Skin Transplantation

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  Subject Areas on Research

  • A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. 
  • A model of sequential heart and composite tissue allotransplant in rats. 
  • A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. 
  • A treatment strategy for postburn neck reconstruction: emphasizing the functional and aesthetic importance of the cervicomental angle. 
  • Accelerated rejection of skin grafts in recipients sensitized with extracted human histocompatibility antigens. 
  • Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • An Algorithmic Approach to the Management of Ballistic Facial Trauma in the Civilian Population. 
  • An adherence tensiometer for evaluation of burn dressings. 
  • Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology. 
  • Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. 
  • B lymphocytes differentially influence acute and chronic allograft rejection in mice. 
  • Characteristics of corneal xenograft rejection in a discordant species combination. 
  • Comparison of free flaps with pedicled flaps for coverage of defects of the leg or foot. 
  • Comparison of in vivo efficacy and mechanism of action of antimurine monoclonal antibodies directed against TCR alpha beta (H57-597) and CD3 (145-2C11). 
  • Comparison of native porcine skin and a dermal substitute using tensiometry and digital image speckle correlation. 
  • Comparisons of mixed leukocyte reactions with skin graft survival in families genotyped for HL-A. 
  • Contemporary analysis of management of isolated pendulous urethral strictures using pedicled skin flap urethroplasty repair. 
  • Correlations of test skin grafts and renal allograft function in human subjects genotyped for HL-A. 
  • Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes. 
  • Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. 
  • Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow. 
  • Demographic characteristics of patients requiring full-thickness skin grafts for cicatricial ectropion at Duke Eye Center from 2000 to 2010. 
  • Dermal Regenerative Templates in Orthopaedic Surgery. 
  • Dermal tissue allograft for the repair of massive irreparable rotator cuff tears. 
  • Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. 
  • Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. 
  • Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells. 
  • Dorsal onlay graft urethroplasty for repair of bulbar urethral stricture. 
  • Dorsal onlay urethroplasty for urethral stricture repair. 
  • Dupuytren contracture. 
  • Effects of bursectomy and rat skin xenografts on natural antibodies in chickens. 
  • Efficacy and mechanism of adenovirus-mediated VEGF-165 gene therapy for augmentation of skin flap viability. 
  • Engineering the tissue which encapsulates subcutaneous implants. II. Plasma-tissue exchange properties. 
  • Engineering the tissue which encapsulates subcutaneous implants. III. Effective tissue response times. 
  • Evaluation of changes in skeletal muscle blood flow in the dog with contrast ultrasonography. 
  • Extent of surgical intervention in primary soft-tissue aspergillosis. 
  • Facial Recognition Pattern before and after Lower Eyelid Blepharoplasty: An Eye Tracking Analysis. 
  • Factors which have a significant effect on the survival of human skin grafts. 
  • Fascio-subcutaneous extension of a free radial forearm flap for frontonasal duct obliteration. 
  • First successful lower-extremity transplantation: technique and functional result. 
  • Fourteen free groin flap transfers. 
  • Graft donor selection based upon single locus (haplotype) analysis within families. 
  • HL A typing, mixed leukocyte reactivity, and skin graft survival in a family with a recombinant at the HL-1 chromosomal region (major transplantation region). 
  • Hailey-Hailey disease. Report of a case treated surgically. 
  • Hepatic transplantation into sensitized recipients. Demonstration of hyperacute rejection. 
  • Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. 
  • High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade. 
  • Histologic Analysis of Porcine Dermal Graft Augmentation in Treatment of Rotator Cuff Tears. 
  • Histopathologic features of rejecting orthotopic corneal xenografts. 
  • Host priming, not target antigen type, decides rejection rate in mice primed with MHC II "knockout" cultured keratinocytes. 
  • Hyperbaric oxygen and cyclosporine as a combined treatment regimen to prevent skin allograft rejection in immunohistoincompatible mice. 
  • IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. 
  • IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses. 
  • Immune competence of germ-free rats. I. Increased responsiveness to transplantation and other antigens. 
  • Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts. 
  • Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping. 
  • Immunohistochemical identification of vascular endothelial growth factor in pig latissimus dorsi musculocutaneous flaps following ischemia-reperfusion injury. 
  • In vivo detection of SERS-encoded plasmonic nanostars in human skin grafts and live animal models. 
  • Increased signs of acute rejection with ischemic time in a rat musculocutaneous allotransplant model. 
  • Increased survival of skin flaps by scavengers of superoxide radical. 
  • Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity. 
  • Interposition Dermal Matrix Xenografts: A Successful Alternative to Traditional Treatment of Massive Rotator Cuff Tears. 
  • L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice. 
  • Laser Doppler blood flow measurements of common cutaneous donor sites for reconstructive surgery. 
  • Laser-assisted indocyanine green dye angiography accurately predicts the split-thickness graft timing of integra artificial dermis. 
  • Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways. 
  • Local Burn Injury Promotes Defects in the Epidermal Lipid and Antimicrobial Peptide Barriers in Human Autograft Skin and Burn Margin: Implications for Burn Wound Healing and Graft Survival. 
  • Management of Complications of Achilles Tendon Surgery. 
  • Massive or 2-tendon rotator cuff tears in active patients with minimal glenohumeral arthritis: clinical and radiographic outcomes of reconstruction using dermal tissue matrix xenograft. 
  • Melanoma arising in a skin graft. 
  • Microsurgical composite tissue transplantation: a method of immediate reconstruction of the head and neck. 
  • Microsurgical composite tissue transplantation: a new horizon in plastic and reconstructive surgery. 
  • Microsurgical composite tissue transplantation: a new method of immediate reconstruction of extensive defects. 
  • Microvascular procedures in reconstructive surgery. 
  • Mixed lymphocyte reactions and skin graft survival in an HL-A recombinant family. 
  • Muscle versus Fasciocutaneous Free Flaps in Lower Extremity Traumatic Reconstruction: A Multicenter Outcomes Analysis. 
  • Nipple-areola reconstruction after mastectomy. 
  • Non-parametric estimation for the difference or ratio of median failure times for paired observations. 
  • One hundred eleven thumb amputations: replantation vs revision. 
  • Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model. 
  • Osteocutaneous face transplantation. 
  • PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue. 
  • Palliative surgery for head and neck cancer with extensive skin involvement. 
  • Patient characteristics and management of dermal allograft extrusions. 
  • Pattern formation on lepidopteran wings: determination of an eyespot. 
  • Perineal and lower extremity reconstruction. 
  • Perioperative Treatment with a Prolyl Hydroxylase Inhibitor Reduces Necrosis in a Rat Ischemic Skin Flap Model. 
  • Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold. 
  • Possible production of immunosuppression in the host by exposure to microorganisms: observations in germfree rats. 
  • Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients. 
  • Primary vascularization of the graft determines the immunodominance of murine minor H antigens during organ transplantation. 
  • Primate skin allotransplantation with anti-CD154 monotherapy. 
  • Rank tests for clustered survival data when dependent subunits are randomized. 
  • Rank tests for matched survival data. 
  • Recipient Myd88 Deficiency Promotes Spontaneous Resolution of Kidney Allograft Rejection. 
  • Reconstruction of nasal defects 1.5 cm or smaller. 
  • Reconstruction of scalp wounds with exposed calvarium using a local flap and a split-thickness skin graft: case series of 20 patients. 
  • Reconstruction of the lower extremity with vascularized composite tissue: improved tissue survival and specific indications. 
  • Renal transplantation between HL-A haploidentical donor-recipient pairs: functional and morphological evaluation. 
  • Repair of a complete glottic-subglottic stenosis with a fibular osseocutaneous free flap. 
  • Restoring the failed cranioplasty: nonanatomical titanium mesh with perforator flap. 
  • Reversal of acute allograft rejection using immunotoxin. 
  • Routine clinical use of laser Doppler flowmeter to monitor free tissue transfer: preliminary results. 
  • Sample size calculation for the weighted rank statistics with paired survival data. 
  • Selection of donors for kidney transplantation. 
  • Single Steinmann pin fixation of arm to leg. Case report. 
  • Skin coverage in occupational hand injuries. 
  • Skin graft rejection between subjects genotyped for HL-A. 
  • Soft Tissue Reconstruction After Total Ankle Arthroplasty. 
  • Soft Tissue Reconstruction After Total Ankle Arthroplasty. 
  • Split tolerance induced by immunotoxin in a rhesus kidney allograft model. 
  • Split-thickness skin graft harvesting from an intraoral flap: a new technique. 
  • Stacking of a dermal regeneration template for reconstruction of a soft-tissue defect after tumor excision from the palm of the hand: a case report. 
  • Stimulation of DNA synthesis in human epidermis by UVB radiation and its inhibition by difluoromethylornithine. 
  • Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. 
  • Suboptimal results in full thickness skin graft urethroplasty using an extrapenile skin donor site. 
  • Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients. 
  • Telomere shortening in cultured autografts of patients with burns. 
  • The Banff 2007 working classification of skin-containing composite tissue allograft pathology. 
  • The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques. 
  • The diversity of wound presentation associated with freon contact frostbite injury. 
  • The effector component of the cytotoxic T-lymphocyte response has a biphasic pattern after burn injury. 
  • The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy: results of a prospective practice improvement study. 
  • The evolution of urethroplasty for bulbar urethral stricture disease: lessons learned from a single center experience. 
  • The examination of several common misconceptions in nasal reconstruction. 
  • The fibula-flexor hallucis longus osteomuscular flap. 
  • The helical arcade: anatomic basis for survival in near-total ear avulsion. 
  • The immunogenicity of human HL-A haplotypesas measured by skin graft survival times and mixed leukocyte reactions. 
  • The lateral femoral cutaneous nerve block. 
  • The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn. 
  • The rehabilitation of renal allograft recipients. 
  • The role of hyaluronan degradation products as innate alloimmune agonists. 
  • The vascularization of free flaps: a clinical and experimental correlation. 
  • Thumb reconstruction by the wrap-around method. 
  • Total lymphoid irradiation and cyclosporine prolongs cardiac allograft survival in the sensitized rat model. 
  • Transfer of free flaps to provide well-vascularized, thick cover for breast reconstructions after radical mastectomy. 
  • Transplantation in miniature swine. 
  • Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs. 
  • Transplantation in miniature swine. III: effects of MSLA and A-O blood group matching on skin allograft survival. 
  • Transplantation in miniature swine. VI. Factors influencing survival of renal allografts. 
  • Transplantation of psoriatic skin onto nude mice. 
  • Treatment of a severe alkali burn. 
  • Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates. 
  • Uninvolved skin from psoriatic patients develops signs of involved psoriatic skin after being grafted onto nude mice. 
  • Urethroplasty management in 100 cases of urethral stricture: a rationale for procedure selection. 
  • Urethroplasty with abdominal skin grafts for long segment urethral strictures. 
  • Use of negative-pressure dressings and split-thickness skin grafts following penile shaft reduction and reduction scrotoplasty in the management of penoscrotal elephantiasis. 
  • Variable allograft responses to pretreatment with donor splenocytes treated with mitomycin C in the rat. 
  • Vascularized composite allotransplantation at a crossroad. 
  • Vascularized rib-periosteal and osteocutaneous reconstruction of the maxilla and mandible: an assessment. 
  • Vascularized tissue transfer for closure of irradiated wounds after soft tissue sarcoma resection. 
  • Viral infection abrogates CD8(+) T-cell deletion induced by costimulation blockade. 
  • Wound healing and treating wounds: Chronic wound care and management. 
  • [Enhanced immune reaction of germ-free rats after skin allotransplantation]. 
  • [Indications for hyperbaric oxygenation in chronic diseases]. 
  • [New developments in skin replacement materials]. 
  • [Plastic surgery coverage of skin defects]. 
  • c-Jun promotes whereas JunB inhibits epidermal neoplasia. 
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  Keywords of People

  • Chen, Jun, Professor of Medicine, Duke Cancer Institute