Tumor Suppressor Protein p53
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Subject Areas on Research
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"Wildcatting" for breakthroughs in urothelial cancer detection and management--a frustrating business.
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5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage.
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A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
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A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.
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A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest.
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A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
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A network of genetic events sufficient to convert normal human cells to a tumorigenic state.
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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
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A prognostic model of recurrence and death in stage I non-small cell lung cancer utilizing presentation, histopathology, and oncoprotein expression.
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A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.
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A spatially and temporally restricted mouse model of soft tissue sarcoma.
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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
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A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.
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ARID1A-mutated ovarian cancers depend on HDAC6 activity.
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
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AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells.
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Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia.
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Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma.
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Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.
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Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells.
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Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation.
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Accelerated decline in lung function in cigarette smokers is associated with TP53/HDM2 polymorphisms.
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Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.
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Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia.
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Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.
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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
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Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
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Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis.
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Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway.
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Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction.
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Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models.
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Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.
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Aggressive B-cell Lymphoma with MYC/TP53 Dual Alterations Displays Distinct Clinicopathobiological Features and Response to Novel Targeted Agents.
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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.
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Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
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Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin.
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An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.
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An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis.
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An animal model of adolescent nicotine exposure: effects on gene expression and macromolecular constituents in rat brain regions.
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An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.
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Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation.
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Apoptosis and P53 induction in human lung fibroblasts exposed to chromium (VI): effect of ascorbate and tocopherol.
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Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.
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Application of an antibody biochip for p53 detection and cancer diagnosis.
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Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma.
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Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.
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Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.
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Association between p53 Arg72Pro polymorphism and colorectal cancer risk: a meta-analysis.
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Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803.
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Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer.
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Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab.
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Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis.
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Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.
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Auto-antibodies to p53 and the Subsequent Development of Colorectal Cancer in a U.S. Prospective Cohort Consortium.
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Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.
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Biostatistical modeling using traditional variables and genetic biomarkers for predicting the risk of prostate carcinoma recurrence after radical prostatectomy.
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C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent.
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CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways.
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Cancer clocks in tumourigenesis: the p53 pathway and beyond.
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Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
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Cell cycle control and cancer.
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Cell cycle deregulation and xeroderma pigmentosum group C cell transformation.
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Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.
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Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
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Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells.
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Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model.
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Characterization of the cytotoxic activities of novel analogues of the antitumor agent, lavendamycin.
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Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking.
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Checkpoint controls and cancer. Introduction.
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Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture.
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Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression.
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Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest.
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Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts.
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Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny.
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Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.
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Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.
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Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma.
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Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study.
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Clinical and genomic characterization of Low PSA Secretors: a unique subset of metastatic castration resistant prostate cancer.
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Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma.
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Clinical significance and prognostic relevance of KRAS, BRAF, PI3K and TP53 genetic mutation analysis for resectable and unresectable colorectal liver metastases: A systematic review of the current evidence.
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Clinicopathologic Features and Genomic Signature of De Novo CD5 + Diffuse Large B-Cell Lymphoma : A Multicenter Collaborative Study.
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Combined p53 and retinoblastoma protein detection identifies persistent and regressive cervical high-grade squamous intraepithelial lesions.
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Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage".
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Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia.
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Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis.
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Compromised HOXA5 function can limit p53 expression in human breast tumours.
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Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent.
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Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers.
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Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.
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DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.
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DNA damage induces phosphorylation of the amino terminus of p53.
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DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture.
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DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis.
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DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival.
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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
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Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
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Development of novel targeted therapies in the treatment of malignant glioma.
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Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.
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Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B.
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Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
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Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.
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Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.
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Do neuroendocrine cells come up large in small cell lung cancer?
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Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells.
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Dosage-dependent requirements of Magoh for cortical interneuron generation and survival.
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Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies.
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.
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E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.
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Editorial comment.
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Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/fl; myristolated p110fl/fl ROSA-gfp mouse.
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Effective blue light photodynamic therapy does not affect cutaneous langerhans cell number or oxidatively damage DNA.
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Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer.
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Eligible and not eligible studies in the recent meta-analysis about p53 polymorphism and breast cancer risk.
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Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents.
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Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression.
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Environmental factors in relation to breast cancer characterized by p53 protein expression.
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Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors.
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Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice.
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Evidence of a Monoclonal Origin for Bilateral Serous Tubal Intraepithelial Neoplasia.
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Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.
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Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
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Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors.
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Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.
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Expression of p53 and pRb in bladder and prostate cancers of patients having both cancers.
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Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines.
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Expression signatures of TP53 mutations in serous ovarian cancers.
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FAK overexpression and p53 mutations are highly correlated in human breast cancer.
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Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
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Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
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Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression.
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Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
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Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues.
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G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder.
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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program.
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Gene expression profiling and genetic markers in glioblastoma survival.
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Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.
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Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
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Genetic basis for p53 overexpression in human breast cancer.
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Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
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Genetically engineered human cancer models utilizing mammalian transgene expression.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
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Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
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Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.
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Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis.
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Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
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Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.
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Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.
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Gliomas of the optic nerve: histological, immunohistochemical (MIB-1 and p53), and MRI analysis.
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Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein.
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Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.
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Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway.
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HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression.
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HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.
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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
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HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest.
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HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
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Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.
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Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
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High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA.
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Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
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Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein.
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Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma.
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INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.
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Ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial treatment for younger patients with chronic lymphocytic leukaemia: a single-arm, multicentre, phase 2 trial.
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Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
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Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.
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Identification of prohibitin and prohibiton as novel factors binding to the p53 induced gene 3 (PIG3) promoter (TGYCC)(15) motif.
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Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.
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Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome.
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Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
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Immunohistochemical and mutational analysis of the p53 tumour suppressor gene and the bcl-2 oncogene in primary testicular germ cell tumours.
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Immunohistochemical examination of an orbital alveolar soft part sarcoma.
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Immunohistochemical expression of mutant p53 oncogene in transitional mucosa adjacent to human colon cancer.
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Impact of age at diagnosis on racial disparities in endometrial cancer patients.
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In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.
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Increased p53 protein does not correlate to p53 gene mutations in microdissected human testicular germ cell tumors.
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Induction of CD56 and TCR-independent activation of T cells with aging.
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Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts.
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Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
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Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure.
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Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
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Inhibition of the growth of pre-established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector.
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Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma.
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Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program.
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Injury promotes sarcoma development in a genetically and temporally restricted manner.
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Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.
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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
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Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.
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Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA.
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Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas.
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Ionizing radiation activates the ATM kinase throughout the cell cycle.
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Isogenic normal basal and luminal mammary epithelial isolated by a novel method show a differential response to ionizing radiation.
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Ki-67, p53, and p16 expression, and G691S RET polymorphism in desmoplastic melanoma (DM): A clinicopathologic analysis of predictors of outcome.
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Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence.
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LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.
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Lack of p53 induction in fish cells by model chemotherapeutics.
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Levels of p53 protein increase with maturation in human hematopoietic cells.
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Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium.
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Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.
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Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues.
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Linking the history of radiation biology to the hallmarks of cancer.
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Localized adenocarcinoma of the lung: oncogene expression of erbB-2 and p53 in 150 patients.
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Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence.
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Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.
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Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
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Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate.
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Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases.
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MDM2 phenotypic and genotypic profiling, respective to TP53 genetic status, in diffuse large B-cell lymphoma patients treated with rituximab-CHOP immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program.
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MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation.
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MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival.
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Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease.
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Maintenance of p53 alterations throughout breast cancer progression.
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Male breast carcinoma: correlation of ER, PR, Ki-67, Her2-Neu, and p53 with treatment and survival, a study of 65 cases.
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Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation.
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Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.
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Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26.
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Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
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Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
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Mesotheliomas induced in rats by the fibrous mineral erionite are independent from p53 alterations.
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Metabolic stress in autophagy and cell death pathways.
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Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.
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Metastatic Melanoma Patient-Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition.
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Methods to generate genetically engineered mouse models of soft tissue sarcoma.
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Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
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Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes.
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Molecular and genetic biomarkers implemented from next-generation sequencing provide treatment insights in clinical practice for Waldenström macroglobulinemia.
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Molecular characterization of adenocarcinoma of the cervix.
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Molecular genetic and immunohistochemical analysis of the tumor suppressor genes Rb and p53 in palmar and aggressive fibromatosis.
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Molecular testing for endometrial cancer: An SGO clinical practice statement.
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More than 1 TP53 abnormality is a dominant characteristic of pure erythroid leukemia.
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Morphologic and molecular genetic aspects of oligodendroglial neoplasms.
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Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).
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Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.
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Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer.
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Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells.
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Mutant p53 as an Antigen in Cancer Immunotherapy.
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Mutant p53 regulates LPA signaling through lysophosphatidic acid phosphatase type 6.
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Mutated p53 portends improvement in outcomes when bevacizumab is combined with chemotherapy in advanced/recurrent endometrial cancer: An NRG Oncology study.
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Mutation and overexpression of p53 in early-stage epithelial ovarian cancer.
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Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases.
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Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center.
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Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.
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Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study.
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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.
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Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma.
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NAD+ modulates p53 DNA binding specificity and function.
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NCIC CTG IND.181: phase I study of AT9283 given as a weekly 24 hour infusion in advanced malignancies.
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NCKAP1 improves patient outcome and inhibits cell growth by enhancing Rb1/p53 activation in hepatocellular carcinoma.
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NF-κB p50 activation associated with immune dysregulation confers poorer survival for diffuse large B-cell lymphoma patients with wild-type p53.
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Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product.
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Necrosis and apoptosis of tumor cells in embolized meningiomas: histopathology and P53, BCL-2, CD-68 immunohistochemistry.
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Need for clarification of data in the recent meta-analysis about p53 polymorphism and gastric cancer risk.
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Negative regulation of the tumor suppressor p53 gene by microRNAs.
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Neoadjuvant Radiation Therapy and Surgery Improves Metastasis-Free Survival over Surgery Alone in a Primary Mouse Model of Soft Tissue Sarcoma.
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Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice.
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Neuroendocrine differentiation of prostate cancer.
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Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy.
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Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.
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Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
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Obesity and altered angiogenic-related gene expression in endometrial cancer.
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Oligonucleotide enhanced cytotoxicity of Idarubicin for lymphoma cells.
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On the TRAIL from p53 to apoptosis?
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Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet.
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Oncogenic Signaling Pathways in The Cancer Genome Atlas.
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Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.
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Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
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Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.
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Overexpression of p53 is not a feature of benign and early-stage borderline epithelial ovarian tumors.
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P53 codon 72 polymorphism and risk of gastric cancer in a Chinese population.
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P53, cell cycle control and apoptosis: implications for cancer.
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PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.
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PI3K/Akt and apoptosis: size matters.
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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
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PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma.
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Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events.
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Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.
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Parc-ing p53 in the cytoplasm.
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Participation of p53 protein in the cellular response to DNA damage.
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Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway.
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Perineal seeding of prostate cancer as the only evidence of clinical recurrence 14 years after needle biopsy and radical prostatectomy: molecular correlation.
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Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.
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Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia.
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Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
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Photodynamic therapy of Barrett's esophagus: ablation of Barrett's mucosa and reduction in p53 protein expression after treatment.
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Placenta-Specific Protein 1 Expression in Human Papillomavirus 16/18-Positive Cervical Cancers Is Associated With Tumor Histology.
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Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
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Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.
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Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma.
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Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.
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Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells.
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Prevalence of pulmonary atypical alveolar cell hyperplasia in an autopsy population: a study of 100 cases.
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Prognostic factors for fibromatoses: a correlation of proliferation index, estrogen receptor, p53, retinoblastoma, and src gene products and clinical features with outcome.
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Prognostic factors in resectable pancreatic cancer: p53 and bcl-2.
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Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma.
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Prognostic risk factors that identify patients with clinical stage I nonseminomatous germ cell tumors at low risk and high risk for metastasis.
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Prognostic significance of mucin and p53 expression in stage IB non-small cell lung cancer: a laboratory companion study to CALGB 9633.
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Prognostic significance of p53 mutation and p53 overexpression in advanced epithelial ovarian cancer: a Gynecologic Oncology Group Study.
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Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.
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Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary.
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Protecting the hedgerow: p53 and hedgehog pathway interactions.
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Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer.
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RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer.
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RGS-GAIP-interacting protein controls breast cancer progression.
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RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.
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RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
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RNAi the natural way.
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Racial disparity in overexpression of the p53 tumor suppressor gene in stage I endometrial cancer.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rational Manual and Automated Scoring Thresholds for the Immunohistochemical Detection of TP53 Missense Mutations in Human Breast Carcinomas.
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Re: Jiang et al.: Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk (Urology 2010;76:765).
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Reactivation of Epstein-Barr Virus by HIF-1α Requires p53.
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Recombinant adenovirus vector expressing wild-type p53 is a potent inhibitor of prostate cancer cell proliferation.
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Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.
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Regulation of mast cell survival and function by tuberous sclerosis complex 1.
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Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.
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Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
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Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma.
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Relation between p53 overexpression and established prognostic factors in breast cancer.
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Relationship between lifetime ovulatory cycles and overexpression of mutant p53 in epithelial ovarian cancer.
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Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells.
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Replicative senescence revisited.
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Reproductive factors in relation to breast cancer characterized by p53 protein expression (United States).
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Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.
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Resection of adrenocortical carcinoma liver metastasis: is it justified?
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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
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Restoration of p53 function leads to tumour regression in vivo.
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Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor.
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Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.
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Role of p53 in apoptosis.
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Sensitization of Endothelial Cells to Ionizing Radiation Exacerbates Delayed Radiation Myelopathy in Mice.
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Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.
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Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.
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Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.
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Signal transduction. Three paths to stress relief.
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Signalling to p53: where does it all start?
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Significance of familial history of prostate cancer to traditional prognostic variables, genetic biomarkers, and recurrence after radical prostatectomy.
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Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program.
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Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.
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Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation.
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Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis.
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Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation.
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Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
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Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.
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Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.
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Stacking the DEK: from chromatin topology to cancer stem cells.
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Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.
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Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study.
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Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function.
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Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.
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Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
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Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy.
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Survival analysis of presumptive prognostic markers among oligodendrogliomas.
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Systematic Analysis of Splice-Site-Creating Mutations in Cancer.
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TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.
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TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.
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TP53 Sequencing and p53 Immunohistochemistry Predict Outcomes When Bevacizumab Is Added to Frontline Chemotherapy in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study.
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TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).
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TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases.
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TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
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TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice.
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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
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Targeted cytotoxic somatostatin analogue AN-238 inhibits somatostatin receptor-positive experimental colon cancers independently of their p53 status.
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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
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Telomere dysfunction causes alveolar stem cell failure.
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The Cancer Genome Atlas expression profiles of low-grade gliomas.
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The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.
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The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells.
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The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
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The Genetic Basis of Hepatosplenic T-cell Lymphoma.
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The TP53 tumor suppressor and autophagy in malignant lymphoma.
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The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group.
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The complexity of p53 modulation: emerging patterns from divergent signals.
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The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.
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The dichotomy of p53 regulation by noncoding RNAs.
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The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells.
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The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability.
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The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
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The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.
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The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts.
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The p53 Transactivation Domain 1-Dependent Response to Acute DNA Damage in Endothelial Cells Protects against Radiation-Induced Cardiac Injury.
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The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.
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The p53 tumor suppressor gene frequently is altered in gynecologic cancers.
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The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
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The p53-dependent gamma-ray response of GADD45.
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The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer.
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The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.
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The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans.
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The role of p53 in cell-cycle control and apoptosis: implications for cancer.
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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response.
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The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.
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Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC.
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Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
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Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant.
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Tp53 Suppression Promotes Cardiomyocyte Proliferation during Zebrafish Heart Regeneration.
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Transcriptional biomarkers distinguish between vulnerable periods for developmental neurotoxicity of chlorpyrifos: Implications for toxicogenomics.
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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.
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Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.
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Tumor marker expression is predictive of survival in patients with esophageal cancer.
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Tumor-suppressor p53: implications for tumor development and prognosis.
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Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome.
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Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome.
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UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.
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Ubiquitylation of p53 by the APC/C inhibitor Trim39.
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Use of neuroendocrine markers, p53, and HER2 to predict response to chemotherapy in patients with stage III non-small cell lung cancer: a Cancer and Leukemia Group B study.
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Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.
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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.
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WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
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Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma.
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Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.
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Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer.
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Wild-type p53: tumors can't stand it.
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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.
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Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.
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XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53.
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Yin Yang 1 Promotes Thymocyte Survival by Downregulating p53.
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ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.
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[The effect of adenovirus-mediated wild-type p53 expression on the growth of human pancreatic carcinoma cell line cells].
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bcl-2 and p53 expression in resectable pancreatic adenocarcinomas: association with clinical outcome.
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hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation.
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hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage.
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mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma.
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mTOR Activation Initiates Renal Cell Carcinoma Development by Coordinating ERK and p38MAPK.
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p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome.
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p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.
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p53 Immunostaining guided laser capture microdissection (p53-LCM) defines the presence of p53 gene mutations in focal regions of primary prostate cancer positive for p53 protein.
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p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.
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p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway.
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p53 alterations in all stages of breast cancer.
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p53 and ATM: cell cycle, cell death, and cancer.
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p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas.
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p53 and bcl-2 immunohistochemistry in pretreatment prostate needle biopsies to predict recurrence of prostate cancer after radical prostatectomy.
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p53 and mdm-2 expression in malignant melanoma: an immunocytochemical study of expression of p53, mdm-2, and markers of cell proliferation in primary versus metastatic tumors.
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p53 codon 72 Arg homozygotes are associated with an increased risk of cutaneous melanoma.
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p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers.
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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
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p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene.
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p53 expression is a strong marker of inferior survival in de novo diffuse large B-cell lymphoma and may have enhanced negative effect with MYC coexpression: a single institutional clinicopathologic study.
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p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
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p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.
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p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.
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p53 nuclear protein expression is an independent prognostic marker in clinically localized prostate cancer patients undergoing radical prostatectomy.
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p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.
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p53 protein expression status and recurrence in men treated with radiation and androgen suppression therapy for higher-risk prostate cancer: a prospective phase II Cancer and Leukemia Group B Study (CALGB 9682).
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p53 regulates the expression of the tumor suppressor gene maspin.
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p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase.
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p53, c-erbB2, and PCNA status in benign, proliferative and malignant ovarian surface epithelial neoplasms: a study of 75 cases.
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p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
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p53-dependent control of transactivation of the Pen2 promoter by presenilins.
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p53-dependent induction of heat shock protein 27 (HSP27) expression.
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p53: a two-faced cancer gene.
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p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function.
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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
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p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature.
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Keywords of People
-
Badea, Cristian Tudorel,
Professor in Radiology,
Biomedical Engineering
-
Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
-
Ciofani, Maria,
Associate Professor of Immunology,
Cell Biology
-
Clyde, Merlise,
Professor of Statistical Science,
Statistical Science
-
Linardic, Corinne Mary,
Associate Professor of Pediatrics,
Cell Biology
-
Luftig, Micah Alan,
Associate Professor of Molecular Genetics and Microbiology,
Cell Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute
-
Yan, Hai,
Adjunct Professor of Pathology,
Pathology