Cadherins

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  Subject Areas on Research

  • A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. 
  • A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening. 
  • A common clathrin-mediated machinery co-ordinates cell-cell adhesion and bacterial internalization. 
  • A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. 
  • A new method for selection of angular aqueous plexus cells from porcine eyes: a model for Schlemm's canal endothelium. 
  • A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. 
  • A precisely defined role for the tip link-associated protein TMIE in the mechanoelectrical transduction channel complex of inner ear hair cells. 
  • A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. 
  • A simple and robust fluorescent labeling method to quantify trophoblast fusion. 
  • A single divergent exon inhibits ankyrin-B association with the plasma membrane. 
  • APOB Genotypes and CDH13 Haplotypes in the Cholesterol-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival. 
  • Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. 
  • Aberrant promoter methylation of multiple genes in non-small cell lung cancers. 
  • Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling. 
  • Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. 
  • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells. 
  • Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Anchor cell invasion into the vulval epithelium in C. elegans. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. 
  • Array-based comparative genomic hybridization of ductal carcinoma in situ and synchronous invasive lobular cancer. 
  • Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis. 
  • CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways. 
  • Ca++-switch induction of RPE differentiation. 
  • Cadherin 17 is frequently expressed by 'sclerosing variant' pancreatic neuroendocrine tumour. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. 
  • Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. 
  • Cell adhesion protein expression in melanocytic matricoma. 
  • Cell adhesion: separation of p120's powers? 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Cell ingression and apical shape oscillations during dorsal closure in Drosophila. 
  • Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. 
  • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. 
  • Characterization of the role of cadherin in regulating cell adhesion during sea urchin development. 
  • Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform. 
  • Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface. 
  • Colorectal Neoplasia in CDH1 Pathogenic Variant Carriers: A Multicenter Analysis. 
  • Common genetic variants on 5p14.1 associate with autism spectrum disorders. 
  • Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. 
  • Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects. 
  • Decreased E-cadherin expression correlates with higher stage of Wilms' tumors. 
  • Development of a method to isolate circulating tumor cells using mesenchymal-based capture. 
  • Developmental defects in mouse embryos lacking N-cadherin. 
  • Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer. 
  • Differential expression of N-cadherin distinguishes a subset of metastasizing desmoplastic melanomas. 
  • Diffuse hypopigmented macules. 
  • Dissecting cell adhesion cross-talk with micropatterns. 
  • Distinct regions of the cadherin cytoplasmic domain are essential for functional interaction with Galpha 12 and beta-catenin. 
  • Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. 
  • Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin 
  • Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. 
  • Drosophila betaHeavy-spectrin is essential for development and contributes to specific cell fates in the eye. 
  • Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. 
  • E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. 
  • E-cadherin in gastric carcinomas: Relations with histological parameters and its prognostic value. 
  • E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer. 
  • E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • Endogenous Tagging at the cdh1 Locus for Live Visualization of E-Cadherin Dynamics. 
  • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. 
  • Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy. 
  • Evaluation of an epithelial plasticity biomarker panel in men with localized prostate cancer. 
  • Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas. 
  • Exploring a peptidomimetic approach of N-cadherin in modulating fibroblast growth factor receptor signaling for corneal endothelial regeneration. 
  • Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway. 
  • Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain. 
  • Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. 
  • Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion. 
  • Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy. 
  • Fibrotic Changes to Schlemm's Canal Endothelial Cells in Glaucoma. 
  • Fidelity in planar cell polarity signalling. 
  • Fine mapping of Wilms' tumors with 16q loss of heterozygosity localizes the putative tumor suppressor gene to a region of 6.7 megabases. 
  • Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. 
  • Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. 
  • Genome-scan for IQ discrepancy in autism: evidence for loci on chromosomes 10 and 16. 
  • Genome-wide association study of kidney function decline in individuals of European descent. 
  • Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. 
  • Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck. 
  • Human Schlemm's canal cells express the endothelial adherens proteins, VE-cadherin and PECAM-1. 
  • Hypotrichosis with juvenile macular dystrophy: a case report with molecular study. 
  • ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. 
  • Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure. 
  • Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). 
  • Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition 
  • Inhibition of matrix metalloproteinase activity reverses corneal endothelial-mesenchymal transition. 
  • Integrins and other cell adhesion molecules in endometrium and endometriosis. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. 
  • Involvement of R-cadherin in the early stage of glomerulogenesis. 
  • Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta. 
  • Lovastatin-induced cytoskeletal reorganization in lens epithelial cells: role of Rho GTPases. 
  • Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. 
  • Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration. 
  • Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. 
  • Mouse germ cell clusters form by aggregation as well as clonal divisions. 
  • Mutations of the E-cadherin gene in human gynecologic cancers. 
  • N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN. 
  • N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions. 
  • N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. 
  • NgBR is essential for endothelial cell glycosylation and vascular development. 
  • Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration. 
  • Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo. 
  • Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. 
  • Pathologic Proteolytic Processing of N-Cadherin as a Marker of Human Fibrotic Disease. 
  • Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer. 
  • Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. 
  • Prognostic risk factors that identify patients with clinical stage I nonseminomatous germ cell tumors at low risk and high risk for metastasis. 
  • Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma. 
  • Protein markers and differentiation in culture for Schlemm's canal endothelial cells. 
  • Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. 
  • Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. 
  • Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. 
  • Regulated exocytosis and sequential construction of the extracellular matrix surrounding the sea urchin zygote. 
  • Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 
  • Regulation of cell-cell adhesion by Abi/Diaphanous complexes. 
  • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. 
  • Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. 
  • Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. 
  • Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. 
  • Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. 
  • Roles of cadherins in patterning of the developing brain. 
  • Selective uncoupling of G alpha 12 from Rho-mediated signaling. 
  • Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. 
  • Somatic variants in diverse genes leads to a spectrum of focal cortical malformations. 
  • Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. 
  • Sphingosine-1-phosphate effects on the inner wall of Schlemm's canal and outflow facility in perfused human eyes. 
  • Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. 
  • Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment. 
  • Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. 
  • Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. 
  • The Snail repressor is required for PMC ingression in the sea urchin embryo. 
  • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 
  • The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression. 
  • The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. 
  • The role of N-cadherin/c-Jun/NDRG1 axis in the progression of prostate cancer. 
  • Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury. 
  • Towards a Dynamic Understanding of Cadherin-Based Mechanobiology. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis. 
  • UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. 
  • VE-Cadherin Is Required for Cardiac Lymphatic Maintenance and Signaling. 
  • Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS). 
  • Vascular leukocytes contribute to tumor vascularization. 
  • Vascular leukocytes: a population with angiogenic and immunossuppressive properties highly represented in ovarian cancer. 
  • WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
  • [A study of E-cadherin and beta-catenin expression and their correlation with prognosis of nonsmall cell lung carcinoma]. 
  • mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology