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Subject Areas on Research
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1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway.
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A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
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A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation.
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A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae.
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A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans.
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A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.
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A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.
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A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.
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A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity.
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A fast neutron deletion mutagenesis-based reverse genetics system for plants
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A feedback loop in the polo-like kinase activation pathway.
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A functional analysis of the spacer of V(D)J recombination signal sequences.
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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia.
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A model for RAS mutation patterns in cancers: finding the sweet spot.
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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.
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A negative coregulator for the human ER.
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A new role for phytochromes in temperature-dependent germination.
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A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity.
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A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.
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A role for the Pkc1p/Mpk1p kinase cascade in the morphogenesis checkpoint.
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A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.
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A single stem-loop structure within the HTLV-1 Rex response element is sufficient to mediate Rex activity in vivo.
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A surface of Escherichia coli sigma 70 required for promoter function and antitermination by phage lambda Q protein.
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A system of transposon mutagenesis for bacteriophage T4.
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A yeast TATA-binding protein mutant that selectively enhances gene expression from weak RNA polymerase II promoters.
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APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses.
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
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Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells.
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Abundant gene conversion between arms of palindromes in human and ape Y chromosomes.
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Advancing Functional Genetics Through Agrobacterium-Mediated Insertional Mutagenesis and CRISPR/Cas9 in the Commensal and Pathogenic Yeast Malassezia.
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Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.
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An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15.
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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
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An effector site that stimulates G-protein GTPase in photoreceptors.
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An inner activation gate controls TMEM16F phospholipid scrambling.
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Analysis of SCARECROW expression using a rapid system for assessing transgene expression in Arabidopsis roots.
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Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
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Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors.
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Analysis of recombinant Phex: an endopeptidase in search of a substrate.
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Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.
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Antibody response to a T-dependent antigen requires B cell expression of complement receptors.
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Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
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Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains.
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Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia.
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Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase'.
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Atomic structures of excited state A-T Hoogsteen base pairs in duplex DNA by combining NMR relaxation dispersion, mutagenesis, and chemical shift calculations.
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Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin.
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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice.
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Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.
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Bimodal activation of SMC ATPase by intra- and inter-molecular interactions.
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Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis.
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Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol.
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Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.
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Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis.
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CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes.
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Calcineurin is required for virulence of Cryptococcus neoformans.
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Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.
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Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells.
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Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish.
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Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types.
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Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis.
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Checkpoint controls and cancer. Introduction.
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Chromosomes with high gene density are preferentially repaired in human cells.
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Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
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Combinatorial mutagenesis of the reactive site region in plasminogen activator inhibitor I.
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Comparative evolutionary analysis of chalcone synthase and alcohol dehydrogenase loci in Arabidopsis, Arabis, and related genera (Brassicaceae).
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Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes.
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Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
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Computational design of a Zn2+ receptor that controls bacterial gene expression.
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Computational design of receptors for an organophosphate surrogate of the nerve agent soman.
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Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
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Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties.
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Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor.
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Construction of a fluorescent biosensor family.
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Construction of new ligand binding sites in proteins of known structure. I. Computer-aided modeling of sites with pre-defined geometry.
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Contribution of a 28-kilodalton membrane protein to the virulence of Haemophilus influenzae.
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Converting a maltose receptor into a nascent binuclear copper oxygenase by computational design.
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Coupled mutagenesis screens and genetic mapping in zebrafish.
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Cryo-EM structure of a mitochondrial calcium uniporter.
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Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.
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Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans.
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Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.
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Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii.
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DNA polymerase zeta introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae.
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DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis.
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Data and animal management software for large-scale phenotype screening.
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De novo engineering of intracellular condensates using artificial disordered proteins.
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Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells.
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Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.
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Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus.
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Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.
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Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).
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Determinants of molecular motor directionality.
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Determination of mitotic recombination rates by fluctuation analysis in Saccharomyces cerevisiae.
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Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8.
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Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.
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Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
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Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.
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Dissection of the protein G B1 domain binding site for human IgG Fc fragment.
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Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate.
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Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu.
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Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells.
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Dynamic basis for dG•dT misincorporation via tautomerization and ionization.
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ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit.
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Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae.
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Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences.
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Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.
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Electron transfer in the photosynthetic reaction center: mechanistic implications of mutagenesis studies.
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Elevated frequency of microsatellite mutations in TK6 human lymphoblast clones selected for mutations at the thymidine kinase locus.
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Endogenous RGS proteins attenuate Galpha(i)-mediated lysophosphatidic acid signaling pathways in ovarian cancer cells.
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Epistatic roles for Pseudomonas aeruginosa MutS and DinB (DNA Pol IV) in coping with reactive oxygen species-induced DNA damage.
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Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase.
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Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene.
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Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.
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Experimental determination of rates of concerted evolution.
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Formaldehyde-induced mutagenesis in Saccharomyces cerevisiae: molecular properties and the roles of repair and bypass systems.
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Forward and Reverse Genetic Analysis of Chlamydia.
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Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae.
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Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling.
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Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
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Functions of fission yeast orp2 in DNA replication and checkpoint control.
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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.
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Gene disruption with PCR products in Saccharomyces cerevisiae.
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Gene targeting of a CFTR allele in HT29 human epithelial cells.
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Genetic evidence for long-term population decline in a savannah-dwelling primate: inferences from a hierarchical bayesian model.
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Genetic evidence that the endodermis is essential for shoot gravitropism in Arabidopsis thaliana.
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Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins.
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Genomic sequencing-based mutational enrichment analysis identifies motility genes in a genetically intractable gut microbe.
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Global transcriptional and proteomic analysis of the Sig1 heat shock regulon of Deinococcus radiodurans.
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Glycosaminoglycan binding properties of natural venezuelan equine encephalitis virus isolates.
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Group I intron self-splicing with adenosine: evidence for a single nucleoside-binding site.
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HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.
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Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.
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Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4.
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Hedgehog signaling patterns mesoderm in the sea urchin.
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High-frequency S-layer protein variation in Campylobacter fetus revealed by sapA mutagenesis.
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Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.
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Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
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Hot Spot Mutagenesis Improves the Functional Expression of Unique Mammalian Odorant Receptors.
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Hrp pilus: an hrp-dependent bacterial surface appendage produced by Pseudomonas syringae pv. tomato DC3000.
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Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag.
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Human mitochondrial DNA polymerase gamma exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers
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Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody.
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Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity.
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Identification and characterization of the sodium-binding site of activated protein C.
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Identification of a negative regulatory function for steroid receptors.
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Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor.
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Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis.
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Imidazole rescue of a cytosine mutation in a self-cleaving ribozyme.
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Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
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In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis.
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In vivo mutagenesis of the reporter plasmid pSP189 induced by exposure of host Ad293 cells to activated polymorphonuclear leukocytes.
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In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors.
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Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta.
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Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins.
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Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts.
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Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake.
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Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1.
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Initial sequencing and comparative analysis of the mouse genome.
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Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
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Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.
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Integrating chemical mutagenesis and whole-genome sequencing as a platform for forward and reverse genetic analysis of Chlamydia.
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Interactions between dystrophin and the sarcolemma membrane.
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Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage.
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Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association.
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Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast.
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Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function.
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Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae.
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Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.
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Loss-of-function genetic tools for animal models: cross-species and cross-platform differences.
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MYB36 regulates the transition from proliferation to differentiation in the Arabidopsis root.
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Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis.
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Mechanism of Reduction of an Aminyl Radical Intermediate in the Radical SAM GTP 3',8-Cyclase MoaA.
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Mechanism of intracellular allosteric β2
AR antagonist revealed by X-ray crystal structure.
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Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel.
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Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.
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Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners.
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MicroRNA antagonism of the picornaviral life cycle: alternative mechanisms of interference.
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Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes.
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Mitochondrial DNA Mutagenesis: Feature of and Biomarker for Environmental Exposures and Aging.
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Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury.
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Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.
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Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools.
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Molecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolates.
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Molecular biology techniques and their applicability to the study of diabetes and hypertension: the renin-angiotensin system as an example.
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Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling.
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Multidrug-binding transcription factor QacR binds the bivalent aromatic diamidines DB75 and DB359 in multiple positions.
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Mutagenesis and the three R's in yeast.
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Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species.
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Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function.
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Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates.
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Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus.
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Mutagenic effects of abasic and oxidized abasic lesions in Saccharomyces cerevisiae.
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Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I.
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Mutants of the Drosophila ncd microtubule motor protein cause centrosomal and spindle pole defects in mitosis.
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Mutants of the EcoRI endonuclease with promiscuous substrate specificity implicate residues involved in substrate recognition.
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Mutational fingerprints of aging.
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Mutational hotspots in the mitochondrial genome of lung cancer.
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Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.
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Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.
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N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo.
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Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.
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Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
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Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice.
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Novel disulfide engineering in human carbonic anhydrase II using the PAIRWISE side-chain geometry database.
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Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
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Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy.
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Optimized regimen for expression of heat-inducible Cre in mice.
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Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae.
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Pan-cancer analysis of whole genomes.
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Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
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Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.
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Physiological genomics: implications in hypertension research.
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Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass.
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Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
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Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis.
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Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
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REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks.
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RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila.
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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
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Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish.
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Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.
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Recombination-dependent DNA replication stimulated by double-strand breaks in bacteriophage T4.
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Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers.
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Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.
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Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.
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Reliability of mutagen sensitivity assay: an inter-laboratory comparison.
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Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae.
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Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes.
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Rev7 loss alters cisplatin response and increases drug efficacy in chemotherapy-resistant lung cancer.
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Ribonucleotides and Transcription-Associated Mutagenesis in Yeast.
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Role for topoisomerase 1 in transcription-associated mutagenesis in yeast.
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Role of MotA transcription factor in bacteriophage T4 DNA replication.
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Role of Pseudomonas aeruginosa dinB-encoded DNA polymerase IV in mutagenesis.
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Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.
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Role of proliferating cell nuclear antigen interactions in the mismatch repair-dependent processing of mitotic and meiotic recombination intermediates in yeast.
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Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae.
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Roles of exonucleases and translesion synthesis DNA polymerases during mitotic gap repair in yeast.
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Sequence requirements for micro RNA processing and function in human cells.
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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program.
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Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.
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Simultaneous genotyping and species identification using hybridization pattern recognition analysis of generic Mycobacterium DNA arrays.
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Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability.
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Specific peptide probes for G-protein interaction with effectors.
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Stretching single molecules into novel conformations using the atomic force microscope.
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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.
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Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor.
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Structure-guided reprogramming of serine recombinase DNA sequence specificity.
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Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.
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Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock.
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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
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The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway.
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The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice.
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The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus.
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The Oct-2 transcription factor represses tyrosine hydroxylase expression via a heptamer TAATGARAT-like motif in the gene promoter.
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The Pseudomonas syringae pv. tomato HrpW protein has domains similar to harpins and pectate lyases and can elicit the plant hypersensitive response and bind to pectate.
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The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.
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The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation.
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The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.
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The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.
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The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans.
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The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice.
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The developmental basis for germline mosaicism in mouse and Drosophila melanogaster.
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The effect of oxidative metabolism on spontaneous Pol zeta-dependent translesion synthesis in Saccharomyces cerevisiae.
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The effect of sequence context on spontaneous Polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
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The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions.
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The gene coding for the Hrp pilus structural protein is required for type III secretion of Hrp and Avr proteins in Pseudomonas syringae pv. tomato.
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The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis.
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The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region.
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The mechanism of nucleotide excision repair-mediated UV-induced mutagenesis in nonproliferating cells.
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The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats.
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The mismatch repair system promotes DNA polymerase zeta-dependent translesion synthesis in yeast.
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The organizer factors Chordin and Noggin are required for mouse forebrain development.
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The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.
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The rate of mitochondrial mutagenesis is faster in mice than humans.
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The role of Dbf4-dependent protein kinase in DNA polymerase ζ-dependent mutagenesis in Saccharomyces cerevisiae.
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The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype.
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The specificity of topoisomerase-mediated DNA cleavage defines acridine-induced frameshift specificity within a hotspot in bacteriophage T4.
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There is substantial agreement among interspecies estimates of DNA repair activity.
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Topoisomerase 1-dependent deletions initiated by incision at ribonucleotides are biased to the non-transcribed strand of a highly activated reporter.
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Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.
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Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication.
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Transcription-associated mutagenesis.
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Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.
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Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
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Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates.
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Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site.
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Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.
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Translocator proteins in the two-partner secretion family have multiple domains.
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Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro.
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Two distinct mechanisms of Topoisomerase 1-dependent mutagenesis in yeast.
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Two-dimensional gel analysis of rolling circle replication in the presence and absence of bacteriophage T4 primase.
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Unselected mutations in the human immunodeficiency virus type 1 genome are mostly nonsynonymous and often deleterious.
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Vertical transmission of multidrug-resistant human immunodeficiency virus type 1 (HIV-1) and continued evolution of drug resistance in an HIV-1-infected infant.
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Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.
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Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development.
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Yeast base excision repair: interconnections and networks.
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Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration.
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Keywords of People
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Bejsovec, Amy,
Associate Professor of Biology,
Biology
-
Bennett, Vann,
George Barth Geller Distinguished Professor of Molecular Biology,
Duke Cancer Institute
-
Erickson, Harold Paul,
Professor Emeritus of Cell Biology,
Cell Biology
-
Hogan, Brigid L. M.,
Research Professor of Cell Biology,
Cell Biology
-
Jinks-Robertson, Sue,
James B. Duke Distinguished Professor of Molecular Genetics and Microbiology,
Cell Biology
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Krangel, Michael S.,
George Barth Geller Distinguished Professor of Immunology,
Immunology