Up-Regulation

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  Subject Areas on Research

  • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. 
  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A mathematical model of the folate cycle: new insights into folate homeostasis. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A reappraisal of loop diuretic choice in heart failure patients. 
  • A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. 
  • A spatially and temporally restricted mouse model of soft tissue sarcoma. 
  • A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice. 
  • A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction. 
  • A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. 
  • Aberrant planar cell polarity induced by urinary tract obstruction. 
  • Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Activated leukocyte cell adhesion molecule and prognosis in acute ischemic stroke. 
  • Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 
  • Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury. 
  • Activation of Wnt signaling in hematopoietic regeneration. 
  • Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. 
  • Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation. 
  • Acute pancreatitis induces FasL gene expression and apoptosis in the liver. 
  • Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. 
  • Administration of nicotine to adolescent rats evokes regionally selective upregulation of CNS alpha 7 nicotinic acetylcholine receptors. 
  • Adolescent nicotine administration alters serotonin receptors and cell signaling mediated through adenylyl cyclase. 
  • Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation. 
  • Alpha7 nicotinic acetylcholine receptors targeted by cholinergic developmental neurotoxicants: nicotine and chlorpyrifos. 
  • Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Ameroid constrictor versus hydraulic occluder: creation of hibernating myocardium. 
  • Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. 
  • Amplification of HER-2/neu gene in human gastric adenocarcinomas: correlation with primary site. 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting. 
  • Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Anomalous regulation of beta-adrenoceptor signaling in brain regions of the newborn rat. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. 
  • Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. 
  • Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. 
  • Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos. 
  • Association of chronic congestive heart failure in humans with an intrinsic upregulation in skeletal muscle sarcoplasmic reticulum calcium ion adenosine triphosphatase activity. 
  • Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. 
  • BMP signaling modulates hedgehog-induced secondary heart field proliferation. 
  • Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. 
  • Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. 
  • Basic fibroblast growth factor is upregulated in hibernating myocardium. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Beta-catenin mediates soft tissue contracture in clubfoot. 
  • Biomarkers, mineralocorticoid receptor antagonism, and cardiorenal remodeling. 
  • Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis. 
  • Blood Transfusion and the Risk of Acute Kidney Injury Among Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery. 
  • Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. 
  • Bombesin-like peptide and receptors in lung injury models: diverse gene expression, similar function. 
  • Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage. 
  • Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. 
  • Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. 
  • Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression. 
  • CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse model. 
  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. 
  • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. 
  • CXCL10 is upregulated in synovium and cartilage following articular fracture. 
  • CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation. 
  • CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial. 
  • Cardiac catheterization within 1 to 3 days of proximal aortic surgery is not associated with increased postoperative acute kidney injury. 
  • Cardiac troponin T concentrations above the 99th percentile value as measured by a new high-sensitivity assay predict long-term prognosis in patients with acute coronary syndromes undergoing routine early invasive strategy. 
  • Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. 
  • Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. 
  • Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. 
  • Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. 
  • Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course. 
  • Changes in tumour expression of programmed death-ligand 1 after neoadjuvant concurrent chemoradiotherapy in patients with squamous oesophageal cancer. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Chemoattractant receptor-induced phosphorylation of L-selectin. 
  • Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. 
  • Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. 
  • Chronic ethanol intoxication enhances the production of cytokine-induced neutrophil chemoattractant and macrophage inflammatory protein-2 by hepatocytes after human immunodeficiency virus-1 glycoprotein 120 vaccination. 
  • Chronic prenatal nicotine exposure sensitizes rat brain to acute postnatal nicotine challenge as assessed with ornithine decarboxylase. 
  • Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. 
  • Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study. 
  • Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. 
  • Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation. 
  • Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells. 
  • Common cancer biomarkers. 
  • Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. 
  • Complement activation contributes to perioperative neurocognitive disorders in mice. 
  • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. 
  • Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Consequences of unilateral hearing loss: time dependent regulation of protein synthesis in auditory brainstem nuclei. 
  • Conservation of hearing and protection of auditory hair cells against trauma-induced losses by local dexamethasone therapy: molecular and genetic mechanisms. 
  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. 
  • Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. 
  • Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic adenocarcinoma cells by hypoxia. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Copper signaling axis as a target for prostate cancer therapeutics. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease. 
  • Correlating notch signaling with thymocyte maturation. 
  • Correlation of concentrations of high-sensitivity troponin T and high-sensitivity C-reactive protein with plaque progression as measured by CT coronary angiography. 
  • Critical prenatal and postnatal periods for persistent effects of dexamethasone on serotonergic and dopaminergic systems. 
  • Cti6 is an Rpd3-Sin3 histone deacetylase-associated protein required for growth under iron-limiting conditions in Saccharomyces cerevisiae. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. 
  • Cytokines and adhesion molecules in the pathogenesis of vasculitis. 
  • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. 
  • DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA. 
  • Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta. 
  • Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint. 
  • Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Design of a phase 2b trial of intracoronary administration of AAV1/SERCA2a in patients with advanced heart failure: the CUPID 2 trial (calcium up-regulation by percutaneous administration of gene therapy in cardiac disease phase 2b). 
  • Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. 
  • Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). 
  • Development of a rapid whole blood flow cytometry procedure for the diagnosis of X-linked hyper-IgM syndrome patients and carriers. 
  • Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. 
  • Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine. 
  • Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio). 
  • Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. 
  • Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans. 
  • Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes. 
  • Differential collagen I gene expression in fetal fibroblasts. 
  • Differential development of cholinergic nerve terminal markers in rat brain regions: implications for nerve terminal density, impulse activity and specific gene expression. 
  • Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain. 
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. 
  • Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. 
  • Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Disruption of the Ang II type 1 receptor promotes longevity in mice. 
  • Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. 
  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. 
  • Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. 
  • Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. 
  • Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. 
  • Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth. 
  • Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch. 
  • E protein transcription factors are required for the development of CD4(+) lineage T cells. 
  • E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. 
  • E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program. 
  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 
  • ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. 
  • Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling. 
  • Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor. 
  • Early trends in serum phosphate and creatinine levels are associated with mortality following major hepatectomy. 
  • Effect of UV-B phototherapy on plasma HIV type 1 RNA viral level: a self-controlled prospective study. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. 
  • Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. 
  • Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach. 
  • Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization. 
  • Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. 
  • Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women. 
  • Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. 
  • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. 
  • Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis. 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells. 
  • Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation. 
  • Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium. 
  • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. 
  • Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. 
  • Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression. 
  • Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction. 
  • Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. 
  • Expression and modulation of RPE cell membrane complement regulatory proteins. 
  • Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. 
  • Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. 
  • Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. 
  • Expression of heme oxygenase-1 in the lung in chronic hypoxia. 
  • Expression of proliferation-specific genes in the mucosa adjacent to colon carcinoma. 
  • Expression of terminin in the rat brain during neuronal differentiation. 
  • Expression of the CD7 ligand K-12 in human thymic epithelial cells: regulation by IFN-gamma. 
  • Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. 
  • Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways. 
  • Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. 
  • Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood. 
  • Fetal nicotine exposure produces postnatal up-regulation of adenylate cyclase activity in peripheral tissues. 
  • Fibroblast growth factor 23 and incident CKD in type 2 diabetes. 
  • Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. 
  • Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. 
  • Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. 
  • Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. 
  • Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation. 
  • GW112, a novel antiapoptotic protein that promotes tumor growth. 
  • Gallbladder Na+/H+ exchange activity is up-regulated prior to cholesterol crystal formation. 
  • Gene expression during normal and FSHD myogenesis. 
  • Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. 
  • Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. 
  • Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. 
  • Gene products promoting remyelination are up-regulated in a cell therapy product manufactured from banked human cord blood. 
  • Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. 
  • Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model. 
  • Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue. 
  • Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Gq-dependent signaling upregulates COX2 in glomerular podocytes. 
  • Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification. 
  • HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis. 
  • HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. 
  • HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. 
  • Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. 
  • Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. 
  • Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway. 
  • Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. 
  • Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. 
  • Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation. 
  • Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. 
  • Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. 
  • Heterogeneity of glycolysis in cancers and therapeutic opportunities. 
  • Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community. 
  • Higher high-density lipoprotein cholesterol in African-American women with polycystic ovary syndrome compared with Caucasian counterparts. 
  • Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds. 
  • Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. 
  • Hypoxic Gene Expression of Donor Bronchi Linked to Airway Complications after Lung Transplantation. 
  • ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. 
  • Identification of a human heme exporter that is essential for erythropoiesis. 
  • Identification of differentially expressed microRNAs in human hepatocellular adenoma associated with type I glycogen storage disease: a potential utility as biomarkers. 
  • Identification of novel cellular targets in biliary tract cancers using global gene expression technology. 
  • Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice. 
  • Immunomodulatory Activity of Nivolumab in Metastatic Renal Cell Carcinoma. 
  • Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1. 
  • In vitro chondrogenesis of mesenchymal stem cells in recombinant silk-elastinlike hydrogels. 
  • In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis. I. Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN gamma mRNAs in the cornea due to experimental interstitial keratitis. 
  • In vivo regulation of hTERT expression and telomerase activity by androgen. 
  • Increased AKT or MEK1/2 activity influences progesterone receptor levels and localization in endometriosis. 
  • Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. 
  • Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. 
  • Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. 
  • Increased expression of p130 in Alzheimer disease. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Increased renal dopamine and acute renal adaptation to a high-phosphate diet. 
  • Increasing atmospheric CO2 reduces metabolic and physiological differences between isoprene- and non-isoprene-emitting poplars. 
  • Induction of T cell CD7 gene transcription by nonmitogenic ionomycin-induced transmembrane calcium flux. 
  • Induction of hippocampal long-term potentiation during waking leads to increased extrahippocampal zif-268 expression during ensuing rapid-eye-movement sleep. 
  • Induction of protein secretory pathway is required for systemic acquired resistance. 
  • Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation. 
  • Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. 
  • Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease. 
  • Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. 
  • Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways. 
  • Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. 
  • Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. 
  • Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. 
  • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. 
  • Interleukin-1 stimulates the beta-amyloid precursor protein promoter. 
  • Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. 
  • Ischemic Stroke with Troponin Elevation: Patient Characteristics, Resource Utilization, and In-Hospital Outcomes. 
  • Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. 
  • Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2. 
  • L-Threonine induces heat shock protein expression and decreases apoptosis in heat-stressed intestinal epithelial cells. 
  • LPS elicits a much larger and broader inflammatory response than Escherichia coli infection within the hippocampus of neonatal rats. 
  • Lactose supports Muller cell protein expression patterns in the absence of the retinal pigment epithelium. 
  • Lasting effects of developmental dexamethasone treatment on neural cell number and size, synaptic activity, and cell signaling: critical periods of vulnerability, dose-effect relationships, regional targets, and sex selectivity. 
  • Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse. 
  • Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. 
  • Leukotriene C4 induces migration of human monocyte-derived dendritic cells without loss of immunostimulatory function. 
  • Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. 
  • Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages. 
  • Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. 
  • Lipopolysaccharide up-regulates platelet-derived growth factor (PDGF) alpha-receptor expression in rat lung myofibroblasts and enhances response to all PDGF isoforms. 
  • LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. 
  • Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood. 
  • Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. 
  • Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds. 
  • Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss. 
  • Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. 
  • Lymphangitis after self-administration of lipopolysaccharide. 
  • Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. 
  • Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. 
  • Manipulating large-scale Arabidopsis microarray expression data: identifying dominant expression patterns and biological process enrichment. 
  • Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. 
  • Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma. 
  • Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2. 
  • Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells. 
  • Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1. 
  • Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia. 
  • Mineralocorticoid receptor antagonists modulate galectin-3 and interleukin-33/ST2 signaling in left ventricular systolic dysfunction after acute myocardial infarction. 
  • Mitochondrial adaptations to obesity-related oxidant stress. 
  • Mitogen-activated protein kinase (MAPK) hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells. 
  • Modulation of IL-33/ST2 system in postinfarction heart failure: correlation with cardiac remodelling markers. 
  • Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases. 
  • Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. 
  • Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. 
  • Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. 
  • Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. 
  • Molecular markers in ductal carcinoma in situ of the breast. 
  • Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. 
  • Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. 
  • Myocardial overexpression of adrenergic receptors and receptor kinases. 
  • Negative regulation of lymphocyte activation by the adaptor protein LAX. 
  • Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study. 
  • Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. 
  • Neural input and the development of adrenergic intracellular signaling: neonatal denervation evokes neither receptor upregulation nor persistent supersensitivity of adenylate cyclase. 
  • Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes. 
  • Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone. 
  • Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. 
  • Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos. 
  • Non-erythroid effects of erythropoietin. 
  • Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. 
  • Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. 
  • Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. 
  • Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. 
  • Nuclear translocation of β-catenin correlates with CD44 upregulation in Helicobacter pylori-infected gastric carcinoma. 
  • Oestrogen receptors enhance dopamine neurone survival in rat midbrain. 
  • Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus. 
  • Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts. 
  • Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling. 
  • Osteopontin Is Upregulated in Human and Murine Acute Schistosomiasis Mansoni. 
  • Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis. 
  • Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. 
  • Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication. 
  • Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice. 
  • Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. 
  • Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function. 
  • Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma. 
  • Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. 
  • Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. 
  • Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. 
  • Oxygen-induced mitochondrial biogenesis in the rat hippocampus. 
  • PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. 
  • PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion. 
  • PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. 
  • Pattern of liver enzyme elevations in acute ST-elevation myocardial infarction. 
  • Pax3 expression enhances PDGF-B-induced brainstem gliomagenesis and characterizes a subset of brainstem glioma. 
  • Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. 
  • Perinatal exposure to environmental tobacco smoke upregulates nicotinic cholinergic receptors in monkey brain. 
  • Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. 
  • Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. 
  • Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. 
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. 
  • Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans. 
  • Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing. 
  • Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems. 
  • Postnatal alterations in beta-adrenergic receptor binding in rat brain regions after continuous prenatal exposure to propranolol via maternal infusion. 
  • Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA. 
  • Predictors of morbidity and mortality with endovascular and open thoracic aneurysm repair. 
  • Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig. 
  • Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress. 
  • Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. 
  • Pretreatment with an inhibitor of mac-1 alters regional and systemic platelet function during ischemia-reperfusion in swine. 
  • Prevalence and incidence of liver enzyme elevations in a pooled oncology clinical trial cohort. 
  • Prevalence of low ankle-brachial index, elevated plasma fibrinogen and CRP across Framingham risk categories: data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004. 
  • Prevention of ischemically induced neointimal hyperplasia using ex vivo antisense oligodeoxynucleotides. 
  • Progesterone, Inflammatory Cytokine (TNF-α), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 Expression in Fetal Membrane Cells. 
  • Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors. 
  • Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. 
  • Protective effects of resveratrol in experimental retinal detachment. 
  • Protein expression and functional analysis of the FHIT gene in human tumor cells. 
  • Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. 
  • Pseudo-pseudo Meigs' syndrome in a patient with systemic lupus erythematosus. 
  • Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension. 
  • Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. 
  • Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation. 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 
  • Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping. 
  • Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB. 
  • Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. 
  • Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions. 
  • Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. 
  • Regulation of myeloid leukaemia by the cell-fate determinant Musashi. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Relationship Between Peak Troponin Values and Long-Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes. 
  • Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer. 
  • Relaxin suppresses atrial fibrillation in aged rats by reversing fibrosis and upregulating Na+ channels. 
  • Release of endogenous danger signals from HIFU-treated tumor cells and their stimulatory effects on APCs. 
  • Renin-angiotensin-aldosterone genotype influences ventricular remodeling in infants with single ventricle. 
  • Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. 
  • Restoration of the cystic fibrosis transmembrane conductance regulator function by splicing modulation. 
  • Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β. 
  • Rising PSA Level in an Anxious Postprostatectomy Patient. 
  • Role of JAK3 in CD40-mediated signaling. 
  • Role of alternative oxidase gene in pathogenesis of Cryptococcus neoformans. 
  • Role of hyaluronan and hyaluronan-binding proteins in human asthma. 
  • Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype. 
  • SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. 
  • SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro. 
  • ST2 as a cardiovascular risk biomarker: from the bench to the bedside. 
  • STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. 
  • Scarecrow-like 3 promotes gibberellin signaling by antagonizing master growth repressor DELLA in Arabidopsis. 
  • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. 
  • Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage. 
  • Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study. 
  • Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. 
  • Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons. 
  • Selective upregulated expression of the alpha2-macroglobulin signaling receptor in highly metastatic 1-LN prostate carcinoma cells. 
  • Serum C-reactive protein level and prehypertension in two Asian populations. 
  • Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial. 
  • Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses. 
  • ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis. 
  • Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry. 
  • Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. 
  • Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF. 
  • Single-molecule analysis of myocyte differentiation reveals bimodal lineage commitment. 
  • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. 
  • Soluble CXCL16 and long-term outcome in acute ischemic stroke. 
  • Soluble alpha2-macroglobulin receptor is increased in endotracheal aspirates from infants and children after cardiopulmonary bypass. 
  • Soluble miniagrin enhances contractile function of engineered skeletal muscle. 
  • Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. 
  • Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. 
  • Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Surgery upregulates high mobility group box-1 and disrupts the blood-brain barrier causing cognitive dysfunction in aged rats. 
  • Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. 
  • Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. 
  • Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. 
  • T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+. 
  • T-cell receptor α enhancer is inactivated in αβ T lymphocytes. 
  • TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. 
  • TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination. 
  • TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. 
  • TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. 
  • TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. 
  • TSC-36 (follistatin-related polypeptide) gene expression in estrogen receptor positive osteoblastic cell line, CDO7F. 
  • Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function. 
  • Targeting UDP-α-D-glucose 6-dehydrogenase inhibits glioblastoma growth and migration. 
  • Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling. 
  • Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes. 
  • The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression. 
  • The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development. 
  • The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. 
  • The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. 
  • The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells. 
  • The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. 
  • The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth. 
  • The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling. 
  • The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. 
  • The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. 
  • The aorta wall of patients presenting to the emergency department with acute myocardial infarction by cardiac magnetic resonance. 
  • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. 
  • The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages. 
  • The class I HDAC inhibitor MGCD0103 induces cell cycle arrest and apoptosis in colon cancer initiating cells by upregulating Dickkopf-1 and non-canonical Wnt signaling. 
  • The conformation-dependent interaction of alpha 2-macroglobulin with vascular endothelial growth factor. A novel mechanism of alpha 2-macroglobulin/growth factor binding. 
  • The effects of IL-1, IL-2, and tumor necrosis factor on polymorphonuclear leukocyte Fc gamma receptor-mediated phagocytosis. IL-2 down-regulates the effect of tumor necrosis factor. 
  • The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. 
  • The influence of various patient characteristics on D-dimer concentration in critically ill patients and its role as a prognostic indicator in the intensive care unit setting. 
  • The monomeric receptor binding domain of tetrameric α2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades. 
  • The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. 
  • The pulling, pushing and fusing of lens fibers: a role for Rho GTPases. 
  • The release of microparticles by apoptotic cells and their effects on macrophages. 
  • The role of membrane lipids in the induction of macrophage apoptosis by microparticles. 
  • The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. 
  • Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. 
  • Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. 
  • Thymic microenvironment induces HIV expression. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. 
  • Thymic model for examining BRCA2 expression and function. 
  • Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. 
  • Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. 
  • Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. 
  • Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells. 
  • Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. 
  • Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. 
  • Transcriptional response to hypoxia in human tumors. 
  • Transdifferentiation of human endothelial progenitors into smooth muscle cells. 
  • Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. 
  • Transglutaminase 2 protects against ischemic stroke. 
  • Transiently overexpressed alpha2-adrenoceptors and their control of DNA synthesis in the developing brain. 
  • Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression. 
  • Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. 
  • Type I interferon pathway in adult and juvenile dermatomyositis. 
  • Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. 
  • Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. 
  • Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis. 
  • Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells. 
  • Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication. 
  • Up-regulation of SNCA gene expression: implications to synucleinopathies. 
  • Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection. 
  • Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. 
  • Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer. 
  • Up-regulation of recombination activating gene expression by signal transduction through the surface Ig receptor. 
  • Up-regulation of the alpha2-macroglobulin signaling receptor on rheumatoid synovial fibroblasts. 
  • Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure. 
  • Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. 
  • Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter. 
  • Upregulation of Bcl-2 and elevation of ceramide in Batten disease. 
  • Upregulation of CD4 expression during MHC class II-specific positive selection is essential for error-free lineage choice. 
  • Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury. 
  • Upregulation of PAI-1 is mediated through TGF-beta/Smad pathway in transplant arteriopathy. 
  • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. 
  • Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. 
  • Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development. 
  • Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. 
  • Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins. 
  • Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. 
  • Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats. 
  • Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons. 
  • Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. 
  • Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression. 
  • Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma. 
  • Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism. 
  • Wnt proteins synergize to activate β-catenin signaling. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • c-FLIP protects eosinophils from TNF-α-mediated cell death in vivo. 
  • c-Jun promotes whereas JunB inhibits epidermal neoplasia. 
  • eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer. 
  • miR-21-mediated decreased neutrophil apoptosis is a determinant of impaired coronary collateral growth in metabolic syndrome. 
  • miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling. 
  • p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. 
• 

  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Bradford, Daniel William, Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry
  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Cunningham, Coleen Kathryn, Professor of Pediatrics, Pathology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hirschey, Matthew, Associate Professor, Pharmacology & Cancer Biology
  • Juvvadi, Praveen Rao, Assistant Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Luftig, Micah Alan, Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology
  • McDonnell, Donald Patrick, Chair, Department of Pharmacology & Cancer Biology, Duke Innovation & Entrepreneurship
  • Milano, Carmelo Alessio, Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery
  • Steinbach, William J., Professor of Pediatrics, Duke Innovation & Entrepreneurship
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology