Dizocilpine Maleate

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  Subject Areas on Research

  • Acute effects of MK801 on kainic acid-induced seizures in neonatal rats. 
  • Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. 
  • Amino acid determinants for NMDA receptor inhibition by conantokin-T. 
  • An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats. 
  • Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Attention-modulating effects of cognitive enhancers. 
  • Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats. 
  • Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. 
  • Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats. 
  • Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding. 
  • Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response. 
  • Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA. 
  • Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. 
  • Decreased hyperthermic effect of MK-801 in selectively bred hypercholinergic rats. 
  • Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats. 
  • Differential effects of the antidepressant mirtazapine on amphetamine- and dizocilpine-induced PPI deficits. 
  • Dynorphin A increases substance P release from trigeminal primary afferent C-fibers. 
  • Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats. 
  • Effects of MK-801 on DNA synthesis in neonatal rat brain regions under normoxic and hypoxic conditions. 
  • Effects of NMDA receptor antagonists and body temperature in the gerbil carotid occlusion model of transient forebrain ischemia. 
  • Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat. 
  • Effects of ethanol, MK-801, and chlordiazepoxide on locomotor activity in different rat lines: dissociation of locomotor stimulation from ethanol preference. 
  • Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. 
  • Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures. 
  • Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. 
  • Glycine antagonism does not block ischemic spontaneous depolarization in the rat. 
  • Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms. 
  • Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. 
  • Idazoxan blocks the nicotine-induced reversal of the memory impairment caused by the NMDA glutamate receptor antagonist dizocilpine. 
  • Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. 
  • Improvement of attentional function with antagonism of nicotinic receptors in female rats. 
  • Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. 
  • Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T. 
  • Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. 
  • Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain. 
  • MK-801 impedes the acquisition of a spatial memory task in rats. 
  • MK-801 potently inhibits alcohol withdrawal seizures in rats. 
  • Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death. 
  • Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. 
  • MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. 
  • N-methyl-D-aspartate receptor binding in brains of rats at different ages. 
  • NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. 
  • NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. 
  • NMDA receptor dependence of kindling and mossy fiber sprouting: evidence that the NMDA receptor regulates patterning of hippocampal circuits in the adult brain. 
  • NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function. 
  • NMDA-Receptor-dependent synaptic activation of voltage-dependent calcium channels in basolateral amygdala. 
  • NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. 
  • Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. 
  • Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. 
  • Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade. 
  • Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats. 
  • Nicotine-dizocilpine interactions and working and reference memory performance of rats in the radial-arm maze. 
  • Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats. 
  • Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. 
  • Opposite modulation of capsaicin-evoked substance P release by glutamate receptors. 
  • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. 
  • Persistent behavioral alterations in rats neonatally exposed to low doses of the organophosphate pesticide, parathion. 
  • Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction. 
  • Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor. 
  • Post-ischemic RSR13 amplifies the effect of dizocilpine on outcome from transient focal cerebral ischemia in the rat. 
  • Post-lesion administration of the NMDA receptor antagonist MK-801 does not impair motor recovery after unilateral sensorimotor cortex injury in the rat. 
  • Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. 
  • Prenatal choline supplementation protects against postnatal neurotoxicity. 
  • Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat. 
  • Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. 
  • Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain. 
  • Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil. 
  • Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat. 
  • Role of nicotinic receptors in the lateral habenula in the attenuation of amphetamine-induced prepulse inhibition deficits of the acoustic startle response in rats. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats. 
  • The drug MK-801 attenuates the development, but not the expression, of long-term potentiation and stimulus train-induced bursting in hippocampal slices. 
  • The α₂-adrenergic antagonist idazoxan counteracts prepulse inhibition deficits caused by amphetamine or dizocilpine in rats. 
  • Ventral hippocampal NMDA blockade and nicotinic effects on memory function. 
  • Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
  • β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. 
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  Keywords of People

  • Bradford, Daniel William, Associate Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Social and Community Psychiatry
  • Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology