Free Radical Scavengers

• 

  Subject Areas on Research

  • A comparative study of antioxidative activities of cell-wall polysaccharides. 
  • Adaptive responses to peroxynitrite: increased glutathione levels and cystine uptake in vascular cells. 
  • An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation. 
  • Antioxidant defense mechanisms in cultured pleural mesothelial cells. 
  • Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE). 
  • Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. 
  • Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid. 
  • Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae. 
  • Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide. 
  • Consumption of biogenic nitric oxide in hydrated soil. 
  • Dependence of the cyanobacterium Prochlorococcus on hydrogen peroxide scavenging microbes for growth at the ocean's surface. 
  • Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. 
  • Different roles of radical scavengers--ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. 
  • Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. 
  • Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty. 
  • Effects of genotype and environment on the antioxidant properties of hard winter wheat bran. 
  • Extracellular superoxide dismutase: structural and functional considerations of a protein shaped by two different disulfide bridge patterns. 
  • Formation of the excited ferryl species following Fenton reaction. 
  • Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. 
  • Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions. 
  • Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. 
  • Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. 
  • In vivo assessment of free radical activity during shock wave lithotripsy using a microdialysis system: the renoprotective action of allopurinol. 
  • Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments. 
  • Involvement of reactive oxygen species in the electrochemical inhibition of barnacle (Amphibalanus amphitrite) settlement. 
  • Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. 
  • L-N-Acetylcysteine treatment is associated with improved hearing outcome in sudden idiopathic sensorineural hearing loss. 
  • LKB1 reduces ROS-mediated cell damage via activation of p38. 
  • Limiting impairment of muscle function following ischemia and reperfusion in rabbits. 
  • Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. 
  • Location-dependent artifact for no measurement using multiwell plates. 
  • Manganese porphyrins and related compounds as mimics of superoxide dismutase. 
  • Manganese-porphyrin reactions with lipids and lipoproteins. 
  • Metalloporphyrins are potent inhibitors of lipid peroxidation. 
  • Mitochondria in sporadic amyotrophic lateral sclerosis. 
  • Mitochondrial Quality Control as a Therapeutic Target. 
  • Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. 
  • Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. 
  • Neuroprotective effect of curcumin in an experimental rat model of subarachnoid hemorrhage. 
  • Neutrophil elastase induces MUC5AC messenger RNA expression by an oxidant-dependent mechanism. 
  • New series of aryloxypropanolamines with both human beta(3)-adrenoceptor agonistic activity and free radical scavenging properties. 
  • Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells. 
  • Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. 
  • Predicted effects of nitric oxide and superoxide on the vasoactivity of the afferent arteriole. 
  • Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. 
  • Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. 
  • Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology. 
  • Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. 
  • RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice. 
  • Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis. 
  • Redox changes of cultured endothelial cells and actin dynamics. 
  • Redox signaling of the arteriolar myogenic response. 
  • Rotational isomers of N-alkylpyridylporphyrins and their metal complexes. HPLC separation, (1)H NMR and X-ray structural characterization, electrochemistry, and catalysis of O(2)(.-) disproportionation. 
  • Synthetic surfactant scavenges oxidants and protects against hyperoxic lung injury. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • The actin cytoskeleton reorganization induced by Rac1 requires the production of superoxide. 
  • The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic. 
  • The role of allopurinol and deferoxamine in preventing pressure ulcers in pigs. 
  • Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum. 
  • Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study. 
• 

  Keywords of People

  • Preminger, Glenn Michael, James F. Glenn, M.D. Professor of Urology, Surgery
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology