Sp1 Transcription Factor

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  Subject Areas on Research

  • A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. 
  • A human gamma globin gene variant binds SP1. 
  • A naturally occurring gamma globin gene mutation enhances SP1 binding activity. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer. 
  • ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. 
  • Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1. 
  • An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. 
  • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. 
  • Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma. 
  • Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. 
  • Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation. 
  • Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2. 
  • Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • Heterogeneous nuclear ribonucleoprotein K is a transcription factor. 
  • Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • RB regulates transcription of the p21/WAF1/CIP1 gene. 
  • Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites. 
  • Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. 
  • Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells. 
  • Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. 
  • Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. 
  • Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat. 
  • Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites. 
  • The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. 
  • Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. 
  • Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. 
  • Transcriptional regulation of N-acetylglutamate synthase. 
  • Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region. 
  • Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. 
  • Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells. 
  • UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. 
  • c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.