Subject Areas on Research
- A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.
- Activated protein C cleaves factor Va more efficiently on endothelium than on platelet surfaces.
- Anti-beta(2)-glycoprotein I antibody-mediated inhibition of activated protein C requires binding of beta(2)-glycoprotein I to phospholipids.
- Characterization of an acquired inhibitor to coagulation factor V. Antibody binding to the second C-type domain of factor V inhibits the binding of factor V to phosphatidylserine and neutralizes procoagulant activity.
- Crystal structures of the membrane-binding C2 domain of human coagulation factor V.
- Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex.
- Properties of procoagulant platelets: defining and characterizing the subpopulation binding a functional prothrombinase.
- Transmission of a procoagulant signal from tissue factor-bearing cell to platelets.