Extracellular Matrix Proteins
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Subject Areas on Research
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A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations.
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A mutation in cartilage oligomeric matrix protein (COMP) causes early-onset osteoarthritis in a large kindred study.
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A novel alternative splice domain in zebrafish tenascin-C.
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A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network.
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A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels.
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Abnormal extracellular material in the levator palpebrae superioris complex in congenital ptosis.
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Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians.
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Advances in bioengineered conduits for peripheral nerve regeneration.
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Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network.
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Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells.
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Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study.
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Analysis of the RELN gene as a genetic risk factor for autism.
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Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade.
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Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model.
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Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds.
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Assessment of the utility of biomarkers of osteoarthritis in the guinea pig.
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Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.
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Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.
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Astrocytes refine cortical connectivity at dendritic spines.
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Auditory and olfactory findings in patients with USH2A-related retinal degeneration-Findings at baseline from the rate of progression in USH2A-related retinal degeneration natural history study (RUSH2A).
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Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability.
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BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1.
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Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin.
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Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity.
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Biaxial strain effects on cells from the inner and outer regions of the meniscus.
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Biology of aortic aneurysms and dissections.
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Biology of vascular calcification in renal disease.
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Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.
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Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms?
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CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension.
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Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
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Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds.
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Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix.
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Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C.
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Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins.
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Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells.
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Characteristic features of granular deposit formation in granular corneal dystrophy type 2.
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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
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Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro.
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Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds.
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Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.
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Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc.
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Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow.
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Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades.
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Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC.
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Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern
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Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone.
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Deployment of extracellular matrix proteins in sea urchin embryogenesis.
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Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al.
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Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils.
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Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse.
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Differential response and withdrawal profile of glucocorticoid-treated human trabecular meshwork cells.
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Disentangling the genetics of lean mass.
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Disruption of mindin exacerbates cardiac hypertrophy and fibrosis.
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Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
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Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma.
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Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis.
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Double mutant fibrillin-1 (FBN1) allele in a patient with neonatal Marfan syndrome.
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Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.
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Echinonectin: a new embryonic substrate adhesion protein.
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Ectoderm cell--ECM interaction is essential for sea urchin embryo skeletogenesis.
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Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin.
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Elucidating the Molecular Composition of Cartilage by Proteomics.
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Endo16 is required for gastrulation in the sea urchin Lytechinus variegatus.
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Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin.
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Epithelial cells are an important source of tenascin in normal and malignant human breast tissue.
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Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project.
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Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin.
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Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain.
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Exacerbation of Avellino corneal dystrophy after laser in situ keratomileusis.
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Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia.
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Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway.
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Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.
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Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer.
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FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development.
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Fibulin-2 is a driver of malignant progression in lung adenocarcinoma.
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Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment.
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Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin.
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Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation.
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Gene expression studies in leiomyomata: new directions for research.
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Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins.
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Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin.
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Genetic basis of murine responses to hyperoxia-induced lung injury.
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Genetic comparisons yield insight into the evolution of enamel thickness during human evolution.
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Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).
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Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
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Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
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Global analysis of gene expression in renal ischemia-reperfusion in the mouse.
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Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells.
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Growth factor control of extracellular proteolysis.
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HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase.
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Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth.
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Hemicentin-mediated type IV collagen assembly strengthens juxtaposed basement membrane linkage.
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Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling.
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Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
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Identification of genes expressed in a human scleral cDNA library.
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Identification of the promoter region of the human betaIGH3 gene.
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Immunogold fine structural localization of extracellular matrix components in aged human cornea. I. Types I-IV collagen and laminin.
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Immunogold fine structural localization of extracellular matrix components in aged human cornea. II. Collagen types V and VI.
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Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate.
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In vitro biological activities of echinonectin.
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Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways.
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Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels.
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Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.
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Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis.
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Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma.
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Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture.
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Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels.
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Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk.
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Iris vasculopathy in exfoliation syndrome. An immunocytochemical study.
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
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Lithographic patterning of photoreactive cell-adhesive proteins.
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Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells.
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Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.
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Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer.
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Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
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Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor.
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Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.
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Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.
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Microarray analysis of gene expression in human donor sclera.
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Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis.
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Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo.
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Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition.
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Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA.
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More than skin deep: connecting melanocyte pigmentation and angiogenic diseases.
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Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.
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Mouse models of diabetic nephropathy.
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Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.
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Multiplex protein analysis to determine fibrosis stage and progression in patients with chronic hepatitis C.
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Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.
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Need radioprotection? A MEPE/OF45 mimetic may do the job.
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Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine.
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Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.
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Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells.
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PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells.
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PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.
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Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses.
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Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness.
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Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.
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Protein markers and differentiation in culture for Schlemm's canal endothelial cells.
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Protein modification by deamidation indicates variations in joint extracellular matrix turnover.
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Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity.
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Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH.
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Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids.
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Reelin signals survival through Src-family kinases that inactivate BAD activity.
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Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.
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Response of zonal chondrocytes to extracellular matrix-hydrogels.
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Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells.
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Role of hypoxia in inflammatory upper airway disease.
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Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma.
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Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis.
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Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology.
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Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.
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Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis.
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Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.
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Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease.
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Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction.
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Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP.
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Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin.
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Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.
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Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells.
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Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.
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Structural organization of the human insulin receptor ectodomain.
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Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
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Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.
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Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
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TGF-beta regulates expression of tenascin alternative-splicing isoforms in fetal rat lung.
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Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells.
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Tenascin expression in human glioma cell lines and normal tissues.
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Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma.
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Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion.
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Tenascin knockout mice: barrels, boundary molecules, and glial scars.
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Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis.
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Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments.
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Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions.
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The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue.
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The RUSH2A Study: Dark-Adapted Visual Fields in Patients With Retinal Degeneration Associated With Biallelic Variants in the USH2A Gene.
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The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants.
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The extracellular matrix protein agrin promotes heart regeneration in mice.
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The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
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The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace.
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The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment.
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The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis.
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The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants.
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The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.
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The micro-mechanics of single molecules studied with atomic force microscopy.
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The role of Gla proteins in vascular calcification.
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The role of integrins in saphenous vein vascular smooth muscle cell migration.
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The role of the extracellular matrix protein TGFBI in cancer.
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The role of the extracellular matrix protein mindin in airway response to environmental airways injury.
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Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.
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Tissue-specific genotype-phenotype correlations among USH2A-related disorders in the RUSH2A study.
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Tissue-specific, temporal changes in cell adhesion to echinonectin in the sea urchin embryo.
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Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.
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Transcriptional regulation of matrix gla protein.
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Urea as a passive transport marker for arthritis biomarker studies.
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VALIDATION OF A DEEP LEARNING-BASED ALGORITHM FOR SEGMENTATION OF THE ELLIPSOID ZONE ON OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AN USH2A-RELATED RETINAL DEGENERATION CLINICAL TRIAL.
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Variation in osteoarthritis biomarkers from activity not food consumption.
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Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials.
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Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells.
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Vibratory loading decreases extracellular matrix and matrix metalloproteinase gene expression in rabbit annulus cells.
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Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation.
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[Experimental approaches for gene therapy modification of vascular remodeling].
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hapln1 Defines an Epicardial Cell Subpopulation Required for Cardiomyocyte Expansion During Heart Morphogenesis and Regeneration.
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