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Subject Areas on Research
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A survival guide to early T cell development.
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Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen.
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Alterations in human trabecular meshwork cell homeostasis by selenium.
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Alterations in stimulus-induced integrin expression in peripheral blood neutrophils of patients with diabetic retinopathy.
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Altering integrin engagement regulates membrane localization of Kir2.1 channels.
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An equilibrium model of endothelial cell adhesion via integrin-dependent and integrin-independent ligands.
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Antibody to VLA-4, but not to L-selectin, protects neuronal M2 muscarinic receptors in antigen-challenged guinea pig airways.
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Asymmetric cell divisions promote stratification and differentiation of mammalian skin.
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CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte function-associated antigen-1 (LFA-1) and intercellular cell adhesion molecule 1 (ICAM-1).
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Characterization of gut-derived intraepithelial lymphocyte (IEL) residing in human papillomavirus (HPV)-infected intraepithelial neoplastic lesions.
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Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
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Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism.
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Current and Emerging Treatment for Diabetic Macular Edema.
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Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
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Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells.
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Differential recognition by proteins of alpha-galactosyl residues on endothelial cell surfaces.
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Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro.
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Dissecting cell adhesion cross-talk with micropatterns.
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Distinctive gene transduction efficiencies of commonly used viral vectors in the retina.
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Distribution of integrin cell adhesion molecules in endometrial cancer.
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Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.
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Effect of streptavidin affinity mutants on the integrin-independent adhesion of biotinylated endothelial cells.
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Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin.
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Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.
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Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis.
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Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.
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Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin.
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Envelope glycoprotein binding to the integrin α4β7 is not a general property of most HIV-1 strains.
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Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels.
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Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin.
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Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.
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Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels.
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Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy.
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Fibronectin and avidin-biotin as a heterogeneous ligand system for enhanced endothelial cell adhesion.
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Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury.
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Forces for morphogenesis investigated with laser microsurgery and quantitative modeling.
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Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.
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Functional analysis of the putative integrin recognition motif on adeno-associated virus 9.
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Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival.
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HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression.
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How vinculin regulates force transmission.
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Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation.
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Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.
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Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials.
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Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes.
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Inhibition of αvβ6 promotes acute renal allograft rejection in nonhuman primates.
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Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.
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Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.
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Integrin functions play a key role in the differentiation of thymocytes in vivo.
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Integrin interactions with immobilized peptides in polyethylene glycol diacrylate hydrogels.
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Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation.
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Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.
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Integrins and other cell adhesion molecules in endometrium and endometriosis.
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Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways.
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JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.
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KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
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L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro.
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L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
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LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
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Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers.
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Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis.
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Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling.
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Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.
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MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans.
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Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles.
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Microporous annealed particle hydrogel stiffness, void space size, and adhesion properties impact cell proliferation, cell spreading, and gene transfer.
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Modification of integrin-mediated cell attachment to substrata by serine proteinases in the presence and absence of divalent cations.
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Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line.
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Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.
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Morphogenesis and Compartmentalization of the Intestinal Crypt.
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Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations.
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Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries.
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Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium.
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Nonmucosal alphavirus vaccination stimulates a mucosal inductive environment in the peripheral draining lymph node.
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Out of Eden: stem cells and their niches.
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P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury.
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Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.
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Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design.
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Polar axis fixation in Fucus zygotes: components of the cytoskeleton and extracellular matrix.
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Porcine endothelial cell membrane antigens recognized by human and baboon xenoreactive antibodies during organ perfusion.
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Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.
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Progesterone function in human endometrium: clinical perspectives.
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Protein unfolding under isometric tension-what force can integrins generate, and can it unfold FNIII domains?
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Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid.
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Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents.
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Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires.
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Role of adhesion molecules in the pathogenesis of rheumatoid arthritis.
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Secondary lymphoid-tissue chemokine (SLC) stimulates integrin alpha 4 beta 7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow.
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Sensing heart stress.
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Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin.
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Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia.
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Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.
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Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization.
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Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes.
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Systematic review and meta-analysis: opportunistic infections and malignancies during treatment with anti-integrin antibodies in inflammatory bowel disease.
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TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
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Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.
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Tenascin supports lymphocyte rolling.
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The "Stressful" Life of Cell Adhesion Molecules: On the Mechanosensitivity of Integrin Adhesome.
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The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
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The bridge between dendritic cells and asthma.
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The compact conformation of fibronectin is determined by intramolecular ionic interactions.
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The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study.
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The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.
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The modulation of MSC integrin expression by RGD presentation
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The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates.
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The nephritogenic immune response.
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The role of adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation.
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The role of glycoprotein IIb/IIIa platelet inhibition in percutaneous coronary intervention in the stent era.
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The role of integrins in saphenous vein vascular smooth muscle cell migration.
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The role of platelet receptors and adhesion molecules in coronary artery disease.
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The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.
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Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells.
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Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis.
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Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.
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Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation.
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Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.
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Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C.
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Vascular morphogenesis: tales of two syndromes.
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alpha-Crystallin localizes to the leading edges of migrating lens epithelial cells.
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alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo.
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zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation.
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α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
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Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
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Shinohara, Mari L.,
Associate Professor of Immunology,
Cell Biology