T-Lymphocyte Subsets

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  Subject Areas on Research

  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. 
  • A high endothelial cell-derived chemokine induces rapid, efficient, and subset-selective arrest of rolling T lymphocytes on a reconstituted endothelial substrate. 
  • A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A role for MAPK in feedback inhibition of Tcrb recombination. 
  • A threshold for central T cell tolerance to an inducible serum protein. 
  • AD2, a human molecule involved in the interaction of T cells with epidermal keratinocytes and thymic epithelial cells. 
  • ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. 
  • Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma: cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. 
  • Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. 
  • Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens. 
  • Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma. 
  • Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. 
  • Acute HIV infection: the impact of anti-retroviral treatment on cellular immune responses. 
  • Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • Analysis of clones derived from human CD7+CD4-CD8-CD3- thymocytes. 
  • Analysis of the T-cell receptor beta-chain variable-region (V beta) repertoire in monozygotic twins discordant for human immunodeficiency virus: evidence for perturbations of specific V beta segments in CD4+ T cells of the virus-positive twins. 
  • Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. 
  • Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia. 
  • Antigen-specific T-lymphocyte function after cord blood transplantation. 
  • Antiretroviral therapy corrects HIV-1-induced expansion of CD8+ CD45RA+ CD2-) CD11a(bright) activated T cells. 
  • Antiretroviral therapy restores diversity in the T-cell receptor Vbeta repertoire of CD4 T-cell subpopulations among human immunodeficiency virus type 1-infected children and adolescents. 
  • Association of CD8(+) T lymphocyte repertoire spreading with the severity of DRESS syndrome. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • BLyS and APRIL in rheumatoid arthritis. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • CD4+Thy1- thymocytes with a Th-type 2 cytokine response. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. 
  • CD8+ T lymphocyte-mediated inhibition of HIV-1 long terminal repeat transcription: a novel antiviral mechanism. 
  • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. 
  • COMPASS identifies T-cell subsets correlated with clinical outcomes. 
  • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. 
  • Carbohydrate recognition on MUC1-expressing targets enhances cytotoxicity of a T cell subpopulation. 
  • Characterization of CD8(-) HLA class I/epitope tetrameric complexes binding T cells. 
  • Characterization of T cells expressing the gamma/delta antigen receptor in human renal allografts. 
  • Chronic dry eye disease is principally mediated by effector memory Th17 cells. 
  • Clinical implications of discordant viral and immune outcomes following protease inhibitor containing antiretroviral therapy for HIV-infected children. 
  • Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients. 
  • Coexistent naïve phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. 
  • Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Con A-induced suppressor cell function depends on the activation of the CD4+CD45RA inducer T cell subpopulation. 
  • Conversion of an immunogenic human immunodeficiency virus (HIV) envelope synthetic peptide to a tolerogen in chimpanzees by the fusogenic domain of HIV gp41 envelope protein. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. 
  • Deficient Mismatch Repair and the Role of Immunotherapy in Metastatic Colorectal Cancer. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Determination of CD4 and CD8 lymphocyte subsets by a new alternative fluorescence immunoassay. 
  • Determining γδ versus αß T cell development. 
  • Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. 
  • Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. 
  • Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Dynamics of Circulating γδ T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. 
  • Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. 
  • Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. 
  • Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis. 
  • Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets. 
  • Effects of human immunodeficiency virus type 1 infection on CCR5 and CXCR4 coreceptor expression on CD4 T lymphocyte subsets in infants and adolescents. 
  • Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution. 
  • Elevated level of peripheral CD8(+)CD28(-) T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy. 
  • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Essential role of LAT in T cell development. 
  • Evaluation of T-lymphocyte subsets present in semen and peripheral blood of healthy donors: a report from the heterosexual transmission study. 
  • Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo. 
  • Extended evaluation of a phase 1/2 trial on dosing, safety, immunogenicity, and overall survival after immunizations with an advanced-generation Ad5 [E1-, E2b-]-CEA(6D) vaccine in late-stage colorectal cancer. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. 
  • Gene expression signatures of interleukin-2 in vivo and in vitro and their relation to anticancer therapy. 
  • Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Graft-versus-host disease: the viewpoint from the donor T cell. 
  • Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. 
  • HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool. 
  • HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts. 
  • Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms. 
  • High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes. 
  • Histone deacetylation critically determines T cell subset radiosensitivity. 
  • Human dendritic cells transfected with RNA encoding prostate-specific antigen stimulate prostate-specific CTL responses in vitro. 
  • Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases. 
  • Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. 
  • Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development. 
  • Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis. 
  • IFN-gamma production in response to neuropathogenic Cas-Br-M murine leukemia virus infection. 
  • IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • IL-7 enhancement of antigen-driven activation/expansion of HIV-1-specific cytotoxic T lymphocyte precursors (CTLp). 
  • Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. 
  • Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. 
  • Idiopathic CD4+ T-lymphocytopenia. 
  • Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection. 
  • Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies. 
  • Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. 
  • Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study. 
  • Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation. 
  • Immunopathogenic events in acute infection of rhesus monkeys with simian immunodeficiency virus of macaques. 
  • Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. 
  • Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. 
  • Induction in vitro of primary cytotoxic T-lymphocyte responses with DNA encoding herpes simplex virus proteins. 
  • Induction of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T lymphocyte responses in seronegative adults by a nonreplicating, host-range-restricted canarypox vector (ALVAC) carrying the HIV-1MN env gene. 
  • Inflammatory bowel disease following solid organ transplantation. 
  • Influence of HIV-1 infection and cigarette smoking on leukocyte profile in homosexual men. 
  • Inhibiting inhibitory pathways in human γδ T cells. 
  • Integrin functions play a key role in the differentiation of thymocytes in vivo. 
  • Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice. 
  • Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells. 
  • Intraepithelial lymphocytes: exploring the Third Way in immunology. 
  • Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways. 
  • Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. 
  • L-selectin is not required for T cell-mediated autoimmune diabetes. 
  • LAT-mediated signaling in CD4+CD25+ regulatory T cell development. 
  • Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. 
  • Long-term efficacy of enzyme replacement therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). 
  • Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice. 
  • Lymphocyte and monocyte subset changes during cardiopulmonary bypass: effects of aging and gender. 
  • Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments. 
  • Lymphocyte subsets in children younger than 2 years old: normal values in a population at risk for human immunodeficiency virus infection and diagnostic and prognostic application to infected children. 
  • Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system. 
  • Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV. 
  • Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 
  • Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. 
  • Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection. 
  • Metabolic regulation of T lymphocytes. 
  • Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. 
  • Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. 
  • Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. 
  • Multiple gamma c-dependent cytokines regulate T-cell development. 
  • Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. 
  • Naïve T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function. 
  • Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Oral vaccine models: multiple delivery systems employing tetanus toxoid. 
  • Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire. 
  • Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. 
  • Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. 
  • Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination. 
  • Post-transplantation B cell function in different molecular types of SCID. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Prevention of autoimmune islet allograft destruction by engraftment of donor T cells. 
  • Primate renal transplants using immunotoxin. 
  • Protection against Mycobacterium avium by DNA vaccines expressing mycobacterial antigens as fusion proteins with green fluorescent protein. 
  • Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis. 
  • Questionable relevance of gamma delta T lymphocytes in renal cell carcinoma. 
  • Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies. 
  • Recognition by human gut gamma delta cells of stress inducible major histocompatibility molecules on enterocytes. 
  • Regulation of CD8(+) T cell functions by RARgamma. 
  • Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. 
  • Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. 
  • Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II. 
  • Robust vaccine-elicited cellular immune responses in breast milk following systemic simian immunodeficiency virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys. 
  • STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. 
  • Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB. 
  • Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. 
  • Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells. 
  • Status of activation of circulating vaccine-elicited CD8+ T cells. 
  • Status of colon cancer vaccines. [An interview with Michael Morse by H&O]. 
  • Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. 
  • T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation. 
  • T helper subsets in allergic eye disease. 
  • T-Cell receptor Vbeta repertoire CDR3 length diversity differs within CD45RA and CD45RO T-cell subsets in healthy and human immunodeficiency virus-infected children. 
  • T-bet-dependent expression of osteopontin contributes to T cell polarization. 
  • Th17 cells are long lived and retain a stem cell-like molecular signature. 
  • Th2 cells: orchestrating barrier immunity. 
  • The IFN pregnancy recognition hormone IFN-tau blocks both development and superantigen reactivation of experimental allergic encephalomyelitis without associated toxicity. 
  • The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The effects of donor-specific blood transfusion enhancement of rat renal allografts on cytotoxic activity and phenotypes of peripheral blood lymphocytes, splenocytes, and graft-infiltrating cells. 
  • The impact of HIV-1 infection on phenotypic and functional parameters of cellular immunity in chimpanzees. 
  • The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells. 
  • Thymic involution and immune reconstitution. 
  • Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes. 
  • Thymus transplantation in complete DiGeorge anomaly. 
  • Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly. 
  • Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. 
  • Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination. 
  • Transcriptional analysis of tumor-specific T-cell responses in cancer patients. 
  • Transfer of CD8+ T cell memory using Bcl-2 as a marker. 
  • Type 17 CD8+ T cells display enhanced antitumor immunity. 
  • Unexpected role of clathrin adaptor AP-1 in MHC-dependent positive selection of T cells. 
  • [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. 
  • [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. 
  • [Lymphocyte subpopulations in spleen and blood after early wound debridement and acute/chronic treatment with hyperbaric oxygen]. 
  • beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct. 
  • gamma delta cells in gut infection, immunopathology, and organogenesis. 
  • gammadelta T cells are a component of early immunity against preerythrocytic malaria parasites. 
  • gammadelta cells and the regulation of mucosal immune responses. 
  • polyethylene glycol-conjugated adenosine deaminase (ADA) therapy provides temporary immune reconstitution to a child with delayed-onset ADA deficiency. 
  • γδ T Cells and B Cells. 
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  Keywords of People

  • Chen, Jun, Associate Professor of Medicine, Duke Cancer Institute
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • Cunningham, Coleen Kathryn, Professor of Pediatrics, Pathology
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Krangel, Michael S., Mary Bernheim Professor of Immunology, Immunology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology
  • Zhong, Xiaoping, Professor of Pediatrics, Immunology