Extracellular Matrix Proteins

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  Subject Areas on Research

  • A complete algorithm to resolve ambiguity for intersubunit NOE assignment in structure determination of symmetric homo-oligomers. 
  • A mutation in cartilage oligomeric matrix protein (COMP) causes early-onset osteoarthritis in a large kindred study. 
  • A novel alternative splice domain in zebrafish tenascin-C. 
  • A novel fibrotic disorder associated with increased dermal fibroblast proliferation and downregulation of genes of the microfibrillar network. 
  • Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. 
  • Accumulation of beta ig-h3 gene product in corneas with granular dystrophy. 
  • Advances in bioengineered conduits for peripheral nerve regeneration. 
  • Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. 
  • Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells. 
  • Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. 
  • Altered synthesis of cartilage-specific proteoglycans by mutant human cartilage oligomeric matrix protein. 
  • Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. 
  • Analysis of the RELN gene as a genetic risk factor for autism. 
  • Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. 
  • Ascorbic acid promotes extracellular matrix deposition while preserving valve interstitial cell quiescence within 3D hydrogel scaffolds. 
  • Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. 
  • Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. 
  • Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Astrocytes refine cortical connectivity at dendritic spines. 
  • Atypical asymmetric lattice corneal dystrophy associated with a novel homozygous mutation (Val624Met) in the TGFBI gene. 
  • BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. 
  • Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin. 
  • Beta ig-h3 is synthesized by corneal epithelium and perhaps endotheliumin Fuchs' dystrophic corneas. 
  • Biaxial strain effects on cells from the inner and outer regions of the meniscus. 
  • Biology of aortic aneurysms and dissections. 
  • Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study. 
  • Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms? 
  • CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. 
  • Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. 
  • Caught in the matrix: how vitronectin controls neuronal differentiation. 
  • Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. 
  • Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Cell- and heparin-binding domains of the hexabrachion arm identified by tenascin expression proteins. 
  • Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. 
  • Characteristic features of granular deposit formation in granular corneal dystrophy type 2. 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro. 
  • Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction. 
  • Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix. 
  • Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. 
  • Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression. 
  • Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan. 
  • Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene. 
  • Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. 
  • Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc. 
  • Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern. 
  • Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. 
  • Deployment of extracellular matrix proteins in sea urchin embryogenesis. 
  • Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al. 
  • Different G(i)-coupled chemoattractant receptors signal qualitatively different functions in human neutrophils. 
  • Differential effects of static and dynamic compression on meniscal cell gene expression. 
  • Differential expression and processing of transforming growth factor beta induced protein (TGFBIp) in the normal human cornea during postnatal development and aging. 
  • Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse. 
  • Differential response and withdrawal profile of glucocorticoid-treated human trabecular meshwork cells. 
  • Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. 
  • Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma. 
  • Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. 
  • Double mutant fibrillin-1 (FBN1) allele in a patient with neonatal Marfan syndrome. 
  • Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse. 
  • Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome. 
  • Ectoderm cell--ECM interaction is essential for sea urchin embryo skeletogenesis. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Elucidating the Molecular Composition of Cartilage by Proteomics. 
  • Endo16 is required for gastrulation in the sea urchin Lytechinus variegatus. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Epithelial cells are an important source of tenascin in normal and malignant human breast tissue. 
  • Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. 
  • Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene. 
  • Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Exacerbation of Avellino corneal dystrophy after laser in situ keratomileusis. 
  • Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia. 
  • Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer. 
  • Extremely varied phenotypes in granular corneal dystrophy type 2 heterozygotes. 
  • FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development. 
  • Fibril Core of Transforming Growth Factor Beta-Induced Protein (TGFBIp) Facilitates Aggregation of Corneal TGFBIp. 
  • Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. 
  • Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment. 
  • Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. 
  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin. 
  • Focus on molecules: Transforming growth factor beta induced protein (TGFBIp). 
  • Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation. 
  • Gene expression studies in leiomyomata: new directions for research. 
  • Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. 
  • Genetic basis of murine responses to hyperoxia-induced lung injury. 
  • Genetic comparisons yield insight into the evolution of enamel thickness during human evolution. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. 
  • Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family. 
  • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. 
  • Global analysis of gene expression in renal ischemia-reperfusion in the mouse. 
  • HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Human phenotypically distinct TGFBI corneal dystrophies are linked to the stability of the fourth FAS1 domain of TGFBIp. 
  • Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. 
  • Identification of genes expressed in a human scleral cDNA library. 
  • Identification of the promoter region of the human betaIGH3 gene. 
  • Immunolocalization of beta ig-h3 protein in 5q31-linked corneal dystrophies and normal corneas. 
  • Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate. 
  • Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. 
  • Influence of cell surface hydrophobicity on attachment of Candida albicans to extracellular matrix proteins. 
  • Influence of discrete and continuous culture conditions on human mesenchymal stem cell lineage choice in RGD concentration gradient hydrogels. 
  • Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. 
  • Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. 
  • Interaction of human mesenchymal stem cells with disc cells: changes in extracellular matrix biosynthesis. 
  • Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-β1 in airway fibroblasts in asthma. 
  • Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture. 
  • Intracellular calcium transients are necessary for platelet-derived growth factor but not extracellular matrix protein-induced vascular smooth muscle cell migration. 
  • Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels. 
  • Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. 
  • Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13. 
  • LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp). 
  • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 
  • Localization of tenascin in uterine sarcomas and partially transformed endometrial stromal cells. 
  • Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces. 
  • Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer. 
  • Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. 
  • Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. 
  • Matrix protein gene expression in intervertebral disc cells subjected to altered osmolarity. 
  • Matrix regulation of lung injury, inflammation, and repair: the role of innate immunity. 
  • Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. 
  • Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. 
  • Microarray analysis of gene expression in human donor sclera. 
  • Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. 
  • Modification of surfaces with cell adhesion peptides alters extracellular matrix deposition. 
  • Molecular phenotypes of notochordal cells purified from immature nucleus pulposus. 
  • Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA. 
  • More than skin deep: connecting melanocyte pigmentation and angiogenic diseases. 
  • Mouse models of diabetic nephropathy. 
  • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. 
  • Multiplex protein analysis to determine fibrosis stage and progression in patients with chronic hepatitis C. 
  • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. 
  • Mutation in transforming growth factor beta induced protein associated with granular corneal dystrophy type 1 reduces the proteolytic susceptibility through local structural stabilization. 
  • Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T. 
  • Need radioprotection? A MEPE/OF45 mimetic may do the job. 
  • Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. 
  • Nucleus pulposus cell-matrix interactions with laminins. 
  • PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Pattern recognition molecule mindin promotes intranasal clearance of influenza viruses. 
  • Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. 
  • Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. 
  • Protein markers and differentiation in culture for Schlemm's canal endothelial cells. 
  • Protein modification by deamidation indicates variations in joint extracellular matrix turnover. 
  • Proteomics of Fuchs' endothelial corneal dystrophy support that the extracellular matrix of Descemet's membrane is disordered. 
  • Purification, crystallization and preliminary X-ray diffraction of wild-type and mutant recombinant human transforming growth factor beta-induced protein (TGFBIp). 
  • Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. 
  • Rapid epithelialisation of fetal wounds is associated with the early deposition of tenascin. 
  • Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. 
  • Reelin signals survival through Src-family kinases that inactivate BAD activity. 
  • Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. 
  • Response of zonal chondrocytes to extracellular matrix-hydrogels. 
  • Role of hypoxia in inflammatory upper airway disease. 
  • Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. 
  • SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation. 
  • Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. 
  • Serine protease HtrA1 accumulates in corneal transforming growth factor beta induced protein (TGFBIp) amyloid deposits. 
  • Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis. 
  • Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology. 
  • Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project. 
  • Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis. 
  • Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis. 
  • Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. 
  • Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. 
  • Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. 
  • Specific binding of urinary-type plasminogen activator (u-PA) to vitronectin and its role in mediating u-PA-dependent adhesion of U937 cells. 
  • Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter. 
  • Static compression induces zonal-specific changes in gene expression for extracellular matrix and cytoskeletal proteins in intervertebral disc cells in vitro. 
  • Structural organization of the human insulin receptor ectodomain. 
  • Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. 
  • TGF-beta regulates expression of tenascin alternative-splicing isoforms in fetal rat lung. 
  • TGFBI gene mutations in corneal dystrophies. 
  • Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells. 
  • Tenascin expression in human glioma cell lines and normal tissues. 
  • Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. 
  • Tenascin is induced at implantation sites in the mouse uterus and interferes with epithelial cell adhesion. 
  • Tenascin knockout mice: barrels, boundary molecules, and glial scars. 
  • Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis. 
  • Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments. 
  • Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. 
  • The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue. 
  • The Haemophilus influenzae Hap autotransporter binds to fibronectin, laminin, and collagen IV. 
  • The IL-1 type 1 receptor is required for the development of LPS-induced airways disease. 
  • The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. 
  • The extracellular matrix protein agrin promotes heart regeneration in mice. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. 
  • The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. 
  • The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. 
  • The insoluble TGFBIp fraction of the cornea is covalently linked via a disulfide bond to type XII collagen. 
  • The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis. 
  • The micro-mechanics of single molecules studied with atomic force microscopy. 
  • The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons. 
  • The role of electrospinning in the emerging field of nanomedicine. 
  • The role of integrins in saphenous vein vascular smooth muscle cell migration. 
  • The role of the extracellular matrix protein mindin in airway response to environmental airways injury. 
  • Thousands of human mobile element fragments undergo strong purifying selection near developmental genes. 
  • Tissue-specific, temporal changes in cell adhesion to echinonectin in the sea urchin embryo. 
  • Transforming growth factor beta induced protein accumulation in granular corneal dystrophy type III (Reis-Bücklers dystrophy). Identification by mass spectrometry in 15 year old two-dimensional protein gels. 
  • Two mutations in the TGFBI (BIGH3) gene associated with lattice corneal dystrophy in an extensively studied family. 
  • Urea as a passive transport marker for arthritis biomarker studies. 
  • Variation in osteoarthritis biomarkers from activity not food consumption. 
  • Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials. 
  • Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. 
  • Vibratory loading decreases extracellular matrix and matrix metalloproteinase gene expression in rabbit annulus cells. 
  • Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation. 
  • [Experimental approaches for gene therapy modification of vascular remodeling]. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Liton, Paloma Borrajo, Associate Professor in Ophthalmology, Pathology
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship