Gene Expression Regulation, Fungal
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Subject Areas on Research
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A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae.
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A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus.
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A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides.
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A Rac homolog functions downstream of Ras1 to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans.
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A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans.
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A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans.
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A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans.
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A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.
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A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans.
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A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides.
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A non-canonical RNAi pathway controls virulence and genome stability in Mucorales.
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A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae.
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A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
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All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae.
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Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans.
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Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases.
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Analyzing transcription dynamics during the budding yeast cell cycle.
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Aquaporin expression and freeze tolerance in Candida albicans.
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Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis.
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Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program.
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Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans.
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Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
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Calcineurin is essential for survival during membrane stress in Candida albicans.
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Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.
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Calcineurin is required for virulence of Cryptococcus neoformans.
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Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
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Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.
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Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae.
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Cell cycle-regulated transcription: effectively using a genomics toolbox.
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Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans.
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Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans.
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Characterizing the role of RNA silencing components in Cryptococcus neoformans.
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Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast.
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Chitinases are essential for sexual development but not vegetative growth in Cryptococcus neoformans.
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Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii.
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Chitosan, the deacetylated form of chitin, is necessary for cell wall integrity in Cryptococcus neoformans.
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Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites.
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Circadian clock-controlled genes isolated from Neurospora crassa are late night- to early morning-specific.
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Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.
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Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.
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Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans.
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Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism.
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Connecting virulence pathways to cell-cycle progression in the fungal pathogen Cryptococcus neoformans.
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Conserved cAMP signaling cascades regulate fungal development and virulence.
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Control of meiotic recombination and gene expression in yeast by a simple repetitive DNA sequence that excludes nucleosomes.
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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.
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Cross talk between the cell wall integrity and cyclic AMP/protein kinase A pathways in Cryptococcus neoformans.
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Cryptococcus gattii virulence composite: candidate genes revealed by microarray analysis of high and less virulent Vancouver island outbreak strains.
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Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis.
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Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.
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Cryptococcus neoformans differential gene expression detected in vitro and in vivo with green fluorescent protein.
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Cryptococcus neoformans gene expression during experimental cryptococcal meningitis.
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Cryptococcus neoformans gene expression during murine macrophage infection.
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Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host.
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Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence.
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Cryptococcus neoformans: a sugar-coated killer with designer genes.
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Cryptococcus neoformans: the yeast that likes it hot.
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Cryptococcus neoformans: virulence and host defences.
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Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights.
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Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.
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Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.
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Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.
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Daughter-specific transcription factors regulate cell size control in budding yeast.
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Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae.
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Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins.
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Diploid strains of the pathogenic basidiomycete Cryptococcus neoformans are thermally dimorphic.
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Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.
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Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.
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Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans.
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Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans.
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Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae.
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Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence.
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Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.
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Emerging Issues in Antifungal Resistance.
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Erg6 affects membrane composition and virulence of the human fungal pathogen Cryptococcus neoformans.
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Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay.
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Evaluating the mycostimulation potential of select carbon amendments for the degradation of a model PAH by an ascomycete strain enriched from a superfund site.
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Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).
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Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi.
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Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450.
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Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators.
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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.
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Fungal pathogenesis: gene clusters unveiled as secrets within the Ustilago maydis code.
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Galactose-Inducible promoters in Cryptococcus neoformans var. grubii.
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Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture.
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Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.
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Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans.
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Global control of cell-cycle transcription by coupled CDK and network oscillators.
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Going green in Cryptococcus neoformans: the recycling of a selectable drug marker.
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Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans.
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Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast.
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HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin is required for NO resistance and host interaction.
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Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans.
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Heterochronic meiotic misexpression in an interspecific yeast hybrid.
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Heterogeneity in mitochondrial morphology and membrane potential is independent of the nuclear division cycle in multinucleate fungal cells.
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Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway.
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Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.
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Identification of a Cryptococcus neoformans gene that directs expression of the cryptic Saccharomyces cerevisiae mannitol dehydrogenase gene.
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Identification of a strand-related bias in the PCNA-mediated bypass of spontaneous lesions by yeast Poleta.
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Identification of cell cycle-regulated, putative hyphal genes in Candida albicans.
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Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts.
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Impact of Protein Palmitoylation on the Virulence Potential of Cryptococcus neoformans.
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Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi.
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In situ distinction between steroid receptor binding and transactivation at a target gene.
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Inferring gene expression from ribosomal promoter sequences, a crowdsourcing approach.
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Inositol Metabolism Regulates Capsule Structure and Virulence in the Human Pathogen Cryptococcus neoformans.
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Inositol phosphate multikinase dependent transcriptional control.
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Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae.
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Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone.
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Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.
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Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance.
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Intrinsic and cyclin-dependent kinase-dependent control of spindle pole body duplication in budding yeast.
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Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans.
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Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae.
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Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses.
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Layers of regulation of cell-cycle gene expression in the budding yeast Saccharomyces cerevisiae.
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Ligand-dependent and -independent function of the transactivation regions of the human estrogen receptor in yeast.
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Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells.
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Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes.
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Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection.
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Metatranscriptomic Study of Common and Host-Specific Patterns of Gene Expression between Pines and Their Symbiotic Ectomycorrhizal Fungi in the Genus Suillus.
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Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant.
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Molecular characterization of CLPT1, a SEC4-like Rab/GTPase of the phytopathogenic fungus Colletotrichum lindemuthianum which is regulated by the carbon source.
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Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae.
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Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination Pathway.
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Neurospora clock-controlled gene 9 (ccg-9) encodes trehalose synthase: circadian regulation of stress responses and development.
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Neurospora crassa female development requires the PACC and other signal transduction pathways, transcription factors, chromatin remodeling, cell-to-cell fusion, and autophagy.
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Novel Sfp1 transcriptional regulation of Saccharomyces cerevisiae gene expression changes during spaceflight.
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Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
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Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae.
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Nutrient signaling through TOR kinases controls gene expression and cellular differentiation in fungi.
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Nutritional control via Tor signaling in Saccharomyces cerevisiae.
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PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.
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PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex.
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Pathogenesis of Cryptococcus neoformans is associated with quantitative differences in multiple virulence factors.
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Pbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in Cryptococcus neoformans.
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Pcp1p, an Spc110p-related calmodulin target at the centrosome of the fission yeast Schizosaccharomyces pombe.
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Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans.
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Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.
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Pleiotropic signaling pathways orchestrate yeast development.
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Positive feedback of G1 cyclins ensures coherent cell cycle entry.
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Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems.
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Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans.
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Posttranslational, translational, and transcriptional responses to nitric oxide stress in Cryptococcus neoformans: implications for virulence.
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Prolyl isomerases in yeast.
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Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans.
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Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control.
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Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation.
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Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
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RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans.
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RNA Controls PolyQ Protein Phase Transitions.
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Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway.
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Ras1 acts through duplicated Cdc42 and Rac proteins to regulate morphogenesis and pathogenesis in the human fungal pathogen Cryptococcus neoformans.
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Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans.
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Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans.
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Ratiometric GPCR signaling enables directional sensing in yeast.
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Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada.
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Recombination in yeast and the recombinant DNA technology.
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Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.
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Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans.
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Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways.
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Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK.
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RoboCOP: jointly computing chromatin occupancy profiles for numerous factors from chromatin accessibility data.
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Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis.
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Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo.
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Role of phosphatidylinositol 3-phosphate in formation of forespore membrane in Schizosaccharomyces pombe.
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Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans.
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Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans.
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Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae.
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Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension culture.
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Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
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Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast.
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Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans.
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Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans.
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Signaling repression of transcription by RNA polymerase III in yeast.
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Sir2 suppresses transcription-mediated displacement of Mcm2-7 replicative helicases at the ribosomal DNA repeats.
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Sirtuin 5 Is Regulated by the SCFCyclin F Ubiquitin Ligase and Is Involved in Cell Cycle Control.
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Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion.
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Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.
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Structural impact of K63 ubiquitin on yeast translocating ribosomes under oxidative stress.
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Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.
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Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
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Study of Cryptococcus neoformans actin gene regulation with a beta-galactosidase-actin fusion.
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Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway in Cryptococcus neoformans and contributes to fungal virulence.
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Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis.
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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
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The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast.
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The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function.
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The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.
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The Cryptococcus neoformans capsule: a sword and a shield.
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The Cryptococcus neoformans catalase gene family and its role in antioxidant defense.
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The Cryptococcus neoformans transcriptome at the site of human meningitis.
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The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.
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The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
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The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
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The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.
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The RNAi Mechanism Regulates a New Exonuclease Gene Involved in the Virulence of Mucorales.
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The TOR signaling cascade regulates gene expression in response to nutrients.
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The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The compact chromatin structure of a Ty repeated sequence suppresses recombination hotspot activity in Saccharomyces cerevisiae.
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The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin.
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The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae.
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The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo.
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The protein kinase Tor1 regulates adhesin gene expression in Candida albicans.
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The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation.
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The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA.
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Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans.
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Three galactose inducible promoters for use in C. neoformans var. grubii.
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Threonine biosynthetic genes are essential in Cryptococcus neoformans.
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Topology and control of the cell-cycle-regulated transcriptional circuitry.
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Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth.
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Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.
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Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication.
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Transcriptional regulation improves the throughput of three-hybrid counter selections in Saccharomyces cerevisiae.
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Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.
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Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans.
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Two glutathione peroxidases in the fungal pathogen Cryptococcus neoformans are expressed in the presence of specific substrates.
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Uncoupling of genomic and epigenetic signals in the maintenance and inheritance of heterochromatin domains in fission yeast.
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Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.
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Using graphical models and genomic expression data to statistically validate models of genetic regulatory networks.
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Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae.
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Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation.
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Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog.
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Keywords of People
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Carbrey, Jennifer Mehlman,
Assistant Research Professor of Cell Biology,
Cell Biology
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Haase, Steven B.,
Professor of Biology,
Biology
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Hartemink, Alexander J.,
Professor in the Department of Computer Science,
Biology
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Pitt, Geoffrey Stuart,
Adjunct Professor in the Department of Medicine,
Medicine, Cardiology
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Shinohara, Mari L.,
Professor of Integrative Immunobiology,
Cell Biology
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Taylor, Gregory Alan,
Professor in Medicine,
Integrative Immunobiology