Guanosine 5'-O-(3-Thiotriphosphate)
-
Subject Areas on Research
- A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol.
- Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.
- An effector site that stimulates G-protein GTPase in photoreceptors.
- Arachidonate and related unsaturated fatty acids selectively inactivate the guanine nucleotide-binding regulatory protein, Gz.
- Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
- Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.
- Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins.
- CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages.
- Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues.
- Characteristics of GTP-mediated microsomal Ca2+ release.
- Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver.
- Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
- Cross-desensitization among receptors for platelet activating factor and peptide chemoattractants. Evidence for independent regulatory pathways.
- Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity.
- Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation.
- Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
- Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase.
- Enhanced morphine analgesia in mice lacking beta-arrestin 2.
- Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion.
- Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
- Functional consequences of A1 adenosine-receptor phosphorylation by the beta-adrenergic receptor kinase.
- Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles.
- G alpha t/G alpha i1 chimeras used to define structural basis of specific functions of G alpha t.
- G protein involvement in receptor-effector coupling.
- G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.
- G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
- Gz, a guanine nucleotide-binding protein with unique biochemical properties.
- Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.
- Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets.
- Inhibition of cardiac Na+ currents by isoproterenol.
- Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.
- Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages.
- Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
- Molecular determinants of selectivity in 5-hydroxytryptamine1B receptor-G protein interactions.
- Monitor peptide binding sites are expressed in the rat liver and small intestine.
- Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
- Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.
- Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.
- Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse.
- Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.
- Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.
- Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.
- Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle.
- Rac1, a low-molecular-mass GTP-binding-protein with high intrinsic GTPase activity and distinct biochemical properties.
- Role for the target enzyme in deactivation of photoreceptor G protein in vivo.
- Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium.
- Secretin receptors in a new preparation of plasma membranes from intrahepatic biliary epithelium.
- Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch.
- Specific peptide probes for G-protein interaction with effectors.
- Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
- Structural and functional studies of cyclic GMP phosphodiesterase.
- Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant.
- The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit.
- The formylpeptide chemoattractant receptor copurifies with a GTP-binding protein containing a distinct 40-kDa pertussis toxin substrate.
- The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.
- The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.
- Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.
- Upregulation of macrophage plasma membrane and nuclear phospholipase D activity on ligation of the alpha2-macroglobulin signaling receptor: involvement of heterotrimeric and monomeric G proteins.
- beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
-
Keywords of People
- Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology