Cell Adhesion Molecules, Neuronal

• 

  Subject Areas on Research

  • A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. 
  • A novel alternative splice domain in zebrafish tenascin-C. 
  • Activated leukocyte cell adhesion molecule and prognosis in acute ischemic stroke. 
  • Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. 
  • Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Analysis of the RELN gene as a genetic risk factor for autism. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis. 
  • Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. 
  • Binding of hexabrachion (tenascin) to the extracellular matrix and substratum and its effect on cell adhesion. 
  • Biochemical and structural studies of tenascin/hexabrachion proteins. 
  • Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. 
  • Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. 
  • Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan. 
  • Common genetic variants on 5p14.1 associate with autism spectrum disorders. 
  • Developmental regulation of neural cell adhesion molecule in human prefrontal cortex. 
  • Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate. 
  • Epithelial cells are an important source of tenascin in normal and malignant human breast tissue. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. 
  • Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. 
  • Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. 
  • Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. 
  • Immunohistochemistry of the canine vomeronasal organ. 
  • Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate. 
  • Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. 
  • Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • Localization and quantitation of hexabrachion (tenascin) in skin, embryonic brain, tumors, and plasma. 
  • Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells. 
  • Medulloblastoma cell-substrate interaction in vitro. 
  • Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. 
  • Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease. 
  • Purification of hexabrachion (tenascin) from cell culture conditioned medium, and separation from a cell adhesion factor. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. 
  • TGF-beta regulates expression of tenascin alternative-splicing isoforms in fetal rat lung. 
  • Tenascin expression in human glioma cell lines and normal tissues. 
  • Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. 
  • Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion. 
  • Tenascin knockout mice: barrels, boundary molecules, and glial scars. 
  • Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis. 
  • Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. 
  • Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. 
  • Tenascin: an extracellular matrix protein prominent in specialized embryonic tissues and tumors. 
  • Thousands of human mobile element fragments undergo strong purifying selection near developmental genes. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering