Integrins

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  Subject Areas on Research

  • A survival guide to early T cell development. 
  • Activation of p53 function in carcinoma cells by the alpha6beta4 integrin. 
  • Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. 
  • Alterations in human trabecular meshwork cell homeostasis by selenium. 
  • Alterations in stimulus-induced integrin expression in peripheral blood neutrophils of patients with diabetic retinopathy. 
  • Altering integrin engagement regulates membrane localization of Kir2.1 channels. 
  • An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands. 
  • Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa integrin in patients undergoing percutaneous coronary intervention. EPIC Investigators. 
  • CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1). 
  • Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. 
  • Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism. 
  • Current and Emerging Treatment for Diabetic Macular Edema. 
  • Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells. 
  • Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces. 
  • Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro. 
  • Dissecting cell adhesion cross-talk with micropatterns. 
  • Distinctive gene transduction efficiencies of commonly used viral vectors in the retina. 
  • Distribution of integrin cell adhesion molecules in endometrial cancer. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Effect of streptavidin affinity mutants on the integrin-independent adhesion of biotinylated endothelial cells. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. 
  • Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis. 
  • Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Envelope glycoprotein binding to the integrin α4β7 is not a general property of most HIV-1 strains. 
  • Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. 
  • Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy. 
  • Fibronectin and avidin-biotin as a heterogeneous ligand system for enhanced endothelial cell adhesion. 
  • Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. 
  • Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. 
  • Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival. 
  • HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression. 
  • How vinculin regulates force transmission. 
  • Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials. 
  • Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes. 
  • Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates. 
  • Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. 
  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. 
  • Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells. 
  • Integrin functions play a key role in the differentiation of thymocytes in vivo. 
  • Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels. 
  • Integrin laminin receptors and breast carcinoma progression. 
  • Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. 
  • Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways. 
  • JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. 
  • KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. 
  • L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. 
  • L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. 
  • Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. 
  • Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis. 
  • Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. 
  • Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles. 
  • Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer. 
  • Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations. 
  • Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line. 
  • Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. 
  • Morphogenesis and Compartmentalization of the Intestinal Crypt. 
  • Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations. 
  • Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries. 
  • Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node. 
  • Out of Eden: stem cells and their niches. 
  • P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury. 
  • Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. 
  • Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. 
  • Polar axis fixation in Fucus zygotes: components of the cytoskeleton and extracellular matrix. 
  • Porcine endothelial cell membrane antigens recognized by human and baboon xenoreactive antibodies during organ perfusion. 
  • Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. 
  • Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains? 
  • Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid. 
  • Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents. 
  • Role of adhesion molecules in the pathogenesis of rheumatoid arthritis. 
  • Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow. 
  • Sensing heart stress. 
  • Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. 
  • Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. 
  • Systematic review and meta-analysis: opportunistic infections and malignancies during treatment with anti-integrin antibodies in inflammatory bowel disease. 
  • TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. 
  • Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. 
  • Tenascin supports lymphocyte rolling. 
  • The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome. 
  • The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. 
  • The bridge between dendritic cells and asthma. 
  • The compact conformation of fibronectin is determined by intramolecular ionic interactions. 
  • The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study. 
  • The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. 
  • The metastatic odyssey: the integrin connection. 
  • The modulation of MSC integrin expression by RGD presentation 
  • The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates. 
  • The nephritogenic immune response. 
  • The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. 
  • The role of glycoprotein IIb/IIIa platelet inhibition in percutaneous coronary intervention in the stent era. 
  • The role of integrins in saphenous vein vascular smooth muscle cell migration. 
  • The role of platelet receptors and adhesion molecules in coronary artery disease. 
  • The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. 
  • Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. 
  • Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis. 
  • Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. 
  • Vascular morphogenesis: tales of two syndromes. 
  • alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells. 
  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. 
  • p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
  • α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology