Serpins

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  Subject Areas on Research

  • A mouse model for human osteogenesis imperfecta type VI. 
  • Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence. 
  • Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis. 
  • Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL). 
  • Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor. 
  • Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor. 
  • Biomarkers to help guide management of patients with pulmonary nodules. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice. 
  • DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130. 
  • Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths. 
  • Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors. 
  • Deep thoughts on lipids and cognition. 
  • Diagnostic value of three tumor markers determined in pleural effusions. 
  • Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model. 
  • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. 
  • Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors. 
  • Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor. 
  • Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. 
  • Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. 
  • Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia. 
  • Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients. 
  • L-DOPA is an endogenous ligand for OA1. 
  • Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF. 
  • Localization of heparin cofactor II in injured human skin: a potential role in wound healing. 
  • Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. 
  • Multiple origins of green coloration in frogs mediated by a novel biliverdin-binding serpin. 
  • Mutations in SERPINF1 cause osteogenesis imperfecta type VI. 
  • Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. 
  • PEDF & stem cells: niche vs. nurture. 
  • PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE. 
  • PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration. 
  • PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. 
  • PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts. 
  • Panel of serum biomarkers for the diagnosis of lung cancer. 
  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. 
  • Peritumoral expression of adipokines and fatty acids in breast cancer. 
  • Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. 
  • Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. 
  • Pigment epithelium-derived factor decreases outflow facility. 
  • Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha. 
  • Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1. 
  • Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. 
  • Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. 
  • Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor. 
  • Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. 
  • Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. 
  • Pigment epithelium-derived factor: chemistry, structure, biology, and applications. 
  • Polyethylene glycol modification of serpins improves therapeutic potential. 
  • Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. 
  • Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. 
  • Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients. 
  • Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors. 
  • Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. 
  • Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes. 
  • Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma. 
  • Sex-specific genetic predictors of Alzheimer's disease biomarkers. 
  • Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop. 
  • Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. 
  • The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. 
  • The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study. 
  • The roles of MASPIN expression and subcellular localization in non-small cell lung cancer. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hoffman, Maureane, Professor of Pathology, Integrative Immunobiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology