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Subject Areas on Research
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Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.
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Acidic stress promotes a glioma stem cell phenotype.
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Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
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Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin.
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Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor.
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Biomarkers to help guide management of patients with pulmonary nodules.
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Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.
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Deep thoughts on lipids and cognition.
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Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
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Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors.
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Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA.
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Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis.
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Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique.
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Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.
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Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.
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Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
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Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia.
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L-DOPA is an endogenous ligand for OA1.
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Localization of heparin cofactor II in injured human skin: a potential role in wound healing.
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Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study.
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Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation.
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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
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Multiple origins of green coloration in frogs mediated by a novel biliverdin-binding serpin.
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Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4.
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Panel of serum biomarkers for the diagnosis of lung cancer.
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Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.
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Pigment epithelium-derived factor decreases outflow facility.
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Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium.
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Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal.
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Polyethylene glycol modification of serpins improves therapeutic potential.
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Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases.
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Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients.
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Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors.
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Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.
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Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.
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Sex-specific genetic predictors of Alzheimer's disease biomarkers.
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Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop.
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Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.
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The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene.
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The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.
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Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
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p53 regulates the expression of the tumor suppressor gene maspin.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Hoffman, Maureane,
Professor of Pathology,
Immunology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Patz Jr., Edward F.,
James and Alice Chen Distinguished Professor of Radiology,
Pathology
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Taboada, Carlos,
Postdoctoral Scholar,
Biology