Frail Elderly

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  Subject Areas on Research

  • A Cumulative Deficit Laboratory Test-based Frailty Index: Personal and Neighborhood Associations. 
  • A Novel Adaptation of the HOME Inventory for Elders: The Importance of the Home Environment Across the Life Course. 
  • A Simplified Approach for Classifying Physical Resilience among Community-Dwelling Older Adults: The Health, Aging, and Body Composition Study. 
  • A controlled trial of geriatric evaluation. 
  • A controlled trial of inpatient and outpatient geriatric evaluation and management. 
  • A duality in aging: the equivalence of mortality models based on radically different concepts. 
  • A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus. 
  • A pilot study of partial unweighted treadmill training in mobility-impaired older adults. 
  • A team approach: comprehensive evaluation for functional decline in older patients. 
  • Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity. 
  • Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty. 
  • Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 
  • Anemia in the elderly: clinical impact and practical diagnosis. 
  • Application of assessing care of vulnerable elders-3 quality indicators to patients with advanced dementia and poor prognosis. 
  • Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample. 
  • Association of Frailty With Recovery From Disability Among Community-Dwelling Older Adults: Results From Two Large U.S. Cohorts. 
  • Association of Frailty with recovery from disability among community-dwelling Chinese older adults: China health and retirement longitudinal study. 
  • Association of Hearing Impairment With Incident Frailty and Falls in Older Adults. 
  • Association of a cancer diagnosis with vulnerability and frailty in older Medicare beneficiaries. 
  • Association of adverse drug reactions with drug-drug and drug-disease interactions in frail older outpatients. 
  • Associations of Body Mass Index and Waist Circumference with 3-Year All-Cause Mortality Among the Oldest Old: Evidence from a Chinese Community-Based Prospective Cohort Study. 
  • Attitudes of elderly patients and their families toward physician-assisted suicide. 
  • Biological, clinical, and psychosocial correlates at the interface of cancer and aging research. 
  • Blood Pressure, Antihypertensive Polypharmacy, Frailty, and Risk for Serious Fall Injuries Among Older Treated Adults With Hypertension. 
  • Breaking the cycle of functional decline in older dialysis patients. 
  • Caring for frail older adults: a theoretical and methodological agenda. 
  • Case management decision making: goal transformation through discretion and client interpretation. 
  • Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. 
  • Clinical Frailty Scale classes are independently associated with 6-month mortality for patients after acute myocardial infarction. 
  • Clinical update on nursing home medicine: 2014. 
  • Clinically important drug-disease interactions and their prevalence in older adults. 
  • Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. 
  • Comparison of Frequency of Frailty and Severely Impaired Physical Function in Patients ≥60 Years Hospitalized With Acute Decompensated Heart Failure Versus Chronic Stable Heart Failure With Reduced and Preserved Left Ventricular Ejection Fraction. 
  • Comparison of methods for detecting potential adverse drug events in frail elderly inpatients and outpatients. 
  • Complexity theory: a long-term care specialty practice exemplar for the education of advanced practice nurses. 
  • Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist. 
  • Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. 
  • Cumulative index of health deficiencies as a characteristic of long life. 
  • Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study. 
  • Dementia caregiver interventions in Chinese people: A systematic review. 
  • Depression in hospitalized older patients with congestive heart failure. 
  • Depressive symptoms among informal caregivers of older adults: insights from the Singapore Survey on Informal Caregiving. 
  • Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US Task Force recommendations. 
  • Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. 
  • Development of a Metastatic Spinal Tumor Frailty Index (MSTFI) Using a Nationwide Database and Its Association with Inpatient Morbidity, Mortality, and Length of Stay After Spine Surgery. 
  • Development, Construct Validity, and Predictive Validity of a Continuous Frailty Scale: Results From 2 Large US Cohorts. 
  • Disability and frailty among elderly Canadians: a comparison of six surveys. 
  • Does assistive technology substitute for personal assistance among the disabled elderly? 
  • Drug discovery and development for ageing: opportunities and challenges. 
  • Drug use management in board and care facilities. 
  • Dynamics of functional impairment in late adulthood. 
  • Effect of telephone exercise counseling on frailty in older veterans: project LIFE. 
  • Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. 
  • Effects of muscle strength training and testosterone in frail elderly males. 
  • Epidemiology of chronic kidney disease among older adults: a focus on the oldest old. 
  • Evaluation of two frailty indices, with practical application in a vaccine clinical trial. 
  • Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults. 
  • Exercise training and nutritional supplementation for physical frailty in very elderly people. 
  • Factors associated with suboptimal analgesic use in community-dwelling elderly. 
  • Feasibility and Functional Testing for Frailty in Chronic Kidney Disease. 
  • Forecasts of active life expectancy: policy and fiscal implications. 
  • Frailty Assessment in Hospitalized Older Adults Using the Electronic Health Record. 
  • Frailty and Clinical Outcomes in Chronic Obstructive Pulmonary Disease. 
  • Frailty and aging-associated syndromes in lung transplant candidates and recipients. 
  • Frailty and health-related quality of life in older women with breast cancer. 
  • Frailty and its potential relevance to cardiovascular care. 
  • Frailty and length of stay in older adults with blunt injury in a national multicentre prospective cohort study. 
  • Frailty and mortality among Chinese at advanced ages. 
  • Frailty and muscle metabolism dysregulation in the elderly. 
  • Frailty and risk in proximal aortic surgery. 
  • Frailty and sarcopenia: definitions and outcome parameters. 
  • Frailty and type of death among older adults in China: prospective cohort study. 
  • Frailty as a Risk Predictor of Morbidity and Mortality Following Liver Surgery. 
  • Frailty as an instrument for evaluation of elderly patients with non-ST-segment elevation myocardial infarction: A follow-up after more than 5 years. 
  • Frailty as a predictor of all-cause mortality and readmission in older patients with acute coronary syndrome : A systematic review and meta-analysis. 
  • Frailty assessment in the cardiovascular care of older adults. 
  • Frailty is associated with worse outcomes in non-ST-segment elevation acute coronary syndromes: Insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial. 
  • Frailty predicts some but not all adverse outcomes in older adults discharged from the emergency department. 
  • Frailty thy name is ... Phrailty? 
  • Frailty, core muscle size, and mortality in patients undergoing open abdominal aortic aneurysm repair. 
  • Frailty: A Vital Sign for Older Adults With Cardiovascular Disease. 
  • From Hospital to Home: Impact of Transitional Care on Cost, Hospitalisation and Mortality. 
  • Functional decline in older adults. 
  • Functional disability, disability transitions, and depressive symptoms in late life. 
  • Functional outcomes for clinical trials in frail older persons: time to be moving. 
  • Futility, benefit, and transcatheter aortic valve replacement. 
  • Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. 
  • Geriatric assessment with management in cancer care: Current evidence and potential mechanisms for future research. 
  • Geriatric evaluation and management units in the care of the frail elderly cancer patient. 
  • Getting meaningful informed consent from older adults: a structured literature review of empirical research. 
  • Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research. 
  • Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival. 
  • Health Services Use and Functional Recovery Following Blunt Trauma in Older Persons - A National Multicentre Prospective Cohort Study. 
  • Health and social care of home-dwelling frail older adults in Switzerland: a mixed methods study. 
  • High prevalence of geriatric syndromes in older adults. 
  • Higher dietary variety is associated with better nutritional status in frail elderly people. 
  • Hip Fracture in the Elderly Patients: A Sentinel Event. 
  • Hospital stressors experienced by elderly medical inpatients: developing a Hospital Stress Index. 
  • How long can humans live? Lower bound for biological limit of human longevity calculated from Danish twin data using correlated frailty model. 
  • Identifying frailty in hospitalized older adults with significant coronary artery disease. 
  • Identifying the frailty phenotype: The evidence for good enough. 
  • If the Patient Is Frail, Emergency Abdominal Surgery Is High Risk. 
  • Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people. 
  • Implementation of Vulnerable Elders Survey-13 Frailty Tool to Identify At-Risk Geriatric Surgical Patients. 
  • Improved Function With Enhanced Protein Intake per Meal: A Pilot Study of Weight Reduction in Frail, Obese Older Adults. 
  • In search of the underlying mechanisms of frailty. 
  • Inappropriate medication use among frail elderly inpatients. 
  • Incidence and predictors of all and preventable adverse drug reactions in frail elderly persons after hospital stay. 
  • Incidence of frailty among community-dwelling older adults: a nationally representative profile in China. 
  • Incorporating Geriatric Assessment into a Nephrology Clinic: Preliminary Data from Two Models of Care. 
  • Index of Healthy Aging in Chinese Older Adults: China Health and Retirement Longitudinal Study. 
  • Indications, labeling, and outcomes assessment for drugs aimed at improving functional status in older persons: a conversation between aging researchers and FDA regulators. 
  • Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study. 
  • Influence of Weight Reduction and Enhanced Protein Intake on Biomarkers of Inflammation in Older Adults with Obesity. 
  • Informal and formal care infrastructure and perceived need for caregiver training for frail US veterans referred to home and community-based services. 
  • Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. 
  • Integrating Frailty Research into the Medical Specialties-Report from a U13 Conference. 
  • Intergroup LEAP trial (S1612): A randomized phase 2/3 platform trial to test novel therapeutics in medically less fit older adults with acute myeloid leukemia. 
  • Interventions Against Disability in Frail Older Adults: Lessons Learned from Clinical Trials. 
  • Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review. 
  • Interventions to improve transitional care between nursing homes and hospitals: a systematic review. 
  • Issues related to using a short-form of the Center for Epidemiological Studies-Depression Scale. 
  • Just for Us: an academic medical center-community partnership to maintain the health of a frail low-income senior population. 
  • Just for Us: in-home care for frail elderly and disabled individuals with low incomes. 
  • Leading the Way in Exercise and Diet (Project LEAD): intervening to improve function among older breast and prostate cancer survivors. 
  • Local Anesthesia is Associated with Fewer Complications in Umbilical Hernia Repair in Frail Veterans. 
  • Long-term care, Medicaid, and impoverishment of the elderly. 
  • Management of osteoporosis among home health and long-term care patients with a prior fracture. 
  • Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. 
  • Multisystem physiological perspective of human frailty and its modulation by physical activity. 
  • New developments in geriatric surgery. 
  • New light on an age-old issue. 
  • Nutritional risk predicts quality of life in elderly community-living Canadians. 
  • Obesity Interventions for Older Adults: Diet as a Determinant of Physical Function. 
  • Obesity and physical frailty in older adults: a scoping review of lifestyle intervention trials. 
  • Osteoporosis considerations in the frail elderly. 
  • Patients' time in therapeutic range on warfarin among US patients with atrial fibrillation: Results from ORBIT-AF registry. 
  • Patterns and health effects of caring for people with dementia: the impact of changing cognitive and residential status. 
  • Perioperative frailty: lessons learned and future directions. 
  • Perspective: Dietary protein needs of elderly people: protein supplementation as an effective strategy to counteract sarcopenia. 
  • Physical Rehabilitation for Older Patients Hospitalized for Heart Failure. 
  • Physical Resilience: Not Simply the Opposite of Frailty. 
  • Physical activity as a preventative factor for frailty: the health, aging, and body composition study. 
  • Physical fitness and functional limitations in community-dwelling older adults. 
  • Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions. 
  • Plasma hypertonicity: another marker of frailty? 
  • Potential drug-disease interactions in frail, hospitalized elderly veterans. 
  • Preexisting frailty and outcomes in older patients with acute myocardial infarction. 
  • Preoperative Cognitive Impairment As a Predictor of Postoperative Outcomes in a Collaborative Care Model. 
  • Preoperative Frailty Increases Risk of Nonhome Discharge after Elective Vascular Surgery in Home-Dwelling Patients. 
  • Prevalence and Correlates of Frailty Among Community-Dwelling Chinese Older Adults: The China Health and Retirement Longitudinal Study. 
  • Project LIFE: a partnership to increase physical activity in elders with multiple chronic illnesses. 
  • Protocol for a mixed methods feasibility and implementation study of a community-based integrated care model for home-dwelling older adults: The INSPIRE project. 
  • Rapid assessment of rehabilitation options for functional disability. 
  • Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty. 
  • Recombinant Zoster Vaccine Is Efficacious and Safe in Frail Individuals. 
  • Reducing frailty and falls in older persons: an investigation of Tai Chi and computerized balance training. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies of Intervention Techniques. 
  • Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale. 
  • Relationship between persistent pain and 5-year mortality: a population-based prospective cohort study. 
  • Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women. 
  • Religious coping in the nursing home: a biopsychosocial model. 
  • Reported activities of daily living: agreement between elderly subjects with and without dementia and their caregivers. 
  • Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study. 
  • Role of frailty in patients with cardiovascular disease. 
  • Secondary stroke prevention strategies for the oldest patients: possibilities and challenges. 
  • Senior adult oncology clinical practice guidelines in oncology. 
  • Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study. 
  • Smaller orbital frontal cortex volumes associated with functional disability in depressed elders. 
  • Spiritual considerations in suicide and depression among the elderly. 
  • Symptoms of depression among community-dwelling elderly African-American and white older adults. 
  • The Association between Frailty and Healthcare Expenditure among Chinese Older Adults. 
  • The Association of Frailty With In-Hospital Bleeding Among Older Adults With Acute Myocardial Infarction: Insights From the ACTION Registry. 
  • The Boston FICSIT study: the effects of resistance training and nutritional supplementation on physical frailty in the oldest old. 
  • The Effect and Relationship of Frailty Indices on Survival After Transcatheter Aortic Valve Replacement. 
  • The Oldest Old: A National Analysis of Outcomes for Patients 90 Years or Older With Lung Cancer. 
  • The heritability of mortality due to heart diseases: a correlated frailty model applied to Danish twins. 
  • The impact of functional dependency on outcomes after complex general and vascular surgery. 
  • The relative importance of strength and balance in chair rise by functionally impaired older individuals. 
  • The role of strength in rising from a chair in the functionally impaired elderly. 
  • Therapeutic failure-related hospitalisations in the frail elderly. 
  • Toward a threshold for subthreshold depression: an analysis of correlates of depression by severity of symptoms using data from an elderly community sample. 
  • Trajectories of impairment, social support, and depressive symptoms in later life. 
  • Transitional care from skilled nursing facilities to home: study protocol for a stepped wedge cluster randomized trial. 
  • Treatment considerations for elderly and frail patients with neuropathic pain. 
  • Underreporting of nursing home utilization on the CMS-2728 in older incident dialysis patients and implications for assessing mortality risk. 
  • Underuse of indicated medications among physically frail older US veterans at the time of hospital discharge: results of a cross-sectional analysis of data from the Geriatric Evaluation and Management Drug Study. 
  • Unnecessary drug use in frail older people at hospital discharge. 
  • Use of Functional Assessment to Define Therapeutic Goals and Treatment. 
  • Use of Medicare services before and after introduction of the prospective payment system. 
  • Using local rather than general anesthesia for inguinal hernia repair may significantly reduce complications for frail Veterans. 
  • Validating administratively derived frailty scores for use in Veterans Health Administration emergency departments. 
  • Walking speed predicts health status and hospital costs for frail elderly male veterans. 
  • Weight loss, exercise, or both and physical function in obese older adults. 
  • What does it mean to be "at nutritional risk"? Seeking clarity on behalf of the elderly. 
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  Keywords of People

  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, School of Nursing
  • Ostbye, Truls, Professor of Family Medicine and Community Health, Family Medicine and Community Health