Serpins

• 

  Subject Areas on Research

  • Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Activation of Complement by Pigment Epithelium-Derived Factor in Rheumatoid Arthritis. 
  • Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: comparison of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, antithrombin III, alpha 2-antiplasmin, angiotensinogen, and ovalbumin. 
  • Antithrombin III, a serpin family protease inhibitor, is a major heparin binding protein in porcine aqueous humor. 
  • Biomarkers to help guide management of patients with pulmonary nodules. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis. 
  • Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils. 
  • Deep thoughts on lipids and cognition. 
  • Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. 
  • Heparin binding induces a conformational change in pigment epithelium-derived factor. 
  • Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors. 
  • Hereditary angioedema. 
  • Hereditary angioedema: the rewards of studying a rare disease. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • Identification and characterization of a serpin from Eimeria acervulina. 
  • Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. 
  • Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. 
  • Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. 
  • Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence. 
  • Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. 
  • Insight into the mechanism of asparaginase-induced depletion of antithrombin III in treatment of childhood acute lymphoblastic leukemia. 
  • L-DOPA is an endogenous ligand for OA1. 
  • Localization of heparin cofactor II in injured human skin: a potential role in wound healing. 
  • Maspin expression in epithelial ovarian cancer and associations with poor prognosis: a Gynecologic Oncology Group study. 
  • Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. 
  • Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. 
  • Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop. 
  • Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. 
  • Panel of serum biomarkers for the diagnosis of lung cancer. 
  • Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. 
  • Pigment epithelium-derived factor decreases outflow facility. 
  • Pigment epithelium-derived factor supports normal Müller cell development and glutamine synthetase expression after removal of the retinal pigment epithelium. 
  • Pigment epithelium-derived factor supports normal development of photoreceptor neurons and opsin expression after retinal pigment epithelium removal. 
  • Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization. 
  • Polyethylene glycol modification of serpins improves therapeutic potential. 
  • Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. 
  • Race-specific molecular alterations correlate with differential outcomes for black and white endometrioid endometrial cancer patients. 
  • Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors. 
  • Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes. 
  • Sex-specific genetic predictors of Alzheimer's disease biomarkers. 
  • Sodium dodecyl sulfate-stable complexes between serpins and active or inactive proteinases contain the region COOH-terminal to the reactive site loop. 
  • Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. 
  • The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition. 
  • The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. 
  • The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin. 
  • The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study. 
  • Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. 
  • p53 regulates the expression of the tumor suppressor gene maspin. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hoffman, Maureane, Professor of Pathology, Immunology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor of Immunology, Cell Biology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology