Gene Expression Regulation, Neoplastic
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Subject Areas on Research
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27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells.
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5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
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58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
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A Bayesian hierarchical model to estimate DNA methylation conservation in colorectal tumors.
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A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.
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A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
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A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors.
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A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
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A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.
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A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates.
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A Multi-Institutional Study to Evaluate Automated Whole Slide Scoring of Immunohistochemistry for Assessment of Programmed Death-Ligand 1 (PD-L1) Expression in Non-Small Cell Lung Cancer.
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A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma.
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A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.
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A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.
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A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.
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A clinical-grade liquid biomarker detects neuroendocrine differentiation in prostate cancer.
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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
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A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation.
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A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures.
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A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
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A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes.
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A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.
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A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia.
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A genomic strategy to elucidate modules of oncogenic pathway signaling networks.
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A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.
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A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer.
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A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors.
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A lower Allred score for progesterone receptor is strongly associated with a higher recurrence score of 21-gene assay in breast cancer.
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A map of human cancer signaling.
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A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling.
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A multi-institutional phase 2 trial of regorafenib in refractory advanced biliary tract cancer.
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A multiple testing procedure to associate gene expression levels with survival.
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A natural history of melanoma: serial gene expression analysis.
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A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.
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A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development.
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A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
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A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.
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A pathway-based classification of human breast cancer.
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A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy.
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A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression.
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A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.
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A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.
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A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers.
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A role for E2F activities in determining the fate of Myc-induced lymphomagenesis.
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A seven-gene signature can predict distant recurrence in patients with triple-negative breast cancers who receive adjuvant chemotherapy following surgery.
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A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.
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A somatic TSHR mutation in a patient with lung adenocarcinoma with bronchioloalveolar carcinoma, coronary artery disease and severe chronic obstructive pulmonary disease.
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A transgenic mouse prostate cancer model.
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A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.
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ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.
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ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.
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ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis.
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ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers.
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AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization.
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AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma.
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APC I1307K and the risk of prostate cancer.
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APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.
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APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses.
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ARID1A-mutated ovarian cancers depend on HDAC6 activity.
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ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.
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Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance.
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Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia.
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Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors.
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Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression.
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Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
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Absence of Y chromosome in human placental site trophoblastic tumor.
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Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma.
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Accentuation of differentially expressed proteins using phage technology.
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Acidic stress promotes a glioma stem cell phenotype.
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Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression.
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Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.
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Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.
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Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.
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Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
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Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation.
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Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis.
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Activation of tyrosine kinases in cancer.
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Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines.
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Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.
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Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1.
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Activity of a Py-Im polyamide targeted to the estrogen response element.
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Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma.
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Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence.
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Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.
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Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer.
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Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets.
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Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.
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Aggressive fibromatosis.
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Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.
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Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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Altered expression of TIM-3, LAG-3, IDO, PD-L1, and CTLA-4 during nimotuzumab therapy correlates with responses and prognosis of oral squamous cell carcinoma patients.
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Alternate statistical tools and limitations in genetic marker association studies in single-arm drug cancer trials.
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Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer.
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Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
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Alternatively spliced human tissue factor promotes tumor growth and angiogenesis in a pancreatic cancer tumor model.
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Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
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Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, in head and neck squamous cell carcinoma.
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Amplification of HER-2/neu gene in human gastric adenocarcinomas: correlation with primary site.
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An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients.
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An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer.
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An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
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An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.
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An animal model of MYC-driven medulloblastoma.
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An association between the 4G polymorphism in the PAI-1 promoter and the development of aggressive fibromatosis (desmoid tumor) in familial adenomatous polyposis patients.
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An improved method for bivariate meta-analysis when within-study correlations are unknown.
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An integrated genomic analysis of human glioblastoma multiforme.
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An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer.
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An integration of complementary strategies for gene-expression analysis to reveal novel therapeutic opportunities for breast cancer.
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An integrative approach identified genes associated with drug response in gastric cancer.
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An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer.
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An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
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An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.
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Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
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Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes.
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Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer.
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Anchorage-independent cell growth signature identifies tumors with metastatic potential.
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Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
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Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors.
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Androgen receptor variant-driven prostate cancer II: advances in laboratory investigations.
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Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting.
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Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis.
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Angiomirs expression profiling in diffuse large B-Cell lymphoma.
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Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.
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Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.
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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor.
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Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
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Apatorsen plus docetaxel versus docetaxel alone in platinum-resistant metastatic urothelial carcinoma (Borealis-2).
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Apoptosis signaling and BCL-2 pathways provide opportunities for novel targeted therapeutic strategies in hematologic malignances.
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Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression.
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Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness.
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Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma.
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Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
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Association between XPF polymorphisms and cancer risk: a meta-analysis.
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Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.
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Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck.
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Association between the ERCC5 Asp1104His polymorphism and cancer risk: a meta-analysis.
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Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer.
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Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer.
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Association of genomic subtypes of lower-grade gliomas with shape features automatically extracted by a deep learning algorithm.
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Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab.
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Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway.
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Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.
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B cells in chronic graft-versus-host disease.
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BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.
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BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation.
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BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway.
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BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation.
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BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis.
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BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.
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Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells.
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Bcl-xL is an oncogenic driver in colorectal cancer.
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Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance.
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Bimodal age distribution at diagnosis in breast cancer persists across molecular and genomic classifications.
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Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.
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Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.
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Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer.
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Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.
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Body mass index is associated with gene methylation in estrogen receptor-positive breast tumors.
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Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non-Bone-Forming Lesions.
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Bone formation induced by BMP-2 in human osteosarcoma cells.
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Broad regulation of gene isoform expression by Wnt signaling in cancer.
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Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.
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CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells.
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CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study.
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CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell-cycle arrest?
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CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation.
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CD44-SLC1A2 gene fusions in gastric cancer.
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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
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CDKN2 in HPV-positive and HPV-negative cervical-carcinoma cell lines.
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CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.
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CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.
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CK1epsilon is required for breast cancers dependent on beta-catenin activity.
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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
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CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.
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Calcitonin elevation in small cell lung cancer without ectopic production.
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Cancer characterization and feature set extraction by discriminative margin clustering.
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Cancer systems biology: exploring cancer-associated genes on cellular networks.
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Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression.
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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
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Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
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Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin.
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Carbonic anhydrase IX in early-stage non-small cell lung cancer.
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Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
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Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis.
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Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy.
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Cav1.3 channel α1D protein is overexpressed and modulates androgen receptor transactivation in prostate cancers.
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Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity.
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Cell cycle control of BRCA2.
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Cell proliferation is insufficient, but loss of tuberin is necessary, for chemically induced nephrocarcinogenicity.
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Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer.
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Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells.
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Central nervous system.
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Characterization of 67 kD laminin receptor, a protein whose gene is overexpressed on treatment of cells with anti-benzo[a]pyrene-7,8-diol-9,10-epoxide.
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Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer.
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Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing.
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Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.
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Characterization of the usage of the serine metabolic network in human cancer.
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Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis.
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Cholangiocarcinoma: Correlation between Molecular Profiling and Imaging Phenotypes.
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Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis.
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Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.
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Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity.
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Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.
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Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma.
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.
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CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.
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Circular ecDNA promotes accessible chromatin and high oncogene expression.
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Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
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Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.
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Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma.
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Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.
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Clinical and therapeutic relevance of PIM1 kinase in gastric cancer.
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Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients.
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Clinicopathological Features of Triple-Negative Breast Cancer Epigenetic Subtypes.
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Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia.
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Clonal origin of epithelial ovarian carcinoma: analysis by loss of heterozygosity, p53 mutation, and X-chromosome inactivation.
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Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue.
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Clustering gene expression time series data using an infinite Gaussian process mixture model.
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Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis.
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Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.
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Combination of PARP Inhibitor Olaparib, and PD-L1 Inhibitor Durvalumab, in Recurrent Ovarian Cancer: a Proof-of-Concept Phase II Study.
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Combination of antisense oligonucleotide and low-dose chemotherapy in hematological malignancies.
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Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
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Common cancer biomarkers.
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Common responses of tumors and wounds to hypoxia.
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Comparative analysis of peritoneum and tumor eicosanoids and pathways in advanced ovarian cancer.
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Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.
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Comparison of methods of measuring HER-2 in metastatic breast cancer patients treated with high-dose chemotherapy.
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Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.
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Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines.
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
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Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer.
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Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.
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Comprehensive molecular characterization of gastric adenocarcinoma.
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Comprehensive molecular characterization of urothelial bladder carcinoma.
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Comprehensive molecular portraits of human breast tumours.
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Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment.
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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.
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Compromised HOXA5 function can limit p53 expression in human breast tumours.
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Concepts of oxygen transport at the microcirculatory level.
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Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays.
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Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma.
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Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.
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Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators.
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Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies.
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Contribution of Histone Deacetylases in Prognosis and Therapeutic Management of Cholangiocarcinoma.
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Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes.
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Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors.
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Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer.
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Copper signaling axis as a target for prostate cancer therapeutics.
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Creation of an active estrogen-responsive element by a single base change in the flanking sequence of a cellular oncogene: a possible mechanism for hormonal carcinogenesis?
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Cross-study projections of genomic biomarkers: an evaluation in cancer genomics.
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Cross-talk between T Cells and Hematopoietic Stem Cells during Adoptive Cellular Therapy for Malignant Glioma.
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Cryopreservation of neurospheres derived from human glioblastoma multiforme.
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Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.
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Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.
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Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.
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Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.
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Cyclin E overexpression relates to ovarian cancer histology but not to risk factors.
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Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer.
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Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes.
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Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer.
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Cytogenetic and molecular correlates between rodent and human renal cell carcinoma.
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Cytokine polymorphism and its possible impact on cancer.
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Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts.
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Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.
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DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway.
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DHX15 is up-regulated in castration-resistant prostate cancer and required for androgen receptor sensitivity to low DHT concentrations.
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DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
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Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells.
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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
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Decreased E-cadherin expression correlates with higher stage of Wilms' tumors.
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Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.
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Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents.
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Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.
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Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma.
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Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells.
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Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.
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Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer.
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Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE).
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Development and Verification of an RNA Sequencing (RNA-Seq) Assay for the Detection of Gene Fusions in Tumors.
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Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses.
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Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells.
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Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression.
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Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells.
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Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.
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Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and Without Endometriosis.
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Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs.
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Differential alternative RNA splicing and transcription events between tumors from African American and White patients in The Cancer Genome Atlas.
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Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
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Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues.
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Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways.
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Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion.
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Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways.
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Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
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Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer.
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Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.
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Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.
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Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
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Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13.
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Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.
-
Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth.
-
Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer.
-
Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma.
-
Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma.
-
Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer.
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Ductal carcinoma in situ in BRCA mutation carriers.
-
Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
-
Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer.
-
Dysregulation of miR-181c expression influences recurrence of endometrial endometrioid adenocarcinoma by modulating NOTCH2 expression: An NRG Oncology/Gynecologic Oncology Group study.
-
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.
-
Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing.
-
E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.
-
EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells.
-
EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1.
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EGF mutant receptor vIII as a molecular target in cancer therapy.
-
EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer.
-
ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.
-
ELF3 is a repressor of androgen receptor action in prostate cancer cells.
-
ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis.
-
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
-
ERCC1 protein expression is associated with differential survival in oropharyngeal head and neck squamous cell carcinoma.
-
EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.
-
EZH2 expression is associated with inferior overall survival in mantle cell lymphoma.
-
Early effects of imatinib mesylate on the expression of insulin-like growth factor binding protein-3 and positron emission tomography in patients with gastrointestinal stromal tumor.
-
Economic analysis of gene expression profile data to guide adjuvant treatment in women with early-stage breast cancer.
-
Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.
-
Ectopic expression of mucins in colorectal cancer metastasis.
-
Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia.
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Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238.
-
Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.
-
Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.
-
Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203.
-
Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.
-
Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer.
-
Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.
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Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy.
-
Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity.
-
Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV‑201): a multicentre, single-arm, phase 2 trial.
-
Enhancer-derived long non-coding RNAs CCAT1 and CCAT2 at rs6983267 has limited predictability for early stage colorectal carcinoma metastasis.
-
Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci.
-
Enrichment of putative prostate cancer stem cells after androgen deprivation: upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines.
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
-
Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.
-
Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6.
-
Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6.
-
Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance.
-
Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.
-
Epigenetic regulation of AXL and risk of childhood asthma symptoms.
-
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.
-
Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.
-
Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
-
Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.
-
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
-
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.
-
Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.
-
Epstein-Barr virus-negative diffuse large B cell lymphoma with aberrant expression of CD3 and other T cell-associated antigens: report of three cases with a review of the literature.
-
Erythropoiesis-stimulating agent use in cancer: preclinical and clinical perspectives.
-
Erythropoietin Stimulates Tumor Growth via EphB4.
-
Erythropoietin and erythropoietin receptor expression in human prostate cancer.
-
Escaping G1 restraints on neoplasia--Cdk4 regulation by Ras and NF-kappa B.
-
Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
-
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.
-
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells.
-
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells.
-
Evaluation of 122 advanced-stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies.
-
Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK.
-
Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
-
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
-
Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.
-
Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans.
-
Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression.
-
Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer.
-
Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.
-
Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells.
-
Expression of multiple chemokine genes by a human mast cell leukemia.
-
Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence.
-
Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours.
-
Expression of platelet-derived endothelial cell growth factor correlates with good prognosis in patients with colorectal carcinoma.
-
Expression of proliferation-specific genes in the mucosa adjacent to colon carcinoma.
-
Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer.
-
Expression signatures of TP53 mutations in serous ovarian cancers.
-
Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.
-
Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
-
FAK overexpression and p53 mutations are highly correlated in human breast cancer.
-
FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.
-
FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
-
FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
-
FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density.
-
Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment.
-
First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
-
First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum.
-
Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer.
-
Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics.
-
Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target.
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Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma.
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Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition.
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Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
-
Frequency of breast cancer subtypes among African American women in the AMBER consortium.
-
Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.
-
Frequent TMPRSS2-ERG rearrangement in prostatic small cell carcinoma detected by fluorescence in situ hybridization: the superiority of fluorescence in situ hybridization over ERG immunohistochemistry.
-
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.
-
Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers.
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From breast to the brain: unraveling the puzzle of metastasis organotropism.
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Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens.
-
Functional expression of sodium-glucose transporters in cancer.
-
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
-
Functional genetic variants of XRCC4 and ERCC1 predict survival of gastric cancer patients treated with chemotherapy by regulating the gene expression.
-
Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.
-
Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.
-
Functional variants in the low-density lipoprotein receptor gene are associated with clear cell renal cell carcinoma susceptibility.
-
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
-
G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program.
-
GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.
-
GPR54 is a target for suppression of metastasis in endometrial cancer.
-
GW112, a novel antiapoptotic protein that promotes tumor growth.
-
Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.
-
Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instability.
-
Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.
-
Gene expression phenotypic models that predict the activity of oncogenic pathways.
-
Gene expression profile assays as predictors of distant recurrence-free survival in early-stage breast cancer.
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Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay.
-
Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma.
-
Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.
-
Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome.
-
Gene expression profiling of anticancer immune responses.
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Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications.
-
Gene expression profiling of cutaneous wound healing.
-
Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation.
-
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
-
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
-
Gene expression signatures and outcome prediction in mature B-cell malignancies.
-
Gene expression signatures as a guide to treatment strategies for in-transit metastatic melanoma.
-
Gene profiling of immune responses against tumors.
-
Gene therapy for lung cancer.
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Gene therapy for prostate cancer: where are we now?
-
Genes with bimodal expression are robust diagnostic targets that define distinct subtypes of epithelial ovarian cancer with different overall survival.
-
Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library.
-
Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma.
-
Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).
-
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis.
-
Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential.
-
Genetic induction of tumorigenesis in swine.
-
Genetic mechanisms of solid tumor oncogenesis.
-
Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.
-
Genetic susceptibility to tobacco carcinogenesis.
-
Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence.
-
Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.
-
Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.
-
Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.
-
Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner.
-
Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.
-
Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.
-
Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.
-
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
-
Genome-wide significant risk associations for mucinous ovarian carcinoma.
-
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
-
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.
-
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer.
-
Genomic and molecular profiling predicts response to temozolomide in melanoma.
-
Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.
-
Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.
-
Germline PTEN mutations as a cause of early-onset endometrial cancer.
-
Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis.
-
Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.
-
Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells.
-
Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia.
-
Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.
-
Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays.
-
Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein.
-
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer.
-
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
-
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.
-
Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme.
-
Gremlin is overexpressed in lung adenocarcinoma and increases cell growth and proliferation in normal lung cells.
-
Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.
-
HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase.
-
HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis.
-
HIF-1 and tumour radiosensitivity.
-
HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.
-
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer.
-
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
-
Heat induces gene amplification in cancer cells.
-
Heat-induced gene expression as a novel targeted cancer gene therapy strategy.
-
Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.
-
Hepatocyte growth factor enhances death receptor-induced apoptosis by up-regulating DR5.
-
Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
-
Heterogeneity of tumor-induced gene expression changes in the human metabolic network.
-
High Dimensional Variable Selection with Error Control.
-
High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels.
-
High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.
-
High gene expression of TS1, GSTP1, and ERCC1 are risk factors for survival in patients treated with trimodality therapy for esophageal cancer.
-
High intensity focused ultrasound-induced gene activation in solid tumors.
-
High intensity focused ultrasound-induced gene activation in sublethally injured tumor cells in vitro.
-
High levels of B-cell activating factor in patients with active chronic graft-versus-host disease.
-
High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines.
-
High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors.
-
Histological and molecular evaluation of patient-derived colorectal cancer explants.
-
Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer.
-
Histone modifications and chromatin organization in prostate cancer.
-
Hsp90, an unlikely ally in the war on cancer.
-
Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
-
Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets.
-
Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.
-
Hurthle cell predominance impacts results of Afirma gene expression classifier and ThyroSeq molecular panel performance in indeterminate thyroid nodules.
-
Hypoexpression and epigenetic regulation of candidate tumor suppressor gene CADM-2 in human prostate cancer.
-
Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.
-
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer.
-
IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.
-
IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells.
-
IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
-
IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity.
-
IRF4 addiction in multiple myeloma.
-
IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression.
-
Identification and Functional Validation of Reciprocal microRNA-mRNA Pairings in African American Prostate Cancer Disparities.
-
Identification and characterization of genes involved in the carcinogenesis of human squamous cell cervical carcinoma.
-
Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
-
Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.
-
Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma.
-
Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus.
-
Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors.
-
Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas.
-
Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate.
-
Identification of genes associated with ovarian cancer metastasis using microarray expression analysis.
-
Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix.
-
Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.
-
Identification of tumor angiogenesis-related genes by subtractive hybridization.
-
Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL.
-
Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy.
-
Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression.
-
Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma.
-
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
-
Immunohistochemical characterization of neuroendocrine cells in prostate cancer.
-
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.
-
Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance).
-
Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy.
-
Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein.
-
Improving frontline treatment for chronic myeloid leukemia: emerging evidence for use of nilotinib and dasatinib.
-
Improving the clinical risk score: an analysis of molecular biomarkers in the era of modern chemotherapy for resectable hepatic colorectal cancer metastases.
-
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
-
In vivo regulation of hTERT expression and telomerase activity by androgen.
-
In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cells.
-
In vivo selection of tumor-targeting RNA motifs.
-
Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.
-
Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression.
-
Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors).
-
Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors.
-
Increased type III TGF-β receptor shedding decreases tumorigenesis through induction of epithelial-to-mesenchymal transition.
-
Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro.
-
Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.
-
Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells.
-
Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity.
-
Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.
-
Inherited variants in regulatory T cell genes and outcome of ovarian cancer.
-
Inhibiting inhibitory pathways in human γδ T cells.
-
Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.
-
Inhibition of Isoprenylcysteine Carboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer.
-
Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer.
-
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
-
Inhibition of growth of MDA-MB-468 estrogen-independent human breast carcinoma by bombesin/gastrin-releasing peptide antagonists RC-3095 and RC-3940-II.
-
Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells.
-
Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors.
-
Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
-
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
-
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.
-
Insulin-like growth factor I induces tumor hexokinase RNA expression in cancer cells.
-
Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo.
-
Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.
-
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.
-
Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.
-
Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.
-
Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
-
Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer.
-
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.
-
Integrated genomic analyses of ovarian carcinoma.
-
Integrated genomic characterization of endometrial carcinoma.
-
Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.
-
Integrative computational immunogenomic profiling of cortisol-secreting adrenocortical carcinoma.
-
Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms.
-
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
-
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.
-
Integrative molecular profiling of routine clinical prostate cancer specimens.
-
Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells.
-
Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation.
-
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
-
Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome.
-
Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.
-
Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.
-
Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.
-
Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.
-
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
-
Ki-67, p53, and p16 expression, and G691S RET polymorphism in desmoplastic melanoma (DM): A clinicopathologic analysis of predictors of outcome.
-
Killing SCLC: insights into how to target a shapeshifting tumor.
-
LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia.
-
LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.
-
LIN28B promotes the development of neuroendocrine prostate cancer.
-
LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression.
-
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer.
-
Laminin alpha 2 enables glioblastoma stem cell growth.
-
Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.
-
Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer.
-
Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.
-
Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
-
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses.
-
LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling.
-
Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer.
-
Loss of ARID1A-associated protein expression is a frequent event in clear cell and endometrioid ovarian cancers.
-
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features.
-
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.
-
Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis.
-
Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
-
Loss of PRDM1/BLIMP-1 function contributes to poor prognosis of activated B-cell-like diffuse large B-cell lymphoma.
-
Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.
-
Loss of cyclin D2 expression in the majority of breast cancers is associated with promoter hypermethylation.
-
Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations.
-
Loss of microRNA-21 leads to profound stromal remodeling and short survival in K-Ras-driven mouse models of pancreatic cancer.
-
Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.
-
Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate.
-
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
-
Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression.
-
Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma.
-
Low-dose fractionated radiation potentiates the effects of cisplatin independent of the hyper-radiation sensitivity in human lung cancer cells.
-
Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.
-
Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells.
-
MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.
-
MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.
-
MIBG avidity correlates with clinical features, tumor biology, and outcomes in neuroblastoma: A report from the Children's Oncology Group.
-
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
-
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
-
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.
-
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.
-
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
-
MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program.
-
MYCN amplification drives an aggressive form of spinal ependymoma.
-
Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.
-
Macrophages Facilitate Resistance to Anti-VEGF Therapy by Altered VEGFR Expression.
-
Maintenance of DNA content and erbB-2 alterations in intraductal and invasive phases of mammary cancer.
-
Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
-
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH.
-
Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance.
-
Mechanical Signaling and Extracellular Matrix in Uterine Fibroids.
-
Mechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP.
-
Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes.
-
Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
-
Melanoma-derived conditioned media efficiently induce the differentiation of monocytes to macrophages that display a highly invasive gene signature.
-
Melatonin inhibits estrogen receptor transactivation and cAMP levels in breast cancer cells.
-
Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility.
-
Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
-
Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells.
-
Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.
-
Mesothelin expression is associated with poor outcomes in breast cancer.
-
Metabolic landscape of the tumor microenvironment at single cell resolution.
-
Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population.
-
Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
-
Methylation profiling of paediatric pilocytic astrocytoma reveals variants specifically associated with tumour location and predictive of recurrence.
-
Methylation subtypes and large-scale epigenetic alterations in gastric cancer.
-
MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.
-
MiR-148a functions to suppress metastasis and serves as a prognostic indicator in triple-negative breast cancer.
-
MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B.
-
MicroRNA expression characterizes oligometastasis(es).
-
MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.
-
MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells.
-
MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells.
-
MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.
-
MicroRNAs associated to single drug components of R-CHOP identifies diffuse large B-cell lymphoma patients with poor outcome and adds prognostic value to the international prognostic index.
-
MicroRNAs in endometrial cancers from black and white patients.
-
Microarray analysis of endometrial carcinomas and mixed mullerian tumors reveals distinct gene expression profiles associated with different histologic types of uterine cancer.
-
Microarray analysis reveals distinct gene expression profiles among different histologic types of endometrial cancer.
-
Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.
-
Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.
-
Microenvironmental regulation of cancer metastasis by miRNAs.
-
Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas.
-
Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma.
-
Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine.
-
Modeling cancer progression via pathway dependencies.
-
Models of epigenetic age capture patterns of DNA methylation in glioma associated with molecular subtype, survival, and recurrence.
-
Modulation of circulating protein biomarkers following TRC105 (anti-endoglin antibody) treatment in patients with advanced cancer.
-
Modulation of interleukin-12 mRNA expression in leukocytes of cancer patients treated with CM101.
-
Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.
-
Molecular Signature to Risk-Stratify Prostate Cancer of Intermediate Risk.
-
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.
-
Molecular characterization of adenocarcinoma of the cervix.
-
Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma.
-
Molecular characterization of the human delta opioid receptor in lung cancer.
-
Molecular characterization of the tumor-suppressive function of nischarin in breast cancer.
-
Molecular classification of human carcinomas by use of gene expression signatures.
-
Molecular determinants for enzalutamide-induced transcription in prostate cancer.
-
Molecular markers in ductal carcinoma in situ of the breast.
-
Molecular pathways and potential biomarkers in gallbladder cancer: A comprehensive review.
-
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.
-
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.
-
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance.
-
Multimodal regulation of E2F1 gene expression by progestins.
-
Multiplatform computational analysis of mast cells in adrenocortical carcinoma tumor microenvironment.
-
Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer.
-
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.
-
Mutant p53 as an Antigen in Cancer Immunotherapy.
-
Mutation and overexpression of p53 in early-stage epithelial ovarian cancer.
-
Mutation and overexpression of the p53 tumor suppressor gene frequently occurs in uterine and ovarian sarcomas.
-
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.
-
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study.
-
Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma.
-
Mutations of the E-cadherin gene in human gynecologic cancers.
-
Myogenic transcription factors regulate pro-metastatic miR-182.
-
N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines.
-
N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
-
NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling.
-
NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
-
NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53.
-
NF-κB signaling pathway and its potential as a target for therapy in lymphoid neoplasms.
-
NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice.
-
NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia.
-
NUAK family kinase 2 is a novel therapeutic target for prostate cancer.
-
Negative regulation of the tumor suppressor p53 gene by microRNAs.
-
Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.
-
Network calisthenics: control of E2F dynamics in cell cycle entry.
-
Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
-
Noncoding RNAs Regulating Cancer Signaling Network.
-
Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice.
-
Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer.
-
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
-
Novel insights into the genetics and epigenetics of MALT lymphoma unveiled by next generation sequencing analyses.
-
Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia.
-
Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
-
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
-
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
-
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
-
Obesity and altered angiogenic-related gene expression in endometrial cancer.
-
Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells.
-
Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.
-
Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma.
-
Oncogenes and anti-oncogenes in human central nervous system tumors.
-
Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.
-
Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.
-
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.
-
Oncogenic and metastatic properties of preprotachykinin-I and neurokinin-1 genes.
-
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
-
Oncogenic pathway combinations predict clinical prognosis in gastric cancer.
-
Oncogenic pathway signatures in human cancers as a guide to targeted therapies.
-
Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics.
-
Optical Imaging of Glucose Uptake and Mitochondrial Membrane Potential to Characterize Her2 Breast Tumor Metabolic Phenotypes.
-
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
-
Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.
-
Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling.
-
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
-
Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis.
-
Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
-
Over-expression of fibroblast growth factor receptor 3 in human hepatocellular carcinoma.
-
Overexpression of CRKL correlates with poor prognosis and cell proliferation in non-small cell lung cancer.
-
Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
-
Overexpression of annexin a1 induced by terephthalic acid calculi in rat bladder cancer.
-
Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix.
-
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions.
-
Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression.
-
Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type I receptor.
-
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
-
Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA.
-
PAX9 regulates squamous cell differentiation and carcinogenesis in the oro-oesophageal epithelium.
-
PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer.
-
PCK1 regulates neuroendocrine differentiation in a positive feedback loop of LIF/ZBTB46 signalling in castration-resistant prostate cancer.
-
PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma.
-
PD-L1 Expression Patterns in Microsatellite Instability-High Intestinal Adenocarcinoma Subtypes.
-
PD-L1 expression is low in large B-cell lymphoma with MYC or double-hit translocation.
-
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
-
PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression.
-
PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma.
-
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
-
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context.
-
Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies.
-
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events.
-
Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.
-
Paradoxical relationship between chromosomal instability and survival outcome in cancer.
-
Parallel Expression of Enzyme Inhibitors of CD8T Cell Activity in Tumor Microenvironments and Secretory Endometrium.
-
Parc-ing p53 in the cytoplasm.
-
Past and present treatment of pancreatic adenocarcinoma: chemotherapy as a standard treatment modality.
-
Pathologic and biologic response to preoperative endocrine therapy in patients with ER-positive ductal carcinoma in situ.
-
Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling.
-
Pathway-Structured Predictive Model for Cancer Survival Prediction: A Two-Stage Approach.
-
Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
-
Patterns of microRNA expression characterize stages of human B-cell differentiation.
-
Pemetrexed Plus Cisplatin Versus Gemcitabine Plus Cisplatin According to Thymidylate Synthase Expression in Nonsquamous Non-Small-Cell Lung Cancer: A Biomarker-Stratified Randomized Phase II Trial.
-
Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer.
-
Phase II trial of cetuximab and carboplatin in relapsed platinum-sensitive ovarian cancer and evaluation of epidermal growth factor receptor expression: a Gynecologic Oncology Group study.
-
Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.
-
PhyloOncology: Understanding cancer through phylogenetic analysis.
-
Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment.
-
Pills of PTEN? In and out for tumor suppression.
-
Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor).
-
Poliovirus Receptor (CD155) Expression in Pediatric Brain Tumors Mediates Oncolysis of Medulloblastoma and Pleomorphic Xanthoastrocytoma.
-
Poliovirus receptor CD155-targeted oncolysis of glioma.
-
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
-
Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women.
-
Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.
-
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
-
Post-transcriptional regulation of MTA family by microRNAs in the context of cancer.
-
Postremission therapy with low-dose interleukin 2 with or without intermediate pulse dose interleukin 2 therapy is well tolerated in elderly patients with acute myeloid leukemia: Cancer and Leukemia Group B study 9420.
-
Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.
-
Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients.
-
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.
-
Preclinical Evaluation of 18F-Labeled Anti-HER2 Nanobody Conjugates for Imaging HER2 Receptor Expression by Immuno-PET.
-
Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors.
-
Predicting the sites of metastases from lung cancer using molecular biologic markers.
-
Prediction of disease-free survival in hepatocellular carcinoma by gene expression profiling.
-
Preparation of apoptotic tumor cells with replication-incompetent HSV augments the efficacy of dendritic cell vaccines.
-
Primary tumor microRNA signature predicts recurrence and survival in patients with locally advanced esophageal adenocarcinoma.
-
Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.
-
Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T cells in patients with malignant glioma reveals differential expression of the immunologic transcriptome compared with T cells from healthy volunteers.
-
Prognosis significance of HER-2/neu overexpression/amplification in Chinese patients with curatively resected gastric cancer after the ToGA clinical trial.
-
Prognostic applications of the epidermal growth factor receptor and its ligand, transforming growth factor-alpha.
-
Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.
-
Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma.
-
Proliferating cell nuclear antigen expression to predict occult disease in clinical stage I nonseminomatous testicular germ cell tumors.
-
Prospective gene signature study using microRNA to identify the tissue of origin in patients with carcinoma of unknown primary.
-
Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.
-
Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.
-
Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells.
-
Prostate-derived Ets factor, an oncogenic driver in breast cancer.
-
Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival.
-
Protein expression and functional analysis of the FHIT gene in human tumor cells.
-
Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
-
Putative biomarkers for predicting tumor sample purity based on gene expression data.
-
Quantitative expression profile of PSGR in prostate cancer.
-
RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.
-
REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.
-
RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.
-
RNA regulons in cancer and inflammation.
-
RNA splicing and aggregate gene expression differences in lung squamous cell carcinoma between patients of West African and European ancestry.
-
RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer.
-
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
-
RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer.
-
RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.
-
Race-associated biological differences among Luminal A breast tumors.
-
Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer.
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.
-
Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic.
-
Raising the bar: how HIF-1 helps determine tumor radiosensitivity.
-
Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer.
-
Rare codons regulate KRas oncogenesis.
-
Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression.
-
Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function.
-
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.
-
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer.
-
Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids.
-
Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study.
-
Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas.
-
Reduced mRNA expression of nucleotide excision repair genes in lymphocytes and risk of squamous cell carcinoma of the head and neck.
-
Regulated expression of p18, a major phosphoprotein of leukemic cells.
-
Regulation of HIF-1alpha stability through S-nitrosylation.
-
Regulation of MUC5AC expression by NAD(P)H:quinone oxidoreductase 1.
-
Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition.
-
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
-
Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.
-
Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.
-
Regulator of G-protein signalling expression and function in ovarian cancer cell lines.
-
Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
-
RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma.
-
Relation between p53 overexpression and established prognostic factors in breast cancer.
-
Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer.
-
Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.
-
Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.
-
Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression.
