Fibroblast Growth Factor 2

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  Subject Areas on Research

  • A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits. 
  • A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. 
  • Adipose stem cell crosstalk with chemo-residual breast cancer cells: implications for tumor recurrence. 
  • An avian model for the reversal of neurobehavioral teratogenicity with neural stem cells. 
  • An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. 
  • Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury. 
  • Atrial natriuretic polypeptide as a novel antigrowth factor of endothelial cells. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Basic fibroblast growth factor expression following surgical delay of rat transverse rectus abdominis myocutaneous flaps. 
  • Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. 
  • Basic fibroblast growth factor is upregulated in hibernating myocardium. 
  • Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons. 
  • Bi-directional migration of lens epithelial cells in a physiological electrical field. 
  • Biological activity of interleukin-10 in the central nervous system. 
  • Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. 
  • Characterization of the murine BEK fibroblast growth factor (FGF) receptor: activation by three members of the FGF family and requirement for heparin. 
  • Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. 
  • Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. 
  • Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. 
  • Conotruncal myocardium arises from a secondary heart field. 
  • Control protocol for robust in vitro glial scar formation around microwires: essential roles of bFGF and serum in gliosis. 
  • Corneal penetration of topical and subconjunctival bevacizumab. 
  • Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. 
  • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 
  • Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. 
  • Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: I. Experimental characterizations. 
  • Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations. 
  • Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. 
  • Effect of basic fibroblast growth factor on myocardial angiogenesis in dogs with mature collateral vessels. 
  • Effects of a single intracoronary injection of basic fibroblast growth factor in stable angina pectoris. 
  • Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • FGF2 suppresses neuronogenesis of a cell line derived from rat olfactory epithelium. 
  • FGF23 induces left ventricular hypertrophy. 
  • Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients. 
  • Fibroblast growth factors regulate calcitonin gene-related peptide mRNA expression in rat motoneurons after lesion and in culture. 
  • Fluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endothelium. 
  • Heparanase and platelet factor-4 induce smooth muscle cell proliferation and migration via bFGF release from the ECM. 
  • Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism. 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules. 
  • Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. 
  • Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. 
  • Intracoronary basic fibroblast growth factor enhances myocardial collateral perfusion in dogs. 
  • Intramyocardial and intracoronary basic fibroblast growth factor in porcine hibernating myocardium: a comparative study. 
  • Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats. 
  • Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. 
  • Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons. 
  • Neurogenic differentiation of murine and human adipose-derived stromal cells. 
  • Neuronal regulation of the spatial patterning of neurogenesis. 
  • Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage. 
  • Novel heparanase-inhibiting antibody reduces neointima formation. 
  • Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. 
  • Overexpression of basic fibroblast growth factor (FGF-2) downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • Pharmacodynamics of basic fibroblast growth factor: route of administration determines myocardial and systemic distribution. 
  • Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma. 
  • Phase I study of recombinant human endostatin in patients with advanced solid tumors. 
  • Prenatal stress elicits regionally selective changes in basal FGF-2 gene expression in adulthood and alters the adult response to acute or chronic stress. 
  • Prevention of restenosis by gene therapy. 
  • Prominent expression of bFGF in dorsal root ganglia after axotomy. 
  • Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. 
  • Regulation of blood vessel versus lymphatic vessel growth in the cornea. 
  • Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. 
  • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. 
  • Responses of vascular endothelial cells to angiogenic signaling are important for tumor cell survival. 
  • Role of AP-1 complex in angiotensin II-mediated transforming growth factor-beta expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. 
  • Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors. 
  • Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing. 
  • Serum protein expression predicts recurrence in patients with early-stage lung cancer after resection. 
  • Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. 
  • Testis development requires the repression of Wnt4 by Fgf signaling. 
  • The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells. 
  • Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF. 
  • Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition. 
  • Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma. 
  • Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients: a cancer and leukemia group B study. 
  • aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology