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Subject Areas on Research
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A mouse model for human osteogenesis imperfecta type VI.
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Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.
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Acidic stress promotes a glioma stem cell phenotype.
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Altered pigment epithelium-derived factor and vascular endothelial growth factor levels in lymphangioma pathogenesis and clinical recurrence.
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Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
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Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin.
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Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis.
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Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL).
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Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor.
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Assays for the antiangiogenic and neurotrophic serpin pigment epithelium-derived factor.
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Biomarkers to help guide management of patients with pulmonary nodules.
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Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors.
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Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.
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DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130.
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Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths.
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Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors.
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Deep thoughts on lipids and cognition.
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Diagnostic value of three tumor markers determined in pleural effusions.
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Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.
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Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
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Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors.
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Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor.
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Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma.
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Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA.
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Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis.
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Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique.
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Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.
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Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study.
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Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
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Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia.
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Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients.
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L-DOPA is an endogenous ligand for OA1.
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Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF.
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Localization of heparin cofactor II in injured human skin: a potential role in wound healing.
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Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study.
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Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation.
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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
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Multiple origins of green coloration in frogs mediated by a novel biliverdin-binding serpin.
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Mutations in SERPINF1 cause osteogenesis imperfecta type VI.
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Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4.
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PEDF & stem cells: niche vs. nurture.
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PEDF Deletion Induces Senescence and Defects in Phagocytosis in the RPE.
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PEDF deficiency increases the susceptibility of rd10 mice to retinal degeneration.
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PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum.
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PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts.
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Panel of serum biomarkers for the diagnosis of lung cancer.
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Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver.
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Peritumoral expression of adipokines and fatty acids in breast cancer.
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Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.
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Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
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Pigment epithelium-derived factor decreases outflow facility.
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Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
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Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.
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Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas.
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Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment.
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Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor.
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Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture.
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Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.
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Pigment epithelium-derived factor: chemistry, structure, biology, and applications.
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Polyethylene glycol modification of serpins improves therapeutic potential.
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Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor.
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Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases.
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Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients.
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Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors.
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Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice.
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Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.
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Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.
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Sex-specific genetic predictors of Alzheimer's disease biomarkers.
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Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop.
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Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage.
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The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene.
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The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.
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The roles of MASPIN expression and subcellular localization in non-small cell lung cancer.
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Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme.
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Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model.
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p53 regulates the expression of the tumor suppressor gene maspin.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Hoffman, Maureane,
Professor of Pathology,
Integrative Immunobiology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Patz Jr., Edward F.,
James and Alice Chen Distinguished Professor of Radiology,
Pathology