-
Relationships Between MRI Breast Imaging-Reporting and Data System (BI-RADS) Lexicon Descriptors and Breast Cancer Molecular Subtypes: Internal Enhancement is Associated with Luminal B Subtype.
-
Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer.
-
Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.
-
Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model.
-
Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904.
-
Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways.
-
Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial.
-
Role of Increased n-acetylaspartate Levels in Cancer.
-
Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.
-
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.
-
SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.
-
SMAD3 promotes expression and activity of the androgen receptor in prostate cancer.
-
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.
-
SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.
-
SRRM4 gene expression correlates with neuroendocrine prostate cancer.
-
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia.
-
STT3A, C1orf24, TFF3: putative markers for characterization of follicular thyroid neoplasms from fine-needle aspirates.
-
SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.
-
Sample type bias in the analysis of cancer genomes.
-
Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.
-
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
-
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3-FOXO1-Positive Alveolar Rhabdomyosarcoma.
-
Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
-
Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha.
-
Separating the wheat from the chaff: focus on "in silico data filtering to identify new angiogenesis targets from a large in vitro gene profile data set".
-
Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection.
-
Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity.
-
Serum levels of HER-2 neu (C-erbB-2) correlate with overexpression of p185neu in human ovarian cancer.
-
Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma.
-
Seven-Year Follow-Up Analysis of Adjuvant Paclitaxel and Trastuzumab Trial for Node-Negative, Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.
-
Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung.
-
Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors.
-
Short-term kinetics of tumor antigen expression in response to vaccination.
-
Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy.
-
Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.
-
Skp2 regulates Myc protein stability and activity.
-
Small cell lung carcinoma cell lines express mRNA for calcitonin and alpha- and beta-calcitonin gene related peptides.
-
Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.
-
Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.
-
Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells.
-
Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells.
-
Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development.
-
Statistical considerations for analysis of microarray experiments.
-
Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism.
-
Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.
-
Strategic Therapeutic Targeting to Overcome Venetoclax Resistance in Aggressive B-cell Lymphomas.
-
Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma.
-
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.
-
Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling.
-
Stromal gene signatures in large-B-cell lymphomas.
-
Structure-guided DOT1L probe optimization by label-free ligand displacement.
-
Suberoylanilide hydroxamic acid represses glioma stem-like cells.
-
Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.
-
Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.
-
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
-
Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.
-
Suppressor of fused negatively regulates beta-catenin signaling.
-
Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric.
-
Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs.
-
Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers.
-
Syndecan-1 facilitates breast cancer metastasis to the brain.
-
Synergistic association of FOXP3+ tumor infiltrating lymphocytes with CCL20 expressions with poor prognosis of primary breast cancer: A retrospective cohort study.
-
Synthesis and biological evaluation of a 99mTc-labelled sulfonamide conjugate for in vivo visualization of carbonic anhydrase IX expression in tumor hypoxia.
-
Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells.
-
Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.
-
Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.
-
T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.
-
TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice.
-
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
-
TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
-
TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3.
-
THZ531 Induces a State of BRCAness in Multiple Myeloma Cells: Synthetic Lethality with Combination Treatment of THZ 531 with DNA Repair Inhibitors.
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TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts.
-
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
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TP53 dysfunction in diffuse large B-cell lymphoma.
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TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).
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TSPO-targeted PET and Optical Probes for the Detection and Localization of Premalignant and Malignant Pancreatic Lesions.
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Targeted suppression of beta-catenin blocks intestinal adenoma formation in APC Min mice.
-
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
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Targeting A20 decreases glioma stem cell survival and tumor growth.
-
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.
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Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment.
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Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
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Targeting RET Kinase in Neuroendocrine Prostate Cancer.
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Targeting eNOS in pancreatic cancer.
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Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.
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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.
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Targeting of cytotoxic somatostatin analog AN-238 to somatostatin receptor subtypes 5 and/or 3 in experimental pancreatic cancers.
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Targeting ovarian cancer-initiating cells.
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Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma.
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Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney.
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Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.
-
Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes.
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Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour).
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Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway.
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The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
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The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.
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The CLN3 gene is a novel molecular target for cancer drug discovery.
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The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
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The Cancer Genome Atlas expression profiles of low-grade gliomas.
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The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer.
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The DNA methylation landscape of advanced prostate cancer.
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The Dynamic and Transient Immune Microenvironment in Locally Advanced Esophageal Adenocarcinoma Post Chemoradiation.
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The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
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The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
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The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition.
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The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
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The GNA13-RhoA signaling axis suppresses expression of tumor protective Kallikreins.
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The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
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The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
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The Molecular Taxonomy of Primary Prostate Cancer.
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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
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The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
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The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.
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The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level.
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The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.
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The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis.
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The Transcriptional Coactivator TAZ Is a Potent Mediator of Alveolar Rhabdomyosarcoma Tumorigenesis.
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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.
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The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas.
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The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types.
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The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.
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The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
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The clinical significance of activated p-AKT expression in peripheral T-cell lymphoma.
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The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.
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The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting.
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The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer.
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The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells.
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The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.
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The efficacy and safety of gemcitabine, cisplatin, prednisone, thalidomide versus CHOP in patients with newly diagnosed peripheral T-cell lymphoma with analysis of biomarkers.
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The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.
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The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide.
-
The genomic analysis of lactic acidosis and acidosis response in human cancers.
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The genomic relationship between primary breast carcinomas and their nodal metastases.
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The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences.
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The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters.
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The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype.
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The integrated genomic and epigenomic landscape of brainstem glioma.
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The integrated landscape of driver genomic alterations in glioblastoma.
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The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma.
-
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
-
The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas.
-
The oncogenic microRNA miR-21 promotes regulated necrosis in mice.
-
The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3.
-
The p53 tumor suppressor gene frequently is altered in gynecologic cancers.
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The potential role of intrinsic hypoxia markers as prognostic variables in cancer.
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The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer.
-
The prognostic value of interleukin-17 in lung cancer: A systematic review with meta-analysis based on Chinese patients.
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The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.
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The role of AR-V7 testing in the management of metastatic CRPC.
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The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma.
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The role of glutathione S-transferase P1-1 in colorectal cancer: friend or foe?
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The roles of MASPIN expression and subcellular localization in non-small cell lung cancer.
-
The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma.
-
The transcriptional landscape of Shh medulloblastoma.
-
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.
-
The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling.
-
The type III TGF-beta receptor suppresses breast cancer progression.
-
The unique DEK oncoprotein in women's health: A potential novel biomarker.
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Therapeutic aspects of chaperones/heat-shock proteins in neuro-oncology.
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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
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Thioredoxin and hematologic malignancies.
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Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.
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Thrombin expression in prostate: a novel finding.
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Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.
-
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
-
Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer.
-
Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression.
-
Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells.
-
Transcriptional profiling reveals distinct classes of parathyroid tumors in PHPT.
-
Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.
-
Transcriptional response to hypoxia in human tumors.
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Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma.
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Transduction of human melanoma cells with the gamma interferon gene enhances cellular immunity.
-
Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas.
-
Transforming growth factor-beta differentially inhibits epithelial ovarian carcinoma cells from primary and metastatic isolates without up-regulation of p21WAF1.
-
Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma.
-
Translating genomics into clinical practice: applications in lung cancer.
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Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors.
-
Tumor acquisition for biomarker research in lung cancer.
-
Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients.
-
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway.
-
Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle.
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Tumor-associated antigen-based personalized dendritic cell vaccine in solid tumor patients.
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Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.
-
Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma.
-
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.
-
Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.
-
Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer.
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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
-
U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia.
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Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
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Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas.
-
Understanding the tumor microenvironment and radioresistance by combining functional imaging with global gene expression.
-
Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes.
-
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq.
-
Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.
-
Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer.
-
Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.
-
Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner.
-
Urinary-type plasminogen activator receptor/alpha 3 beta 1 integrin signaling, altered gene expression, and oral tumor progression.
-
Use of SMART-generated cDNA for gene expression studies in multiple human tumors.
-
Use of gene expression and pathway signatures to characterize the complexity of human melanoma.
-
Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.
-
Use of tissue microarray and automated quantitative analysis for screening and validation of potential biomarkers in mantle cell lymphoma.
-
Uteroglobin: a potential novel tumor suppressor and molecular therapeutic for prostate cancer.
-
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
-
Validating the meta-analytical results on MDM2, CASP8, XRCC3 polymorphisms and breast cancer risk: examination of Hardy-Weinberg Equilibrium.
-
Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS).
-
Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial.
-
Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.
-
Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues.
-
Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer.
-
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.
-
Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group.
-
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
-
WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration.
-
Whole Recombinant Saccharomyces cerevisiae Yeast Expressing Ras Mutations as Treatment for Patients With Solid Tumors Bearing Ras Mutations: Results From a Phase 1 Trial.
-
Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
-
Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers.
-
Widespread Repression of Gene Expression in Cancer by a Wnt/β-Catenin/MAPK Pathway.
-
Wnt addiction of genetically defined cancers reversed by PORCN inhibition.
-
Wnt proteins synergize to activate β-catenin signaling.
-
Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation.
-
X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.
-
X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor.
-
XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53.
-
Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.
-
Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression.
-
Zinc transporter ZIP7 is a novel determinant of ferroptosis.
-
c-Jun Contributes to Transcriptional Control of GNA12 Expression in Prostate Cancer Cells.
-
c-MET and HGF mRNA expression in hepatocellular carcinoma: correlation with clinicopathological features and survival.
-
c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.
-
c-Myc is required for maintenance of glioma cancer stem cells.
-
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.
-
cDNA arrays and the enigma of melanoma immune responsiveness.
-
eIF4E-phosphorylation-mediated Sox2 upregulation promotes pancreatic tumor cell repopulation after irradiation.
-
hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.
-
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
-
mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
-
miR-19 is a key oncogenic component of mir-17-92.
-
miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma.
-
miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy.
-
miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.
-
miR-301a as an NF-κB activator in pancreatic cancer cells.
-
mir-17-92: a polycistronic oncomir with pleiotropic functions.
-
p16 Improves interobserver agreement in diagnosis of anal intraepithelial neoplasia.
-
p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.
-
p38 MAPK in development and cancer.
-
p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.
-
p53 and mdm-2 expression in malignant melanoma: an immunocytochemical study of expression of p53, mdm-2, and markers of cell proliferation in primary versus metastatic tumors.
-
p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic study.
-
p53 gene expression in node-positive breast cancer: relationship to DNA ploidy and prognosis.
-
p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.
-
p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.
-
p53 regulates the expression of the tumor suppressor gene maspin.
-
p53-dependent induction of heat shock protein 27 (HSP27) expression.
-
p53: a two-faced cancer gene.
-
rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
-
β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.
-
Keywords of People
-
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Buckley, Anne Frances,
Assistant Professor of Pathology,
Pathology
-
Choi, Steven Sok,
Associate Professor of Medicine,
Medicine, Gastroenterology
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Cell Biology
-
McCall, Shannon Jones,
Associate Professor of Pathology,
Pathology
-
McDonnell, Donald Patrick,
Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Mruthyunjaya, Prithvi,
Adjunct Associate Professor in the Department of Ophthalmology,
Ophthalmology, Vitreoretinal Diseases & Surgery
-
Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering