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Subject Areas on Research
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A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency.
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A Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3.
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A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation.
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A promoter sequence variant of ZNF750 is linked with familial psoriasis.
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A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism.
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Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine.
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Adaptive evolution drives the diversification of zinc-finger binding domains.
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Adult patients with de novo acute myeloid leukemia and t(9; 11)(p22; q23) have a superior outcome to patients with other translocations involving band 11q23: a cancer and leukemia group B study.
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Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci.
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An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.
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An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia.
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An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation.
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Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes.
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Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins.
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Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus.
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Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates.
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Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1.
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Characterization of a zinc finger DNA-binding protein expressed specifically in Petunia petals and seedlings.
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Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth.
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Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases.
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Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.
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Directed evolution of recombinase specificity by split gene reassembly.
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Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
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Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex.
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Enabling functional genomics with genome engineering.
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Engineered zinc finger-activating vascular endothelial growth factor transcription factor plasmid DNA induces therapeutic angiogenesis in rabbits with hindlimb ischemia.
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Engineering Delivery Vehicles for Genome Editing.
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Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis.
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Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein.
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Evidence for the involvement of the Gli gene family in embryonic mouse lung development.
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Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors.
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Functional equivalence of an evolutionarily conserved RNA binding module.
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GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells.
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Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases.
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Genome engineering: a new approach to gene therapy for neuromuscular disorders.
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Genome engineering: the next genomic revolution.
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Highly active zinc-finger nucleases by extended modular assembly.
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Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.
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Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins.
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In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA.
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In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia.
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Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors.
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Joubert syndrome: a haplotype segregation strategy and exclusion of the zinc finger protein of cerebellum 1 (ZIC1) gene.
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LKLF: A transcriptional regulator of single-positive T cell quiescence and survival.
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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
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Light-inducible gene regulation with engineered zinc finger proteins.
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Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors.
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Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
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Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor.
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Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations.
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Mutational spectrum of the ZEB1 gene in corneal dystrophies supports a genotype-phenotype correlation.
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Nuclear protein CBP is a coactivator for the transcription factor CREB.
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Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region.
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Orthogonal site-specific protein modification by engineering reversible thiol protection mechanisms.
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Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro.
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Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin.
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Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.
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Repurposing an endogenous degradation system for rapid and targeted depletion of C. elegans proteins.
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Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence.
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Signatures of protein-DNA recognition in free DNA binding sites.
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Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.
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Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.
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Study of a US cohort supports the role of ZNF644 and high-grade myopia susceptibility.
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Synthesis of programmable integrases.
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Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.
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Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.
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The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153.
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The HDAC complex and cytoskeleton.
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The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2.
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The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.
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The unusual UBZ domain of Saccharomyces cerevisiae polymerase η.
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The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.
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Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans.
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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.
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Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins.
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Zinc finger binding motifs do not explain recombination rate variation within or between species of Drosophila.
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Zinc finger protein binding to DNA: an energy perspective using molecular dynamics simulation and free energy calculations on mutants of both zinc finger domains and their specific DNA bases.
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p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.
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Keywords of People
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Hartemink, Alexander J.,
Professor in the Department of Computer Science,
Biology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Steinbach, William J.,
Samuel L. Katz Distinguished Professor of Pediatrics,
Duke Innovation & Entrepreneurship
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Taylor, Gregory Alan,
Professor in Medicine,
Immunology