Endothelins
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Subject Areas on Research
- A vasoactive peptide, endothelin-3, is produced by and specifically binds to primary astrocytes.
- Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators.
- Analysis of responses to big endothelin in the hindquarters vascular bed of the cat.
- Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.
- Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans.
- Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest.
- Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban.
- Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels.
- Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat.
- Endothelin activates voltage-dependent Ca2+ current by a G protein-dependent mechanism in rabbit cardiac myocytes.
- Endothelin-1 induces an increase in total protein synthesis and expression of the smooth muscle alpha-actin gene in vascular smooth muscle cells.
- Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension.
- Hypercholesterolemia and experimental vein grafts: accelerated development of intimal hyperplasia and an increase in abnormal vasomotor function.
- Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes.
- Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed.
- Inhibitory effects of DuP 753 and EXP3174 on responses to angiotensin II in pulmonary vascular bed of the cat.
- Plasma endothelin in chronic heart failure.
- Posttransplant diastolic hypertension: associations with intragraft transforming growth factor-beta, endothelin, and renin transcription.
- Pulmonary vascular and airway responses to endothelin-1 are mediated by different mechanisms in the cat.
- Remodeling and reparation of the cardiovascular system.
- Response of pulpal blood flow to intra-arterial infusion of endothelin.
- Selective activation of human atrial Galpha12 and Galpha13 by Galphaq-coupled angiotensin and endothelin receptors.
- Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion.
- Targeting heart failure therapeutics: a historical perspective.
- Tezosentan in patients with acute heart failure and acute coronary syndromes: design of the Randomized Intravenous Tezosentan study (RITZ-4).
- The effect of endothelin-1 on muscle microcirculation and its attenuation by verapamil.
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Keywords of People
- O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology