
  • Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc. 
  • Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. 
  • Expression, distribution, and biochemistry of human CD39. Role in activation-associated homotypic adhesion of lymphocytes. 
  • Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells. 
  • Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration. 
  • G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. 
  • GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. 
  • Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. 
  • Genetic architecture of gene expression traits across diverse populations. 
  • Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. 
  • Graft-versus-host disease: the viewpoint from the donor T cell. 
  • Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. 
  • Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. 
  • HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. 
  • Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. 
  • High on-treatment platelet reactivity assessed by various platelet function tests: is the consensus-defined cut-off of VASP-P platelet reactivity index too low? 
  • High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. 
  • Homeostatic control of lymphocyte survival: potential origins and implications. 
  • Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation. 
  • Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. 
  • Hyaluronan interactions with innate immunity in lung biology. 
  • Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer. 
  • ICAM-1 (CD54) expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7. 
  • ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. 
  • IL-2, IL-4, and IFN-gamma gene expression versus secretion in superantigen-activated T cells. Distinct requirement for costimulatory signals through adhesion molecules. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Immune plexins and semaphorins: old proteins, new immune functions. 
  • Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. 
  • Influence of platelet reactivity on BARC classification in East Asian patients undergoing percutaneous coronary intervention. Results of the ACCEL-BLEED study. 
  • Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level. 
  • Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. 
  • Inhibition of leukocyte L-selectin function with a monoclonal antibody attenuates reperfusion injury to the rabbit ear. 
  • Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells. 
  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. 
  • Integrins and other cell adhesion molecules in endometrium and endometriosis. 
  • Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22. 
  • Isolation and characterization of a bovine cDNA encoding a functional homolog of human P-selectin. 
  • Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. 
  • L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. 
  • L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. 
  • LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino acids. 
  • LW protein: a promiscuous integrin receptor activated by adrenergic signaling. 
  • Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. 
  • Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. 
  • Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. 
  • Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells. 
  • Lithographic patterning of photoreactive cell-adhesive proteins. 
  • Location of the PH-20 protein on acrosome-intact and acrosome-reacted spermatozoa of cynomolgus macaques. 
  • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. 
  • Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. 
  • Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger. 
  • Mechanisms of inflammation and leukocyte activation. 
  • Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition. 
  • Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. 
  • Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. 
  • Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. 
  • Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • Multi-institutional external validation of urinary TWIST1 and NID2 methylation as a diagnostic test for bladder cancer. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus. 
  • Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. 
  • New surrogate markers for autoimmune disease activity. 
  • Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. 
  • Obesity and altered angiogenic-related gene expression in endometrial cancer. 
  • On the ultrastructure of hyalin, a cell adhesion protein of the sea urchin embryo extracellular matrix. 
  • Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs. 
  • Oxidative stress impact on barrier function of porcine angular aqueous plexus cell monolayers. 
  • P-selectin induces the expression of tissue factor on monocytes. 
  • POT1 association with TRF2 regulates telomere length. 
  • Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. 
  • Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. 
  • Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. 
  • Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth. 
  • Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation. 
  • Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. 
  • Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation. 
  • Promoter logic. 
  • Pulmonary complications of primary immunodeficiencies. 
  • Purification of hexabrachion (tenascin) from cell culture conditioned medium, and separation from a cell adhesion factor. 
  • Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading. 
  • Quantitative measurement of cell adhesion using centrifugal force. 
  • Rapid de-localization of actin leading edge components with BDM treatment. 
  • Rare and low-frequency coding variants alter human adult height. 
  • Receptor-mediated endocytosis of carcinoembryonic antigen by rat alveolar macrophages in vitro. 
  • Red blood cell surface adhesion molecules: their possible roles in normal human physiology and disease. 
  • Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. 
  • Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. 
  • Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases. 
  • Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. 
  • Regulation of leukocyte migration by L-selectin: mechanisms, domains and ligands. 
  • Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. 
  • Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin. 
  • Relation between the vasodilator-stimulated phosphoprotein phosphorylation assay and light transmittance aggregometry in East Asian patients after high-dose clopidogrel loading. 
  • Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. 
  • Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4. 
  • Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. 
  • Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. 
  • Rho1 regulates Drosophila adherens junctions independently of p120ctn. 
  • Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. 
  • Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. 
  • Role of adhesion molecules and vascular endothelium in the pathogenesis of sickle cell disease. 
  • Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. 
  • Role of selectins in development of adult respiratory distress syndrome. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • SVEP1 as a Genetic Modifier of TEK-Related Primary Congenital Glaucoma. 
  • Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. 
  • Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent. 
  • Selectins: a family of adhesion receptors. 
  • Sequential contribution of L- and P-selectin to leukocyte rolling in vivo. 
  • Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Soluble L-selectin is present in human plasma at high levels and retains functional activity. 
  • Stage-specific adhesion molecules in human intrathymic T-cell development. 
  • Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation. 
  • Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. 
  • Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. 
  • Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. 
  • Substance P and adrenocorticotropic hormone do not affect T-lymphocyte adhesion to vascular endothelium or surface expression of adhesion receptors. 
  • Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • TSG-6 - a double-edged sword for osteoarthritis (OA). 
  • TSG-6 activity as a novel biomarker of progression in knee osteoarthritis. 
  • Tenascin supports lymphocyte rolling. 
  • The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome. 
  • The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 
  • The Role of Biliary Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6 (CEACAM6) as a Biomarker in Cholangiocarcinoma. 
  • The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. 
  • The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. 
  • The cell and molecular basis of leukocyte common antigen (CD45)-triggered, lymphocyte function-associated antigen-1-/intercellular adhesion molecule-1-dependent, leukocyte adhesion. 
  • The clinical application of monoclonal antibody therapies in renal transplantation. 
  • The distinct roles of JAM-A in reovirus pathogenesis. 
  • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP2C19*2 genotype: first experience in patients. 
  • The future of rheumatoid arthritis treatment. 
  • The genome of the sea urchin Stongylocentrotus purpuratus 
  • The inflammatory response to cardiopulmonary bypass. 
  • The manganese(III) porphyrin MnTnHex-2-PyP5+ modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells. 
  • The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. 
  • The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. 
  • The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. 
  • The role of adhesion molecules in epithelial-T-cell interactions in thymus and skin. 
  • The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. 
  • The role of leukocyte adhesion molecules in cellular interactions: implications for the pathogenesis of inflammatory synovitis. 
  • The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides. 
  • The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes. 
  • The selectins: vascular adhesion molecules. 
  • Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. 
  • Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. 
  • Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells. 
  • Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. 
  • Tissue-specific, temporal changes in cell adhesion to echinonectin in the sea urchin embryo. 
  • Topology of cell adhesion molecules. 
  • Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo. 
  • Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. 
  • Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. 
  • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity 
  • Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation. 
  • Urinary NID2 and TWIST1 methylation to augment conventional urine cytology for the detection of bladder cancer. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Kiehart, Daniel P., Professor of Biology, Duke Science & Society
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology
  • Zennadi, Rahima, Associate Professor in Medicine, Pathology