Receptors, N-Methyl-D-Aspartate

• 

  Subject Areas on Research

  • A Monte Carlo model reveals independent signaling at central glutamatergic synapses. 
  • A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. 
  • A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. 
  • A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain. 
  • AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons. 
  • Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. 
  • Activity dependent localization of synaptic NMDA receptors in spinal neurons. 
  • Adolescent Ethanol Exposure Enhances NMDA Receptor-Mediated Currents in Hippocampal Neurons: Reversal by Gabapentin. 
  • Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults. 
  • Altered prefrontal dopaminergic function in chronic recreational ketamine users. 
  • Alzheimer's disease and the glutamate NMDA receptor. 
  • Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling. 
  • An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats. 
  • An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro. 
  • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. 
  • Androgens modulate NMDA receptor-mediated EPSCs in the zebra finch song system. 
  • Angiotensin protects cortical neurons from hypoxic-induced apoptosis via the angiotensin type 2 receptor. 
  • Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models. 
  • Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. 
  • Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. 
  • Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways. 
  • Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. 
  • Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. 
  • Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Autoimmune Encephalitis: NMDA Receptor Encephalitis as an Example of Translational Neuroscience. 
  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • Autoreceptor regulation of glutamate and aspartate release from slices of the hippocampal CA1 area. 
  • Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors. 
  • Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. 
  • Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel. 
  • Blockade of NMDA receptors in the dorsomedial striatum prevents action-outcome learning in instrumental conditioning. 
  • Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. 
  • Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini. 
  • Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure. 
  • Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. 
  • Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. 
  • Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response. 
  • Comparative cardiovascular safety of dementia medications: a cross-national study. 
  • Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. 
  • Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds. 
  • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 
  • D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response. 
  • Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats. 
  • Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats. 
  • Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. 
  • Development of intrinsic and synaptic properties in a forebrain nucleus essential to avian song learning. 
  • Developmental increase in the sensitivity to magnesium of NMDA receptors on CA1 hippocampal pyramidal cells. 
  • Developmental modification of synaptic NMDAR composition and maturation of glutamatergic synapses: matching postsynaptic slots with receptor pegs 
  • Differential effect of ethanol on NMDA EPSCs in pyramidal cells in the posterior cingulate cortex of juvenile and adult rats. 
  • Differential expression of GABA and glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. 
  • Differential expression of glutamate receptors in avian neural pathways for learned vocalization. 
  • Differential sensitivity of NMDA receptor-mediated synaptic potentials to ethanol in immature versus mature hippocampus. 
  • Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons. 
  • Difficult behaviors in long-term care patients with dementia. 
  • Difficult behaviors in long-term care patients with dementia. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities? 
  • Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. 
  • Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. 
  • Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline. 
  • Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate. 
  • Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats. 
  • Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions. 
  • Effects of NMDA receptor antagonists and body temperature in the gerbil carotid occlusion model of transient forebrain ischemia. 
  • Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat. 
  • Effects of adolescent intermittent ethanol on hippocampal expression of glutamate homeostasis and astrocyte-neuronal tethering proteins in male and female rats. 
  • Effects of calcium channel inhibitors on the hypothermic response to oxotremorine in normo and hypercholinergic rats. 
  • Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference. 
  • Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials. 
  • Effects of mRNA untranslated regions on translational efficiency of NMDA receptor subunits. 
  • Effects of neuromodulation in a cortical network model of object working memory dominated by recurrent inhibition. 
  • Effects of prenatal ethanol exposure on hippocampal ionotropic-quisqualate and kainate receptors. 
  • Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. 
  • Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. 
  • Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. 
  • Endogenous opioids regulate long-term potentiation of synaptic inhibition in the dentate gyrus of rat hippocampus. 
  • Enhancement of transmission at the developing retinogeniculate synapse. 
  • Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding. 
  • Excitatory amino acid receptors and epilepsy. 
  • Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons. 
  • Expression of PSD-95/SAP90 is critical for N-methyl-D-aspartate receptor-mediated thermal hyperalgesia in the spinal cord. 
  • Familiarity Detection is an Intrinsic Property of Cortical Microcircuits with Bidirectional Synaptic Plasticity. 
  • Fulfilling Koch's postulates of autoimmunity: anti-NR2 antibodies in mice and men. 
  • GABAB receptors mediate disinhibition and facilitate long-term potentiation in the dentate gyrus. 
  • GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. 
  • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. 
  • Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. 
  • Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation. 
  • Glycine regulation of the N-methyl-D-aspartate receptor-gated ion channel in hippocampal membranes. 
  • Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. 
  • Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. 
  • Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. 
  • Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death. 
  • Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine. 
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. 
  • Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. 
  • In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. 
  • Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus. 
  • Increased spontaneous unit activity and appearance of spontaneous negative potentials in the goldfish tectum during refinement of the optic projection. 
  • Independent sources of quantal variability at single glutamatergic synapses. 
  • Induction and reversal of long-term potentiation by low- and high-intensity theta pattern stimulation. 
  • Induction and reversal of long-term potentiation by low- and high-intensity theta pattern stimulation. 
  • Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. 
  • Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. 
  • Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. 
  • Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways. 
  • Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? 
  • Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. 
  • Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons. 
  • Kindling reduces sensitivity of CA3 hippocampal pyramidal cells to competitive NMDA receptor antagonists. 
  • Kindling, prenatal exposure to ethanol and postnatal development selectively alter responses of hippocampal pyramidal cells to NMDA. 
  • LTP in the mouse nucleus accumbens is developmentally regulated. 
  • Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy. 
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor. 
  • Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain. 
  • Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels. 
  • MK-801 impedes the acquisition of a spatial memory task in rats. 
  • MK-801 potently inhibits alcohol withdrawal seizures in rats. 
  • Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. 
  • Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain. 
  • Measurement of NMDA receptor protein subunits in discrete hippocampal regions of kindled animals. 
  • Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death. 
  • Mechanisms of specificity in neuronal activity-regulated gene transcription. 
  • Minocycline attenuates mechanical allodynia and expression of spinal NMDA receptor 1 subunit in rat neuropathic pain model. 
  • Modulation of NMDA and AMPA-mediated synaptic transmission by CB1 receptors in frontal cortical pyramidal cells. 
  • Molecular mechanisms of glutamate receptor clustering at excitatory synapses. 
  • Monoaminergic dysregulation in glutathione-deficient mice: possible relevance to schizophrenia? 
  • Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation. 
  • N-methyl-D-aspartate receptor autoradiography in rat brain after angular bundle kindling. 
  • N-methyl-D-aspartate receptor binding in brains of rats at different ages. 
  • N-methyl-D-aspartate receptor plasticity in kindling: quantitative and qualitative alterations in the N-methyl-D-aspartate receptor-channel complex. 
  • N-methyl-D-aspartate receptor regulation of uncompetitive antagonist binding in rat brain membranes: kinetic analysis. 
  • N-methyl-D-aspartate receptor-dependent denitrosylation of neuronal nitric oxide synthase increase the enzyme activity. 
  • N-methyl-D-aspartate receptors activate transcription of c-fos and NGFI-A by distinct phospholipase A2-requiring intracellular signaling pathways. 
  • N-methyl-D-aspartate receptors strongly regulate postsynaptic activity levels during optic nerve regeneration. 
  • NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. 
  • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. 
  • NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes. 
  • NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. 
  • NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. 
  • NMDA receptor plasticity in the kindling model. 
  • NMDA receptor-mediated depolarizing action of proline on CA1 pyramidal cells. 
  • NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • NMDA-glutamate receptors regulate phosphorylation of dendritic cytoskeletal proteins in the hippocampus. 
  • Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome. 
  • Neuroprotection by nitrous oxide and xenon and its relation to minimum alveolar concentration. 
  • Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled. 
  • Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration. 
  • Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors. 
  • Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade. 
  • Nitroxyl anion regulation of the NMDA receptor. 
  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. 
  • Opioid-mediated facilitation of long-term potentiation at the lateral perforant path-dentate granule cell synapse. 
  • Opposing action of conantokin-G on synaptically and extrasynaptically-activated NMDA receptors. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Overexpression of human NR2B receptor subunit in LMAN causes stuttering and song sequence changes in adult zebra finches. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Pharmacologically defined components of the normal porcine multifocal ERG. 
  • Plasticity and behavior: new genetic techniques to address multiple forms and functions. 
  • Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. 
  • Polyamine metabolism in different pathological states of the brain. 
  • Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor. 
  • Post-lesion administration of the NMDA receptor antagonist MK-801 does not impair motor recovery after unilateral sensorimotor cortex injury in the rat. 
  • Post-transcriptional regulation of gene expression in hippocampal neurons by glutamate receptor activation. 
  • Postischemic synaptic excitation and N-methyl-D-aspartate receptor activation in gerbils. 
  • Postischemic synaptic physiology of CA1 hippocampal pyramidal cells. 
  • Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs. 
  • Postsynaptic response to stimulation of the Schaffer collaterals with properties similar to those of synaptosomal aspartate release. 
  • Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats. 
  • Prenatal choline supplementation protects against postnatal neurotoxicity. 
  • Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. 
  • Proline-induced potentiation of glutamate transmission. 
  • Prostaglandin F2alpha is required for NMDA receptor-mediated induction of c-fos mRNA in dentate gyrus neurons. 
  • Radiohistochemical demonstration of NMDA/glycine-channel activation in rat hippocampus. 
  • Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth. 
  • Redox regulation of neuronal migration in a Down Syndrome model. 
  • Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. 
  • Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. 
  • Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain. 
  • Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil. 
  • Regulation of alternative splicing of NMDAR1 in the kindling model. 
  • Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. 
  • Regulation of synaptic strength by protein phosphatase 1. 
  • Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat. 
  • Release of glutamate and aspartate from CA1 synaptosomes: selective modulation of aspartate release by ionotropic glutamate receptor ligands. 
  • Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. 
  • Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation. 
  • Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. 
  • Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors. 
  • Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation. 
  • Role of analgesic adjuncts in postoperative pain management. 
  • Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia. 
  • Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial. 
  • Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. 
  • Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals. 
  • Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. 
  • Serotonin depletion exacerbates changes in striatal gene expression following quinolinic acid injection. 
  • Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain. 
  • Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. 
  • Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons. 
  • Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments. 
  • Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. 
  • Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. 
  • Structural conservation of ion conduction pathways in K channels and glutamate receptors. 
  • Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats. 
  • Synapse-specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex. 
  • Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex. 
  • Synaptic basis for developmental plasticity in a birdsong nucleus. 
  • Synaptic connections from multiple subfields contribute to granule cell hyperexcitability in hippocampal slice cultures. 
  • Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. 
  • Synaptic plasticity in morphologically identified CA1 stratum radiatum interneurons and giant projection cells. 
  • Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. 
  • TCP binding: a tool for studying NMDA receptor-mediated neurotransmission in kindling. 
  • TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5. 
  • TRPC6 expression in neurons is differentially regulated by NR2A- and NR2B-containing NMDA receptors. 
  • TRPing into excitotoxic neuronal death. 
  • Thalamic relay of spontaneous retinal activity prior to vision. 
  • The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation. 
  • The HVC microcircuit: the synaptic basis for interactions between song motor and vocal plasticity pathways. 
  • The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. 
  • The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening. 
  • The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. 
  • The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription. 
  • The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor. 
  • The development of excitatory synapses in cultured spinal neurons. 
  • The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. 
  • The genesis of seizures in vitro: axon terminal excitability. 
  • The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. 
  • The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. 
  • The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice. 
  • The role of NMDA receptors in in vitro epileptogenesis. 
  • The role of the N-methyl-D-aspartate receptor in Alzheimer's disease: therapeutic potential. 
  • Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs. 
  • Two affinity states of N-methyl-D-aspartate recognition sites: modulation by cations. 
  • Two patients with an anti-N-methyl-D-aspartate receptor antibody syndrome-like presentation and negative results of testing for autoantibodies. 
  • Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel. 
  • Ventral hippocampal NMDA blockade and nicotinic effects on memory function. 
  • What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance. 
  • Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. 
  • [The influence of labyrinthectomy on the expression of NMDA R1 mRNA]. 
  • beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
  • pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH. 
  • β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. 
• 

  Keywords of People

  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society
  • Jabba, Sairam V., Research Scientist, Anesthesiology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology